HDAC6 modulates cell motility by altering the acetylation level of cortactin.

PubWeight™: 3.99‹?› | Rank: Top 1%

🔗 View Article (PMC 2684874)

Published in Mol Cell on July 20, 2007

Authors

Xiaohong Zhang1, Zhigang Yuan, Yingtao Zhang, Sarah Yong, Alexis Salas-Burgos, John Koomen, Nancy Olashaw, J Thomas Parsons, Xiang-Jiao Yang, Sharon R Dent, Tso-Pang Yao, William S Lane, Edward Seto

Author Affiliations

1: Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Articles citing this

(truncated to the top 100)

The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet (2009) 9.68

Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell (2008) 6.93

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol (2008) 6.90

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90

Histone deacetylase inhibitors: Potential in cancer therapy. J Cell Biochem (2009) 3.88

Tubulin modifications and their cellular functions. Curr Opin Cell Biol (2008) 3.52

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85

Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell (2008) 2.71

Cortactin branches out: roles in regulating protrusive actin dynamics. Cell Motil Cytoskeleton (2008) 2.26

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res (2008) 2.17

HDAC6 is a target for protection and regeneration following injury in the nervous system. Proc Natl Acad Sci U S A (2009) 2.14

MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling. Dev Cell (2010) 2.11

Cortactin in tumor invasiveness. Cancer Lett (2008) 1.88

Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol (2011) 1.82

The clinical development of histone deacetylase inhibitors as targeted anticancer drugs. Expert Opin Investig Drugs (2010) 1.79

The role of HDAC6 in cancer. J Biomed Biotechnol (2010) 1.77

In vivo identification of regulators of cell invasion across basement membranes. Sci Signal (2010) 1.77

Aggresome formation and neurodegenerative diseases: therapeutic implications. Curr Med Chem (2008) 1.68

HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration. EMBO J (2012) 1.55

Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia. J Cell Sci (2010) 1.53

The tale of protein lysine acetylation in the cytoplasm. J Biomed Biotechnol (2010) 1.44

The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis. J Cell Biol (2010) 1.41

MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis. J Hematol Oncol (2016) 1.41

Histone deacetylase 6 interacts with the microtubule-associated protein tau. J Neurochem (2008) 1.38

Cortactin: a multifunctional regulator of cellular invasiveness. Cell Adh Migr (2011) 1.36

The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem (2010) 1.36

Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions. Biochim Biophys Acta (2010) 1.35

Cortactin in cell migration and cancer at a glance. J Cell Sci (2012) 1.34

The chemical complexity of cellular microtubules: tubulin post-translational modification enzymes and their roles in tuning microtubule functions. Cytoskeleton (Hoboken) (2012) 1.32

HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J Biol Chem (2008) 1.31

HDAC4 protein regulates HIF1α protein lysine acetylation and cancer cell response to hypoxia. J Biol Chem (2011) 1.25

Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation. Cell Rep (2012) 1.24

Differential VASP phosphorylation controls remodeling of the actin cytoskeleton. J Cell Sci (2009) 1.19

Erasers of histone acetylation: the histone deacetylase enzymes. Cold Spring Harb Perspect Biol (2014) 1.18

The role of ubiquitin in autophagy-dependent protein aggregate processing. Genes Cancer (2010) 1.15

Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoid-induced hepatic gluconeogenesis. Diabetes (2011) 1.15

Alcohol-induced protein hyperacetylation: mechanisms and consequences. World J Gastroenterol (2009) 1.15

SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol (2012) 1.15

Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development. PLoS One (2010) 1.14

PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin. EMBO J (2011) 1.13

Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J (2011) 1.12

HDAC6 deacetylates Ku70 and regulates Ku70-Bax binding in neuroblastoma. Neoplasia (2011) 1.11

Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. Mol Cell (2013) 1.10

Activation of autophagy in mesenchymal stem cells provides tumor stromal support. Carcinogenesis (2011) 1.10

Regulation of Tat acetylation and transactivation activity by the microtubule-associated deacetylase HDAC6. J Biol Chem (2011) 1.10

Uropathogenic Escherichia coli invades host cells via an HDAC6-modulated microtubule-dependent pathway. J Biol Chem (2008) 1.09

Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein. J Biol Chem (2010) 1.09

Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. PLoS One (2012) 1.08

Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates. J Biomed Biotechnol (2010) 1.08

A novel GRK2/HDAC6 interaction modulates cell spreading and motility. EMBO J (2011) 1.08

Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease. PLoS One (2011) 1.07

Histone deacetylase 8 regulates cortactin deacetylation and contraction in smooth muscle tissues. Am J Physiol Cell Physiol (2014) 1.06

Chronic ethanol consumption induces global hepatic protein hyperacetylation. Alcohol Clin Exp Res (2009) 1.05

HDAC signaling in neuronal development and axon regeneration. Curr Opin Neurobiol (2014) 1.03

Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production. Nat Commun (2014) 1.02

Histone deacetylase (HDAC) 10 suppresses cervical cancer metastasis through inhibition of matrix metalloproteinase (MMP) 2 and 9 expression. J Biol Chem (2013) 1.02

The emerging role of acetylation in the regulation of autophagy. Autophagy (2013) 1.01

Dynamin 2 orchestrates the global actomyosin cytoskeleton for epithelial maintenance and apical constriction. Proc Natl Acad Sci U S A (2009) 1.00

Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation. J Biol Chem (2012) 1.00

Development of a histone deacetylase 6 inhibitor and its biological effects. Proc Natl Acad Sci U S A (2013) 1.00

Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol Metab (2012) 0.98

The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner. J Biol Chem (2009) 0.98

HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Mol Cell (2014) 0.98

Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells. PLoS One (2012) 0.97

Increasing CD44+/CD24(-) tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesis. Mol Cancer (2010) 0.97

Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation. J Biol Chem (2010) 0.97

Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion. Mol Biol Cell (2014) 0.96

Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation. PLoS One (2011) 0.96

Hdac6 regulates Tip60-p400 function in stem cells. Elife (2013) 0.96

IIp45 inhibits cell migration through inhibition of HDAC6. J Biol Chem (2009) 0.96

Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration. J Biol Chem (2013) 0.95

Alcohol-induced alterations in hepatic microtubule dynamics can be explained by impaired histone deacetylase 6 function. Hepatology (2008) 0.95

Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly. Sci Rep (2015) 0.94

Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome. J Neurosci (2008) 0.94

Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells. Protein Cell (2014) 0.94

SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity. PLoS One (2013) 0.94

Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability. Neuropsychopharmacology (2013) 0.93

Histone deacetylase 10 relieves repression on the melanogenic program by maintaining the deacetylation status of repressors. J Biol Chem (2009) 0.93

Growing the growth cone: remodeling the cytoskeleton to promote axon regeneration. Trends Neurosci (2011) 0.93

Histone deacetylase inhibitors as novel anticancer therapeutics. Curr Oncol (2008) 0.92

Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients. Neurobiol Dis (2014) 0.91

A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth. Br J Cancer (2013) 0.91

Alcohol-induced alterations of the hepatocyte cytoskeleton. World J Gastroenterol (2010) 0.90

Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src. Mol Cell Biol (2013) 0.89

Small GTPases and cilia. Protein Cell (2011) 0.89

Effect of EGF-induced HDAC6 activation on corneal epithelial wound healing. Invest Ophthalmol Vis Sci (2010) 0.89

Extracellular signal-regulated kinase (ERK) regulates cortactin ubiquitination and degradation in lung epithelial cells. J Biol Chem (2012) 0.89

Enterolobium contortisiliquum trypsin inhibitor (EcTI), a plant proteinase inhibitor, decreases in vitro cell adhesion and invasion by inhibition of Src protein-focal adhesion kinase (FAK) signaling pathways. J Biol Chem (2011) 0.89

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells. Mol Immunol (2014) 0.88

Inhibition of HDAC6 deacetylase activity increases its binding with microtubules and suppresses microtubule dynamic instability in MCF-7 cells. J Biol Chem (2013) 0.87

Subcellular localization of class II HDAs in Arabidopsis thaliana: nucleocytoplasmic shuttling of HDA15 is driven by light. PLoS One (2012) 0.87

Paxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration. J Cell Biol (2014) 0.86

A proteomic approach to identify candidate substrates of human adenovirus E4orf6-E1B55K and other viral cullin-based E3 ubiquitin ligases. J Virol (2009) 0.86

Histone deacetylase 6 inhibits influenza A virus release by downregulating the trafficking of viral components to the plasma membrane via its substrate, acetylated microtubules. J Virol (2014) 0.86

A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs. J Immunol (2014) 0.86

Microtubule stabilization by Mdp3 is partially attributed to its modulation of HDAC6 in addition to its association with tubulin and microtubules. PLoS One (2014) 0.85

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Nat Chem Biol (2016) 0.85

Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. Protein Cell (2014) 0.85

HDAC6 deacetylase activity is critical for lipopolysaccharide-induced activation of macrophages. PLoS One (2014) 0.85

HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion. PLoS One (2013) 0.84

Articles cited by this

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell (1995) 24.99

HDAC6 is a microtubule-associated deacetylase. Nature (2002) 12.76

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell (2003) 7.71

The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol Cell Biol (1995) 7.23

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell (2005) 6.00

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A (2003) 5.56

Histone-like TAFs within the PCAF histone acetylase complex. Cell (1998) 5.26

Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem (2005) 4.62

Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38

In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J (2002) 4.28

Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol (2001) 4.16

HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J (2003) 3.96

Identification and characterization of a novel cytoskeleton-associated pp60src substrate. Mol Cell Biol (1991) 3.83

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex. J Cell Biol (1993) 3.56

Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. Mol Cell Biol (2001) 3.09

Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. J Cell Biol (2000) 2.94

An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation. Oncogene (1999) 2.86

Cortactin promotes cell motility by enhancing lamellipodial persistence. Curr Biol (2005) 2.78

HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J (2006) 2.52

Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science (2005) 2.47

The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells. J Biol Chem (1998) 2.39

Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles. J Cell Sci (2000) 2.04

Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. J Cell Sci (1998) 1.99

Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Exp Cell Res (2006) 1.96

Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Mol Biol Cell (2003) 1.90

Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. Proc Natl Acad Sci U S A (2002) 1.89

Cortactin potentiates bone metastasis of breast cancer cells. Cancer Res (2001) 1.85

Histone H2A.Z acetylation modulates an essential charge patch. Mol Cell (2001) 1.81

Cortactin regulates cell migration through activation of N-WASP. J Cell Sci (2004) 1.61

The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites. Mol Cell Biol (1993) 1.53

Cortactin has an essential and specific role in osteoclast actin assembly. Mol Biol Cell (2006) 1.52

EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck. Clin Cancer Res (2000) 1.44

Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro. Oncogene (1998) 1.41

Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma. J Hepatol (2004) 1.37

Phosphorylation of linker histone H1 regulates gene expression in vivo by creating a charge patch. Mol Cell (2000) 1.32

Prediction of prognosis of estrogen receptor-positive breast cancer with combination of selected estrogen-regulated genes. Cancer Sci (2004) 1.31

Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells. Am J Physiol Cell Physiol (2005) 1.10

The nonessential H2A N-terminal tail can function as an essential charge patch on the H2A.Z variant N-terminal tail. Mol Cell Biol (2003) 1.02

Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases. J Biol Chem (2004) 0.97

Articles by these authors

Cell migration: integrating signals from front to back. Science (2003) 29.13

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

HDAC6 is a microtubule-associated deacetylase. Nature (2002) 12.76

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell (2006) 11.38

FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature (2007) 7.74

Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell (2008) 6.93

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol (2008) 6.90

Acetylation and deacetylation of non-histone proteins. Gene (2005) 6.87

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell (2005) 6.00

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem (2003) 5.86

Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell (2006) 5.01

Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again. Nat Cell Biol (2002) 4.74

Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem (2005) 4.62

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol (2004) 4.31

Src family kinases, key regulators of signal transduction. Oncogene (2004) 4.30

Feature extraction and quantification for mass spectrometry in biomedical applications using the mean spectrum. Bioinformatics (2005) 4.26

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell (2011) 3.95

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90

Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem (2007) 3.87

Ordered phosphorylation governs oscillation of a three-protein circadian clock. Science (2007) 3.78

Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell (2002) 3.71

PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. Nat Immunol (2004) 3.39

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol (2010) 3.37

Interaction of cortactin and N-WASp with Arp2/3 complex. Curr Biol (2002) 3.34

A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J Biol Chem (2002) 3.33

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J (2002) 3.29

HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol (2003) 3.22

A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol (2005) 3.04

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy (2010) 2.99

A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A (2002) 2.78

AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J (2005) 2.76

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev (2007) 2.56

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer. Nat Chem Biol (2010) 2.53

Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (2009) 2.48

SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol (2007) 2.47

SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42

Regulation of histone deacetylase activities. J Cell Biochem (2004) 2.41

Bacterial glycosidases for the production of universal red blood cells. Nat Biotechnol (2007) 2.41

Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev (2003) 2.30

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J (2005) 2.29

Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol (2005) 2.28

Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. Mol Cell Biol (2007) 2.25

HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. J Cell Sci (2007) 2.22

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. J Cell Biol (2003) 2.20

Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Mol Cell Biol (2005) 2.18

Molecular cloning and characterization of a novel histone deacetylase HDAC10. J Biol Chem (2001) 2.18

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res (2008) 2.17

Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev (2006) 2.15

The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13

Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1. Genes Dev (2003) 2.08

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. J Biol Chem (2004) 2.05

Functional domains of histone deacetylase-3. J Biol Chem (2002) 2.05

Dynamin2 and cortactin regulate actin assembly and filament organization. Curr Biol (2002) 2.02

Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem (2005) 2.01

Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol (2006) 2.01

Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. J Neurosci (2005) 2.00

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nat Immunol (2008) 1.98

System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol (2008) 1.97

Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. Mol Cell (2003) 1.95

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev (2010) 1.95

Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression. Curr Opin Genet Dev (2003) 1.95

Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes Dev (2005) 1.94

Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol (2007) 1.93

Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem (2005) 1.93

Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Mol Biol Cell (2003) 1.90

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol (2008) 1.89

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A (2003) 1.83

Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. J Biol Chem (2005) 1.81

YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease. Biochem Cell Biol (2009) 1.81

Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J (2003) 1.80

Direct identification of PTEN phosphorylation sites. FEBS Lett (2002) 1.80

Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. J Cell Sci (2005) 1.80

Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem (2005) 1.76

An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell (2003) 1.76

Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A (2002) 1.75

Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. Curr Biol (2003) 1.72

Matrix rigidity regulates cancer cell growth and cellular phenotype. PLoS One (2010) 1.70

VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron (2013) 1.70

The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. J Biol Chem (2007) 1.70

Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem (2008) 1.68

JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun. EMBO J (2003) 1.67

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem (2002) 1.67

Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin Cancer Biol (2007) 1.64

Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J Cell Biol (2008) 1.64

MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem (2009) 1.63

Regulation of histone deacetylase 2 by protein kinase CK2. J Biol Chem (2002) 1.63

Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin. Cell Cycle (2010) 1.62

Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Mol Cancer Ther (2011) 1.61

Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A. Mol Cell Biol (2004) 1.60

Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA (2005) 1.59

HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail. Mol Cell (2009) 1.58

Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation. J Biol Chem (2005) 1.58

Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter. J Biol Chem (2005) 1.57

Functional analysis of the subunits of the chromatin assembly factor RSF. Mol Cell Biol (2003) 1.56

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. EMBO J (2009) 1.56