Published in Cell on November 17, 2006
The human keratins: biology and pathology. Histochem Cell Biol (2008) 5.13
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science (2012) 3.24
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol Cell Proteomics (2008) 2.56
Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol (2008) 2.20
The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites. Mol Biol Cell (2009) 2.09
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Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) (2009) 1.89
A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide. Proc Natl Acad Sci U S A (2009) 1.83
14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation. EMBO J (2007) 1.69
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PP2A regulates the pro-apoptotic activity of FOXO1. J Biol Chem (2008) 1.36
The expanding significance of keratin intermediate filaments in normal and diseased epithelia. Curr Opin Cell Biol (2012) 1.36
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. J Biol Chem (2008) 1.31
Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. Proc Natl Acad Sci U S A (2007) 1.24
Protein phosphatases and their regulation in the control of mitosis. EMBO Rep (2012) 1.20
Regulation of Mih1/Cdc25 by protein phosphatase 2A and casein kinase 1. J Cell Biol (2008) 1.19
Clk2 and B56β mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt. Mol Cell (2011) 1.18
A tobacco calcium-dependent protein kinase, CDPK1, regulates the transcription factor REPRESSION OF SHOOT GROWTH in response to gibberellins. Plant Cell (2008) 1.15
A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins. Cancer Metastasis Rev (2008) 1.14
A bifunctional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export. Mol Cell Biol (2010) 1.10
Cell cycle checkpoint regulators reach a zillion. Cell Cycle (2013) 1.10
Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling. Mol Biol Cell (2009) 1.09
Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. Proc Natl Acad Sci U S A (2011) 1.09
A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A. Oncogene (2010) 1.09
Aven-dependent activation of ATM following DNA damage. Curr Biol (2008) 1.08
Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair. Clin Cancer Res (2013) 1.05
Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation. J Biol Chem (2010) 1.00
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The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol Cell Biol (2008) 0.97
Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway. Br J Cancer (2013) 0.95
14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus. J Biol Chem (2011) 0.94
E2F4 function in G2: maintaining G2-arrest to prevent mitotic entry with damaged DNA. Cell Cycle (2007) 0.94
S100A8/A9 (calprotectin) negatively regulates G2/M cell cycle progression and growth of squamous cell carcinoma. PLoS One (2013) 0.89
Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε. BMC Cancer (2011) 0.88
The molecular basis of human keratin disorders. Hum Genet (2009) 0.88
PP2A function toward mitotic kinases and substrates during the cell cycle. BMB Rep (2013) 0.86
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The phosphorylation of ARPP19 by Greatwall renders the auto-amplification of MPF independently of PKA in Xenopus oocytes. J Cell Sci (2013) 0.84
Human immunodeficiency virus type 1 Vpr induces cell cycle G2 arrest through Srk1/MK2-mediated phosphorylation of Cdc25. J Virol (2007) 0.83
The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity. Mol Cancer Ther (2014) 0.83
Inhibition of protein phosphatase 2A with the small molecule LB100 overcomes cell cycle arrest in osteosarcoma after cisplatin treatment. Cell Cycle (2015) 0.81
HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive function. J Biol Chem (2012) 0.81
Identification of testis 14-3-3 binding proteins by tandem affinity purification. Spermatogenesis (2011) 0.81
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PP2A: The Achilles Heal in MDS with 5q Deletion. Front Oncol (2014) 0.79
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14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradation. Mol Cell Biol (2014) 0.78
Identification of relevant cancer related-genes in the flat oyster Ostrea edulis affected by disseminated neoplasia. Mar Biotechnol (NY) (2012) 0.78
Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21. PLoS One (2012) 0.78
Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer. World J Gastroenterol (2016) 0.78
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The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1. Oncotarget (2016) 0.75
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Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A). J Biol Chem (2014) 0.75
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A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature (2006) 3.28
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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature (2006) 11.90
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature (2009) 11.46
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Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
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AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell (2009) 4.71
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Genome-scale loss-of-function screening with a lentiviral RNAi library. Nat Methods (2006) 4.12
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Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell (2003) 3.33
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Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell (2005) 3.32
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Caspases and kinases in a death grip. Cell (2009) 2.47
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PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. Nat Cell Biol (2009) 2.20