Published in Am J Physiol Lung Cell Mol Physiol on August 01, 2008
PAK1 as a therapeutic target. Expert Opin Ther Targets (2010) 1.48
Atrial natriuretic peptide attenuates LPS-induced lung vascular leak: role of PAK1. Am J Physiol Lung Cell Mol Physiol (2010) 1.10
Association between adherens junctions and tight junctions via Rap1 promotes barrier protective effects of oxidized phospholipids. J Cell Physiol (2011) 1.05
Endothelial barrier disruption and recovery is controlled by substrate stiffness. Microvasc Res (2013) 0.97
Afadin controls p120-catenin-ZO-1 interactions leading to endothelial barrier enhancement by oxidized phospholipids. J Cell Physiol (2012) 0.97
Activation of aortic endothelial cells by oxidized phospholipids: a phosphoproteomic analysis. J Proteome Res (2010) 0.97
Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels. Cardiovasc Res (2010) 0.96
Oxidized phospholipids in control of inflammation and endothelial barrier. Transl Res (2009) 0.92
Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus. Am J Physiol Lung Cell Mol Physiol (2015) 0.81
Identification of paxillin domains interacting with β-catenin. FEBS Lett (2012) 0.81
Oxidized phosphatidylcholine formation and action in oligodendrocytes. J Neurochem (2009) 0.81
c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury. Am J Physiol Lung Cell Mol Physiol (2015) 0.80
Blood Brothers: Hemodynamics and Cell-Matrix Interactions in Endothelial Function. Antioxid Redox Signal (2016) 0.75
Role of IQGAP1 in endothelial barrier enhancement caused by OxPAPC. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Paxillin: a crossroad in pathological cell migration. J Hematol Oncol (2017) 0.75
Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol (2005) 11.74
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol (2001) 9.73
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31
Biology of the p21-activated kinases. Annu Rev Biochem (2003) 7.63
Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again. Nat Cell Biol (2002) 4.74
Paxillin: adapting to change. Physiol Rev (2004) 4.48
Paxillin and focal adhesion signalling. Nat Cell Biol (2000) 4.37
Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J Biol Chem (1997) 3.91
Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics. J Cell Biol (2006) 3.15
Paxillin: a focal adhesion-associated adaptor protein. Oncogene (2001) 3.03
Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. Mol Cell Biol (2000) 2.92
Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch. Am J Physiol Lung Cell Mol Physiol (2003) 2.89
Biomarkers of lipid peroxidation, airway inflammation and asthma. Eur Respir J (2003) 2.70
Paxillin interactions. J Cell Sci (2000) 2.67
Reactive oxygen species in acute lung injury. Eur Respir J (1998) 2.50
Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. J Biol Chem (1995) 2.44
Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch. Am J Pathol (2006) 2.25
The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL). J Cell Biol (2001) 2.10
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res (2004) 2.07
Protective role of phospholipid oxidation products in endotoxin-induced tissue damage. Nature (2002) 2.06
Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J (2004) 1.98
Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. Circ Res (2004) 1.88
Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res (2007) 1.83
GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol (2005) 1.81
Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration. J Cell Biol (2002) 1.78
Oxidant-antioxidant balance in acute lung injury. Chest (2002) 1.78
Focal adhesions: paradigm for a signaling nexus. Circ Res (2006) 1.73
Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. Mol Biol Cell (2002) 1.72
Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol (2004) 1.70
Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol Biol Cell (2005) 1.69
Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species. J Biol Chem (2004) 1.68
Oxidized phospholipids as modulators of inflammation in atherosclerosis. Curr Opin Lipidol (2003) 1.65
Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells. Exp Cell Res (2004) 1.63
Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils. Proc Natl Acad Sci U S A (1999) 1.53
S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin. J Appl Physiol (1985) (2002) 1.52
Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT. Blood (2002) 1.50
Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT. FASEB J (2003) 1.48
Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol (2007) 1.37
Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury. Am J Respir Crit Care Med (2006) 1.36
Paxillin-ARF GAP signaling and the cytoskeleton. Curr Opin Cell Biol (2001) 1.35
Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium. Am J Physiol Lung Cell Mol Physiol (2006) 1.31
The isoprostanes: their role as an index of oxidant stress status in human pulmonary disease. Am J Respir Crit Care Med (2002) 1.22
Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40. J Immunol (2005) 1.18
Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function. J Physiol (2002) 1.13
Tiam1 and betaPIX mediate Rac-dependent endothelial barrier protective response to oxidized phospholipids. J Cell Physiol (2007) 1.12
Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins. Microvasc Res (2004) 1.10
Inhibition of LPS- and CpG DNA-induced TNF-alpha response by oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol (2003) 1.08
Signaling pathways involved in OxPAPC-induced pulmonary endothelial barrier protection. Microvasc Res (2007) 1.08
PKCdelta regulates endothelial basal barrier function through modulation of RhoA GTPase activity. Exp Cell Res (2005) 1.03
Nitrated lipids: a class of cell-signaling molecules. Proc Natl Acad Sci U S A (2004) 1.01
Reactive oxygen species in mechanotransduction. Am J Physiol Lung Cell Mol Physiol (2004) 1.01
Anti-inflammatory properties of lipid oxidation products. J Mol Med (Berl) (2003) 0.99
Oxidized lipids: the two faces of vascular inflammation. Curr Atheroscler Rep (2006) 0.96
Resealing of endothelial junctions by focal adhesion kinase. Am J Physiol Lung Cell Mol Physiol (2006) 0.94
Influence of tidal volume on pulmonary NO release, tissue lipid peroxidation and surfactant phospholipids. Biochim Biophys Acta (2003) 0.89
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31
Paxillin: adapting to change. Physiol Rev (2004) 4.48
Paxillin comes of age. J Cell Sci (2008) 3.57
Functional evolution of a cis-regulatory module. PLoS Biol (2005) 3.21
Retracted G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C. J Biol Chem (2010) 2.81
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol (2002) 2.73
Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. J Biol Chem (2004) 2.44
Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes. J Am Soc Nephrol (2006) 2.41
Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch. Am J Pathol (2006) 2.25
Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury. Crit Care Med (2011) 2.24
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res (2004) 2.07
Generation and biological activities of oxidized phospholipids. Antioxid Redox Signal (2010) 2.04
Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J (2004) 1.98
Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res (2007) 1.83
Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol (2004) 1.83
GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol (2005) 1.81
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol (2009) 1.79
RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. Mol Cell Biol (2003) 1.75
Measurement of local permeability at subcellular level in cell models of agonist- and ventilator-induced lung injury. Lab Invest (2012) 1.74
Focal adhesions: paradigm for a signaling nexus. Circ Res (2006) 1.73
Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. Mol Biol Cell (2002) 1.72
Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol (2004) 1.70
Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol Biol Cell (2005) 1.69
Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids. Circ Res (2009) 1.64
Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells. Exp Cell Res (2004) 1.63
Tension development during contractile stimulation of smooth muscle requires recruitment of paxillin and vinculin to the membrane. Am J Physiol Cell Physiol (2003) 1.56
Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. Am J Respir Cell Mol Biol (2003) 1.56
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis. Mol Biol Cell (2011) 1.54
S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin. J Appl Physiol (1985) (2002) 1.52
Involvement of microtubules and Rho pathway in TGF-beta1-induced lung vascular barrier dysfunction. J Cell Physiol (2005) 1.50
Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT. FASEB J (2003) 1.48
Targeted nonviral gene-based inhibition of Gα(i/o)-mediated vagal signaling in the posterior left atrium decreases vagal-induced atrial fibrillation. Heart Rhythm (2011) 1.48
Canalization of segmentation and its evolution in Drosophila. Proc Natl Acad Sci U S A (2007) 1.47
Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability. Am J Physiol Lung Cell Mol Physiol (2010) 1.46
Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization. J Biol Chem (2001) 1.45
Hic-5 promotes invadopodia formation and invasion during TGF-β-induced epithelial-mesenchymal transition. J Cell Biol (2012) 1.45
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection. J Cell Physiol (2008) 1.42
Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways. Am J Physiol Lung Cell Mol Physiol (2006) 1.42
Role of phospholipid oxidation products in atherosclerosis. Circ Res (2012) 1.41
HGF attenuates thrombin-induced endothelial permeability by Tiam1-mediated activation of the Rac pathway and by Tiam1/Rac-dependent inhibition of the Rho pathway. FASEB J (2007) 1.39
Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol (2007) 1.37
Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury. Am J Respir Crit Care Med (2006) 1.36
Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites. J Cell Sci (2008) 1.34
Novel interaction of cortactin with endothelial cell myosin light chain kinase. Biochem Biophys Res Commun (2002) 1.34
Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium. Am J Physiol Lung Cell Mol Physiol (2006) 1.31
Regulation of paxillin family members during epithelial-mesenchymal transformation: a putative role for paxillin delta. J Cell Sci (2005) 1.31
FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas. J Cell Sci (2009) 1.29
Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo. Crit Care (2008) 1.23
Hic-5 contributes to epithelial-mesenchymal transformation through a RhoA/ROCK-dependent pathway. J Cell Physiol (2007) 1.22
Magnitude-dependent effects of cyclic stretch on HGF- and VEGF-induced pulmonary endothelial remodeling and barrier regulation. Am J Physiol Lung Cell Mol Physiol (2008) 1.22
Endothelial permeability is controlled by spatially defined cytoskeletal mechanics: atomic force microscopy force mapping of pulmonary endothelial monolayer. Nanomedicine (2008) 1.21
Differential regulation of human lung epithelial and endothelial barrier function by thrombin. Am J Respir Cell Mol Biol (2004) 1.19
MAP kinases in lung endothelial permeability induced by microtubule disassembly. Am J Physiol Lung Cell Mol Physiol (2005) 1.18
Paxillin is involved in the differential regulation of endothelial barrier by HGF and VEGF. Am J Respir Cell Mol Biol (2008) 1.17
The paxillin LD motifs. FEBS Lett (2002) 1.17
Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts. Mol Biol Cell (2003) 1.16
Rac GTPase is a hub for protein kinase A and Epac signaling in endothelial barrier protection by cAMP. Microvasc Res (2009) 1.16
Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop. J Invest Dermatol (2008) 1.16
Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin. Biophys J (2008) 1.16
Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement. Microvasc Res (2009) 1.16
Stimulation of Rho signaling by pathologic mechanical stretch is a "second hit" to Rho-independent lung injury induced by IL-6. Am J Physiol Lung Cell Mol Physiol (2012) 1.15
Expression of non-phosphorylatable paxillin mutants in canine tracheal smooth muscle inhibits tension development. J Physiol (2003) 1.15
Tiam1 and betaPIX mediate Rac-dependent endothelial barrier protective response to oxidized phospholipids. J Cell Physiol (2007) 1.12
Atrial natriuretic peptide attenuates LPS-induced lung vascular leak: role of PAK1. Am J Physiol Lung Cell Mol Physiol (2010) 1.10
The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner. J Biol Chem (2004) 1.08
p190RhoGAP mediates protective effects of oxidized phospholipids in the models of ventilator-induced lung injury. Exp Cell Res (2010) 1.08
EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118. J Biol Chem (2004) 1.08
Signaling pathways involved in OxPAPC-induced pulmonary endothelial barrier protection. Microvasc Res (2007) 1.08
IL-17RA signaling amplifies antibody-induced arthritis. PLoS One (2011) 1.07
Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing. Mol Biol Cell (2003) 1.05
Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker. J Cell Sci (2005) 1.05
Association between adherens junctions and tight junctions via Rap1 promotes barrier protective effects of oxidized phospholipids. J Cell Physiol (2011) 1.05
ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability. FEBS Lett (2005) 1.04
Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages. J Biol Chem (2010) 1.04
A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. J Biol Chem (2002) 1.03
CdGAP associates with actopaxin to regulate integrin-dependent changes in cell morphology and motility. Curr Biol (2006) 1.03
Autonomic remodeling in the left atrium and pulmonary veins in heart failure: creation of a dynamic substrate for atrial fibrillation. Circ Arrhythm Electrophysiol (2011) 1.03
EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation. Am J Respir Cell Mol Biol (2006) 1.02
Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA. PLoS One (2012) 1.00
LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration. FASEB J (2012) 1.00
VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost. J Cell Physiol (2012) 1.00
Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling. Transl Res (2010) 1.00
Phorbol esters increase MLC phosphorylation and actin remodeling in bovine lung endothelium without increased contraction. Am J Physiol Lung Cell Mol Physiol (2003) 0.99
Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. J Biol Chem (2005) 0.98
Focal adhesion kinase regulation of mechanotransduction and its impact on endothelial cell functions. Microvasc Res (2011) 0.98
Diverse roles for the paxillin family of proteins in cancer. Genes Cancer (2012) 0.98
Endothelial barrier disruption and recovery is controlled by substrate stiffness. Microvasc Res (2013) 0.97
Afadin controls p120-catenin-ZO-1 interactions leading to endothelial barrier enhancement by oxidized phospholipids. J Cell Physiol (2012) 0.97
Roles for the tubulin- and PTP-PEST-binding paxillin LIM domains in cell adhesion and motility. Int J Biochem Cell Biol (2002) 0.97
Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration. Mol Biol Cell (2009) 0.97
Phosphorylation of actopaxin regulates cell spreading and migration. J Cell Biol (2004) 0.97