Published in Nature on May 02, 2002
The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process. Proc Natl Acad Sci U S A (2003) 2.37
Copper active sites in biology. Chem Rev (2014) 1.90
Energy transduction: proton transfer through the respiratory complexes. Annu Rev Biochem (2006) 1.81
Exploring the proton pump mechanism of cytochrome c oxidase in real time. Proc Natl Acad Sci U S A (2007) 1.63
Biological inorganic chemistry at the beginning of the 21st century. Proc Natl Acad Sci U S A (2003) 1.43
The catalytic cycle of cytochrome c oxidase is not the sum of its two halves. Proc Natl Acad Sci U S A (2003) 1.41
Structural proton diffusion along lipid bilayers. Biophys J (2003) 1.35
Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells. In Vitro Cell Dev Biol Anim (2003) 1.22
Theoretical and computational analysis of the membrane potential generated by cytochrome c oxidase upon single electron injection into the enzyme. Biochim Biophys Acta (2008) 1.12
Direct observation of protonation reactions during the catalytic cycle of cytochrome c oxidase. Proc Natl Acad Sci U S A (2003) 1.12
Controlled uncoupling and recoupling of proton pumping in cytochrome c oxidase. Proc Natl Acad Sci U S A (2006) 1.11
Mapping protein dynamics in catalytic intermediates of the redox-driven proton pump cytochrome c oxidase. Proc Natl Acad Sci U S A (2006) 1.11
Plant mitochondrial function during anaerobiosis. Ann Bot (2008) 1.06
Replacing Asn207 by aspartate at the neck of the D channel in the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides results in decoupling the proton pump. Biochemistry (2006) 0.97
Time-resolved electrometric and optical studies on cytochrome bd suggest a mechanism of electron-proton coupling in the di-heme active site. Proc Natl Acad Sci U S A (2005) 0.96
Mannheimia haemolytica leukotoxin induces apoptosis of bovine lymphoblastoid cells (BL-3) via a caspase-9-dependent mitochondrial pathway. Infect Immun (2005) 0.94
Electronic wiring of a multi-redox site membrane protein in a biomimetic surface architecture. Biophys J (2008) 0.92
An arginine to lysine mutation in the vicinity of the heme propionates affects the redox potentials of the hemes and associated electron and proton transfer in cytochrome c oxidase. Biochemistry (2005) 0.92
Dielectric relaxation of cytochrome c oxidase: Comparison of the microscopic and continuum models. J Chem Phys (2009) 0.90
Proton-transport mechanisms in cytochrome c oxidase revealed by studies of kinetic isotope effects. Biochim Biophys Acta (2011) 0.84
Could the tyrosine-histidine ligand to CuB in cytochrome c oxidase be coordinatively labile? Implications from a quantum chemical model study of histidine substitutional lability and the effects of the covalent tyrosine-histidine cross-link. J Biol Inorg Chem (2003) 0.83
Partial steps of charge translocation in the nonpumping N139L mutant of Rhodobacter sphaeroides cytochrome c oxidase with a blocked D-channel. Biochemistry (2010) 0.82
Coupled electron and proton transfer reactions during the O→E transition in bovine cytochrome c oxidase. Biochim Biophys Acta (2011) 0.78
Communication between R481 and Cu(B) in cytochrome bo(3) ubiquinol oxidase from Escherichia coli. Biochemistry (2009) 0.78
Computational prediction and in vitro analysis of potential physiological ligands of the bile acid binding site in cytochrome c oxidase. Biochemistry (2013) 0.76
Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proc Natl Acad Sci U S A (2003) 15.17
Multimodal fast optical interrogation of neural circuitry. Nature (2007) 14.68
Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses. Curr Biol (2005) 8.01
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc (2011) 5.96
Channelrhodopsin-1: a light-gated proton channel in green algae. Science (2002) 5.73
Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH. Nature (2005) 3.74
Spectral characteristics of the photocycle of channelrhodopsin-2 and its implication for channel function. J Mol Biol (2007) 2.88
Overcoming barriers to membrane protein structure determination. Nat Biotechnol (2011) 2.49
Ultra light-sensitive and fast neuronal activation with the Ca²+-permeable channelrhodopsin CatCh. Nat Neurosci (2011) 2.37
Structural guidance of the photocycle of channelrhodopsin-2 by an interhelical hydrogen bond. Biochemistry (2010) 2.11
Spatially asymmetric reorganization of inhibition establishes a motion-sensitive circuit. Nature (2010) 2.01
Channelrhodopsin-2 is a leaky proton pump. Proc Natl Acad Sci U S A (2009) 1.87
A gene-fusion strategy for stoichiometric and co-localized expression of light-gated membrane proteins. Nat Methods (2011) 1.87
Proteorhodopsin is a light-driven proton pump with variable vectoriality. J Mol Biol (2002) 1.81
The structure of cbb3 cytochrome oxidase provides insights into proton pumping. Science (2010) 1.68
Phloem-localized, proton-coupled sucrose carrier ZmSUT1 mediates sucrose efflux under the control of the sucrose gradient and the proton motive force. J Biol Chem (2005) 1.59
Crystallisation of membrane proteins mediated by antibody fragments. Curr Opin Struct Biol (2002) 1.50
Enhancing functional production of G protein-coupled receptors in Pichia pastoris to levels required for structural studies via a single expression screen. Protein Sci (2006) 1.46
Direct observation of tiers in the energy landscape of a chromoprotein: a single-molecule study. Proc Natl Acad Sci U S A (2003) 1.33
Transport mechanism and pH regulation of the Na+/H+ antiporter NhaA from Escherichia coli: an electrophysiological study. J Biol Chem (2011) 1.31
"Vision" in single-celled algae. News Physiol Sci (2004) 1.30
Conformational changes of channelrhodopsin-2. J Am Chem Soc (2009) 1.28
Electrophysiological characterization of LacY. Proc Natl Acad Sci U S A (2009) 1.26
SSM-based electrophysiology. Methods (2008) 1.26
The structure of Aquifex aeolicus sulfide:quinone oxidoreductase, a basis to understand sulfide detoxification and respiration. Proc Natl Acad Sci U S A (2009) 1.26
Dynamic water networks in cytochrome C oxidase from Paracoccus denitrificans investigated by molecular dynamics simulations. Biophys J (2004) 1.26
Projection structure of channelrhodopsin-2 at 6 Å resolution by electron crystallography. J Mol Biol (2011) 1.24
Comparative analysis and "expression space" coverage of the production of prokaryotic membrane proteins for structural genomics. Protein Sci (2006) 1.21
High resolution crystal structure of Paracoccus denitrificans cytochrome c oxidase: new insights into the active site and the proton transfer pathways. Biochim Biophys Acta (2009) 1.20
Single-molecule study of the electronic couplings in a circular array of molecules: light-harvesting-2 complex from Rhodospirillum molischianum. Phys Rev Lett (2003) 1.20
Functional cell-free synthesis of a seven helix membrane protein: in situ insertion of bacteriorhodopsin into liposomes. J Mol Biol (2007) 1.18
Transient protonation changes in channelrhodopsin-2 and their relevance to channel gating. Proc Natl Acad Sci U S A (2013) 1.12
The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions. Nucleic Acids Res (2011) 1.11
Two simple and generic antibody-independent kinase assays: comparison of a bioluminescent and a microfluidic assay format. J Biomol Screen (2004) 1.11
Diverse functional consequences of mutations in the Na+/K+-ATPase alpha2-subunit causing familial hemiplegic migraine type 2. J Biol Chem (2008) 1.11
Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis. Structure (2007) 1.10
The DC gate in Channelrhodopsin-2: crucial hydrogen bonding interaction between C128 and D156. Photochem Photobiol Sci (2010) 1.10
Multiconformation continuum electrostatics analysis of the NhaA Na+/H+ antiporter of Escherichia coli with functional implications. Proc Natl Acad Sci U S A (2006) 1.08
Delineating electrogenic reactions during lactose/H+ symport. Biochemistry (2010) 1.08
Structural genomics on membrane proteins: comparison of more than 100 GPCRs in 3 expression systems. J Struct Funct Genomics (2006) 1.08
The MAM (meprin/A5-protein/PTPmu) domain is a homophilic binding site promoting the lateral dimerization of receptor-like protein-tyrosine phosphatase mu. J Biol Chem (2004) 1.08
A new structure-based classification of sulfide:quinone oxidoreductases. Proteins (2010) 1.05
A D-pathway mutation decouples the Paracoccus denitrificans cytochrome c oxidase by altering the side-chain orientation of a distant conserved glutamate. J Mol Biol (2008) 1.05
Optogenetic long-term manipulation of behavior and animal development. PLoS One (2011) 1.05
Glutamate residue 90 in the predicted transmembrane domain 2 is crucial for cation flux through channelrhodopsin 2. Biochem Biophys Res Commun (2011) 1.03
Structure and function of prokaryotic glutamate transporters from Escherichia coli and Pyrococcus horikoshii. Biochemistry (2006) 1.03
The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One (2010) 1.02
The retinal structure of channelrhodopsin-2 assessed by resonance Raman spectroscopy. FEBS Lett (2009) 1.02
The photocycle of channelrhodopsin-2: ultrafast reaction dynamics and subsequent reaction steps. Chemphyschem (2010) 1.02
Titration behavior of residues at the entrance of the D-pathway of cytochrome c oxidase from paracoccus denitrificans investigated by continuum electrostatic calculations. Biophys J (2005) 1.02
Na,K-ATPase mutations in familial hemiplegic migraine lead to functional inactivation. Biochim Biophys Acta (2005) 1.01
Investigation of the sodium-binding sites in the sodium-coupled betaine transporter BetP. Proc Natl Acad Sci U S A (2012) 1.01
Specific anion and cation binding to lipid membranes investigated on a solid supported membrane. Langmuir (2007) 1.01
Rapid activation of the melibiose permease MelB immobilized on a solid-supported membrane. Langmuir (2008) 1.00
Electrophysiological analysis of the mutated Na,K-ATPase cation binding pocket. J Biol Chem (2003) 1.00
The influence of protonation states on the dynamics of the NhaA antiporter from Escherichia coli. Biophys J (2007) 1.00
Conformational dynamics of the Na+/K+-ATPase probed by voltage clamp fluorometry. Proc Natl Acad Sci U S A (2003) 0.98
The inner interhelix loop 4-5 of the melibiose permease from Escherichia coli takes part in conformational changes after sugar binding. J Biol Chem (2006) 0.98
Agonist- and competitive antagonist-induced movement of loop 5 on the alpha subunit of the neuronal alpha4beta4 nicotinic acetylcholine receptor. J Neurochem (2007) 0.97
Isolation, characterization and electron microscopic single particle analysis of the NADH:ubiquinone oxidoreductase (complex I) from the hyperthermophilic eubacterium Aquifex aeolicus. Biochemistry (2003) 0.97
Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension (2009) 0.97
Crystallization and preliminary X-ray crystallographic analysis of strictosidine synthase from Rauvolfia: the first member of a novel enzyme family. Biochim Biophys Acta (2004) 0.97
Conformational dynamics of Na+/K+- and H+/K+-ATPase probed by voltage clamp fluorometry. Ann N Y Acad Sci (2003) 0.95
Tyrosine 167: the origin of the radical species observed in the reaction of cytochrome c oxidase with hydrogen peroxide in Paracoccus denitrificans. Biochemistry (2004) 0.95
Crucial steps in the structure determination of the Na+/H+ antiporter NhaA in its native conformation. J Mol Biol (2006) 0.95
Characterization of Na,K-ATPase and H,K-ATPase enzymes with glycosylation-deficient beta-subunit variants by voltage-clamp fluorometry in Xenopus oocytes. Biochemistry (2008) 0.95
Editorial: the nonsense of biofuels. Angew Chem Int Ed Engl (2012) 0.94
Heterologous expression and comparative characterization of the human neuromedin U subtype II receptor using the methylotrophic yeast Pichia pastoris and mammalian cells. Int J Biochem Cell Biol (2007) 0.94
Kinetics of proton release and uptake by channelrhodopsin-2. FEBS Lett (2012) 0.94
pH-dependent photoisomerization of retinal in proteorhodopsin. Biochemistry (2005) 0.93
Optogenetic stimulation of the auditory pathway. J Clin Invest (2014) 0.93
Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons. Biochim Biophys Acta (2004) 0.92
Probing the sensory rhodopsin II binding domain of its cognate transducer by calorimetry and electrophysiology. J Mol Biol (2003) 0.92
Dimethylsulphoxide as a tool to increase functional expression of heterologously produced GPCRs in mammalian cells. FEBS Lett (2006) 0.91
The beta subunit of the Na+/K+-ATPase follows the conformational state of the holoenzyme. J Gen Physiol (2005) 0.91
Functional significance of E2 state stabilization by specific alpha/beta-subunit interactions of Na,K- and H,K-ATPase. J Biol Chem (2008) 0.91
Heterologous expression of human Neuromedin U receptor 1 and its subsequent solubilization and purification. Biochim Biophys Acta (2008) 0.91
Charge transfer in P-type ATPases investigated on planar membranes. Arch Biochem Biophys (2008) 0.91
Bacterial transporters: charge translocation and mechanism. Biochim Biophys Acta (2009) 0.90
Crystallization and preliminary X-ray analysis of strictosidine synthase and its complex with the substrate tryptamine. Acta Crystallogr D Biol Crystallogr (2005) 0.89
The role of tryptophan 272 in the Paracoccus denitrificans cytochrome c oxidase. FEBS Lett (2006) 0.89
Voltage- and pH-dependent changes in vectoriality of photocurrents mediated by wild-type and mutant proteorhodopsins upon expression in Xenopus oocytes. J Mol Biol (2009) 0.89
Fluorometric measurements of intermolecular distances between the alpha- and beta-subunits of the Na+/K+-ATPase. J Biol Chem (2006) 0.89
Sugar binding induced charge translocation in the melibiose permease from Escherichia coli. Biochemistry (2004) 0.89
Ultrafast infrared spectroscopy on channelrhodopsin-2 reveals efficient energy transfer from the retinal chromophore to the protein. J Am Chem Soc (2013) 0.89
Multivariate analysis of single-molecule spectra: surpassing spectral diffusion. Phys Rev Lett (2005) 0.89
Light-induced movement of the transmembrane helix B in channelrhodopsin-2. Angew Chem Int Ed Engl (2013) 0.88
Employing Rhodobacter sphaeroides to functionally express and purify human G protein-coupled receptors. Biol Chem (2008) 0.88
The nitrite transport protein NirC from Salmonella typhimurium is a nitrite/proton antiporter. Biochim Biophys Acta (2012) 0.88
Studying the stoichiometries of membrane proteins by mass spectrometry: microbial rhodopsins and a potassium ion channel. Phys Chem Chem Phys (2010) 0.88
Evaluation of parameters critical for observing nucleic acids inside living Xenopus laevis oocytes by in-cell NMR spectroscopy. J Am Chem Soc (2009) 0.88
Vibrational modes of tyrosines in cytochrome c oxidase from Paracoccus denitrificans: FTIR and electrochemical studies on Tyr-D4-labeled and on Tyr280His and Tyr35Phe mutant enzymes. Biochemistry (2002) 0.87
Biochemical and biophysical characterization of the two isoforms of cbb3-type cytochrome c oxidase from Pseudomonas stutzeri. J Bacteriol (2013) 0.87
High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices. Mol Pharmacol (2007) 0.87
Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7. J Biol Chem (2008) 0.86