Published in J Cell Biol on August 14, 2006
Dual-color superresolution imaging of genetically expressed probes within individual adhesion complexes. Proc Natl Acad Sci U S A (2007) 5.36
Multilayer three-dimensional super resolution imaging of thick biological samples. Proc Natl Acad Sci U S A (2008) 2.37
Quantitative approaches to uncover physical mechanisms of tissue morphogenesis. Curr Opin Biotechnol (2013) 0.78
Deciphering subcellular processes in live imaging datasets via dynamic probabilistic networks. Bioinformatics (2010) 0.76
Imaging intracellular fluorescent proteins at nanometer resolution. Science (2006) 38.97
Optical sectioning deep inside live embryos by selective plane illumination microscopy. Science (2004) 13.77
Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. J Microsc (2000) 10.19
Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex. Nature (2005) 9.02
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol (2003) 7.89
Two distinct actin networks drive the protrusion of migrating cells. Science (2004) 7.69
Spatiotemporal dynamics of RhoA activity in migrating cells. Nature (2006) 6.84
Regulated fast nucleocytoplasmic shuttling observed by reversible protein highlighting. Science (2004) 6.52
Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy. Proc Natl Acad Sci U S A (2005) 5.96
Kinesin and dynein move a peroxisome in vivo: a tug-of-war or coordinated movement? Science (2005) 5.58
Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase. Nat Methods (2005) 5.21
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res (2005) 4.33
Targeting quantum dots to surface proteins in living cells with biotin ligase. Proc Natl Acad Sci U S A (2005) 4.15
Measuring fast dynamics in solutions and cells with a laser scanning microscope. Biophys J (2005) 3.99
Activation of endogenous Cdc42 visualized in living cells. Science (2004) 3.57
Fluorescence cross-correlation spectroscopy in living cells. Nat Methods (2006) 3.31
Fluctuation correlation spectroscopy with a laser-scanning microscope: exploiting the hidden time structure. Biophys J (2005) 2.74
Quantitative fluorescent speckle microscopy of cytoskeleton dynamics. Annu Rev Biophys Biomol Struct (2006) 2.62
Objective clustering of proteins based on subcellular location patterns. J Biomed Biotechnol (2005) 2.37
Defocused orientation and position imaging (DOPI) of myosin V. Proc Natl Acad Sci U S A (2006) 2.27
Highly fluorescent, water-soluble, size-tunable gold quantum dots. Phys Rev Lett (2004) 2.12
Recent advances in fluorescence correlation spectroscopy. Curr Opin Struct Biol (2002) 2.10
Tracking quasi-stationary flow of weak fluorescent signals by adaptive multi-frame correlation. J Microsc (2005) 2.06
The embryonic vertebrate heart tube is a dynamic suction pump. Science (2006) 1.96
X-ray tomography of whole cells. Curr Opin Struct Biol (2005) 1.87
Living cells as test tubes. Science (2006) 1.85
Full-length myosin VI dimerizes and moves processively along actin filaments upon monomer clustering. Mol Cell (2006) 1.80
Observing spontaneous branch migration of Holliday junctions one step at a time. Proc Natl Acad Sci U S A (2005) 1.60
Automated interpretation of subcellular patterns in fluorescence microscope images for location proteomics. Cytometry A (2006) 1.53
Studying slow membrane dynamics with continuous wave scanning fluorescence correlation spectroscopy. Biophys J (2006) 1.52
Family of site-selective molecular optical switches. J Org Chem (2005) 1.41
Ligand-receptor kinetics measured by total internal reflection with fluorescence correlation spectroscopy. Biophys J (2003) 1.39
Optical switching of dipolar interactions on proteins. Proc Natl Acad Sci U S A (2005) 1.28
Fast and reversible photoswitching of the fluorescent protein dronpa as evidenced by fluorescence correlation spectroscopy. Biophys J (2006) 1.04
Wide-field optically sectioning fluorescence microscopy with laser illumination. J Microsc (2000) 0.97
Man the nanoscopes. J Cell Biol (2004) 0.77
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31
A genetically encoded photoactivatable Rac controls the motility of living cells. Nature (2009) 7.25
Spatiotemporal dynamics of RhoA activity in migrating cells. Nature (2006) 6.84
Coordination of Rho GTPase activities during cell protrusion. Nature (2009) 6.54
Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again. Nat Cell Biol (2002) 4.74
Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells. J Cell Biol (2007) 4.03
Automated subcellular location determination and high-throughput microscopy. Dev Cell (2007) 3.85
Activation of endogenous Cdc42 visualized in living cells. Science (2004) 3.57
Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI. Nat Cell Biol (2002) 3.50
Mapping the number of molecules and brightness in the laser scanning microscope. Biophys J (2007) 3.29
Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev Cell (2010) 3.19
Automated image analysis for high-content screening and analysis. J Biomol Screen (2010) 3.02
Biological imaging software tools. Nat Methods (2012) 2.91
Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol (2010) 2.65
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell (2007) 2.52
A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. J Neurosci (2005) 2.48
Boosting accuracy of automated classification of fluorescence microscope images for location proteomics. BMC Bioinformatics (2004) 2.46
Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nat Cell Biol (2010) 2.45
Engineered allosteric activation of kinases in living cells. Nat Biotechnol (2010) 2.44
Improved recognition of figures containing fluorescence microscope images in online journal articles using graphical models. Bioinformatics (2007) 2.43
Objective clustering of proteins based on subcellular location patterns. J Biomed Biotechnol (2005) 2.37
Effects of cell tension on the small GTPase Rac. J Cell Biol (2002) 2.24
Segregation and activation of myosin IIB creates a rear in migrating cells. J Cell Biol (2008) 2.15
Advances in molecular labeling, high throughput imaging and machine intelligence portend powerful functional cellular biochemistry tools. J Cell Biochem Suppl (2002) 2.14
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol (2006) 2.10
Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: clinical and pharmacologic factors affecting outcome. J Clin Oncol (2010) 2.05
Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. Nat Methods (2013) 2.05
Automated learning of generative models for subcellular location: building blocks for systems biology. Cytometry A (2007) 2.05
Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis. Curr Biol (2002) 2.01
Synapse formation is regulated by the signaling adaptor GIT1. J Cell Biol (2003) 2.00
Designing photoswitchable peptides using the AsLOV2 domain. Chem Biol (2012) 1.99
In vivo dynamics of Rac-membrane interactions. Mol Biol Cell (2006) 1.95
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol (2007) 1.93
A framework for the automated analysis of subcellular patterns in human protein atlas images. J Proteome Res (2008) 1.91
An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol (2013) 1.89
Deformation-based nuclear morphometry: capturing nuclear shape variation in HeLa cells. Cytometry A (2008) 1.88
Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol (2004) 1.83
Determining the distribution of probes between different subcellular locations through automated unmixing of subcellular patterns. Proc Natl Acad Sci U S A (2010) 1.82
Spatial and temporal regulation of focal adhesion kinase activity in living cells. Mol Cell Biol (2007) 1.72
Automated image analysis of protein localization in budding yeast. Bioinformatics (2007) 1.69
Determination of particle number and brightness using a laser scanning confocal microscope operating in the analog mode. Microsc Res Tech (2008) 1.69
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog (2008) 1.67
Transferrin recycling and dextran transport to lysosomes is differentially affected by bafilomycin, nocodazole, and low temperature. Cell Tissue Res (2005) 1.66
Large-scale automated analysis of location patterns in randomly tagged 3T3 cells. Ann Biomed Eng (2007) 1.63
High-resolution quantification of focal adhesion spatiotemporal dynamics in living cells. PLoS One (2011) 1.63
Vimentin organization modulates the formation of lamellipodia. Mol Biol Cell (2011) 1.60
High-recall protein entity recognition using a dictionary. Bioinformatics (2005) 1.60
NUCLEAR SEGMENTATION IN MICROSCOPE CELL IMAGES: A HAND-SEGMENTED DATASET AND COMPARISON OF ALGORITHMS. Proc IEEE Int Symp Biomed Imaging (2009) 1.59
Designing biosensors for Rho family proteins--deciphering the dynamics of Rho family GTPase activation in living cells. J Cell Sci (2004) 1.58
From quantitative microscopy to automated image understanding. J Biomed Opt (2004) 1.58
The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. Am J Physiol Renal Physiol (2009) 1.56
A multiresolution approach to automated classification of protein subcellular location images. BMC Bioinformatics (2007) 1.56
Automated interpretation of subcellular patterns in fluorescence microscope images for location proteomics. Cytometry A (2006) 1.53
Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nat Neurosci (2012) 1.50
Talin: an emerging focal point of adhesion dynamics. Curr Opin Cell Biol (2004) 1.49
Imaging the coordination of multiple signalling activities in living cells. Nat Rev Mol Cell Biol (2011) 1.47
A graphical model approach to automated classification of protein subcellular location patterns in multi-cell images. BMC Bioinformatics (2006) 1.47
A generative model of microtubule distributions, and indirect estimation of its parameters from fluorescence microscopy images. Cytometry A (2010) 1.44
Object type recognition for automated analysis of protein subcellular location. IEEE Trans Image Process (2005) 1.44
Illuminating adhesion complexes in migrating cells: moving toward a bright future. Curr Opin Cell Biol (2003) 1.39
Methods for the detection of paxillin post-translational modifications and interacting proteins by mass spectrometry. J Proteome Res (2005) 1.38
Merocyanine dyes with improved photostability. Org Lett (2007) 1.37
Automated interpretation of subcellular patterns from immunofluorescence microscopy. J Immunol Methods (2004) 1.37
Deleted in colorectal carcinoma and differentially expressed integrins mediate the directional migration of neural precursors in the rostral migratory stream. J Neurosci (2002) 1.37
Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation. J Biol Chem (2006) 1.30
Putting proteins on the map. Nat Biotechnol (2006) 1.29
Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells. J Cell Biol (2007) 1.25
Objective evaluation of differences in protein subcellular distribution. Traffic (2002) 1.24
Light regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP. J Am Chem Soc (2010) 1.23
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp Cell Res (2008) 1.22
Quantifying the distribution of probes between subcellular locations using unsupervised pattern unmixing. Bioinformatics (2010) 1.22
Data File Standard for Flow Cytometry, version FCS 3.1. Cytometry A (2010) 1.21
Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2. J Biol Chem (2004) 1.20
Boron polylactide nanoparticles exhibiting fluorescence and phosphorescence in aqueous medium. ACS Nano (2008) 1.20
Design and optimization of genetically encoded fluorescent biosensors: GTPase biosensors. Methods Cell Biol (2008) 1.20
Automated Analysis of Human Protein Atlas Immunofluorescence Images. Proc IEEE Int Symp Biomed Imaging (2009) 1.18
Spatiotemporal control of small GTPases with light using the LOV domain. Methods Enzymol (2011) 1.18
alpha5 integrin signaling regulates the formation of spines and synapses in hippocampal neurons. J Biol Chem (2007) 1.17
Image-derived, three-dimensional generative models of cellular organization. Cytometry A (2011) 1.16
A stacked graphical model for associating sub-images with sub-captions. Pac Symp Biocomput (2007) 1.16
Biosensor Förster resonance energy transfer detection by the phasor approach to fluorescence lifetime imaging microscopy. Microsc Res Tech (2011) 1.15
New dimensions in cell migration. Nat Cell Biol (2003) 1.15
Migration of perilesional microglia after focal brain injury and modulation by CC chemokine receptor 5: an in situ time-lapse confocal imaging study. J Neurosci (2005) 1.11
Opening of size-selective pores in endosomes during human rhinovirus serotype 2 in vivo uncoating monitored by single-organelle flow analysis. J Virol (2005) 1.11
Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells. PLoS Comput Biol (2010) 1.10
A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics. Biochemistry (2007) 1.10
A biosensor generated via high-throughput screening quantifies cell edge Src dynamics. Nat Chem Biol (2011) 1.09
Endogenous RhoG is rapidly activated after epidermal growth factor stimulation through multiple guanine-nucleotide exchange factors. Mol Biol Cell (2010) 1.08
Rational design of a ligand-controlled protein conformational switch. Proc Natl Acad Sci U S A (2013) 1.08
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. J Cell Sci (2007) 1.07
PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. Mol Cell Biol (2006) 1.07
CellGeo: a computational platform for the analysis of shape changes in cells with complex geometries. J Cell Biol (2014) 1.04
Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion. J Biol Chem (2009) 1.02
External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Nat Cell Biol (2012) 1.00
Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM. Proc Natl Acad Sci U S A (2012) 1.00
Simple one-pot preparation of water-soluble, cysteine-reactive cyanine and merocyanine dyes for biological imaging. Bioconjug Chem (2007) 1.00
Automated analysis and reannotation of subcellular locations in confocal images from the Human Protein Atlas. PLoS One (2012) 0.99
Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. BMC Biotechnol (2007) 0.98
Phosphorylation of serine 709 in GIT1 regulates protrusive activity in cells. Biochem Biophys Res Commun (2006) 0.98
High glucose-mediated oxidative stress impairs cell migration. PLoS One (2011) 0.98