Published in EMBO J on June 10, 2004
Structure of a yeast RNase III dsRBD complex with a noncanonical RNA substrate provides new insights into binding specificity of dsRBDs. Structure (2011) 1.69
RNA sequence- and shape-dependent recognition by proteins in the ribonucleoprotein particle. EMBO Rep (2005) 1.48
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Structural domains in RNAi. FEBS Lett (2005) 0.92
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Solution structure of the Drosha double-stranded RNA-binding domain. Silence (2010) 0.86
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Post-transcriptional regulation of iron homeostasis in Saccharomyces cerevisiae. Int J Mol Sci (2013) 0.80
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RNAse III-mediated degradation of unspliced pre-mRNAs and lariat introns. Mol Cell (2003) 1.83
A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR. EMBO J (2000) 1.68
A novel family of RNA tetraloop structure forms the recognition site for Saccharomyces cerevisiae RNase III. EMBO J (2001) 1.43
Evaluation of the RNA determinants for bacterial and yeast RNase III binding and cleavage. J Biol Chem (2003) 1.19
The N-terminal domain that distinguishes yeast from bacterial RNase III contains a dimerization signal required for efficient double-stranded RNA cleavage. Mol Cell Biol (2000) 1.19
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Solution structure of conserved AGNN tetraloops: insights into Rnt1p RNA processing. EMBO J (2001) 1.06
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A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. J Am Chem Soc (2002) 0.94
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A physical interaction between Gar1p and Rnt1pi is required for the nuclear import of H/ACA small nucleolar RNA-associated proteins. Mol Cell Biol (2002) 0.91
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Thirty-three years later, a glimpse at the ribonuclease III active site. Mol Cell (2001) 0.84
On the computation of structure factors by FFT techniques. Acta Crystallogr A (2002) 0.82
A high-resolution structure of a DNA-chromomycin-Co(II) complex determined from pseudocontact shifts in nuclear magnetic resonance. Structure (2000) 0.81
Design of a novel globular protein fold with atomic-level accuracy. Science (2003) 13.06
An RNA gene expressed during cortical development evolved rapidly in humans. Nature (2006) 7.23
Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays. Science (2002) 6.52
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev (2007) 5.83
RNA-binding proteins: modular design for efficient function. Nat Rev Mol Cell Biol (2007) 5.33
Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay. Genes Dev (2007) 4.75
Unusual intron conservation near tissue-regulated exons found by splicing microarrays. PLoS Comput Biol (2006) 4.63
Accumulation of unstable promoter-associated transcripts upon loss of the nuclear exosome subunit Rrp6p in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2006) 3.49
Detection and measurement of alternative splicing using splicing-sensitive microarrays. Methods (2005) 3.21
Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy. Nat Struct Mol Biol (2010) 3.07
Gene structure-based splice variant deconvolution using a microarray platform. Bioinformatics (2003) 2.97
Genome-wide searching for pseudouridylation guide snoRNAs: analysis of the Saccharomyces cerevisiae genome. Nucleic Acids Res (2004) 2.94
Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins. Cell Rep (2012) 2.76
The structure and function of small nucleolar ribonucleoproteins. Nucleic Acids Res (2007) 2.50
Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae. RNA (2003) 2.36
Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution. PLoS One (2011) 2.29
Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA. J Am Chem Soc (2008) 2.26
The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain. Nat Genet (2011) 2.10
Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein. EMBO J (2003) 2.01
Purification of RNA using TRIzol (TRI reagent). Cold Spring Harb Protoc (2010) 1.89
Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase. Nat Struct Mol Biol (2009) 1.88
Exploring functional relationships between components of the gene expression machinery. Nat Struct Mol Biol (2005) 1.87
Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy. Neuron (2012) 1.78
Protein families and RNA recognition. FEBS J (2005) 1.65
Prp43p is a DEAH-box spliceosome disassembly factor essential for ribosome biogenesis. Mol Cell Biol (2006) 1.64
Zinc induces structural reorganization of gelatin binding domain from human fibronectin and affects collagen binding. Structure (2010) 1.63
Competition between pre-mRNAs for the splicing machinery drives global regulation of splicing. Mol Cell (2013) 1.62
Ssu72 is a phosphatase essential for transcription termination of snoRNAs and specific mRNAs in yeast. EMBO J (2003) 1.59
Genome-wide analysis reveals SR protein cooperation and competition in regulated splicing. Mol Cell (2013) 1.56
Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing. Genes Dev (2007) 1.53
The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. Nat Struct Mol Biol (2005) 1.52
Polyacrylamide gel electrophoresis of RNA. Cold Spring Harb Protoc (2010) 1.51
High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design. J Mol Biol (2006) 1.49
Structure of stem-loop IV of Tetrahymena telomerase RNA. EMBO J (2006) 1.49
Thermodynamic analysis of ligand binding and ligand binding-induced tertiary structure formation by the thiamine pyrophosphate riboswitch. RNA (2009) 1.48
The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Genes Dev (2012) 1.48
Competencies: a cure for pre-med curriculum. Science (2011) 1.47
The highly cooperative folding of small naturally occurring proteins is likely the result of natural selection. Cell (2007) 1.46
ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA. Proc Natl Acad Sci U S A (2003) 1.43
Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis. RNA (2007) 1.40
Structure of hepatitis C virus polymerase in complex with primer-template RNA. J Virol (2012) 1.39
Structure of yeast Dom34: a protein related to translation termination factor Erf1 and involved in No-Go decay. J Biol Chem (2008) 1.39
Sam68 regulates a set of alternatively spliced exons during neurogenesis. Mol Cell Biol (2008) 1.38
High-throughput protein production and purification at the Seattle Structural Genomics Center for Infectious Disease. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 1.37
Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots". J Mol Biol (2004) 1.37
Prp43p contains a processive helicase structural architecture with a specific regulatory domain. EMBO J (2010) 1.36
An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro. Nucleic Acids Res (2007) 1.36
Removal of a single alpha-tubulin gene intron suppresses cell cycle arrest phenotypes of splicing factor mutations in Saccharomyces cerevisiae. Mol Cell Biol (2002) 1.36
Structural basis for specific, high-affinity tetracycline binding by an in vitro evolved aptamer and artificial riboswitch. Chem Biol (2008) 1.35
The structure of a rigorously conserved RNA element within the SARS virus genome. PLoS Biol (2004) 1.35
Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein. Proc Natl Acad Sci U S A (2009) 1.33
Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain. Nat Struct Mol Biol (2010) 1.32
Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX. J Biol Chem (2006) 1.31
A conserved RNA structure within the HCV IRES eIF3-binding site. Nat Struct Biol (2002) 1.31
Structural inhibition of the colicin D tRNase by the tRNA-mimicking immunity protein. EMBO J (2004) 1.31
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets. Proc Natl Acad Sci U S A (2012) 1.28
An all-atom, distance-dependent scoring function for the prediction of protein-DNA interactions from structure. Proteins (2007) 1.28
Structural genomics of infectious disease drug targets: the SSGCID. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 1.27
A new hydrogen-bonding potential for the design of protein-RNA interactions predicts specific contacts and discriminates decoys. Nucleic Acids Res (2004) 1.27
A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins. FEBS J (2007) 1.26
The C-terminal domain of the bacterial SSB protein acts as a DNA maintenance hub at active chromosome replication forks. PLoS Genet (2010) 1.24
NMR studies of dynamics in RNA and DNA by 13C relaxation. Biopolymers (2007) 1.24
SAD phasing using iodide ions in a high-throughput structural genomics environment. J Struct Funct Genomics (2011) 1.23
Combining functional and structural genomics to sample the essential Burkholderia structome. PLoS One (2013) 1.21
Nanometer distance measurements on RNA using PELDOR. J Am Chem Soc (2003) 1.21
Searching yeast intron data at Ares lab Web site. Methods Enzymol (2002) 1.21
Cell type and culture condition-dependent alternative splicing in human breast cancer cells revealed by splicing-sensitive microarrays. Cancer Res (2006) 1.21
Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex. EMBO J (2008) 1.21
Crystal structure of the yeast Phox homology (PX) domain protein Grd19p complexed to phosphatidylinositol-3-phosphate. J Biol Chem (2003) 1.20
Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs. Nucleic Acids Res (2011) 1.20
Structure-guided peptidomimetic design leads to nanomolar beta-hairpin inhibitors of the Tat-TAR interaction of bovine immunodeficiency virus. Biochemistry (2007) 1.20
How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape. Nucleic Acids Res (2009) 1.20
The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3'-end processing. J Biol Chem (2006) 1.20
HalX: an open-source LIMS (Laboratory Information Management System) for small- to large-scale laboratories. Acta Crystallogr D Biol Crystallogr (2005) 1.19
Real-time multidimensional NMR follows RNA folding with second resolution. Proc Natl Acad Sci U S A (2010) 1.18
13C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein. J Mol Biol (2005) 1.18
Hydration dependent dynamics in RNA. J Biomol NMR (2009) 1.17
Quaking and PTB control overlapping splicing regulatory networks during muscle cell differentiation. RNA (2013) 1.17
The structure of an archaeal homodimeric ligase which has RNA circularization activity. Protein Sci (2008) 1.16
Activation of the LicT transcriptional antiterminator involves a domain swing/lock mechanism provoking massive structural changes. J Biol Chem (2005) 1.15
Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity. J Biol Chem (2003) 1.15
The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. Nucleic Acids Res (2007) 1.14
Design, production and molecular structure of a new family of artificial alpha-helicoidal repeat proteins (αRep) based on thermostable HEAT-like repeats. J Mol Biol (2010) 1.13
Dissection of Dom34-Hbs1 reveals independent functions in two RNA quality control pathways. Nat Struct Mol Biol (2010) 1.12