Published in Nat Cell Biol on April 01, 2002
Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27
Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nat Cell Biol (2008) 5.87
A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev Cell (2009) 4.89
Paxillin comes of age. J Cell Sci (2008) 3.57
p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev (2004) 3.16
Integrins in cell migration. Cold Spring Harb Perspect Biol (2011) 3.15
Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis. Cell (2012) 2.98
Cytoskeletal coordination during neuronal migration. Proc Natl Acad Sci U S A (2005) 2.47
Focal adhesions as mechanosensors: a physical mechanism. Proc Natl Acad Sci U S A (2005) 2.43
Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells. J Cell Biol (2009) 2.28
Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. Biomaterials (2010) 2.17
Paxillin dynamics measured during adhesion assembly and disassembly by correlation spectroscopy. Biophys J (2007) 2.16
Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nat Cell Biol (2009) 1.99
Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Mol Biol Cell (2004) 1.98
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem J (2007) 1.95
Functions of cofilin in cell locomotion and invasion. Nat Rev Mol Cell Biol (2013) 1.95
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Mol Biol Cell (2003) 1.90
A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes. J Cell Biol (2005) 1.88
Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol (2004) 1.87
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. J Clin Invest (2003) 1.85
Mathematics of cell motility: have we got its number? J Math Biol (2008) 1.84
Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures. Mol Biol Cell (2003) 1.82
Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasis. Cancer Res (2007) 1.76
New roles for endosomes: from vesicular carriers to multi-purpose platforms. Nat Rev Mol Cell Biol (2009) 1.75
Control of axonal branching and synapse formation by focal adhesion kinase. Nat Neurosci (2004) 1.74
Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration. EMBO J (2006) 1.66
High-resolution quantification of focal adhesion spatiotemporal dynamics in living cells. PLoS One (2011) 1.63
Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins. FEBS Lett (2009) 1.61
Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. J Cell Biol (2003) 1.58
Cells move when ions and water flow. Pflugers Arch (2006) 1.52
Integrated morphodynamic signalling of the mammary gland. Nat Rev Mol Cell Biol (2011) 1.50
Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange. J Physiol (2005) 1.49
Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol Cell Biol (2007) 1.48
Protons make tumor cells move like clockwork. Pflugers Arch (2009) 1.48
Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway. Proc Natl Acad Sci U S A (2003) 1.46
alpha4beta1 integrin regulates lamellipodia protrusion via a focal complex/focal adhesion-independent mechanism. Mol Biol Cell (2002) 1.45
Amniotic Membrane Modifies the Genetic Program Induced by TGFß, Stimulating Keratinocyte Proliferation and Migration in Chronic Wounds. PLoS One (2015) 1.44
Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med (2010) 1.43
To move or not to move? Semaphorin signalling in cell migration. EMBO Rep (2004) 1.42
Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. Mol Cell Biol (2006) 1.41
Tip cells act as dynamic cellular anchors in the morphogenesis of looped renal tubules in Drosophila. Dev Cell (2013) 1.41
Tipping the balance: robustness of tip cell selection, migration and fusion in angiogenesis. PLoS Comput Biol (2009) 1.40
Focal adhesion size uniquely predicts cell migration. FASEB J (2012) 1.40
The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin. Mol Biol Cell (2007) 1.39
ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines. Br J Cancer (2010) 1.38
The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. Mol Cell Biol (2005) 1.34
Molecular signatures of cell migration in C. elegans Q neuroblasts. J Cell Biol (2009) 1.32
Integrins traffic rapidly via circular dorsal ruffles and macropinocytosis during stimulated cell migration. J Cell Biol (2011) 1.30
Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. PLoS Biol (2012) 1.29
R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho. Mol Biol Cell (2004) 1.28
Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. Blood (2008) 1.28
Regulation of signal transduction by reactive oxygen species in the cardiovascular system. Circ Res (2015) 1.27
bFGF regulates PI3-kinase-Rac1-JNK pathway and promotes fibroblast migration in wound healing. PLoS One (2010) 1.23
Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med (2012) 1.23
Turnover of focal adhesions and cancer cell migration. Int J Cell Biol (2012) 1.22
Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration. J Cell Biol (2007) 1.21
c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Mol Cell Biol (2005) 1.20
GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover. EMBO J (2006) 1.18
A photoactivatable marker protein for pulse-chase imaging with superresolution. Nat Methods (2010) 1.17
P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts. J Cell Biol (2006) 1.16
Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts. Mol Biol Cell (2003) 1.16
Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase. Breast Cancer Res (2011) 1.15
Distinct phospho-forms of cortactin differentially regulate actin polymerization and focal adhesions. Am J Physiol Cell Physiol (2008) 1.15
Annexin 2 regulates intestinal epithelial cell spreading and wound closure through Rho-related signaling. Am J Pathol (2007) 1.15
Cell biology of embryonic migration. Birth Defects Res C Embryo Today (2008) 1.14
CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility. EMBO J (2006) 1.14
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion. J Biol Chem (2008) 1.12
Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly. J Cell Biol (2006) 1.12
Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. Proc Natl Acad Sci U S A (2010) 1.10
A lipid-signaled myosin phosphatase surge disperses cortical contractile force early in cell spreading. Mol Biol Cell (2008) 1.07
Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain. J Biol Chem (2011) 1.07
Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC. Oncogene (2009) 1.07
Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I γ by HECTD1 regulates focal adhesion dynamics and cell migration. J Cell Sci (2013) 1.06
Dynamic adhesions and MARCKS in melanoma cells. J Cell Sci (2009) 1.05
PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion. PLoS One (2011) 1.04
Autotaxin (ATX): a multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular properties. Biochim Biophys Acta (2008) 1.04
RACK1 regulates Src activity and modulates paxillin dynamics during cell migration. Exp Cell Res (2007) 1.03
Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol (2008) 1.01
Endocytosis regulates cell soma translocation and the distribution of adhesion proteins in migrating neurons. PLoS One (2011) 1.01
Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3. Cell Rep (2016) 1.01
SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study. Exp Dermatol (2011) 1.01
Fascin protein is critical for transforming growth factor β protein-induced invasion and filopodia formation in spindle-shaped tumor cells. J Biol Chem (2011) 1.00
A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src. Mol Biol Cell (2011) 1.00
Gleevec, an Abl family inhibitor, produces a profound change in cell shape and migration. PLoS One (2013) 1.00
Type I phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting beta1 integrin endocytosis. Mol Cell Biol (2010) 1.00
Kinetic model for lamellipodal actin-integrin 'clutch' dynamics. Cell Adh Migr (2008) 0.99
Both contractile axial and lateral traction force dynamics drive amoeboid cell motility. J Cell Biol (2014) 0.99
High glucose-mediated oxidative stress impairs cell migration. PLoS One (2011) 0.98
Regulation of integrin endocytic recycling and chemotactic cell migration by syntaxin 6 and VAMP3 interaction. J Cell Sci (2012) 0.98
Integrin-mediated cell attachment induces a PAK4-dependent feedback loop regulating cell adhesion through modified integrin alpha v beta 5 clustering and turnover. Mol Biol Cell (2010) 0.98
Phosphodiesterase-Ialpha/autotaxin's MORFO domain regulates oligodendroglial process network formation and focal adhesion organization. Mol Cell Neurosci (2007) 0.97
Transactivation of the epidermal growth factor receptor by heat shock protein 90 via Toll-like receptor 4 contributes to the migration of glioblastoma cells. J Biol Chem (2010) 0.97
srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization. J Biol Chem (2010) 0.97
Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells. J Biol Chem (2010) 0.95
Leader cell positioning drives wound-directed collective migration in TGFβ-stimulated epithelial sheets. Mol Biol Cell (2014) 0.94
Cell migration. Compr Physiol (2012) 0.94
LIM and SH3 protein-1 modulates CXCR2-mediated cell migration. PLoS One (2010) 0.94
Role of VASP phosphorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation. Mol Cell Neurosci (2009) 0.94
FAK/src-family dependent activation of the Ste20-like kinase SLK is required for microtubule-dependent focal adhesion turnover and cell migration. PLoS One (2008) 0.93
Differential regulation of adhesion complex turnover by ROCK1 and ROCK2. PLoS One (2012) 0.93
Cell migration: integrating signals from front to back. Science (2003) 29.13
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31
Src family kinases, key regulators of signal transduction. Oncogene (2004) 4.30
Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells. J Cell Biol (2007) 4.03
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem (2007) 3.87
Interaction of cortactin and N-WASp with Arp2/3 complex. Curr Biol (2002) 3.34
Mapping the number of molecules and brightness in the laser scanning microscope. Biophys J (2007) 3.29
A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. J Neurosci (2005) 2.48
PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. J Cell Biol (2003) 2.20
Segregation and activation of myosin IIB creates a rear in migrating cells. J Cell Biol (2008) 2.15
Dynamin2 and cortactin regulate actin assembly and filament organization. Curr Biol (2002) 2.02
Synapse formation is regulated by the signaling adaptor GIT1. J Cell Biol (2003) 2.00
In vivo dynamics of Rac-membrane interactions. Mol Biol Cell (2006) 1.95
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol (2007) 1.93
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Mol Biol Cell (2003) 1.90
Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. J Cell Sci (2005) 1.80
Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. Curr Biol (2003) 1.72
Matrix rigidity regulates cancer cell growth and cellular phenotype. PLoS One (2010) 1.70
Determination of particle number and brightness using a laser scanning confocal microscope operating in the analog mode. Microsc Res Tech (2008) 1.69
Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin Cancer Biol (2007) 1.64
Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Mol Cancer Ther (2011) 1.61
Talin: an emerging focal point of adhesion dynamics. Curr Opin Cell Biol (2004) 1.49
Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts. J Cell Sci (2006) 1.47
Integrin connections map: to infinity and beyond. Science (2002) 1.47
Illuminating adhesion complexes in migrating cells: moving toward a bright future. Curr Opin Cell Biol (2003) 1.39
Methods for the detection of paxillin post-translational modifications and interacting proteins by mass spectrometry. J Proteome Res (2005) 1.38
Deleted in colorectal carcinoma and differentially expressed integrins mediate the directional migration of neural precursors in the rostral migratory stream. J Neurosci (2002) 1.37
FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts. J Cell Sci (2008) 1.36
Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape. Hum Mol Genet (2003) 1.33
The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. Mol Biol Cell (2002) 1.28
Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion. Mol Cell Biol (2004) 1.21
Boron polylactide nanoparticles exhibiting fluorescence and phosphorescence in aqueous medium. ACS Nano (2008) 1.20
Mislocalization or reduced expression of Arf GTPase-activating protein ASAP1 inhibits cell spreading and migration by influencing Arf1 GTPase cycling. J Biol Chem (2005) 1.18
alpha5 integrin signaling regulates the formation of spines and synapses in hippocampal neurons. J Biol Chem (2007) 1.17
New dimensions in cell migration. Nat Cell Biol (2003) 1.15
Expression of focal adhesion kinase in normal and pathologic human prostate tissues. Prostate (2002) 1.14
Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells. J Cell Biol (2004) 1.12
Migration of perilesional microglia after focal brain injury and modulation by CC chemokine receptor 5: an in situ time-lapse confocal imaging study. J Neurosci (2005) 1.11
Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells. PLoS Comput Biol (2010) 1.10
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol Cell Biol (2008) 1.09
RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. Mol Cell Biol (2007) 1.09
Cortactin phosphorylation sites mapped by mass spectrometry. J Cell Sci (2006) 1.08
Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells. Am J Physiol Cell Physiol (2009) 1.05
Clinical, molecular and genetic validation of a murine orthotopic xenograft model of pancreatic adenocarcinoma using fresh human specimens. PLoS One (2013) 1.05
Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model. Mol Cancer Ther (2009) 1.05
FRNK expression promotes smooth muscle cell maturation during vascular development and after vascular injury. Arterioscler Thromb Vasc Biol (2008) 1.04
Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion. J Biol Chem (2009) 1.02
FAK phosphorylation sites mapped by mass spectrometry. J Cell Sci (2005) 1.02
From imaging to understanding: Frontiers in Live Cell Imaging, Bethesda, MD, April 19-21, 2006. J Cell Biol (2006) 1.01
Emerging views of integrin signaling: implications for prostate cancer. J Cell Biochem (2004) 1.01
Matrix rigidity regulates cancer cell growth by modulating cellular metabolism and protein synthesis. PLoS One (2012) 0.99
Phosphorylation of serine 709 in GIT1 regulates protrusive activity in cells. Biochem Biophys Res Commun (2006) 0.98
High glucose-mediated oxidative stress impairs cell migration. PLoS One (2011) 0.98
Identification of phosphorylation sites in GIT1. J Cell Sci (2006) 0.97
FRNK, the autonomously expressed C-terminal region of focal adhesion kinase, is uniquely regulated in vascular smooth muscle: analysis of expression in transgenic mice. J Cell Biochem (2005) 0.96
Mechanism of polarized protrusion formation on neuronal precursors migrating in the developing chicken cerebellum. J Cell Sci (2006) 0.93
Cell migration: an overview. Methods Mol Biol (2005) 0.93
Identification of protein networks associated with the PAK1-betaPIX-GIT1-paxillin signaling complex by mass spectrometry. J Proteome Res (2006) 0.91
CaMK-II promotes focal adhesion turnover and cell motility by inducing tyrosine dephosphorylation of FAK and paxillin. Cell Motil Cytoskeleton (2008) 0.91
Focal adhesion kinase (FAK) regulates insulin-stimulated glycogen synthesis in hepatocytes. J Biol Chem (2002) 0.90
Infiltrative microgliosis: activation and long-distance migration of subependymal microglia following periventricular insults. J Neuroinflammation (2005) 0.89
Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells. J Proteomics (2012) 0.89
Breaking barriers through collaboration: the example of the Cell Migration Consortium. Genome Biol (2002) 0.89
A novel role for signal transducer and activator of transcription 5b (STAT5b) in beta1-integrin-mediated human breast cancer cell migration. Breast Cancer Res (2009) 0.88
Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene. J Cell Biochem (2007) 0.88
Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor "switch". Cell Motil Cytoskeleton (2002) 0.86
Directions in cell migration along the rostral migratory stream: the pathway for migration in the brain. Curr Top Dev Biol (2004) 0.85
The reorientation of cell nucleus promotes the establishment of front-rear polarity in migrating fibroblasts. J Mol Biol (2013) 0.84
Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton. Genes Cancer (2012) 0.83
Identification of phosphorylation sites in betaPIX and PAK1. J Cell Sci (2007) 0.81
ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb. Eur J Neurosci (2008) 0.81
Cell migration in slice cultures. Methods Cell Biol (2002) 0.76
Fluorescence imaging of mobility shifts: an expression cloning method for identification of cell signaling targets. Lab Invest (2002) 0.75