Published in J Biol Chem on November 02, 2006
Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit. Proc Natl Acad Sci U S A (2007) 1.93
The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A. Proc Natl Acad Sci U S A (2007) 1.21
Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One (2013) 1.12
Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo. J Biol Chem (2010) 1.11
Molecular determinants for PP2A substrate specificity: charged residues mediate dephosphorylation of tyrosine hydroxylase by the PP2A/B' regulatory subunit. Biochemistry (2010) 1.08
Protein phosphatases and Alzheimer's disease. Prog Mol Biol Transl Sci (2012) 1.03
Dichotomy of tyrosine hydroxylase and dopamine regulation between somatodendritic and terminal field areas of nigrostriatal and mesoaccumbens pathways. PLoS One (2012) 1.01
The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol Cell Biol (2008) 0.97
PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development. J Biol Chem (2010) 0.96
N-terminal phosphorylation of protein phosphatase 2A/Bβ2 regulates translocation to mitochondria, dynamin-related protein 1 dephosphorylation, and neuronal survival. FEBS J (2012) 0.87
The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1. J Biol Chem (2011) 0.87
Complex molecular regulation of tyrosine hydroxylase. J Neural Transm (Vienna) (2014) 0.85
Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A. PLoS One (2011) 0.83
Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. J Biol Chem (2012) 0.82
Dynamic regulation of extracellular signal-regulated kinase (ERK) by protein phosphatase 2A regulatory subunit B56γ1 in nuclei induces cell migration. PLoS One (2013) 0.80
Atypical PP2A protein phosphatase gene families do not expand via paleopolyploidization. Plant Physiol (2016) 0.78
B'-protein phosphatase 2A is a functional binding partner of delta-retroviral integrase. Nucleic Acids Res (2015) 0.76
Post-translational modifications regulate the ticking of the circadian clock. Nat Rev Mol Cell Biol (2007) 5.24
Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep (2007) 4.73
Structure of the protein phosphatase 2A holoenzyme. Cell (2006) 3.07
Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Mol Cell Biol (2005) 3.03
CaMKII determines mitochondrial stress responses in heart. Nature (2012) 2.63
The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. J Biol Chem (2002) 2.48
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. Mol Cell (2003) 2.16
Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell (2006) 2.15
Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. Proc Natl Acad Sci U S A (2002) 2.04
An opposite role for tau in circadian rhythms revealed by mathematical modeling. Proc Natl Acad Sci U S A (2006) 2.02
Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res (2012) 1.89
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet (2005) 1.89
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell (2006) 1.88
A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol Cell Biol (2004) 1.78
Activity-driven postsynaptic translocation of CaMKII. Trends Pharmacol Sci (2005) 1.65
Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol (2010) 1.63
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J (2007) 1.55
WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. J Cell Sci (2010) 1.54
Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. J Biol Chem (2005) 1.53
B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster. Mol Cell Biol (2002) 1.52
Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. Development (2014) 1.49
Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons. J Neurosci (2008) 1.48
Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1. PLoS Biol (2011) 1.45
Protein serine/threonine phosphatases: life, death, and sleeping. Curr Opin Cell Biol (2005) 1.41
Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation. Biochemistry (2006) 1.40
Regulation of casein kinase I epsilon activity by Wnt signaling. J Biol Chem (2004) 1.40
Wnt signaling in development, disease and translational medicine. Curr Drug Targets (2008) 1.36
A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. Differentiation (2012) 1.31
Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes. J Biol Chem (2005) 1.29
Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. Eur J Biochem (2002) 1.28
A developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosis. J Biol Chem (2003) 1.26
PKA/AKAP1 and PP2A/Bβ2 regulate neuronal morphogenesis via Drp1 phosphorylation and mitochondrial bioenergetics. J Neurosci (2011) 1.24
Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. Proc Natl Acad Sci U S A (2007) 1.24
A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. Dev Cell (2007) 1.22
Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. J Biol Chem (2002) 1.21
Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties. J Biol Chem (2010) 1.19
The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission. J Biol Chem (2008) 1.15
Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate. Chem Res Toxicol (2009) 1.15
BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression. Biol Open (2013) 1.12
Molecular determinants for PP2A substrate specificity: charged residues mediate dephosphorylation of tyrosine hydroxylase by the PP2A/B' regulatory subunit. Biochemistry (2010) 1.08
Determinants for Substrate Specificity of Protein Phosphatase 2A. Enzyme Res (2011) 1.06
Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease. Neurobiol Dis (2012) 1.05
Precise regulation of porcupine activity is required for physiological Wnt signaling. J Biol Chem (2012) 1.02
Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. PLoS One (2010) 1.00
Protein phosphatase 1 regulates the stability of the circadian protein PER2. Biochem J (2006) 0.99
Functional characterization of phosphorylation sites in dynamin-related protein 1. Methods Enzymol (2009) 0.99
Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. Bioorg Med Chem (2008) 0.99
The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol Cell Biol (2008) 0.97
PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation. PLoS One (2012) 0.96
Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. Cancer Res (2002) 0.96
Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation. J Biol Chem (2006) 0.96
Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A. J Biol Chem (2005) 0.95
Casein kinase I in the mammalian circadian clock. Methods Enzymol (2005) 0.95
A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density. J Biol Chem (2011) 0.91
Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons. J Biol Chem (2012) 0.91
Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling. FEBS J (2006) 0.91
The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation. J Biol Chem (2009) 0.90
Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. J Clin Invest (2014) 0.89
A calcineurin docking motif (LXVP) in dynamin-related protein 1 contributes to mitochondrial fragmentation and ischemic neuronal injury. J Biol Chem (2013) 0.88
Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. J Clin Invest (2015) 0.87
The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1. J Biol Chem (2011) 0.87
N-terminal phosphorylation of protein phosphatase 2A/Bβ2 regulates translocation to mitochondria, dynamin-related protein 1 dephosphorylation, and neuronal survival. FEBS J (2012) 0.87
Updating the Wnt pathways. Biosci Rep (2014) 0.86
Age-dependent targeting of protein phosphatase 1 to Ca2+/calmodulin-dependent protein kinase II by spinophilin in mouse striatum. PLoS One (2012) 0.86
The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas. Am J Pathol (2002) 0.86
Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. Int J Cancer (2007) 0.85
Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp. J Nat Prod (2009) 0.83
Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation. Cell Signal (2010) 0.82
Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. J Biol Chem (2012) 0.82
Unwinding the Wnt action of casein kinase 1. Cell Res (2013) 0.77
Moving upstream in the war on WNTs. J Clin Invest (2015) 0.75