Published in Trends Parasitol on June 01, 2002
The origin of malignant malaria. Proc Natl Acad Sci U S A (2009) 2.67
African apes as reservoirs of Plasmodium falciparum and the origin and diversification of the Laverania subgenus. Proc Natl Acad Sci U S A (2010) 2.31
Contrasting population structures of the genes encoding ten leading vaccine-candidate antigens of the human malaria parasite, Plasmodium falciparum. PLoS One (2009) 1.43
Harnessing genomics and genome biology to understand malaria biology. Nat Rev Genet (2012) 1.41
"Clonal" population structure of the malaria agent Plasmodium falciparum in high-infection regions. Proc Natl Acad Sci U S A (2005) 1.41
Population genetic structure of Plasmodium falciparum in the two main African vectors, Anopheles gambiae and Anopheles funestus. Proc Natl Acad Sci U S A (2007) 1.40
Antigenic diversity and immune evasion by malaria parasites. Clin Diagn Lab Immunol (2004) 1.39
Meager genetic variability of the human malaria agent Plasmodium vivax. Proc Natl Acad Sci U S A (2004) 1.20
Therapeutic efficacy test in malaria falciparum in Antioquia, Colombia. Malar J (2006) 1.09
Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population. Mol Biol Evol (2012) 1.00
Genetic relatedness of Plasmodium falciparum isolates and the origin of allelic diversity at the merozoite surface protein-1 (MSP-1) locus in Brazil and Vietnam. Malar J (2003) 0.95
Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents. BMC Evol Biol (2008) 0.86
Protein-based signatures of functional evolution in Plasmodium falciparum. BMC Evol Biol (2011) 0.84
Genetic diversity in merozoite surface protein-1 and 2 among Plasmodium falciparum isolates from malarious districts of tribal dominant state of Jharkhand, India. Ann Trop Med Parasitol (2011) 0.79
Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10
Discovery of gene function by expression profiling of the malaria parasite life cycle. Science (2003) 10.57
Mechanisms of, and barriers to, horizontal gene transfer between bacteria. Nat Rev Microbiol (2005) 6.55
Spiroindolones, a potent compound class for the treatment of malaria. Science (2010) 5.94
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A (2008) 4.80
A genome-wide map of diversity in Plasmodium falciparum. Nat Genet (2006) 4.50
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res (2004) 3.63
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol (2008) 3.23
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (2011) 3.07
The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification. Mol Biochem Parasitol (2005) 3.02
A systematic map of genetic variation in Plasmodium falciparum. PLoS Pathog (2006) 2.92
Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science (2005) 2.81
High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrob Agents Chemother (2006) 2.70
A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking. Malar J (2008) 2.54
The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. PLoS Med (2012) 2.42
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol (2009) 2.23
Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia. J Infect Dis (2007) 2.11
The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands. J Exp Med (2010) 2.08
Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host Microbe (2012) 2.05
Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biol (2008) 2.00
Population structure and gene evolution in Saccharomyces cerevisiae. FEMS Yeast Res (2006) 1.98
Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell (2007) 1.90
Parallel identification of new genes in Saccharomyces cerevisiae. Genome Res (2002) 1.89
Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax. Gene (2008) 1.89
Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria. J Med Chem (2010) 1.84
The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast. Proc Natl Acad Sci U S A (2002) 1.74
Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes. Proc Natl Acad Sci U S A (2010) 1.74
Population genomics of the immune evasion (var) genes of Plasmodium falciparum. PLoS Pathog (2007) 1.74
Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. Am J Trop Med Hyg (2010) 1.69
Widespread distribution of antisense transcripts in the Plasmodium falciparum genome. Mol Biochem Parasitol (2004) 1.68
Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet (2011) 1.68
Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrob Agents Chemother (2011) 1.67
In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal. Am J Trop Med Hyg (2002) 1.66
Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One (2008) 1.61
Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast. Proc Natl Acad Sci U S A (2002) 1.61
Hybrid selection for sequencing pathogen genomes from clinical samples. Genome Biol (2011) 1.61
Antimalarial drug discovery - approaches and progress towards new medicines. Nat Rev Microbiol (2013) 1.60
Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials. Cell Host Microbe (2013) 1.58
Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci U S A (2012) 1.58
Treasures and traps in genome-wide data sets: case examples from yeast. Nat Rev Genet (2002) 1.57
Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families. PLoS Genet (2013) 1.54
Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science (2002) 1.52
A high-throughput screen targeting malaria transmission stages opens new avenues for drug development. J Infect Dis (2011) 1.49
A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling. Genome Res (2004) 1.49
In silico discovery of transcription regulatory elements in Plasmodium falciparum. BMC Genomics (2008) 1.48
Multilocus haplotypes reveal variable levels of diversity and population structure of Plasmodium falciparum in Papua New Guinea, a region of intense perennial transmission. Malar J (2010) 1.47
In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. J Infect Dis (2005) 1.46
Validation of isoleucine utilization targets in Plasmodium falciparum. Proc Natl Acad Sci U S A (2011) 1.46
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem (2010) 1.46
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol (2012) 1.46
In silico gene function prediction using ontology-based pattern identification. Bioinformatics (2004) 1.44
Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem (2009) 1.42
Harnessing genomics and genome biology to understand malaria biology. Nat Rev Genet (2012) 1.41
Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal. PLoS One (2013) 1.40
Within-population variation in prevalence and lineage distribution of avian malaria in blue tits, Cyanistes caeruleus. Mol Ecol (2007) 1.37
Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem (2008) 1.34
Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination. Malar J (2012) 1.32
A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito. PLoS Negl Trop Dis (2010) 1.31
A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor. ACS Chem Biol (2011) 1.31
Rapid, field-deployable method for genotyping and discovery of single-nucleotide polymorphisms associated with drug resistance in Plasmodium falciparum. Antimicrob Agents Chemother (2012) 1.30
Maternal anemia in Benin: prevalence, risk factors, and association with low birth weight. Am J Trop Med Hyg (2011) 1.27
A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum. BMC Genomics (2008) 1.27
Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites. Genome Res (2010) 1.27
Regulation of the rate of asexual growth and commitment to sexual development by diffusible factors from in vitro cultures of Plasmodium falciparum. Am J Trop Med Hyg (2003) 1.26
Evidence that the erythrocyte invasion ligand PfRh2 is a target of protective immunity against Plasmodium falciparum malaria. J Immunol (2010) 1.26
Monitoring the chromosome 2 intraerythrocytic transcriptome of Plasmodium falciparum using oligonucleotide arrays. Am J Trop Med Hyg (2002) 1.26
PCR-based plasmid typing in Enterococcus faecium strains reveals widely distributed pRE25-, pRUM-, pIP501- and pHTbeta-related replicons associated with glycopeptide resistance and stabilizing toxin-antitoxin systems. FEMS Immunol Med Microbiol (2009) 1.25
Cross-species regulation of Plasmodium parasitemia in semi-immune children from Papua New Guinea. Trends Parasitol (2003) 1.25
On the road to eliminate malaria in Sri Lanka: lessons from history, challenges, gaps in knowledge and research needs. Malar J (2014) 1.24
Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies. BMC Genet (2010) 1.24
The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic area. Mol Cell Proteomics (2011) 1.24
Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome. Mol Biol Evol (2010) 1.23
Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. J Med Chem (2012) 1.22
Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. Exp Parasitol (2007) 1.21
Gene conversion as a source of nucleotide diversity in Plasmodium falciparum. Mol Biol Evol (2003) 1.19
Identification of regulatory elements in the Plasmodium falciparum genome. Mol Biochem Parasitol (2004) 1.18
A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal. Am J Trop Med Hyg (2010) 1.18
Increased microerythrocyte count in homozygous alpha(+)-thalassaemia contributes to protection against severe malarial anaemia. PLoS Med (2008) 1.17
Association of house spraying with suppressed levels of drug resistance in Zimbabwe. Malar J (2004) 1.16
Comparative evolutionary genomics of human malaria parasites. Trends Parasitol (2008) 1.16
RNA polymerase II synthesizes antisense RNA in Plasmodium falciparum. RNA (2005) 1.15
Drug-induced alterations in gene expression of the asexual blood forms of Plasmodium falciparum. Mol Microbiol (2003) 1.15
Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers. J Infect Dis (2013) 1.15
Mapping of the Plasmodium falciparum multidrug resistance gene 5'-upstream region, and evidence of induction of transcript levels by antimalarial drugs in chloroquine sensitive parasites. Mol Microbiol (2003) 1.13