Published in Mol Cell Biol on June 01, 2002
CellProfiler Analyst: data exploration and analysis software for complex image-based screens. BMC Bioinformatics (2008) 2.99
Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol (2004) 2.47
A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide. Proc Natl Acad Sci U S A (2009) 1.83
Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Cancer Lett (2013) 1.74
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection. Mol Cell (2007) 1.60
Alpha4 is an essential regulator of PP2A phosphatase activity. Mol Cell (2009) 1.55
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J (2007) 1.55
Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. PLoS Biol (2007) 1.35
Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements. Proc Natl Acad Sci U S A (2003) 1.26
Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. Proc Natl Acad Sci U S A (2007) 1.24
Disparate roles for the regulatory A subunit isoforms in Arabidopsis protein phosphatase 2A. Plant Cell (2004) 1.22
The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification. J Cell Biol (2011) 1.16
A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins. Cancer Metastasis Rev (2008) 1.14
B56 regulatory subunit of protein phosphatase 2A mediates valproic acid-induced p300 degradation. Mol Cell Biol (2005) 1.09
The genetic basis of rapidly evolving male genital morphology in Drosophila. Genetics (2011) 1.07
Genetic modifier screens on Hairless gain-of-function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster. Genetics (2005) 1.04
Structural basis of protein phosphatase 2A stable latency. Nat Commun (2013) 1.03
Low expression of PP2A regulatory subunit B55α is associated with T308 phosphorylation of AKT and shorter complete remission duration in acute myeloid leukemia patients. Leukemia (2011) 1.03
Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice. Mol Cell Biol (2011) 1.00
Functions of B56-containing PP2As in major developmental and cancer signaling pathways. Life Sci (2010) 0.99
Sequential phosphorylation of smoothened transduces graded hedgehog signaling. Sci Signal (2011) 0.99
Regulatory subunit B'gamma of protein phosphatase 2A prevents unnecessary defense reactions under low light in Arabidopsis. Plant Physiol (2011) 0.98
Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase. Exp Cell Res (2007) 0.98
Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A. J Biol Chem (2010) 0.97
PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development. J Biol Chem (2010) 0.96
Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insult. Invest Ophthalmol Vis Sci (2003) 0.96
Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway. Br J Cancer (2013) 0.95
A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers. Eukaryot Cell (2005) 0.95
Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit. J Biol Chem (2008) 0.94
Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells. J Biol Chem (2007) 0.94
All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase. FEBS J (2015) 0.93
The Protein Phosphatases and Protein Kinases of Arabidopsis thaliana. Arabidopsis Book (2007) 0.92
Mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of spinocerebellar ataxia type 12 (SCA12). J Biol Chem (2011) 0.91
The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation. J Biol Chem (2009) 0.90
The role of serine/threonine protein phosphatases in exocytosis. Biochem J (2003) 0.89
The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1. J Biol Chem (2011) 0.87
PP2A: The Wolf in Sheep's Clothing? Cancers (Basel) (2015) 0.85
Regulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt. Mol Biol Cell (2015) 0.84
Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone. Cell Res (2013) 0.83
Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A. J Virol (2008) 0.83
Anisomycin induces glioma cell death via down-regulation of PP2A catalytic subunit in vitro. Acta Pharmacol Sin (2012) 0.81
Subunit composition and developmental regulation of hepatic protein phosphatase 2A (PP2A). Arch Biochem Biophys (2007) 0.78
Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1. J Biol Chem (2014) 0.78
Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation. PLoS One (2015) 0.78
The broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance. BBA Clin (2016) 0.77
RNA interference with special reference to combating viruses of crustacea. Indian J Virol (2012) 0.77
Role of Protein Phosphatase 2A in Osteoblast Differentiation and Function. J Clin Med (2017) 0.75
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J (2001) 9.40
Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc Natl Acad Sci U S A (2000) 9.02
Programmed cell death in animal development. Cell (1997) 8.95
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Apoptosis signaling. Annu Rev Biochem (2000) 6.18
Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell (1995) 5.01
Programmed cell death during Drosophila embryogenesis. Development (1993) 4.24
Drosophila p53 binds a damage response element at the reaper locus. Cell (2000) 3.92
The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell (1998) 3.56
Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat Cell Biol (1999) 3.45
Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell (2000) 3.41
The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J Biol Chem (1996) 3.00
Protein phosphatase 2A: a panoply of enzymes. Curr Opin Cell Biol (2000) 2.80
Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science (1999) 2.76
Ras promotes cell survival in Drosophila by downregulating hid expression. Cell (1998) 2.75
Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells. Proc Natl Acad Sci U S A (1997) 2.42
The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase. Cell (1993) 2.26
A molecular pathway for light-dependent photoreceptor apoptosis in Drosophila. Neuron (2000) 2.10
Identification and characterization of a p53 homologue in Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 2.04
Identification of a new family of protein phosphatase 2A regulatory subunits. J Biol Chem (1995) 1.96
Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator. Mol Cell (1999) 1.91
Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila. Dev Biol (1998) 1.89
Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. EMBO J (1989) 1.83
Proteolytic activities that mediate apoptosis. Annu Rev Physiol (1998) 1.82
Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells. Mol Cell Biol (1997) 1.79
An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol (1999) 1.77
Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. EMBO J (2001) 1.65
Identification of a Drosophila melanogaster ICE/CED-3-related protease, drICE. EMBO J (1997) 1.61
The proapoptotic function of Drosophila Hid is conserved in mammalian cells. Proc Natl Acad Sci U S A (1999) 1.50
An essential role for the caspase dronc in developmentally programmed cell death in Drosophila. J Biol Chem (2000) 1.46
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Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle. J Biol Chem (1996) 1.41
Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication. Mol Cell Biol (1994) 1.40
Reaper-induced apoptosis in a vertebrate system. EMBO J (1997) 1.40
Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. Blood (2001) 1.38
PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Mol Cell Biol (2000) 1.36
Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A. J Biol Chem (1998) 1.33
Death by design: mechanism and control of apoptosis. Trends Cell Biol (1999) 1.33
Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. Eur J Biochem (2002) 1.28
Apoptosis induced by Drosophila reaper and grim in a human system. Attenuation by inhibitor of apoptosis proteins (cIAPs). J Biol Chem (1998) 1.24
Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes. Cell Death Differ (1998) 1.20
Protein phosphatase 2A is required for the initiation of chromosomal DNA replication. Proc Natl Acad Sci U S A (1998) 1.20
Regulatory arrestin cycle secures the fidelity and maintenance of the fly photoreceptor cell. Proc Natl Acad Sci U S A (1993) 1.19
Drosophila grim induces apoptosis in mammalian cells. EMBO J (1998) 1.17
Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation. J Biol Chem (1997) 1.16
Phosphorylation status of the SCR homeodomain determines its functional activity: essential role for protein phosphatase 2A,B'. EMBO J (2000) 1.09
Alternative cell fate choice induced by low-level expression of a regulator of protein phosphatase 2A in the Drosophila peripheral nervous system. Development (1994) 1.06
Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors. Cell Death Differ (1999) 1.06
Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A. J Biol Chem (2001) 1.05
Post-translational modifications regulate the ticking of the circadian clock. Nat Rev Mol Cell Biol (2007) 5.24
Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Mol Cell Biol (2005) 3.03
The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. J Biol Chem (2002) 2.48
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. Mol Cell (2003) 2.16
Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell (2006) 2.15
Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. Proc Natl Acad Sci U S A (2002) 2.04
An opposite role for tau in circadian rhythms revealed by mathematical modeling. Proc Natl Acad Sci U S A (2006) 2.02
Profiling patterned transcripts in Drosophila embryos. Genome Res (2002) 1.96
Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res (2012) 1.89
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet (2005) 1.89
A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol Cell Biol (2004) 1.78
Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol (2010) 1.63
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J (2007) 1.55
WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. J Cell Sci (2010) 1.54
Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. Development (2014) 1.49
Protein serine/threonine phosphatases: life, death, and sleeping. Curr Opin Cell Biol (2005) 1.41
Regulation of casein kinase I epsilon activity by Wnt signaling. J Biol Chem (2004) 1.40
Wnt signaling in development, disease and translational medicine. Curr Drug Targets (2008) 1.36
A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. Differentiation (2012) 1.31
Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. Eur J Biochem (2002) 1.28
Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. Proc Natl Acad Sci U S A (2007) 1.24
A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. Dev Cell (2007) 1.22
Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. J Biol Chem (2002) 1.21
BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression. Biol Open (2013) 1.12
Amnioserosa is required for dorsal closure in Drosophila. Dev Dyn (2005) 1.08
Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis. J Biol Chem (2006) 1.03
Precise regulation of porcupine activity is required for physiological Wnt signaling. J Biol Chem (2012) 1.02
Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. PLoS One (2010) 1.00
Protein phosphatase 1 regulates the stability of the circadian protein PER2. Biochem J (2006) 0.99
Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. Bioorg Med Chem (2008) 0.99
PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation. PLoS One (2012) 0.96
Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. Cancer Res (2002) 0.96
Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation. J Biol Chem (2006) 0.96
Casein kinase I in the mammalian circadian clock. Methods Enzymol (2005) 0.95
Raw mediates antagonism of AP-1 activity in Drosophila. Genetics (2008) 0.93
Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling. FEBS J (2006) 0.91
Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. J Clin Invest (2014) 0.89
Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. J Clin Invest (2015) 0.87
The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas. Am J Pathol (2002) 0.86
Updating the Wnt pathways. Biosci Rep (2014) 0.86
scylla and charybde, homologues of the human apoptotic gene RTP801, are required for head involution in Drosophila. Dev Biol (2006) 0.86
Head involution in Drosophila: genetic and morphogenetic connections to dorsal closure. Dev Dyn (2008) 0.85
Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. Int J Cancer (2007) 0.85
Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp. J Nat Prod (2009) 0.83
Programmed ribosomal frameshifting in the expression of the regulator of intestinal stem cell proliferation, adenomatous polyposis coli (APC). RNA Biol (2011) 0.81
Unwinding the Wnt action of casein kinase 1. Cell Res (2013) 0.77
Mummy, A UDP-N-acetylglucosamine pyrophosphorylase, modulates DPP signaling in the embryonic epidermis of Drosophila. Dev Biol (2013) 0.75
Moving upstream in the war on WNTs. J Clin Invest (2015) 0.75