Published in Proc Natl Acad Sci U S A on May 14, 2002
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci U S A (2003) 8.20
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr Rev (2010) 4.95
Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proc Natl Acad Sci U S A (2004) 4.27
Intracellular cholesterol transport. J Clin Invest (2002) 2.12
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proc Natl Acad Sci U S A (2007) 2.06
Early steps in steroidogenesis: intracellular cholesterol trafficking. J Lipid Res (2011) 1.71
Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states. Biochim Biophys Acta (2009) 1.67
Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives. Mol Hum Reprod (2009) 1.49
Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain. Proc Natl Acad Sci U S A (2002) 1.47
PC-TP/StARD2: Of membranes and metabolism. Trends Endocrinol Metab (2010) 1.23
Comparative structural analysis of lipid binding START domains. PLoS One (2011) 1.19
Comparative genomics of insect juvenile hormone biosynthesis. Insect Biochem Mol Biol (2006) 1.17
Structure and function of phosphatidylcholine transfer protein (PC-TP)/StarD2. Biochim Biophys Acta (2007) 1.11
Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation. J Lipid Res (2008) 1.08
Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity. Proc Natl Acad Sci U S A (2004) 0.95
Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolism. J Lipid Res (2009) 0.95
Candidate genes for carotenoid coloration in vertebrates and their expression profiles in the carotenoid-containing plumage and bill of a wild bird. Proc Biol Sci (2011) 0.92
Regulation of cholesterol biosynthesis and cancer signaling. Curr Opin Pharmacol (2012) 0.91
Over-expression of COQ10 in Saccharomyces cerevisiae inhibits mitochondrial respiration. Biochem Biophys Res Commun (2010) 0.91
Deleted in liver cancer protein family in human malignancies (Review). Oncol Lett (2011) 0.89
Subcellular localization and regulation of StarD4 protein in macrophages and fibroblasts. Biochim Biophys Acta (2011) 0.87
ER stress increases StarD5 expression by stabilizing its mRNA and leads to relocalization of its protein from the nucleus to the membranes. J Lipid Res (2012) 0.84
Saccharomyces cerevisiae coq10 null mutants are responsive to antimycin A. FEBS J (2010) 0.84
Guardian of corpulence: a hypothesis on p53 signaling in the fat cell. Clin Lipidol (2009) 0.84
Cholesterol side-chain cleavage gene expression in theca cells: augmented transcriptional regulation and mRNA stability in polycystic ovary syndrome. PLoS One (2012) 0.83
Sterols and sphingolipids: dynamic duo or partners in crime? Prog Lipid Res (2010) 0.83
STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane, ER, and ERC. J Lipid Res (2012) 0.82
STARD4 Membrane Interactions and Sterol Binding. Biochemistry (2015) 0.81
Mesenteric lymph node transcriptome profiles in BALB/c mice sensitized to three common food allergens. BMC Genomics (2011) 0.81
Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs. BMC Genet (2011) 0.81
Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity. J Biol Chem (2012) 0.80
Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic Instability. Int J Mol Sci (2016) 0.80
Steroidogenic acute regulatory-related lipid transfer domain protein 5 localization and regulation in renal tubules. Am J Physiol Renal Physiol (2009) 0.80
Overexpression of full-length cholesteryl ester transfer protein in SW872 cells reduces lipid accumulation. J Lipid Res (2015) 0.78
¹H, ¹³C, and ¹⁵N backbone resonance assignments of the L124D mutant of StAR-related lipid transfer domain protein 4 (StARD4). Biomol NMR Assign (2012) 0.77
Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function. J Bioenerg Biomembr (2014) 0.77
StAR-related lipid transfer domain protein 5 binds primary bile acids. J Lipid Res (2012) 0.77
p38 MAPK regulates steroidogenesis through transcriptional repression of STAR gene. J Mol Endocrinol (2014) 0.76
STARD6 is expressed in steroidogenic cells of the ovary and can enhance de novo steroidogenesis. Exp Biol Med (Maywood) (2014) 0.76
Meta-type analysis of dopaminergic effects on gene expression in the neuroendocrine brain of female goldfish. Front Endocrinol (Lausanne) (2012) 0.76
The StarD4 subfamily of steroidogenic acute regulatory-related lipid transfer (START) domain proteins: new players in cholesterol metabolism. Int J Biochem Cell Biol (2014) 0.75
Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS. Reprod Biol Endocrinol (2016) 0.75
Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane. Mol Biol Cell (2017) 0.75
Thirty-Eight-Year Follow-Up of Two Sibling Lipoid Congenital Adrenal Hyperplasia Patients Due to Homozygous Steroidogenic Acute Regulatory (STARD1) Protein Mutation. Molecular Structure and Modeling of the STARD1 L275P Mutation. Front Neurosci (2016) 0.75
The PROSITE database, its status in 2002. Nucleic Acids Res (2002) 14.71
Upstream open reading frames as regulators of mRNA translation. Mol Cell Biol (2000) 4.99
Structure and lipid transport mechanism of a StAR-related domain. Nat Struct Biol (2000) 3.65
START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins. Trends Biochem Sci (1999) 2.89
Making and reading microarrays. Nat Genet (1999) 2.81
Regulation of gene expression by SREBP and SCAP. Biochim Biophys Acta (2000) 2.78
Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Annu Rev Biochem (1999) 2.72
Phospholipid transfer proteins. Annu Rev Biochem (1991) 2.39
StAR protein and the regulation of steroid hormone biosynthesis. Annu Rev Physiol (2001) 2.27
Intracellular cholesterol transport. Biochim Biophys Acta (1999) 2.17
Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle. J Biol Chem (2001) 2.07
Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption. Proc Natl Acad Sci U S A (1998) 1.73
Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain. Proc Natl Acad Sci U S A (2002) 1.47
MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis. Proc Natl Acad Sci U S A (1997) 1.38
Structure of the human steroidogenic acute regulatory protein (StAR) gene: StAR stimulates mitochondrial cholesterol 27-hydroxylase activity. Biochemistry (1995) 1.18
BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity. Biochem J (2001) 1.17
Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. Proc Natl Acad Sci U S A (2001) 1.06
Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl diphosphate isomerase. A PTS1 motif targets the enzyme to peroxisomes. J Biol Chem (1997) 0.95
Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells. J Biol Chem (1996) 0.91
Tissue-specific transcriptional regulation of the cholesterol biosynthetic pathway leads to accumulation of testis meiosis-activating sterol (T-MAS). J Lipid Res (2002) 0.90
Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis. J Lipid Res (2001) 0.85
Meiosis-activating sterols: background, discovery, and possible use. J Mol Med (Berl) (1999) 0.85
The binding of phosphatidylcholine to the phosphatidylcholine transfer protein: affinity and role in folding. Chem Phys Lipids (2001) 0.82
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin. Proc Natl Acad Sci U S A (2009) 4.88
Whole population, genome-wide mapping of hidden relatedness. Genome Res (2008) 4.72
Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proc Natl Acad Sci U S A (2004) 4.27
Protein production and purification. Nat Methods (2008) 3.97
Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition. Mol Cell (2003) 3.66
X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors. Cell (2003) 3.37
Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. EMBO J (2003) 3.35
Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc Natl Acad Sci U S A (2005) 3.15
ModBase, a database of annotated comparative protein structure models, and associated resources. Nucleic Acids Res (2010) 2.96
Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice. J Lipid Res (2003) 2.75
Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J Mol Biol (2002) 2.53
Recipes for creating animal models of diabetic cardiovascular disease. Circ Res (2007) 2.34
Outcome of a workshop on archiving structural models of biological macromolecules. Structure (2006) 2.32
Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A (2002) 2.13
A common allosteric site and mechanism in caspases. Proc Natl Acad Sci U S A (2006) 2.12
Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia. Nat Genet (2006) 2.07
Outcome of a workshop on applications of protein models in biomedical research. Structure (2009) 2.05
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. PLoS Genet (2009) 2.02
Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root. Proc Natl Acad Sci U S A (2004) 2.00
Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1. Structure (2006) 1.99
Structural genomics: a pipeline for providing structures for the biologist. Protein Sci (2002) 1.91
Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. Heart Rhythm (2009) 1.91
X-ray structure of a Rex-family repressor/NADH complex insights into the mechanism of redox sensing. Structure (2005) 1.89
StAR-related lipid transfer (START) proteins: mediators of intracellular lipid metabolism. J Biol Chem (2003) 1.88
Vitamin D may not improve lipid levels: a serial clinical laboratory data study. Circulation (2012) 1.85
A modular cross-linking approach for exploring protein interactions. J Am Chem Soc (2003) 1.85
Intracellular cholesterol transport. Arterioscler Thromb Vasc Biol (2004) 1.75
SGX393 inhibits the CML mutant Bcr-AblT315I and preempts in vitro resistance when combined with nilotinib or dasatinib. Proc Natl Acad Sci U S A (2008) 1.71
Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice: comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement). Arterioscler Thromb Vasc Biol (2003) 1.67
Crystal structure of shikimate 5-dehydrogenase (SDH) bound to NADP: insights into function and evolution. Structure (2003) 1.64
Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity. Cell (2002) 1.64
Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13. Arterioscler Thromb Vasc Biol (2008) 1.63
DASH: a method for identical-by-descent haplotype mapping uncovers association with recent variation. Am J Hum Genet (2011) 1.62
A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse. Genetics (2002) 1.61
Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J Biol Chem (2002) 1.60
A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase. J Biol Chem (2004) 1.55
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases. Protein Sci (2010) 1.53
Systematic comparison of label-free, metabolic labeling, and isobaric chemical labeling for quantitative proteomics on LTQ Orbitrap Velos. J Proteome Res (2012) 1.50
Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia. Proc Natl Acad Sci U S A (2006) 1.48
Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain. Proc Natl Acad Sci U S A (2002) 1.47
The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes. Proc Natl Acad Sci U S A (2007) 1.45
Needed: pragmatic clinical trials for statin-intolerant patients. N Engl J Med (2011) 1.44
Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2. J Biol Chem (2005) 1.44
Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization. Mol Cell (2002) 1.42
Structural genomics of protein phosphatases. J Struct Funct Genomics (2007) 1.40
Structural underpinnings of nitrogen regulation by the prototypical nitrogen-responsive transcriptional factor NrpR. Structure (2010) 1.40
Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet. Circ Res (2009) 1.39
A20, a regulator of NFkappaB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains. Proc Natl Acad Sci U S A (2003) 1.38
In silico quantitative trait locus map for atherosclerosis susceptibility in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2003) 1.38
An allosteric circuit in caspase-1. J Mol Biol (2008) 1.38
She2p is a novel RNA binding protein with a basic helical hairpin motif. Cell (2004) 1.37
High-throughput limited proteolysis/mass spectrometry for protein domain elucidation. J Struct Funct Genomics (2005) 1.36
Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress. J Biol Chem (2005) 1.32
Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. J Clin Invest (2010) 1.32
Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice. Proc Natl Acad Sci U S A (2005) 1.31
High-density lipoproteins retard the progression of atherosclerosis and favorably remodel lesions without suppressing indices of inflammation or oxidation. Arterioscler Thromb Vasc Biol (2004) 1.30
Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. EMBO J (2003) 1.29
Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia. Curr Opin Lipidol (2005) 1.28
Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice. J Lipid Res (2003) 1.24
SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol Cancer Ther (2009) 1.23
Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer. Cell (2002) 1.23
The short-term effects of vitamin D repletion on cholesterol: a randomized, placebo-controlled trial. Arterioscler Thromb Vasc Biol (2012) 1.21
Investigation of the roles of catalytic residues in serotonin N-acetyltransferase. J Biol Chem (2002) 1.20
Mechanism of action of a flavin-containing monooxygenase. Proc Natl Acad Sci U S A (2006) 1.20
How do we improve patient compliance and adherence to long-term statin therapy? Curr Atheroscler Rep (2013) 1.20
High throughput protein production and crystallization at NYSGXRC. Methods Mol Biol (2008) 1.20
The kinetic mechanism of phosphomevalonate kinase. J Biol Chem (2002) 1.19
Cocrystal structures of diaminopimelate decarboxylase: mechanism, evolution, and inhibition of an antibiotic resistance accessory factor. Structure (2002) 1.18
Cas5d processes pre-crRNA and is a member of a larger family of CRISPR RNA endonucleases. RNA (2012) 1.18
Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase. Nucleic Acids Res (2006) 1.15
X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding. J Biol Chem (2003) 1.15
Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett (2008) 1.15
Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae. Proc Natl Acad Sci U S A (2009) 1.13
Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake. J Biol Chem (2001) 1.13
Structure determination of an FMN reductase from Pseudomonas aeruginosa PA01 using sulfur anomalous signal. Acta Crystallogr D Biol Crystallogr (2006) 1.13
Malonate-assisted purification of human caspases. Protein Expr Purif (2005) 1.12
Computation-facilitated assignment of the function in the enolase superfamily: a regiochemically distinct galactarate dehydratase from Oceanobacillus iheyensis . Biochemistry (2009) 1.12
Catalytic mechanism and three-dimensional structure of adenine deaminase. Biochemistry (2011) 1.11
Crystal structure of unphosphorylated STAT3 core fragment. Biochem Biophys Res Commun (2008) 1.11
Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1. Cancer Res (2012) 1.10
X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition. J Mol Biol (2002) 1.09
Vitamin D-binding protein levels do not influence the effect of vitamin D repletion on serum PTH and calcium: data from a randomized, controlled trial. J Clin Endocrinol Metab (2014) 1.07
Discovery and annotation of small proteins using genomics, proteomics, and computational approaches. Genome Res (2011) 1.06
Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross. Proc Natl Acad Sci U S A (2002) 1.06
Structural analysis of a ternary complex of allantoate amidohydrolase from Escherichia coli reveals its mechanics. J Mol Biol (2007) 1.05
Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes. Biochemistry (2009) 1.04
The hunt for 8-oxoguanine deaminase. J Am Chem Soc (2010) 1.04
Crystal structure of the Streptococcus pneumoniae phosphomevalonate kinase, a member of the GHMP kinase superfamily. Proteins (2002) 1.03
X-ray crystal structure of the B component of Hemolysin BL from Bacillus cereus. Proteins (2008) 1.02
Two Hsp70 family members expressed in atherosclerotic lesions. Proc Natl Acad Sci U S A (2003) 1.02
Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1. Structure (2011) 1.01
Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors. Bioorg Med Chem Lett (2008) 1.00
Structure, dynamics, evolution, and function of a major scaffold component in the nuclear pore complex. Structure (2013) 1.00
Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies. J Struct Funct Genomics (2009) 1.00