Published in Dev Cell on June 01, 2007
The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44
Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell (2009) 4.69
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38
Wnt/beta-catenin signaling: new (and old) players and new insights. Curr Opin Cell Biol (2008) 3.87
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development (2007) 3.28
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol (2011) 3.25
The GSK3 hypothesis of Alzheimer's disease. J Neurochem (2007) 3.16
Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell (2013) 3.15
Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell (2012) 3.03
Paths to stemness: building the ultimate antitumour T cell. Nat Rev Cancer (2012) 2.79
Glycogen synthase kinase 3: more than a namesake. Br J Pharmacol (2009) 2.77
Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science (2008) 2.67
The β-catenin destruction complex. Cold Spring Harb Perspect Biol (2013) 2.22
A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell (2013) 2.14
Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol (2011) 2.13
β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell (2011) 2.07
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action. Mol Cell Biol (2008) 2.03
Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci U S A (2009) 2.02
GSK-3: Functional Insights from Cell Biology and Animal Models. Front Mol Neurosci (2011) 1.99
Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. PLoS One (2009) 1.87
Is glycogen synthase kinase-3 a central modulator in mood regulation? Neuropsychopharmacology (2010) 1.87
Prevention of amino acid conversion in SILAC experiments with embryonic stem cells. Mol Cell Proteomics (2008) 1.83
Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest (2008) 1.76
The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation. Mol Cell Biol (2008) 1.67
Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth. Mol Cell Biol (2007) 1.65
Maintaining embryonic stem cell pluripotency with Wnt signaling. Development (2011) 1.57
When pathways collide: collaboration and connivance among signalling proteins in development. Nat Rev Mol Cell Biol (2010) 1.57
GSK-3 as potential target for therapeutic intervention in cancer. Oncotarget (2014) 1.56
Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure. J Am Coll Cardiol (2014) 1.54
Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice. J Clin Invest (2009) 1.52
Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development. J Biol Chem (2008) 1.49
Regulation of Wnt/beta-catenin signaling by protein kinases. Dev Dyn (2010) 1.45
Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44
Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies. Science (2013) 1.43
Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. Cold Spring Harb Perspect Biol (2012) 1.43
Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells. Mol Cell Biol (2008) 1.42
Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor. Biochem J (2011) 1.41
The way Wnt works: components and mechanism. Growth Factors (2012) 1.37
Glycogen synthase kinase 3: a point of convergence for the host inflammatory response. Cytokine (2010) 1.36
GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder. Front Mol Neurosci (2012) 1.34
Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo. Circ Res (2010) 1.33
Robust self-renewal of rat embryonic stem cells requires fine-tuning of glycogen synthase kinase-3 inhibition. Stem Cell Reports (2013) 1.31
Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal. Mol Cell Biol (2009) 1.31
Review of pharmacological treatment in mood disorders and future directions for drug development. Neuropsychopharmacology (2011) 1.28
Delayed administration of a single dose of lithium promotes recovery from AKI. J Am Soc Nephrol (2014) 1.28
GSK-3α is a central regulator of age-related pathologies in mice. J Clin Invest (2013) 1.25
GSK3beta: role in therapeutic landscape and development of modulators. Br J Pharmacol (2010) 1.25
The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia. J Clin Invest (2012) 1.24
Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention. Leukemia (2013) 1.22
Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice. J Clin Invest (2011) 1.20
The liberation of embryonic stem cells. PLoS Genet (2011) 1.20
Glycogen synthase kinase-3 and cancer: good cop, bad cop? Cancer Cell (2008) 1.17
The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. Mol Biol Cell (2010) 1.15
GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest (2010) 1.15
Signal integration in TGF-β, WNT, and Hippo pathways. F1000Prime Rep (2013) 1.15
Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives β-catenin/T cell factor-dependent hepatocarcinogenesis. J Clin Invest (2011) 1.11
Glycogen synthase kinase-3α limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death. Circulation (2011) 1.09
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. J Clin Invest (2008) 1.07
Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling? F1000 Biol Rep (2010) 1.07
Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy. Circ Res (2016) 1.05
Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy. BMC Cancer (2009) 1.04
Nuclear factor-κB modulates osteogenesis of periodontal ligament stem cells through competition with β-catenin signaling in inflammatory microenvironments. Cell Death Dis (2013) 1.02
Targeting GSK-3 family members in the heart: a very sharp double-edged sword. J Mol Cell Cardiol (2010) 1.01
Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J Biol Chem (2010) 1.00
Wnt pathway regulation of embryonic stem cell self-renewal. Cold Spring Harb Perspect Biol (2012) 0.99
Functions of GSK-3 Signaling in Development of the Nervous System. Front Mol Neurosci (2011) 0.99
Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice. Kidney Int (2012) 0.98
Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease. J Neurochem (2011) 0.98
The GSK-3 family as therapeutic target for myocardial diseases. Circ Res (2015) 0.97
Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance. Immunity (2012) 0.97
Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells. PLoS One (2012) 0.95
Exploring pluripotency with chemical genetics. Cell Stem Cell (2009) 0.95
Cdc42 and Gsk3 modulate the dynamics of radial glial growth, inter-radial glial interactions and polarity in the developing cerebral cortex. Development (2010) 0.95
Functional implications of glycogen synthase kinase-3-mediated tau phosphorylation. Int J Alzheimers Dis (2011) 0.94
A Regulatory Network Involving β-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling. Stem Cells (2015) 0.94
E-cadherin can limit the transforming properties of activating β-catenin mutations. EMBO J (2015) 0.94
Stable generation of serum- and feeder-free embryonic stem cell-derived mice with full germline-competency by using a GSK3 specific inhibitor. Genesis (2009) 0.93
Constitutive glycogen synthase kinase-3alpha/beta activity protects against chronic beta-adrenergic remodelling of the heart. Cardiovasc Res (2010) 0.93
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Mol Cell Proteomics (2010) 0.92
Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes. Expert Opin Ther Targets (2008) 0.92
GSK-3 promotes cell survival, growth, and PAX3 levels in human melanoma cells. Mol Cancer Res (2012) 0.92
Wnt: what's needed to maintain pluripotency? Nat Cell Biol (2011) 0.92
Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. J Biol Chem (2010) 0.92
The function of e-cadherin in stem cell pluripotency and self-renewal. Genes (Basel) (2011) 0.92
Role of Indian hedgehog signaling in palatal osteogenesis. Plast Reconstr Surg (2011) 0.91
Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells. Mol Cell Biol (2011) 0.91
GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation. J Biol Chem (2012) 0.91
GSK3 as a Sensor Determining Cell Fate in the Brain. Front Mol Neurosci (2012) 0.90
Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway. Stem Cells (2013) 0.89
The Wnt/β-catenin signaling pathway controls the inflammatory response in infections caused by pathogenic bacteria. Mediators Inflamm (2014) 0.89
Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells. Cell Death Dis (2014) 0.89
GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol (2014) 0.88
The Wnt/β-catenin signaling pathway tips the balance between apoptosis and reprograming of cell fusion hybrids. Stem Cells (2010) 0.87
Gsk3β is required in the epithelium for palatal elevation in mice. Dev Dyn (2010) 0.87
A screen for transcription factor targets of glycogen synthase kinase-3 highlights an inverse correlation of NFκB and androgen receptor signaling in prostate cancer. Oncotarget (2014) 0.86
Activity-dependent regulation of dendritic growth and maintenance by glycogen synthase kinase 3β. Nat Commun (2013) 0.86
Fine-tuning of NFκB by glycogen synthase kinase 3β directs the fate of glomerular podocytes upon injury. Kidney Int (2015) 0.86
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice. Exp Brain Res (2012) 0.86
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med (2003) 12.94
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell (1993) 11.76
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol (2002) 10.95
GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci (2003) 10.89
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell (2002) 10.34
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature (2000) 8.37
The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci (2004) 7.92
The specificities of protein kinase inhibitors: an update. Biochem J (2003) 7.76
GSK3 takes centre stage more than 20 years after its discovery. Biochem J (2001) 7.74
Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol (2003) 6.60
Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J (1990) 6.23
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development (2005) 5.80
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature (2005) 5.50
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J (2005) 4.82
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature (1990) 4.69
Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biochem (1980) 4.43
Cloning of the T gene required in mesoderm formation in the mouse. Nature (1990) 4.20
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev (2002) 3.80
Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol Cell (2000) 3.65
Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling. Nat Genet (2002) 3.60
Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling. J Biol Chem (2002) 3.34
Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling. J Biol Chem (2000) 3.28
Networks and hubs for the transcriptional control of osteoblastogenesis. Rev Endocr Metab Disord (2006) 3.25
T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev (1999) 3.13
Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol Sci (2004) 3.05
wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Cell (1992) 2.85
Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem (2004) 2.82
Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine. Development (2000) 2.59
Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene (2006) 2.42
The biology of teratomas. Adv Morphog (1967) 2.36
The links between axin and carcinogenesis. J Clin Pathol (2005) 2.07
Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site. Mol Cell Biol (1998) 2.03
Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch. Nature (1993) 2.01
TCF transcription factors, mediators of Wnt-signaling in development and cancer. Dev Biol (2002) 1.93
Brachyury is a target gene of the Wnt/beta-catenin signaling pathway. Mech Dev (2000) 1.91
Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol Biol Cell (2000) 1.87
The Akt pathway: molecular targets for anti-cancer drug development. Curr Cancer Drug Targets (2004) 1.48
The Cdx1 homeodomain protein: an integrator of posterior signaling in the mouse. Bioessays (2003) 1.40
Expression and characterization of GSK-3 mutants and their effect on beta-catenin phosphorylation in intact cells. J Biol Chem (2002) 1.40
Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. J Biol Chem (2003) 1.32
Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification. Nat Clin Pract Cardiovasc Med (2006) 1.15
Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin. J Biol Chem (2004) 1.04
Runx2 is a target of mechanical unloading to alter osteoblastic activity and bone formation in vivo. Endocrinology (2006) 0.97
Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta. Biochem J (2004) 0.95
A fast and efficient method for transiently transfecting ES cells: application to the development of systems for conditional gene expression. Transgenic Res (2000) 0.91
Pluripotent differentiation in vitro of murine ES-D3 embryonic stem cells. In Vitro Cell Dev Biol Anim (2004) 0.90
GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci (2003) 10.89
Systematic discovery of in vivo phosphorylation networks. Cell (2007) 6.94
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc Natl Acad Sci U S A (2004) 3.60
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45
Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci (2004) 3.12
Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J (2007) 2.91
IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. Immunity (2006) 2.58
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol (2002) 2.56
Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth. Neuron (2006) 2.23
Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett (2003) 2.22
Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. Cell Metab (2007) 2.12
GSK-3 is a master regulator of neural progenitor homeostasis. Nat Neurosci (2009) 2.11
β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell (2011) 2.07
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action. Mol Cell Biol (2008) 2.03
A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development (2005) 1.93
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway. Mol Cell Biol (2002) 1.91
CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome. Nucleic Acids Res (2005) 1.89
Glycogen synthase kinase-3--an overview of an over-achieving protein kinase. Curr Drug Targets (2006) 1.88
Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration. Trends Cell Biol (2006) 1.86
Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity (2008) 1.77
Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cells Tissues Organs (2007) 1.77
Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest (2008) 1.76
A molecular compendium of genes expressed in multiple myeloma. Blood (2002) 1.70
DREAM is a critical transcriptional repressor for pain modulation. Cell (2002) 1.63
Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathways. Adv Cancer Res (2002) 1.62
Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility. Hypertension (2010) 1.59
IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain. Sci Signal (2009) 1.57
When pathways collide: collaboration and connivance among signalling proteins in development. Nat Rev Mol Cell Biol (2010) 1.57
Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Cancer Res (2009) 1.53
Tests for finding complex patterns of differential expression in cancers: towards individualized medicine. BMC Bioinformatics (2004) 1.49
Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development. J Biol Chem (2008) 1.49
Problems with co-funding in Canada. Science (2005) 1.48
Retracted GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. J Clin Invest (2008) 1.46
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice. Mol Brain (2009) 1.44
Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J Biol Chem (2002) 1.43
Serum and glucocorticoid-regulated protein kinases: variations on a theme. J Cell Biochem (2006) 1.42
Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PLoS Biol (2008) 1.40
Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3. J Biol Chem (2007) 1.37
Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. J Clin Invest (2010) 1.35
Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo. Circ Res (2010) 1.33
GSK-3beta controls osteogenesis through regulating Runx2 activity. PLoS One (2007) 1.29
CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. J Exp Med (2002) 1.22
Efficiency analysis of competing tests for finding differentially expressed genes in lung adenocarcinoma. Cancer Inform (2008) 1.21
CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B. J Immunol (2007) 1.18
The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease. Acta Neuropathol (2001) 1.15
NIH Swiss and Black Swiss mice have retinal degeneration and performance deficits in cognitive tests. Comp Med (2005) 1.15
Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. Mol Cell Biol (2005) 1.12
Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. Proc Natl Acad Sci U S A (2009) 1.12
Glycogen synthase kinase-3beta heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results. Behav Pharmacol (2008) 1.12
GSK3: an in-Toll-erant protein kinase? Nat Immunol (2005) 1.11
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase. J Biol Chem (2004) 1.09
Assessment of social interaction behaviors. J Vis Exp (2011) 1.09
NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo. J Immunol (2005) 1.08
Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling? F1000 Biol Rep (2010) 1.07
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. J Clin Invest (2008) 1.07
Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC. Cell Signal (2003) 1.06
Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats. Int J Cancer (2004) 1.05
Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element. BMC Mol Biol (2004) 1.05
GSK-3α/β kinases and amyloid production in vivo. Nature (2011) 1.05
Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy. BMC Cancer (2009) 1.04
Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium. J Circadian Rhythms (2007) 1.01
Mammary tumor development is directly inhibited by lifelong n-3 polyunsaturated fatty acids. J Nutr Biochem (2012) 1.01
Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3. J Biol Chem (2006) 1.00
Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3. Synapse (2011) 0.99
Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer. Breast Cancer Res (2008) 0.99
GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity. J Am Soc Nephrol (2010) 0.98
Insulin-like growth factor-II regulates PTEN expression in the mammary gland. J Biol Chem (2003) 0.98
Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice. Kidney Int (2012) 0.98
Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance. Immunity (2012) 0.97
Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis. Hum Pathol (2006) 0.97
A classification-based machine learning approach for the analysis of genome-wide expression data. Genome Res (2003) 0.95
Exploring pluripotency with chemical genetics. Cell Stem Cell (2009) 0.95
Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation. Bioorg Med Chem Lett (2012) 0.94
Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3. J Immunol (2013) 0.93
Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas. Mod Pathol (2007) 0.93
Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes. Expert Opin Ther Targets (2008) 0.92
Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. J Biol Chem (2010) 0.92
Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis. BMC Cancer (2005) 0.91
GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation. J Biol Chem (2012) 0.91
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts. Proc Natl Acad Sci U S A (2008) 0.90
Engineered heart tissue enables study of residual undifferentiated embryonic stem cell activity in a cardiac environment. Biotechnol Bioeng (2010) 0.86
Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation. FEBS Lett (2011) 0.85
Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesis. Oncogene (2005) 0.84
Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2. BMC Biol (2014) 0.84
Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor? Breast Cancer Res Treat (2008) 0.84
Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice. Schizophr Res (2011) 0.83
Tissue-specific analysis of glycogen synthase kinase-3α (GSK-3α) in glucose metabolism: effect of strain variation. PLoS One (2011) 0.83
Human congenital perilipin deficiency and insulin resistance. Endocr Dev (2013) 0.81
Modulating autoimmunity: pick your PI3 kinase. Nat Med (2005) 0.80
Can a two-faced kinase be exploited for osteosarcoma? J Natl Cancer Inst (2012) 0.80
JNK1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalase. Exp Cell Res (2003) 0.79
The POZ-ZF transcription factor Kaiso (ZBTB33) induces inflammation and progenitor cell differentiation in the murine intestine. PLoS One (2013) 0.78
Experimental manipulation of radiographic density in mouse mammary gland. Breast Cancer Res (2004) 0.76