Published in J Biol Chem on April 08, 2002
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell (2009) 5.34
Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev Cell (2007) 4.39
Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell (2010) 4.25
Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet (2004) 3.21
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proc Natl Acad Sci U S A (2007) 3.20
The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol (2003) 3.06
Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis. Mol Cell Biol (2010) 2.85
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J (2004) 2.24
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J (2013) 2.24
The β-catenin destruction complex. Cold Spring Harb Perspect Biol (2013) 2.22
Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. Semin Cancer Biol (2010) 1.91
Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev Biol (2007) 1.82
Functional roles of multiple feedback loops in extracellular signal-regulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition. Cancer Res (2010) 1.74
Gene expression patterns in pancreatic tumors, cells and tissues. PLoS One (2007) 1.61
Targeted reduction of vascular Msx1 and Msx2 mitigates arteriosclerotic calcification and aortic stiffness in LDLR-deficient mice fed diabetogenic diets. Diabetes (2014) 1.58
HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells. Nucleic Acids Res (2003) 1.49
Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44
Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Respir Cell Mol Biol (2011) 1.44
Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc Natl Acad Sci U S A (2005) 1.41
HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. EMBO J (2006) 1.41
AXIS inhibition protein 2, orofacial clefts and a family history of cancer. J Am Dent Assoc (2009) 1.36
Mouse axin and axin2/conductin proteins are functionally equivalent in vivo. Mol Cell Biol (2005) 1.35
The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc. EMBO J (2009) 1.33
Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability. Neoplasia (2005) 1.33
Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling. Dis Model Mech (2009) 1.31
A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis. Cell Res (2011) 1.27
Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway. PLoS One (2011) 1.27
Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells. J Biol Chem (2009) 1.26
Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation. Eur J Pharmacol (2008) 1.26
High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A. Cancer Cell (2011) 1.22
Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis. Oncogene (2009) 1.21
Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. PLoS One (2012) 1.21
Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases. Int J Cancer (2008) 1.19
Two-tier transcriptional control of oligodendrocyte differentiation. Curr Opin Neurobiol (2009) 1.17
Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin. Mol Cell Biol (2008) 1.17
MicroRNA-biogenesis and Pre-mRNA splicing crosstalk. J Biomed Biotechnol (2009) 1.15
Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors. Mol Cell Biol (2007) 1.09
Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs. PLoS One (2011) 1.08
Mechanism of early dissemination and metastasis in Her2(+) mammary cancer. Nature (2016) 1.08
The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun (2011) 1.07
Active Wnt signaling in response to cardiac injury. Basic Res Cardiol (2010) 1.06
GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer. Neoplasia (2010) 1.03
Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas. EMBO Mol Med (2010) 1.01
Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk. EMBO J (2015) 1.00
p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells. Cell Cycle (2013) 1.00
Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study. Osteoporos Int (2009) 0.98
Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH. J Bone Miner Res (2013) 0.98
A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer (2008) 0.97
SOX5 controls cell cycle progression in neural progenitors by interfering with the WNT-beta-catenin pathway. EMBO Rep (2010) 0.97
Axin2 regulates chondrocyte maturation and axial skeletal development. J Orthop Res (2010) 0.97
Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells. PLoS One (2012) 0.96
Wnt10b activates the Wnt, notch, and NFκB pathways in U2OS osteosarcoma cells. J Cell Biochem (2011) 0.96
A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice. Bone Res (2013) 0.94
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. World J Gastroenterol (2008) 0.93
Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway. Mol Biol Cell (2006) 0.90
MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma. Oncogene (2011) 0.90
AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/β-catenin signaling pathway. Blood (2013) 0.90
Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Mol Cell Biol (2007) 0.89
Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis. Dev Biol (2010) 0.89
AXIN1 and AXIN2 variants in gastrointestinal cancers. Cancer Lett (2014) 0.88
Inferring drug-disease associations from integration of chemical, genomic and phenotype data using network propagation. BMC Med Genomics (2013) 0.87
Characterization of aneuploid populations with trisomy 7 and 20 derived from diploid human colonic epithelial cells. Neoplasia (2011) 0.87
Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells. Cell Signal (2014) 0.87
Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube by inhibition of the Wnt/beta-catenin pathway. Proc Natl Acad Sci U S A (2011) 0.86
Identification of two Wnt-responsive elements in the intron of RING finger protein 43 (RNF43) gene. PLoS One (2014) 0.85
New insights into the regulation of Axin function in canonical Wnt signaling pathway. Protein Cell (2014) 0.85
The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway. Biochem J (2005) 0.85
Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI. PLoS One (2015) 0.85
Aberrant activation of Wnt/β-catenin signaling drives proliferation of bone sarcoma cells. Oncotarget (2015) 0.85
Wnt pathway activation by ADP-ribosylation. Nat Commun (2016) 0.84
HMGB factors are required for posterior digit development through integrating signaling pathway activities. Dev Dyn (2011) 0.84
Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus. Aging (Albany NY) (2015) 0.83
Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling. Development (2012) 0.83
Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions. Front Physiol (2013) 0.83
Wnt ligand-dependent activation of the negative feedback regulator Nkd1. Mol Biol Cell (2015) 0.83
Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions. Mol Cell Proteomics (2011) 0.83
Construction and Experimental Validation of a Petri Net Model of Wnt/β-Catenin Signaling. PLoS One (2016) 0.82
Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma. Nat Prod Bioprospect (2015) 0.82
Dynamic changes in Wnt signaling are required for neuronal differentiation of mouse embryonic stem cells. Mol Cell Neurosci (2011) 0.82
Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation. EMBO J (2016) 0.80
Expression of β-catenin and AXIN2 in ameloblastomas. Contemp Oncol (Pozn) (2013) 0.80
Extracellular Superoxide Dismutase: Growth Promoter or Tumor Suppressor? Oxid Med Cell Longev (2016) 0.80
Activation of the Wnt/β-catenin pathway and tissue inhibitor of metalloprotease 1 during tertiary dentinogenesis. J Biochem (2012) 0.78
Differential expression of Wnt signaling molecules between pre- and postmenopausal endometrial epithelial cells suggests a population of putative epithelial stem/progenitor cells reside in the basalis layer. Endocrinology (2012) 0.78
Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells. J Neuropathol Exp Neurol (2015) 0.78
Geminin promotes an epithelial-to-mesenchymal transition in an embryonic stem cell model of gastrulation. Stem Cells Dev (2013) 0.78
4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin. J Cell Mol Med (2009) 0.77
Two Natural ent-kauranoids as Novel Wnt Signaling Inhibitors. Nat Prod Bioprospect (2014) 0.77
Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of β-catenin/TCF transcription. Bioorg Med Chem Lett (2013) 0.77
Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PLoS One (2013) 0.77
Targeted repression of AXIN2 and MYC gene expression using designer TALEs. Biochem Biophys Res Commun (2014) 0.77
Wnt/β-Catenin Signaling Activation beyond Robust Nuclear β-Catenin Accumulation in Nondysplastic Barrett's Esophagus: Regulation via Dickkopf-1. Neoplasia (2015) 0.77
BAMBI Promotes C2C12 Myogenic Differentiation by Enhancing Wnt/β-Catenin Signaling. Int J Mol Sci (2015) 0.76
Identification of a novel role of ZMIZ2 protein in regulating the activity of the Wnt/β-catenin signaling pathway. J Biol Chem (2013) 0.76
Downregulation of ring-finger protein 43 in glioma associates with poor prognosis. Int J Clin Exp Pathol (2015) 0.76
Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells. PLoS One (2015) 0.76
Snail1 is required for the maintenance of the pancreatic acinar phenotype. Oncotarget (2016) 0.76
Loss of Axin2 Causes Ocular Defects During Mouse Eye Development. Invest Ophthalmol Vis Sci (2016) 0.76
Nuclear AXIN2 represses MYC gene expression. Biochem Biophys Res Commun (2013) 0.76
Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med (2002) 21.28
Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat Med (2008) 10.12
Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell (2009) 7.09
p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol (2007) 6.87
The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res (2002) 6.47
A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol (2006) 4.55
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature (2012) 4.41
Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res (2003) 4.30
Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study. Lancet Oncol (2012) 3.88
A biomarker panel for acute graft-versus-host disease. Blood (2008) 3.83
Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays. Clin Cancer Res (2005) 3.79
MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One (2009) 3.66
Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas. Cancer Res (2002) 3.62
ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death. N Engl J Med (2013) 3.27
Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem (2005) 3.03
Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Cancer Cell (2007) 3.02
Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Res (2007) 2.97
Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. Nat Genet (2006) 2.92
Magnetic resonance colonography for the detection of colorectal neoplasia in asymptomatic adults. Gastroenterology (2013) 2.71
Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes Dev (2003) 2.59
Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism. Mol Cell Biol (2002) 2.44
Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction. Am J Pathol (2003) 2.38
Cadherin and catenin alterations in human cancer. Genes Chromosomes Cancer (2002) 2.32
Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production. J Clin Invest (2011) 2.32
Survivin and molecular pathogenesis of colorectal cancer. Lancet (2003) 2.25
Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease. Blood (2011) 2.24
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J (2004) 2.24
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol (2011) 2.19
Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas. Cancer Res (2006) 2.16
The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome. Nat Biotechnol (2012) 2.14
Methylation of serum DNA is an independent prognostic marker in colorectal cancer. Clin Cancer Res (2006) 2.13
ConceptGen: a gene set enrichment and gene set relation mapping tool. Bioinformatics (2009) 2.11
Quantitative analysis of acrylamide labeled serum proteins by LC-MS/MS. J Proteome Res (2006) 2.10
Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics. J Biol Chem (2002) 2.08
Elafin is a biomarker of graft-versus-host disease of the skin. Sci Transl Med (2010) 2.08
Mining gene expression databases for association rules. Bioinformatics (2003) 2.06
Contribution of protein fractionation to depth of analysis of the serum and plasma proteomes. J Proteome Res (2007) 2.04
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization. Cancer Cell (2009) 2.04
Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals. Chromosoma (2002) 2.03
Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. Clin Cancer Res (2003) 2.01
Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs. J Cell Biol (2009) 1.99
Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis. Oncogene (2005) 1.99
Heterochromatin and tri-methylated lysine 20 of histone H4 in animals. J Cell Sci (2004) 1.98
Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data. BMC Bioinformatics (2005) 1.96
Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis. Am J Pathol (2003) 1.92
Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci (2004) 1.89
Protein profiles associated with survival in lung adenocarcinoma. Proc Natl Acad Sci U S A (2003) 1.86
ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. Cancer Cell (2002) 1.86
Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool. Gastroenterology (2011) 1.86
Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells. Cancer Cell (2003) 1.81
Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2. Immunity (2013) 1.77
Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling. Clin Cancer Res (2009) 1.76
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol (2012) 1.75
CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors. Am J Pathol (2004) 1.72
Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells. Blood (2011) 1.67
RANTES expression is a predictor of survival in stage I lung adenocarcinoma. Clin Cancer Res (2002) 1.67
CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. Gastroenterology (2002) 1.62
Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. Arthritis Rheum (2004) 1.61
The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas. Cancer Res (2002) 1.60
Prevention of hypertension, hyperglycemia and vascular oxidative stress by aspirin treatment in chronically glucose-fed rats. J Hypertens (2002) 1.55
DNA methylation and chromatin structure regulate T cell perforin gene expression. J Immunol (2003) 1.54
Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. Cancer Res (2007) 1.53
Precursor-ion mass re-estimation improves peptide identification on hybrid instruments. J Proteome Res (2008) 1.53
NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells. J Hypertens (2003) 1.52
Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas. Cancer Res (2003) 1.46