Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.
|
N Engl J Med
|
2005
|
10.16
|
2
|
Vitamin D and human health: lessons from vitamin D receptor null mice.
|
Endocr Rev
|
2008
|
5.28
|
3
|
Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene.
|
Thorax
|
2009
|
4.86
|
4
|
High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial.
|
Ann Intern Med
|
2012
|
3.99
|
5
|
Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma.
|
Am J Respir Cell Mol Biol
|
2003
|
3.60
|
6
|
Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts.
|
J Steroid Biochem Mol Biol
|
2005
|
3.44
|
7
|
Vitamin D: modulator of the immune system.
|
Curr Opin Pharmacol
|
2010
|
3.31
|
8
|
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.
|
J Cell Sci
|
2008
|
2.99
|
9
|
Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long).
|
Diabetes Care
|
2012
|
2.89
|
10
|
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death.
|
EMBO J
|
2012
|
2.45
|
11
|
Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trial.
|
Lancet
|
2011
|
2.34
|
12
|
Leaf mitochondria modulate whole cell redox homeostasis, set antioxidant capacity, and determine stress resistance through altered signaling and diurnal regulation.
|
Plant Cell
|
2003
|
2.22
|
13
|
Sexual dysfunction in women with type 1 diabetes: a controlled study.
|
Diabetes Care
|
2002
|
2.20
|
14
|
Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit.
|
Crit Care Med
|
2009
|
2.10
|
15
|
Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-Dihydroxyvitamin D(3) works as anti-inflammatory.
|
Diabetes Res Clin Pract
|
2006
|
1.84
|
16
|
Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.
|
J Clin Invest
|
2012
|
1.84
|
17
|
Prevalence and predictors of sexual dysfunction in patients with type 1 diabetes.
|
Diabetes Care
|
2003
|
1.82
|
18
|
Vitamin D: a pleiotropic hormone.
|
Kidney Int
|
2010
|
1.76
|
19
|
Vitamin D and cancer.
|
J Steroid Biochem Mol Biol
|
2006
|
1.72
|
20
|
Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation.
|
PLoS One
|
2008
|
1.67
|
21
|
Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act.
|
Am J Respir Crit Care Med
|
2009
|
1.63
|
22
|
Correlation between beta cell mass and glycemic control in type 1 diabetic recipients of islet cell graft.
|
Proc Natl Acad Sci U S A
|
2006
|
1.60
|
23
|
ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death.
|
Autophagy
|
2013
|
1.55
|
24
|
Vitamin D and diabetes.
|
Endocrinol Metab Clin North Am
|
2010
|
1.52
|
25
|
Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells.
|
J Biol Chem
|
2005
|
1.50
|
26
|
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation.
|
J Biol Chem
|
2010
|
1.49
|
27
|
Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine.
|
J Clin Endocrinol Metab
|
2013
|
1.40
|
28
|
1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice.
|
Endocrinology
|
2005
|
1.39
|
29
|
Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients.
|
Blood
|
2009
|
1.37
|
30
|
Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes.
|
J Bone Miner Res
|
2005
|
1.37
|
31
|
Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin.
|
Diabetes
|
2006
|
1.34
|
32
|
Regulation of vitamin D homeostasis: implications for the immune system.
|
Nutr Rev
|
2008
|
1.33
|
33
|
Analogs of 1alpha,25-dihydroxyvitamin D3 as pluripotent immunomodulators.
|
J Cell Biochem
|
2003
|
1.31
|
34
|
Vitamin D and diabetes: its importance for beta cell and immune function.
|
Mol Cell Endocrinol
|
2011
|
1.30
|
35
|
The vitamin D receptor gene FokI polymorphism: functional impact on the immune system.
|
Eur J Immunol
|
2007
|
1.28
|
36
|
Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients.
|
Diabetes
|
2009
|
1.27
|
37
|
Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness.
|
Endocrinology
|
2003
|
1.25
|
38
|
Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation.
|
J Biol Chem
|
2011
|
1.20
|
39
|
Vitamin D insufficiency: implications for the immune system.
|
Pediatr Nephrol
|
2010
|
1.18
|
40
|
Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system.
|
J Steroid Biochem Mol Biol
|
2010
|
1.18
|
41
|
The incidence of type 1 diabetes in the age group 0-39 years has not increased in Antwerp (Belgium) between 1989 and 2000: evidence for earlier disease manifestation.
|
Diabetes Care
|
2002
|
1.16
|
42
|
Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.
|
Diabetes
|
2012
|
1.16
|
43
|
Vitamin D signaling in immune-mediated disorders: Evolving insights and therapeutic opportunities.
|
Mol Aspects Med
|
2008
|
1.16
|
44
|
Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes.
|
Diabetologia
|
2013
|
1.15
|
45
|
Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways.
|
Diabetes
|
2008
|
1.14
|
46
|
Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3).
|
Diabetes
|
2002
|
1.13
|
47
|
Contribution of antibodies against IA-2β and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age.
|
Diabetes Care
|
2011
|
1.12
|
48
|
The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation.
|
J Immunol
|
2010
|
1.12
|
49
|
Air pollution related prothrombotic changes in persons with diabetes.
|
Environ Health Perspect
|
2010
|
1.11
|
50
|
Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells.
|
J Proteome Res
|
2011
|
1.09
|
51
|
Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.
|
Diabetes
|
2005
|
1.09
|
52
|
CCL27 is a critical factor for the development of atopic dermatitis in the keratin-14 IL-4 transgenic mouse model.
|
Int Immunol
|
2006
|
1.08
|
53
|
Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis.
|
Fertil Steril
|
2006
|
1.08
|
54
|
Patients' perceptions of subcutaneous insulin in the OPTIMIZE study: a multicenter follow-up study.
|
Diabetes Technol Ther
|
2008
|
1.06
|
55
|
Vitamin D deficiency and chronic obstructive pulmonary disease: a vicious circle.
|
Vitam Horm
|
2011
|
1.06
|
56
|
Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved.
|
Mol Cell Proteomics
|
2007
|
1.05
|
57
|
Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial.
|
Respir Res
|
2012
|
1.05
|
58
|
The effectiveness of hysteroscopy in improving pregnancy rates in subfertile women without other gynaecological symptoms: a systematic review.
|
Hum Reprod Update
|
2009
|
1.03
|
59
|
Lack of respiratory chain complex I impairs alternative oxidase engagement and modulates redox signaling during elicitor-induced cell death in tobacco.
|
Plant Cell
|
2007
|
1.03
|
60
|
Interdisciplinary diabetes care teams operating on the interface between primary and specialty care are associated with improved outcomes of care: findings from the Leuven Diabetes Project.
|
BMC Health Serv Res
|
2009
|
1.02
|
61
|
Efficacy of vildagliptin versus sulfonylureas as add-on therapy to metformin: comparison of results from randomised controlled and observational studies.
|
Diabetologia
|
2014
|
1.02
|
62
|
Inhibitory and stimulatory effects of cyclosporine A on the development of regulatory T cells in vivo.
|
Transplantation
|
2005
|
1.01
|
63
|
IL-12 contributes to allergen-induced airway inflammation in experimental asthma.
|
J Immunol
|
2006
|
1.01
|
64
|
GLP1 and cancer: friend or foe?
|
Endocr Relat Cancer
|
2012
|
1.01
|
65
|
Blockade of CTLA-4 enhances allergic sensitization and eosinophilic airway inflammation in genetically predisposed mice.
|
Eur J Immunol
|
2002
|
0.99
|
66
|
1alpha,25-dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis.
|
J Autoimmun
|
2004
|
0.99
|
67
|
1,25-Dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism.
|
Immunobiology
|
2012
|
0.98
|
68
|
Vitamin D3 and the immune system: maintaining the balance in health and disease.
|
Nutr Res Rev
|
2007
|
0.98
|
69
|
High rate of Charcot foot attacks early after simultaneous pancreas-kidney transplantation.
|
Transplantation
|
2007
|
0.97
|
70
|
Analysis of Pregnancy Outcomes Using the New IADPSG Recommendation Compared with the Carpenter and Coustan Criteria in an Area with a Low Prevalence of Gestational Diabetes.
|
Int J Endocrinol
|
2013
|
0.97
|
71
|
Pharmacokinetics and antibody responses to the CD3 antibody otelixizumab used in the treatment of type 1 diabetes.
|
J Clin Pharmacol
|
2010
|
0.96
|
72
|
Defect in activation-induced cell death in non-obese diabetic (NOD) T lymphocytes.
|
J Autoimmun
|
2003
|
0.96
|
73
|
Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome.
|
PLoS One
|
2012
|
0.96
|
74
|
1,25-Dihydroxyvitamin D3 alters murine dendritic cell behaviour in vitro and in vivo.
|
Diabetes Metab Res Rev
|
2011
|
0.96
|
75
|
Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection.
|
Diabetes
|
2007
|
0.96
|
76
|
Development and validation of the Economic Assessment of Glycemic Control and Long-Term Effects of diabetes (EAGLE) model.
|
Diabetes Technol Ther
|
2006
|
0.95
|
77
|
1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice.
|
J Immunol
|
2014
|
0.95
|
78
|
The Vitamin D analogue TX 527 blocks NF-kappaB activation in peripheral blood mononuclear cells of patients with Crohn's disease.
|
J Steroid Biochem Mol Biol
|
2006
|
0.95
|
79
|
Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients.
|
Diabetes Metab Res Rev
|
2007
|
0.95
|
80
|
The effects of 1alpha,25-dihydroxyvitamin D3 on the expression of DNA replication genes.
|
J Bone Miner Res
|
2004
|
0.94
|
81
|
Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor.
|
Diabetes
|
2008
|
0.94
|
82
|
Decrease of miR-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin.
|
PLoS One
|
2012
|
0.94
|
83
|
A view on beta cell transplantation in diabetes.
|
Ann N Y Acad Sci
|
2002
|
0.94
|
84
|
Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction.
|
J Clin Endocrinol Metab
|
2006
|
0.94
|
85
|
Unaltered diabetes presentation in NOD mice lacking the vitamin D receptor.
|
Diabetes
|
2007
|
0.94
|
86
|
Feasibility, safety, and efficacy of percutaneous transhepatic injection of beta-cell grafts.
|
J Vasc Interv Radiol
|
2005
|
0.93
|
87
|
Extraskeletal effects of vitamin D.
|
Endocrinol Metab Clin North Am
|
2012
|
0.93
|
88
|
Targeting the NAD7 subunit to mitochondria restores a functional complex I and a wild type phenotype in the Nicotiana sylvestris CMS II mutant lacking nad7.
|
J Biol Chem
|
2005
|
0.93
|
89
|
Barriers and facilitators to evidence based care of type 2 diabetes patients: experiences of general practitioners participating to a quality improvement program.
|
Implement Sci
|
2009
|
0.92
|
90
|
Progesterone in gestational diabetes mellitus: guilty or not guilty?
|
Trends Endocrinol Metab
|
2003
|
0.92
|
91
|
Vitamin D in autoimmune, infectious and allergic diseases: a vital player?
|
Best Pract Res Clin Endocrinol Metab
|
2011
|
0.92
|
92
|
Cytokine signalling in the beta-cell: a dual role for IFNgamma.
|
Biochem Soc Trans
|
2008
|
0.92
|
93
|
Novel insights in the immune function of the vitamin D system: synergism with interferon-beta.
|
J Steroid Biochem Mol Biol
|
2006
|
0.91
|
94
|
Vitamin D and diabetes: the odd couple.
|
Trends Endocrinol Metab
|
2013
|
0.91
|
95
|
Regulation of 25-hydroxyvitamin d-1alpha-hydroxylase by IFNgamma in human monocytic THP1 cells.
|
J Steroid Biochem Mol Biol
|
2004
|
0.91
|
96
|
Modified aquaporin 5 expression and distribution in submandibular glands from NOD mice displaying autoimmune exocrinopathy.
|
Arthritis Rheum
|
2007
|
0.90
|
97
|
Neuropeptides of the islets of Langerhans: a peptidomics study.
|
Gen Comp Endocrinol
|
2007
|
0.90
|
98
|
Diabetic ketoacidosis.
|
Rev Endocr Metab Disord
|
2003
|
0.90
|
99
|
Decreased miR-181a expression in monocytes of obese patients is associated with the occurrence of metabolic syndrome and coronary artery disease.
|
J Clin Endocrinol Metab
|
2012
|
0.89
|
100
|
Patients with Type 2 Diabetes Initiating Exenatide Twice Daily or Insulin in Clinical Practice: CHOICE Study.
|
Diabetes Ther
|
2012
|
0.89
|
101
|
Screening for pregestational and gestational diabetes in pregnancy: a survey of obstetrical centers in the northern part of Belgium.
|
Diabetol Metab Syndr
|
2013
|
0.88
|
102
|
Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection.
|
Proc Natl Acad Sci U S A
|
2014
|
0.88
|
103
|
Hepatocellular neoplasms induced by low-number pancreatic islet transplants in autoimmune diabetic BB/Pfd rats.
|
Cancer Res
|
2006
|
0.88
|
104
|
Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome?
|
AIDS Res Ther
|
2009
|
0.88
|
105
|
Stimulation of A2A-adenosine receptors after myocardial infarction suppresses inflammatory activation and attenuates contractile dysfunction in the remote left ventricle.
|
Am J Physiol Heart Circ Physiol
|
2005
|
0.88
|
106
|
Phosphorylation of p27(KIP1) homologs KRP6 and 7 by SNF1-related protein kinase-1 links plant energy homeostasis and cell proliferation.
|
Plant J
|
2013
|
0.88
|
107
|
Start improving the quality of care for people with type 2 diabetes through a general practice support program: a cluster randomized trial.
|
Diabetes Res Clin Pract
|
2010
|
0.87
|
108
|
Uremia suppresses immune signal-induced CYP27B1 expression in human monocytes.
|
Am J Nephrol
|
2012
|
0.87
|
109
|
A cluster randomized trial to improve adherence to evidence-based guidelines on diabetes and reduce clinical inertia in primary care physicians in Belgium: study protocol [NTR 1369].
|
Implement Sci
|
2008
|
0.87
|
110
|
Vitamin D for infections.
|
Curr Opin Endocrinol Diabetes Obes
|
2014
|
0.87
|
111
|
Cardiovascular risk factors and complications associated with albuminuria and impaired renal function in insulin-treated diabetes.
|
J Diabetes Complications
|
2013
|
0.86
|
112
|
1,25-dihydroxyvitamin D3 and a superagonistic analog in combination with paclitaxel or suberoylanilide hydroxamic acid have potent antiproliferative effects on anaplastic thyroid cancer.
|
J Steroid Biochem Mol Biol
|
2010
|
0.86
|
113
|
Vitamin D and diabetes.
|
Rheum Dis Clin North Am
|
2012
|
0.86
|
114
|
Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin D3.
|
J Biol Chem
|
2005
|
0.86
|
115
|
Quality indicators for type-2 diabetes care in practice guidelines: an example from six European countries.
|
Prim Care Diabetes
|
2006
|
0.86
|
116
|
Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors.
|
J Histochem Cytochem
|
2012
|
0.85
|
117
|
Endometrial and peritoneal expression of aromatase, cytokines, and adhesion factors in women with endometriosis.
|
Fertil Steril
|
2007
|
0.85
|
118
|
Proteome analysis demonstrates profound alterations in human dendritic cell nature by TX527, an analogue of vitamin D.
|
Proteomics
|
2009
|
0.85
|
119
|
Traffic air pollution and oxidized LDL.
|
PLoS One
|
2011
|
0.85
|
120
|
Acute shock induced by antigen vaccination in NOD mice.
|
Diabetes
|
2003
|
0.85
|
121
|
Monocytic expression behavior of cytokines in diabetic patients upon inflammatory stimulation.
|
Ann N Y Acad Sci
|
2004
|
0.85
|
122
|
No evidence for a role of rare CYP27B1 functional variations in multiple sclerosis.
|
Ann Neurol
|
2013
|
0.84
|
123
|
Mechanisms for the selective action of Vitamin D analogs.
|
J Steroid Biochem Mol Biol
|
2005
|
0.84
|
124
|
The role of blood glucose monitoring in non-insulin treated type 2 diabetes: what is the evidence?
|
Prim Care Diabetes
|
2012
|
0.84
|
125
|
High glucose induces dysfunction in insulin secretory cells by different pathways: a proteomic approach.
|
J Proteome Res
|
2010
|
0.84
|
126
|
Otelixizumab in the treatment of type 1 diabetes mellitus.
|
Immunotherapy
|
2011
|
0.84
|
127
|
Posttranslational modifications of proteins in type 1 diabetes: the next step in finding the cure?
|
Diabetes
|
2012
|
0.84
|
128
|
Monitoring modifiable cardiovascular risk in type 2 diabetes care in general practice: the use of an aggregated z-score.
|
Med Care
|
2010
|
0.83
|
129
|
The vitamin D analog TX527 ameliorates disease symptoms in a chemically induced model of inflammatory bowel disease.
|
J Steroid Biochem Mol Biol
|
2012
|
0.83
|
130
|
Combined 'en bloc' liver and pancreas transplantation in patients with liver disease and type 1 diabetes mellitus.
|
Am J Transplant
|
2004
|
0.83
|
131
|
Functional beta-cell mass and insulin sensitivity is decreased in insulin-independent pancreas-kidney recipients.
|
Transplantation
|
2009
|
0.83
|
132
|
1α,25-Dihydroxyvitamin D3 and its analogs as modulators of human dendritic cells: a comparison dose-titration study.
|
J Steroid Biochem Mol Biol
|
2012
|
0.82
|
133
|
IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling.
|
J Immunol
|
2006
|
0.82
|
134
|
A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells.
|
J Biol Chem
|
2014
|
0.82
|
135
|
Light and oxygen are not required for harpin-induced cell death.
|
J Biol Chem
|
2007
|
0.81
|
136
|
Effect of recombinant human TNF-binding protein-1 and GnRH antagonist on mRNA expression of inflammatory cytokines and adhesion and growth factors in endometrium and endometriosis tissues in baboons.
|
Fertil Steril
|
2007
|
0.81
|
137
|
Early presence of regulatory cells in transplanted rats rendered tolerant by donor-specific blood transfusion.
|
J Immunol
|
2005
|
0.81
|
138
|
An integrated proteomics and genomics analysis to unravel a heterogeneous platelet secretion defect.
|
J Proteomics
|
2011
|
0.81
|
139
|
Calcium insufficiency accelerates type 1 diabetes in vitamin D receptor-deficient nonobese diabetic (NOD) mice.
|
Endocrinology
|
2011
|
0.81
|
140
|
IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets.
|
Diabetologia
|
2013
|
0.81
|
141
|
Effects of vitamin D on antigen-specific and non-antigen-specific immune modulation: relevance for type 1 diabetes.
|
Pediatr Diabetes
|
2012
|
0.81
|
142
|
Economic aspects of diabetic foot care in a multidisciplinary setting: a review.
|
Diabetes Metab Res Rev
|
2007
|
0.81
|
143
|
Straight from D-Heart: vitamin D status and cardiovascular disease.
|
Curr Opin Lipidol
|
2012
|
0.80
|
144
|
Impact of vitamin D receptor activity on experimental autoimmune prostatitis.
|
J Autoimmun
|
2009
|
0.80
|
145
|
Two-dimensional gel proteome reference map of INS-1E cells.
|
Proteomics
|
2011
|
0.80
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