Published in EMBO Rep on May 01, 2002
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Functional estrogen receptors in the mitochondria of breast cancer cells. Mol Biol Cell (2006) 1.72
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Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol (2004) 1.43
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The role of a single-stranded nucleotide loop in transcriptional regulation of the human sod2 gene. J Biol Chem (2007) 0.96
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The "two-faced" effects of reactive oxygen species and the lipid peroxidation product 4-hydroxynonenal in the hallmarks of cancer. Cancers (Basel) (2010) 0.93
Hepatic iron overload and hepatocellular carcinoma. Liver Cancer (2014) 0.92
Mutations in the SOD2 promoter reveal a molecular basis for an activating protein 2-dependent dysregulation of manganese superoxide dismutase expression in cancer cells. Mol Cancer Res (2008) 0.92
Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells. Mol Cells (2011) 0.92
Oxidative damage, pro-inflammatory cytokines, TGF-alpha and c-myc in chronic HCV-related hepatitis and cirrhosis. World J Gastroenterol (2006) 0.91
Antioxidant activity of growth hormone-releasing hormone antagonists in LNCaP human prostate cancer line. Proc Natl Acad Sci U S A (2008) 0.91
Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells. Chin Med (2012) 0.90
NF-κB suppresses ROS levels in BCR-ABL(+) cells to prevent activation of JNK and cell death. Oncogene (2011) 0.90
Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway. Cell Death Dis (2013) 0.90
Salvianolic acid B induces apoptosis in human glioma U87 cells through p38-mediated ROS generation. Cell Mol Neurobiol (2013) 0.90
Expression of alpha-crystallin in retinoblastoma. Arch Ophthalmol (2009) 0.89
Oxidative stress induces mitochondrial DNA damage and cytotoxicity through independent mechanisms in human cancer cells. Biomed Res Int (2012) 0.89
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Mitochondrial uncoupling protein 2 expression in colon cancer and its clinical significance. World J Gastroenterol (2010) 0.89
MicroRNAs and liver cancer associated with iron overload: therapeutic targets unravelled. World J Gastroenterol (2013) 0.88
Polyphenols sensitization potentiates susceptibility of MCF-7 and MDA MB-231 cells to Centchroman. PLoS One (2012) 0.88
Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases. Exp Mol Med (2008) 0.88
Endoplasmic reticulum stress and unfolded protein response in Atm-deficient thymocytes and thymic lymphoma cells are attributable to oxidative stress. Neoplasia (2008) 0.88
Acquisition of resistance of pancreatic cancer cells to 2-methoxyestradiol is associated with the upregulation of manganese superoxide dismutase. Mol Cancer Res (2012) 0.87
Late activation of stress-activated protein kinases/c-Jun N-terminal kinases triggered by cisplatin-induced DNA damage in repair-defective cells. J Biol Chem (2011) 0.87
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MAP17 and SGLT1 protein expression levels as prognostic markers for cervical tumor patient survival. PLoS One (2013) 0.86
Pivotal role of reactive oxygen species in differential regulation of lipopolysaccharide-induced prostaglandins production in macrophages. Mol Pharmacol (2012) 0.86
Apoptotic cellular events for selenium compounds involved in cancer prevention. J Bioenerg Biomembr (2007) 0.86
Key regulators in prostate cancer identified by co-expression module analysis. BMC Genomics (2014) 0.86
Phosphorylation and subcellular localization of p27Kip1 regulated by hydrogen peroxide modulation in cancer cells. PLoS One (2012) 0.86
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Alterations of phosphoproteins in NCI-H526 small cell lung cancer cells involved in cytotoxicity of cisplatin and titanocene Y. Neoplasia (2012) 0.85
Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy. Oxid Med Cell Longev (2016) 0.85
A targeted enzyme approach to sensitization of tyrosine kinase inhibitor-resistant breast cancer cells. Exp Cell Res (2012) 0.84
Role of ROS and RNS Sources in Physiological and Pathological Conditions. Oxid Med Cell Longev (2016) 0.84
Deguelin induces the apoptosis of lung cancer cells through regulating a ROS driven Akt pathway. Cancer Cell Int (2015) 0.84
Molecular mechanism implicated in Pemetrexed-induced apoptosis in human melanoma cells. Mol Cancer (2012) 0.84
Bornyl caffeate induces apoptosis in human breast cancer MCF-7 cells via the ROS- and JNK-mediated pathways. Acta Pharmacol Sin (2013) 0.83
Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma. Cell Death Dis (2015) 0.83
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Thymosin β10 expression driven by the human TERT promoter induces ovarian cancer-specific apoptosis through ROS production. PLoS One (2012) 0.83
Hemoglobin induces colon cancer cell proliferation by release of reactive oxygen species. World J Gastroenterol (2006) 0.83
Loss of robustness and addiction to IGF1 during early keratinocyte transformation by human Papilloma virus 16. PLoS One (2007) 0.82
Oxidized ATM promotes abnormal proliferation of breast CAFs through maintaining intracellular redox homeostasis and activating the PI3K-AKT, MEK-ERK, and Wnt-β-catenin signaling pathways. Cell Cycle (2015) 0.82
Iron and reactive oxygen species: friends or foes of cancer cells? Antioxid Redox Signal (2013) 0.82
3-Methyl pyruvate enhances radiosensitivity through increasing mitochondria-derived reactive oxygen species in tumor cell lines. J Radiat Res (2014) 0.81
Mechanisms of Mycotoxin-induced Dermal Toxicity and Tumorigenesis Through Oxidative Stress-related Pathways. J Toxicol Pathol (2014) 0.81
The proapoptotic effect of traditional and novel nonsteroidal anti-inflammatory drugs in mammalian and yeast cells. Oxid Med Cell Longev (2013) 0.80
Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide. PLoS One (2013) 0.80
Topical application of ochratoxin A causes DNA damage and tumor initiation in mouse skin. PLoS One (2012) 0.80
Low-dose ionizing radiation: induction of differential intracellular signalling possibly affecting intercellular communication. Radiat Environ Biophys (2005) 0.80
Mitochondrial reactive oxygen species-mediated genomic instability in low-dose irradiated human cells through nuclear retention of cyclin D1. Cell Cycle (2016) 0.80
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Tyr phosphatase-mediated P-ERK inhibition suppresses senescence in EIA + v-raf transformed cells, which, paradoxically, are apoptosis-protected in a MEK-dependent manner. Neoplasia (2011) 0.80
Comparison of protein expression profiles of the hepatopancreas in Fenneropenaeus chinensis challenged with heat-inactivated Vibrio anguillarum and white spot syndrome virus. Mar Biotechnol (NY) (2013) 0.79
The organotelluride catalyst LAB027 prevents colon cancer growth in the mice. Cell Death Dis (2011) 0.79
Tumor regression by phenethyl isothiocyanate involves DDB2. Cancer Biol Ther (2012) 0.79
Combination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells. Exp Mol Med (2013) 0.79
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Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells. Br J Pharmacol (2013) 0.78
Cytotoxicity of various types of gold-mesoporous silica nanoparticles in human breast cancer cells. Int J Nanomedicine (2015) 0.78
A comparative study of reactive oxygen species (ROS) related parameters in rat tissues. Indian J Clin Biochem (2006) 0.78
Damaged DNA binding protein 2 in reactive oxygen species (ROS) regulation and premature senescence. Int J Mol Sci (2012) 0.78
Dual targeting of the thioredoxin and glutathione systems in cancer and HIV. J Clin Invest (2016) 0.78
Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma. Int J Mol Sci (2015) 0.78
Geminin functions downstream of p53 in K-ras-induced gene amplification of dihydrofolate reductase. Cancer Res (2012) 0.77
Oxidative stress under ambient and physiological oxygen tension in tissue culture. Curr Pharmacol Rep (2016) 0.77
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Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation. Mol Cell Biol (2005) 1.12
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Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinases. J Biol Chem (2008) 1.09
Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription. J Biol Chem (2006) 1.08
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Anomalous features of EMT during keratinocyte transformation. PLoS One (2008) 1.03
Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design. Biochemistry (2002) 1.03
Optimization of energy-consuming pathways towards rapid growth in HPV-transformed cells. PLoS One (2007) 1.02
Targeting the EGFR and the PKB pathway in cancer. Curr Opin Cell Biol (2009) 1.02
Inhibition of glioma growth by tumor-specific activation of double-stranded RNA-dependent protein kinase PKR. Nat Biotechnol (2002) 1.01
A novel lipid binding site formed by the MAP kinase insert in p38 alpha. J Mol Biol (2007) 0.99
p38alpha is active in vitro and in vivo when monophosphorylated at threonine 180. Biochemistry (2009) 0.99
Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone. Mol Cancer Ther (2002) 0.96
The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes. Cancer Res (2002) 0.94
Novel carbon-11 labeled 4-dimethylamino-but-2-enoic acid [4-(phenylamino)-quinazoline-6-yl]-amides: potential PET bioprobes for molecular imaging of EGFR-positive tumors. Nucl Med Biol (2004) 0.92
EGFR-homing dsRNA activates cancer-targeted immune response and eliminates disseminated EGFR-overexpressing tumors in mice. Clin Cancer Res (2010) 0.92
Phosphorylation of Tyr-176 of the yeast MAPK Hog1/p38 is not vital for Hog1 biological activity. J Biol Chem (2003) 0.92
Evaluation of radiolabeled ML04, a putative irreversible inhibitor of epidermal growth factor receptor, as a bioprobe for PET imaging of EGFR-overexpressing tumors. Nucl Med Biol (2007) 0.92
Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation. J Biol Chem (2011) 0.92
A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination. Cell Signal (2011) 0.92
Development of new insulin-like growth factor-1 receptor kinase inhibitors using catechol mimics. J Biol Chem (2003) 0.92
When expressed in yeast, mammalian mitogen-activated protein kinases lose proper regulation and become spontaneously phosphorylated. Biochem J (2009) 0.91
Combination of two activating mutations in one HOG1 gene forms hyperactive enzymes that induce growth arrest. Mol Cell Biol (2003) 0.91
Commonly used Saccharomyces cerevisiae strains (e.g. BY4741, W303) are growth sensitive on synthetic complete medium due to poor leucine uptake. FEMS Microbiol Lett (2007) 0.90
PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors. IUBMB Life (2012) 0.90
Locally delivered nanoencapsulated tyrphostin (AGL-2043) reduces neointima formation in balloon-injured rat carotid and stented porcine coronary arteries. Biomaterials (2005) 0.88
Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit. Bioorg Med Chem (2003) 0.87
Targeted cancer therapy: promise and reality. Adv Cancer Res (2007) 0.87
Novel iodine-124 labeled EGFR inhibitors as potential PET agents for molecular imaging in cancer. Bioorg Med Chem (2004) 0.86
Turbidostat culture of Saccharomyces cerevisiae W303-1A under selective pressure elicited by ethanol selects for mutations in SSD1 and UTH1. FEMS Yeast Res (2012) 0.85
A novel substrate mimetic inhibitor of PKB/Akt inhibits prostate cancer tumor growth in mice by blocking the PKB pathway. Biochemistry (2007) 0.85
The effect of the [18F]-PEG group on tracer qualification of [4-(phenylamino)-quinazoline-6-YL]-amide moiety--an EGFR putative irreversible inhibitor. Appl Radiat Isot (2007) 0.85
Poly(I:C)-mediated tumor growth suppression in EGF-receptor overexpressing tumors using EGF-polyethylene glycol-linear polyethylenimine as carrier. Pharm Res (2010) 0.85
Labeled EGFr-TK irreversible inhibitor (ML03): in vitro and in vivo properties, potential as PET biomarker for cancer and feasibility as anticancer drug. Int J Cancer (2002) 0.85
A cellular screening assay to test the ability of PKR to induce cell death in mammalian cells. Mol Ther (2005) 0.84
Active mutants of the TCR-mediated p38α alternative activation site show changes in the phosphorylation lip and DEF site formation. J Mol Biol (2010) 0.84
Tyrphostin AGL-2043 eluting stent reduces neointima formation in porcine coronary arteries. Cardiovasc Res (2004) 0.83
MAP-quest: could we produce constitutively active variants of MAP kinases? Mol Cell Endocrinol (2006) 0.83
Loss of robustness and addiction to IGF1 during early keratinocyte transformation by human Papilloma virus 16. PLoS One (2007) 0.82
JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol Pharmacol (2006) 0.82
Synthesis and structure-activity relationship studies of peptidomimetic PKB/Akt inhibitors: the significance of backbone interactions. Bioorg Med Chem (2010) 0.82
RNA molecules as anti-cancer agents. Semin Cancer Biol (2004) 0.82
Backbone cyclic peptide inhibitors of protein kinase B (PKB/Akt). J Med Chem (2011) 0.82
A detailed protocol for chromatin immunoprecipitation in the yeast Saccharomyces cerevisiae. Methods Mol Biol (2010) 0.81
Osmostress induces autophosphorylation of Hog1 via a C-terminal regulatory region that is conserved in p38α. PLoS One (2012) 0.81
Targeted cancer immunotherapy. Curr Opin Pharmacol (2013) 0.81
Tumor specific activation of PKR as a non-toxic modality of cancer treatment. Semin Cancer Biol (2003) 0.81
Expression and purification of active PKB kinase from Escherichia coli. Protein Expr Purif (2005) 0.81
A color discriminating broad range cell staining technology for early detection of cell transformation. J Carcinog (2009) 0.81
Novel method for the synthesis of urea backbone cyclic peptides using new Alloc-protected glycine building units. J Pept Sci (2010) 0.81
Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors). Cancer Lett (2006) 0.81
The yeast MAPK Hog1 is not essential for immediate survival under osmostress. FEBS Lett (2009) 0.81
Tyrphostin-like compounds with ubiquitin modulatory activity as possible therapeutic agents for multiple myeloma. Bioorg Med Chem (2011) 0.80
Contribution of gross chromosomal changes to HPV16-induced transformation. Mol Biosyst (2011) 0.80
Overexpression of PDE2 or SSD1-V in Saccharomyces cerevisiae W303-1A strain renders it ethanol-tolerant. FEMS Yeast Res (2012) 0.80
Heterogeneity of gene expression in murine squamous cell carcinoma development-the same tumor by different means. PLoS One (2013) 0.80
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ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents. Eur J Pharmacol (2007) 0.79
Conformational bias imposed by source microseeds results in structural ambiguity. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.78
High-resolution diffracting crystals of intrinsically active p38alpha MAP kinase: a case study for low-throughput approaches. Acta Crystallogr D Biol Crystallogr (2007) 0.78
Subunit S5a of the 26S proteasome is regulated by antiapoptotic signals. FEBS J (2007) 0.78
Microwave-assisted solid-phase aza-peptide synthesis: aza scan of a PKB/Akt inhibitor using aza-arginine and aza-proline precursors. J Org Chem (2011) 0.78
The effect of early and late treatment with the tyrphostin AG-556 on the progression of experimental autoimmune myocarditis. Exp Mol Pathol (2004) 0.77
EGF receptor family: twisting targets for improved cancer therapies. Growth Factors (2014) 0.77
Optimization of liganded polyethylenimine polyethylene glycol vector for nucleic acid delivery. Bioconjug Chem (2014) 0.77
The effect of tyrphostin AG-556 on intimal thickening in a mouse model of arterial injury. Exp Mol Pathol (2005) 0.77
Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat. Exp Mol Pathol (2003) 0.76
The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest. Eur J Biochem (2003) 0.76
Activation of dsRNA dependent protein kinase PKR in Karpas299 does not lead to cell death. Cancer Biol Ther (2005) 0.76
The complex regulation of HIC (Human I-mfa domain containing protein) expression. PLoS One (2009) 0.76
Studying protein-peptide interactions using benzophenone units: a case study of protein kinase B/Akt and its inhibitor PTR6154. Anal Biochem (2011) 0.76
Inhibition of aortic allograft vasculopathy by local delivery of platelet-derived growth factor receptor tyrosine-kinase blocker AG-1295. Transplantation (2002) 0.75
The closure of Sugen. Nat Biotechnol (2003) 0.75
A "molecular evolution" approach for isolation of intrinsically active (MEK-independent) MAP kinases. Methods Mol Biol (2010) 0.75
Design, synthesis, and evaluation of quinazoline T cell proliferation inhibitors. Bioorg Med Chem (2010) 0.75
Nucleic acid-based therapeutics for glioblastoma. Anticancer Agents Med Chem (2011) 0.75
Tyrphostin AG 555 inhibits bovine papillomavirus transcription by changing the ratio between E2 transactivator/repressor function. J Biol Chem (2003) 0.75
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