Published in J Biol Chem on May 14, 2002
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest (2007) 2.26
A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway. Dev Cell (2007) 2.21
Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog (2009) 2.06
GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling. Mol Cell Biol (2006) 1.85
The role of adiponectin in cancer: a review of current evidence. Endocr Rev (2012) 1.78
Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. EMBO J (2007) 1.74
The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci U S A (2003) 1.69
APPL1: role in adiponectin signaling and beyond. Am J Physiol Endocrinol Metab (2008) 1.41
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic (2007) 1.20
APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. Mol Cell Endocrinol (2006) 1.18
Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J Biol Chem (2009) 1.06
Adiponectin signaling and function in insulin target tissues. J Mol Cell Biol (2016) 1.03
Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers. Br J Cancer (2005) 1.00
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. J Biol Chem (2009) 0.97
APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor. Cell Rep (2014) 0.93
Cdo interacts with APPL1 and activates Akt in myoblast differentiation. Mol Biol Cell (2010) 0.93
Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex. Biochem J (2009) 0.91
Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development. Genesis (2010) 0.89
Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity. Cell Death Dis (2013) 0.89
Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming. PLoS One (2013) 0.87
Identification of phosphorylation sites within the signaling adaptor APPL1 by mass spectrometry. J Proteome Res (2010) 0.86
Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes. Arch Biochem Biophys (2011) 0.85
The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration. Mol Biol Cell (2012) 0.84
An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons. Mol Cell Neurosci (2011) 0.83
Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment. Traffic (2011) 0.82
Emerging roles for the FSH receptor adapter protein APPL1 and overlap of a putative 14-3-3τ interaction domain with a canonical G-protein interaction site. Mol Cell Endocrinol (2010) 0.81
Multifunctional protein APPL2 contributes to survival of human glioma cells. Mol Oncol (2012) 0.80
APPL proteins FRET at the BAR: direct observation of APPL1 and APPL2 BAR domain-mediated interactions on cell membranes using FRET microscopy. PLoS One (2010) 0.80
APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain. Oncotarget (2016) 0.78
Dependence receptors: mechanisms of an announced death. Cell Cycle (2010) 0.76
Single-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research. Sci Rep (2016) 0.76
Expression of APPL1 is correlated with clinicopathologic characteristics and poor prognosis in patients with gastric cancer. Curr Oncol (2016) 0.75
Alternative splicing of the OCC-1 gene generates three splice variants and a novel exonic microRNA, which regulate the Wnt signaling pathway. RNA (2016) 0.75
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med (2008) 13.02
The Human Genome Project: lessons from large-scale biology. Science (2003) 4.69
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med (2011) 4.68
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol (2011) 3.17
A Drosophila protein-interaction map centered on cell-cycle regulators. Genome Biol (2004) 2.95
Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes. Blood (2012) 2.69
Autophagy in cancer: good, bad, or both? Cancer Res (2006) 2.66
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest (2007) 2.26
Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia. J Clin Oncol (2009) 2.23
Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization. J Pharmacol Exp Ther (2008) 2.17
Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer. Clin Cancer Res (2012) 2.14
A proteome-wide protein interaction map for Campylobacter jejuni. Genome Biol (2007) 2.13
Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Lett (2008) 2.05
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
Yeast two-hybrid contributions to interactome mapping. Curr Opin Biotechnol (2006) 1.98
Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation. J Biol Chem (2002) 1.92
DroID: the Drosophila Interactions Database, a comprehensive resource for annotated gene and protein interactions. BMC Genomics (2008) 1.89
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy (2012) 1.86
DroID 2011: a comprehensive, integrated resource for protein, transcription factor, RNA and gene interactions for Drosophila. Nucleic Acids Res (2010) 1.86
Autophagy and apoptosis: what is the connection? Trends Cell Biol (2011) 1.81
Differential neural responses to overt and covert presentations of facial expressions of fear and disgust. Neuroimage (2004) 1.69
Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity. Mol Cancer Ther (2010) 1.69
Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation. J Biol Chem (2007) 1.65
Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival. Cancer Res (2007) 1.60
Autophagy and metastasis: another double-edged sword. Curr Opin Cell Biol (2009) 1.57
Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol Ther (2011) 1.55
Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Mol Cell (2005) 1.45
The protein network of bacterial motility. Mol Syst Biol (2007) 1.45
Genome characterization of the oleaginous fungus Mortierella alpina. PLoS One (2011) 1.43
From protein networks to biological systems. FEBS Lett (2005) 1.43
BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing. Mol Pharmacol (2009) 1.38
Paraganglioma-like dermal melanocytic tumor: a unique entity distinct from cellular blue nevus, clear cell sarcoma, and cutaneous melanoma. Am J Surg Pathol (2004) 1.36
Expression signature of the mouse prostate. J Biol Chem (2005) 1.36
Cyclin Y is a novel conserved cyclin essential for development in Drosophila. Genetics (2010) 1.32
Autophagy and cancer therapy. Cancer Biol Ther (2011) 1.32
Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochem Biophys Res Commun (2012) 1.30
Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity. J Med Chem (2007) 1.27
Cost-effective strategies for completing the interactome. Nat Methods (2008) 1.25
High-throughput cloning of Campylobacter jejuni ORfs by in vivo recombination in Escherichia coli. J Proteome Res (2004) 1.25
Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40. J Biol Chem (2003) 1.24
Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? J Pharmacol Exp Ther (2013) 1.24
Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Mol Biol Cell (2005) 1.21
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic (2007) 1.20
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. Sci Signal (2011) 1.20
Oxidant stress is increased during treatment of human immunodeficiency virus infection. Clin Infect Dis (2003) 1.20
Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD. J Biol Chem (2004) 1.18
STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious. Cancer Res (2014) 1.17
Tumor-suppressive maspin regulates cell response to oxidative stress by direct interaction with glutathione S-transferase. J Biol Chem (2005) 1.16
Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein. Clin Cancer Res (2003) 1.16
Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways. Neoplasia (2009) 1.16
Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem (2008) 1.16
Inhibition of autophagy impairs tumor cell invasion in an organotypic model. Cell Cycle (2012) 1.14
PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling. Mol Cancer (2013) 1.14
A strategy for constructing large protein interaction maps using the yeast two-hybrid system: regulated expression arrays and two-phase mating. Genome Res (2003) 1.13
Translational evidence that impaired autophagy contributes to arterial ageing. J Physiol (2012) 1.12
Interstitial diphtheria toxin-epidermal growth factor fusion protein therapy produces regressions of subcutaneous human glioblastoma multiforme tumors in athymic nude mice. Clin Cancer Res (2005) 1.11
The role of mood states underlying sex differences in the perception and tolerance of pain. Pain Pract (2006) 1.11
TNFα induced noncanonical NF-κB activation is attenuated by RIP1 through stabilization of TRAF2. J Cell Sci (2011) 1.09
Genetic diversity in Campylobacter jejuni is associated with differential colonization of broiler chickens and C57BL/6J IL10-deficient mice. Microbiology (2010) 1.07
Integrative prognostic risk score in acute myeloid leukemia with normal karyotype. Blood (2011) 1.07
Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer. Cancer Res (2013) 1.06
Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis. Endocrinology (2008) 1.05
Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev (2011) 1.04
Differential effects of delivery of omega-3 fatty acids to human cancer cells by low-density lipoproteins versus albumin. Clin Cancer Res (2004) 1.04
Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid. Mol Endocrinol (2006) 1.03
Role of malic enzyme during fatty acid synthesis in the oleaginous fungus Mortierella alpina. Appl Environ Microbiol (2014) 1.03
A database and tool, IM Browser, for exploring and integrating emerging gene and protein interaction data for Drosophila. BMC Bioinformatics (2006) 1.03
The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models. Clin Cancer Res (2010) 1.02
Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer. Neoplasia (2010) 1.02
Histological changes associated with mesotherapy for fat dissolution. J Cosmet Laser Ther (2005) 1.02
Combining multiple positive training sets to generate confidence scores for protein-protein interactions. Bioinformatics (2008) 1.02
The vitamin E analogue α-TEA stimulates tumor autophagy and enhances antigen cross-presentation. Cancer Res (2012) 1.01
Identification of new protein interactions between dengue fever virus and its hosts, human and mosquito. PLoS One (2013) 1.01
Lipids and prostate cancer. Prostaglandins Other Lipid Mediat (2012) 1.01
Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms. J Cell Biol (2002) 1.00
Eph/Ephrin signaling in injury and inflammation. Am J Pathol (2012) 1.00
An Official American Thoracic Society/European Respiratory Society Policy Statement: Enhancing Implementation, Use, and Delivery of Pulmonary Rehabilitation. Am J Respir Crit Care Med (2015) 1.00
Prevalence of demarcated hypomineralisation defects in second primary molars in Iraqi children. Int J Paediatr Dent (2012) 0.99
Interaction trap/two-hybrid system to identify interacting proteins. Curr Protoc Mol Biol (2008) 0.99
Silica dust exposures during selected construction activities. AIHA J (Fairfax, Va) (2003) 0.98
Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem (2011) 0.98
Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells. Oncogene (2005) 0.98
Regulation of HMGB1 release by autophagy. Autophagy (2009) 0.97
Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. Carcinogenesis (2011) 0.96
Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents. Cancer Res (2011) 0.96
Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding. J Biol Chem (2007) 0.96
Prognostic importance of histone methyltransferase MLL5 expression in acute myeloid leukemia. J Clin Oncol (2011) 0.95
Autophagy and cell death. Essays Biochem (2013) 0.95
Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells. Carcinogenesis (2013) 0.94
Activation of caspase pathways during iron chelator-mediated apoptosis. J Biol Chem (2002) 0.94
The Roles of Moonlighting Proteins in Bacteria. Curr Issues Mol Biol (2013) 0.94
Assessment of muscarinic and nicotinic acetylcholine receptor expression in primitive neuroectodermal tumor/ewing family of tumor and desmoplastic small round cell tumor: an immunohistochemical and Western blot study of tissue microarray and cell lines. Fetal Pediatr Pathol (2008) 0.93
In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids. J Biol Chem (2008) 0.92
Expression and purification of integral membrane fatty acid desaturases. PLoS One (2013) 0.92