Published in Nat Struct Mol Biol on November 15, 2005
Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10. Hum Mol Genet (2007) 2.61
The structure and function of small nucleolar ribonucleoproteins. Nucleic Acids Res (2007) 2.50
Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita. Proc Natl Acad Sci U S A (2008) 2.37
A core-attachment based method to detect protein complexes in PPI networks. BMC Bioinformatics (2009) 2.10
rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells. Mol Cell (2011) 1.61
Structure of H/ACA RNP protein Nhp2p reveals cis/trans isomerization of a conserved proline at the RNA and Nop10 binding interface. J Mol Biol (2011) 1.53
The genetics of dyskeratosis congenita. Cancer Genet (2011) 1.50
It all comes together at the ends: telomerase structure, function, and biogenesis. Mutat Res (2011) 1.36
Crystal structure determination and site-directed mutagenesis of the Pyrococcus abyssi aCBF5-aNOP10 complex reveal crucial roles of the C-terminal domains of both proteins in H/ACA sRNP activity. Nucleic Acids Res (2006) 1.24
hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase. RNA (2006) 1.24
The box H/ACA ribonucleoprotein complex: interplay of RNA and protein structures in post-transcriptional RNA modification. J Biol Chem (2009) 1.21
RNA pseudouridylation: new insights into an old modification. Trends Biochem Sci (2013) 1.20
H/ACA small nucleolar RNA pseudouridylation pockets bind substrate RNA to form three-way junctions that position the target U for modification. Proc Natl Acad Sci U S A (2007) 1.19
Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA. Nat Struct Mol Biol (2009) 1.17
How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA. Mol Cell (2007) 1.15
Formation of the conserved pseudouridine at position 55 in archaeal tRNA. Nucleic Acids Res (2006) 1.15
Cotranscriptional recognition of human intronic box H/ACA snoRNAs occurs in a splicing-independent manner. Mol Cell Biol (2006) 1.11
Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase. Genes Dev (2011) 1.08
How a single protein complex accommodates many different H/ACA RNAs. Trends Biochem Sci (2006) 1.06
Combined in silico and experimental identification of the Pyrococcus abyssi H/ACA sRNAs and their target sites in ribosomal RNAs. Nucleic Acids Res (2008) 1.04
Dynamic association and localization of human H/ACA RNP proteins. RNA (2006) 1.01
H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation. Cell Rep (2013) 1.01
Identification of determinants in the protein partners aCBF5 and aNOP10 necessary for the tRNA:Psi55-synthase and RNA-guided RNA:Psi-synthase activities. Nucleic Acids Res (2007) 0.99
Unveiling substrate RNA binding to H/ACA RNPs: one side fits all. Curr Opin Struct Biol (2008) 0.97
Pathogenic NAP57 mutations decrease ribonucleoprotein assembly in dyskeratosis congenita. Hum Mol Genet (2009) 0.95
Genomic context analysis in Archaea suggests previously unrecognized links between DNA replication and translation. Genome Biol (2008) 0.94
Long-distance placement of substrate RNA by H/ACA proteins. RNA (2008) 0.91
Genetic Variations in Telomere Maintenance, with Implications on Tissue Renewal Capacity and Chronic Disease Pathologies. Curr Pharmacogenomics Person Med (2010) 0.87
RNA-guided isomerization of uridine to pseudouridine--pseudouridylation. RNA Biol (2014) 0.87
Structures of ribonucleoprotein particle modification enzymes. Q Rev Biophys (2010) 0.86
Analysis of the binding of the N-terminal conserved domain of yeast Cbf5p to a box H/ACA snoRNA. RNA (2006) 0.86
The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells. Elife (2014) 0.85
Different mechanisms for pseudouridine formation in yeast 5S and 5.8S rRNAs. Mol Cell Biol (2008) 0.84
Archaeal proteins Nop10 and Gar1 increase the catalytic activity of Cbf5 in pseudouridylating tRNA. Sci Rep (2012) 0.83
Evolutionary perspectives of telomerase RNA structure and function. RNA Biol (2016) 0.83
Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease. Wiley Interdiscip Rev RNA (2014) 0.83
The coding/non-coding overlapping architecture of the gene encoding the Drosophila pseudouridine synthase. BMC Mol Biol (2007) 0.82
Variable expression of Dkc1 mutations in mice. Genesis (2009) 0.81
Ribonucleoproteins in archaeal pre-rRNA processing and modification. Archaea (2013) 0.79
Insight into the Protein Components of the Box H/ACA RNP. Curr Proteomics (2008) 0.79
Accurate placement of substrate RNA by Gar1 in H/ACA RNA-guided pseudouridylation. Nucleic Acids Res (2015) 0.77
Kinetic and thermodynamic characterization of the reaction pathway of box H/ACA RNA-guided pseudouridine formation. Nucleic Acids Res (2012) 0.77
Comparative study of two box H/ACA ribonucleoprotein pseudouridine-synthases: relation between conformational dynamics of the guide RNA, enzyme assembly and activity. PLoS One (2013) 0.77
Human intron-encoded AluACA RNAs and telomerase RNA share a common element promoting RNA accumulation. RNA Biol (2016) 0.75
Structure-function relationships of archaeal Cbf5 during in vivo RNA-guided pseudouridylation. RNA (2016) 0.75
Design of a novel globular protein fold with atomic-level accuracy. Science (2003) 13.06
RNA-binding proteins: modular design for efficient function. Nat Rev Mol Cell Biol (2007) 5.33
Structural basis of glmS ribozyme activation by glucosamine-6-phosphate. Science (2006) 3.94
Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch. Nat Struct Mol Biol (2009) 3.05
Tension directly stabilizes reconstituted kinetochore-microtubule attachments. Nature (2010) 2.99
Crystal structures of the thi-box riboswitch bound to thiamine pyrophosphate analogs reveal adaptive RNA-small molecule recognition. Structure (2006) 2.85
Transition state stabilization by a catalytic RNA. Science (2002) 2.73
Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA at 1.8 A resolution. Structure (2004) 2.68
Rapid construction of empirical RNA fitness landscapes. Science (2010) 2.52
The structure and function of small nucleolar ribonucleoproteins. Nucleic Acids Res (2007) 2.50
Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA. J Am Chem Soc (2008) 2.26
Riboswitches: small-molecule recognition by gene regulatory RNAs. Curr Opin Struct Biol (2007) 2.11
Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein. EMBO J (2003) 2.01
Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase. Nat Struct Mol Biol (2009) 1.88
Pseudouridine synthases. Chem Biol (2006) 1.73
Protein families and RNA recognition. FEBS J (2005) 1.65
Idiosyncratically tuned switching behavior of riboswitch aptamer domains revealed by comparative small-angle X-ray scattering analysis. RNA (2010) 1.58
Ribozymes and riboswitches: modulation of RNA function by small molecules. Biochemistry (2010) 1.58
Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme. Nature (2008) 1.55
Riboswitches: discovery of drugs that target bacterial gene-regulatory RNAs. Acc Chem Res (2011) 1.52
High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design. J Mol Biol (2006) 1.49
Structure of stem-loop IV of Tetrahymena telomerase RNA. EMBO J (2006) 1.49
Thermodynamic analysis of ligand binding and ligand binding-induced tertiary structure formation by the thiamine pyrophosphate riboswitch. RNA (2009) 1.48
The highly cooperative folding of small naturally occurring proteins is likely the result of natural selection. Cell (2007) 1.46
Essential role of an active-site guanine in glmS ribozyme catalysis. J Am Chem Soc (2007) 1.45
Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA. Nature (2013) 1.45
Requirement of helix P2.2 and nucleotide G1 for positioning the cleavage site and cofactor of the glmS ribozyme. J Mol Biol (2007) 1.43
Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure. Mol Cell (2006) 1.42
Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots". J Mol Biol (2004) 1.37
Structural basis for specific, high-affinity tetracycline binding by an in vitro evolved aptamer and artificial riboswitch. Chem Biol (2008) 1.35
Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein. Proc Natl Acad Sci U S A (2009) 1.33
Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain. Nat Struct Mol Biol (2010) 1.32
A conserved RNA structure within the HCV IRES eIF3-binding site. Nat Struct Biol (2002) 1.31
An all-atom, distance-dependent scoring function for the prediction of protein-DNA interactions from structure. Proteins (2007) 1.28
Structural genomics of infectious disease drug targets: the SSGCID. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 1.27
A new hydrogen-bonding potential for the design of protein-RNA interactions predicts specific contacts and discriminates decoys. Nucleic Acids Res (2004) 1.27
A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins. FEBS J (2007) 1.26
NMR studies of dynamics in RNA and DNA by 13C relaxation. Biopolymers (2007) 1.24
The box H/ACA ribonucleoprotein complex: interplay of RNA and protein structures in post-transcriptional RNA modification. J Biol Chem (2009) 1.21
Structure-guided peptidomimetic design leads to nanomolar beta-hairpin inhibitors of the Tat-TAR interaction of bovine immunodeficiency virus. Biochemistry (2007) 1.20
How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape. Nucleic Acids Res (2009) 1.20
The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3'-end processing. J Biol Chem (2006) 1.20
Real-time multidimensional NMR follows RNA folding with second resolution. Proc Natl Acad Sci U S A (2010) 1.18
13C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein. J Mol Biol (2005) 1.18
Riboswitch function: flipping the switch or tuning the dimmer? RNA Biol (2010) 1.18
Hydration dependent dynamics in RNA. J Biomol NMR (2009) 1.17
YbxF and YlxQ are bacterial homologs of L7Ae and bind K-turns but not K-loops. RNA (2012) 1.16
Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation. Elife (2013) 1.15
A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III. EMBO J (2004) 1.12
Structural mimicry of retroviral tat proteins by constrained beta-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements. J Am Chem Soc (2004) 1.11
TAR RNA recognition by a cyclic peptidomimetic of Tat protein. Biochemistry (2005) 1.09
Allosteric tertiary interactions preorganize the c-di-GMP riboswitch and accelerate ligand binding. ACS Chem Biol (2012) 1.09
How arginine-rich domains coordinate mRNA maturation events. RNA Biol (2007) 1.07
Structure and stability of wild-type and mutant RNA internal loops from the SL-1 domain of the HIV-1 packaging signal. J Mol Biol (2002) 1.07
Protein and RNA dynamics play key roles in determining the specific recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein. J Mol Biol (2005) 1.07
Crystallization of the hairpin ribozyme: illustrative protocols. Methods Mol Biol (2004) 1.07
The solution structure of an essential stem-loop of human telomerase RNA. Nucleic Acids Res (2003) 1.06
Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone). Chem Biol (2009) 1.06
The structure of an enzyme-activating fragment of human telomerase RNA. RNA (2005) 1.06
Engineering RNA-binding proteins for biology. FEBS J (2013) 1.06
γ-AApeptides bind to RNA by mimicking RNA-binding proteins. Org Biomol Chem (2011) 1.06
Validation of automated docking programs for docking and database screening against RNA drug targets. J Med Chem (2004) 1.05
Solid-state deuterium NMR studies reveal micros-ns motions in the HIV-1 transactivation response RNA recognition site. J Am Chem Soc (2008) 1.05
Binding of U1A protein changes RNA dynamics as observed by 13C NMR relaxation studies. Biochemistry (2007) 1.05
AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency. EMBO Mol Med (2011) 1.05
The glmS ribozyme tunes the catalytically critical pK(a) of its coenzyme glucosamine-6-phosphate. J Am Chem Soc (2011) 1.04
Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein. Nucleic Acids Res (2010) 1.00
Novel protein-protein contacts facilitate mRNA 3'-processing signal recognition by Rna15 and Hrp1. J Mol Biol (2010) 1.00
The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p. J Mol Biol (2007) 0.99
Modulation of quaternary structure and enhancement of ligand binding by the K-turn of tandem glycine riboswitches. RNA (2012) 0.98
Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA. PLoS Pathog (2011) 0.97
Structure-guided engineering of the regioselectivity of RNA ligase ribozymes. J Am Chem Soc (2009) 0.96
High-resolution structural validation of the computational redesign of human U1A protein. Structure (2006) 0.96
Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain. Protein Sci (2005) 0.96
Design of beta-hairpin peptidomimetics that inhibit binding of alpha-helical HIV-1 Rev protein to the rev response element RNA. Angew Chem Int Ed Engl (2007) 0.95
Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA. J Med Chem (2009) 0.94
Monitoring tat peptide binding to TAR RNA by solid-state 31P-19F REDOR NMR. Nucleic Acids Res (2005) 0.94
Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase. Mol Biochem Parasitol (2006) 0.93
Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals. J Mol Biol (2007) 0.93
Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution. J Mol Biol (2006) 0.93
Advances in structural and functional analysis of membrane proteins by electron crystallography. Structure (2011) 0.91
The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. Biochem J (2011) 0.91
13C relaxation studies of the DNA target sequence for hhai methyltransferase reveal unique motional properties. Biochemistry (2008) 0.91
U1A RNA-binding domain at 1.8 A resolution. Acta Crystallogr D Biol Crystallogr (2003) 0.91
Theory of nonrigid rotational motion applied to NMR relaxation in RNA. J Phys Chem A (2011) 0.91
Electron crystallography of aquaporins. IUBMB Life (2008) 0.90
A model for C74 addition by CCA-adding enzymes: C74 addition, like C75 and A76 addition, does not involve tRNA translocation. J Biol Chem (2006) 0.89
Intermediate rate atomic trajectories of RNA by solid-state NMR spectroscopy. J Am Chem Soc (2010) 0.89
SEWAL: an open-source platform for next-generation sequence analysis and visualization. Nucleic Acids Res (2010) 0.89
Crystallization of the glmS ribozyme-riboswitch. Methods Mol Biol (2009) 0.88
The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic. Genes Dev (2011) 0.87
How a rotavirus hijacks the human protein synthesis machinery. Nat Struct Biol (2002) 0.87
Contrasting views of the internal dynamics of the HhaI methyltransferase target DNA reported by solution and solid-state NMR spectroscopy. J Am Chem Soc (2006) 0.87
Slow exchange model of nonrigid rotational motion in RNA for combined solid-state and solution NMR studies. J Phys Chem B (2010) 0.86
Solution structure of the influenza A virus cRNA promoter: implications for differential recognition of viral promoter structures by RNA-dependent RNA polymerase. Nucleic Acids Res (2003) 0.85
A small-molecule probe induces a conformation in HIV TAR RNA capable of binding drug-like fragments. J Mol Biol (2011) 0.85
Molecular dynamics simulation of the RNA complex of a double-stranded RNA-binding domain reveals dynamic features of the intermolecular interface and its hydration. Biophys J (2002) 0.85