Published in Cell Cycle on May 15, 2012
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Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion. Cancer Discov (2014) 1.28
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A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. J Immunol (2013) 1.06
Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination. Autophagy (2013) 1.04
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Autophagy modulates cell migration and β1 integrin membrane recycling. Cell Cycle (2013) 1.04
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Autophagy in cancer metastasis. Oncogene (2016) 0.81
Autophagy induction by silibinin positively contributes to its anti-metastatic capacity via AMPK/mTOR pathway in renal cell carcinoma. Int J Mol Sci (2015) 0.79
Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad Signaling. Cancer Res (2016) 0.79
MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation. Autophagy (2015) 0.78
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Decorin-mediated inhibition of the migration of U87MG glioma cells involves activation of autophagy and suppression of TGF-β signaling. FEBS Open Bio (2016) 0.77
Autophagy and tumor cell invasion. Cell Cycle (2012) 0.76
MARCH5 RNA promotes autophagy, migration, and invasion of ovarian cancer cells. Autophagy (2016) 0.75
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Selective Reversible Inhibition of Autophagy in Hypoxic Breast Cancer Cells Promotes Pulmonary Metastasis. Cancer Res (2016) 0.75
The inhibition of lung cancer cell migration by AhR-regulated autophagy. Sci Rep (2017) 0.75
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TET1 exerts its tumor suppressor function by regulating autophagy in glioma cells. Biosci Rep (2017) 0.75
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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59
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Autophagy and the integrated stress response. Mol Cell (2010) 11.21
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell (2006) 9.47
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Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol (2007) 8.29
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev (2011) 7.43
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol (2007) 7.20
Pancreatic cancers require autophagy for tumor growth. Genes Dev (2011) 6.17
Autophagy gone awry in neurodegenerative diseases. Nat Neurosci (2010) 4.72
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem (2007) 4.22
The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy (2005) 4.08
Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial. Ann Intern Med (2006) 3.33
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Autophagy in innate and adaptive immunity. Trends Immunol (2005) 2.48
The multiple roles of autophagy in cancer. Carcinogenesis (2011) 1.63
Autophagy and metastasis: another double-edged sword. Curr Opin Cell Biol (2009) 1.57
Cancer dissemination--lessons from leukocytes. Dev Cell (2010) 1.46
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res (2011) 1.44
New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy. Oncogene (2012) 1.40
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Tumour regulation of fibroblast hyaluronan expression: a mechanism to facilitate tumour growth and invasion. Carcinogenesis (2005) 1.28
A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo. J Clin Invest (2007) 1.27
Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors. Semin Cancer Biol (2010) 1.21
Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context. J Vis Exp (2011) 0.99
A single-step staining procedure for the detection and sorting of unfixed apoptotic thymocytes. Eur J Histochem (1993) 0.93
Different responses in transformation of MDCK cells in 2D and 3D culture by v-Src as revealed by microarray techniques, RT-PCR and functional assays. Lab Invest (2010) 0.86
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DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell (2006) 9.47
p53 and metabolism. Nat Rev Cancer (2009) 5.05
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med (2011) 4.68
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell (2007) 3.84
Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway. Dev Cell (2005) 3.26
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A (2009) 3.08
Autophagy in cancer: good, bad, or both? Cancer Res (2006) 2.66
ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell (2013) 2.32
Polyene-lipids: a new tool to image lipids. Nat Methods (2004) 2.30
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun (2011) 2.18
Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS Biol (2009) 2.16
Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer. Clin Cancer Res (2012) 2.14
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Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. Cell Cycle (2009) 1.95
N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits. J Cell Sci (2005) 1.89
Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Dev Cell (2011) 1.87
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy (2012) 1.86
A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol (2004) 1.81
Autophagy and apoptosis: what is the connection? Trends Cell Biol (2011) 1.81
Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2010) 1.81
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J Cell Biol (2010) 1.79
Nanometer targeting of microtubules to focal adhesions. J Cell Biol (2003) 1.69
Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity. Mol Cancer Ther (2010) 1.69
p53-mediated induction of Noxa and p53AIP1 requires NFkappaB. Cell Cycle (2010) 1.67
Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53. Mol Cell (2013) 1.65
The multiple roles of autophagy in cancer. Carcinogenesis (2011) 1.63
DRAM links autophagy to p53 and programmed cell death. Autophagy (2007) 1.60
Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival. Cancer Res (2007) 1.60
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Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol Ther (2011) 1.55
Does androgen-ablation therapy (AAT) associated autophagy have a pro-survival effect in LNCaP human prostate cancer cells? BJU Int (2012) 1.51
Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Mol Cell (2005) 1.45
N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. J Cell Biol (2012) 1.45
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res (2011) 1.44
The role of autophagy in tumour development and cancer therapy. Expert Rev Mol Med (2009) 1.43
Mediation of the DCC apoptotic signal by DIP13 alpha. J Biol Chem (2002) 1.43
Autophagy and cancer--issues we need to digest. J Cell Sci (2012) 1.39
BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing. Mol Pharmacol (2009) 1.38
A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity. Curr Biol (2010) 1.34
Autophagy and cancer therapy. Cancer Biol Ther (2011) 1.32
Autophagy and cancer. Cold Spring Harb Perspect Biol (2012) 1.30
15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells. J Lipid Res (2002) 1.29
A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo. J Clin Invest (2007) 1.27
Recent advances using green and red fluorescent protein variants. Appl Microbiol Biotechnol (2007) 1.27
Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity. Genes Dev (2009) 1.26
Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development. Cancer Res (2009) 1.25
Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? J Pharmacol Exp Ther (2013) 1.24
Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Mol Biol Cell (2005) 1.21
Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD. J Biol Chem (2004) 1.18
Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov (2013) 1.17
STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious. Cancer Res (2014) 1.17
Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy. Autophagy (2010) 1.16
Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein. Clin Cancer Res (2003) 1.16
Splicing DNA-damage responses to tumour cell death. Biochim Biophys Acta (2004) 1.16
The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly. EMBO Rep (2010) 1.14
Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens. Autophagy (2012) 1.12
Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res (2010) 1.12
Translational evidence that impaired autophagy contributes to arterial ageing. J Physiol (2012) 1.12
Interstitial diphtheria toxin-epidermal growth factor fusion protein therapy produces regressions of subcutaneous human glioblastoma multiforme tumors in athymic nude mice. Clin Cancer Res (2005) 1.11
Mechanically induced actin-mediated rocketing of phagosomes. Mol Biol Cell (2006) 1.10
Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex. Cell Motil Cytoskeleton (2006) 1.10
Analysis of macroautophagy by immunohistochemistry. Autophagy (2012) 1.10
Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells. Cancer Res (2004) 1.09
Autophagy in tumour cell death. Semin Cancer Biol (2013) 1.08
The leading edge is a lipid diffusion barrier. J Cell Sci (2005) 1.07
p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner. EMBO J (2003) 1.06
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J (2008) 1.06
Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer. Cancer Res (2013) 1.06
p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Res (2010) 1.06
Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion. Curr Biol (2012) 1.05
The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models. Clin Cancer Res (2010) 1.02
The vitamin E analogue α-TEA stimulates tumor autophagy and enhances antigen cross-presentation. Cancer Res (2012) 1.01
Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms. J Cell Biol (2002) 1.00
Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context. J Vis Exp (2011) 0.99
DRAM-1 encodes multiple isoforms that regulate autophagy. Autophagy (2012) 0.99
Autophagy: an adaptable modifier of tumourigenesis. Curr Opin Genet Dev (2010) 0.99
Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer. Cancer Res (2013) 0.99
Colloidal synthesis of wurtzite Cu2ZnSnS4 nanorods and their perpendicular assembly. J Am Chem Soc (2012) 0.99
Targeting the p53 family for cancer therapy: 'big brother' joins the fight. Cell Cycle (2007) 0.98
β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity. Nat Cell Biol (2012) 0.97
Regulation of HMGB1 release by autophagy. Autophagy (2009) 0.97
Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding. J Biol Chem (2007) 0.96
MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity. Cell Cycle (2011) 0.96
Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents. Cancer Res (2011) 0.96
Autophagy and cell death. Essays Biochem (2013) 0.95
Activation of caspase pathways during iron chelator-mediated apoptosis. J Biol Chem (2002) 0.94