Published in Cell Host Microbe on June 14, 2012
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature (2016) 2.86
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis. Nature (2017) 2.03
Antimalarial drug discovery - approaches and progress towards new medicines. Nat Rev Microbiol (2013) 1.60
Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor. Chem Biol (2015) 1.42
The yeast deletion collection: a decade of functional genomics. Genetics (2014) 1.15
Using genetic methods to define the targets of compounds with antimalarial activity. J Med Chem (2013) 1.06
Recent advances in malaria drug discovery. Bioorg Med Chem Lett (2013) 1.04
Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials. ACS Chem Biol (2014) 1.03
Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development. Mol Microbiol (2013) 1.00
Identification of pathogen genomic variants through an integrated pipeline. BMC Bioinformatics (2014) 0.97
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med (2015) 0.97
Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor. Sci Rep (2016) 0.92
Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo. Proc Natl Acad Sci U S A (2014) 0.91
Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun (2015) 0.90
Rapid Chagas disease drug target discovery using directed evolution in drug-sensitive yeast. ACS Chem Biol (2016) 0.88
Antiparasitic chemotherapy: from genomes to mechanisms. Annu Rev Pharmacol Toxicol (2013) 0.88
Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin. Br J Pharmacol (2013) 0.85
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease. PLoS Pathog (2015) 0.83
Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon. J Cell Sci (2015) 0.83
Natural products as probes in pharmaceutical research. J Ind Microbiol Biotechnol (2015) 0.82
Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei. Eukaryot Cell (2014) 0.82
Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase. Antimicrob Agents Chemother (2016) 0.82
Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways. J Biol Chem (2015) 0.81
An all-purpose antimalarial drug target. Cell Host Microbe (2012) 0.81
New insight-guided approaches to detect, cure, prevent and eliminate malaria. Protoplasma (2014) 0.81
Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol Biochem Parasitol (2013) 0.81
Next-Generation Sequencing of Plasmodium vivax Patient Samples Shows Evidence of Direct Evolution in Drug-Resistance Genes. ACS Infect Dis (2015) 0.80
An appended domain results in an unusual architecture for malaria parasite tryptophanyl-tRNA synthetase. PLoS One (2013) 0.80
Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase. Antimicrob Agents Chemother (2016) 0.79
A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway. J Biol Chem (2013) 0.79
Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases. Antimicrob Agents Chemother (2015) 0.79
A genomic and evolutionary approach reveals non-genetic drug resistance in malaria. Genome Biol (2014) 0.78
Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African Trypanosomiasis. J Biol Chem (2013) 0.78
Production of New Cladosporin Analogues by Reconstitution of the Polyketide Synthases Responsible for the Biosynthesis of this Antimalarial Agent. Angew Chem Int Ed Engl (2015) 0.78
Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target. J Nat Prod (2013) 0.78
Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetases. Malar J (2016) 0.78
Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification. Life (Basel) (2015) 0.78
Discovery of Dual-Stage Malaria Inhibitors with New Targets. Antimicrob Agents Chemother (2015) 0.77
Generation of rodent malaria parasites with a high mutation rate by destructing proofreading activity of DNA polymerase δ. DNA Res (2014) 0.76
Novel and unique domains in aminoacyl-tRNA synthetases from human fungal pathogens Aspergillus niger, Candida albicans and Cryptococcus neoformans. BMC Genomics (2014) 0.76
Chemical genomics for studying parasite gene function and interaction. Trends Parasitol (2013) 0.76
Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum. Sci Rep (2016) 0.75
Translational regulation in blood stages of the malaria parasite Plasmodium spp.: systems-wide studies pave the way. Wiley Interdiscip Rev RNA (2016) 0.75
Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis. PLoS Negl Trop Dis (2016) 0.75
The growing pipeline of natural aminoacyl-tRNA synthetase inhibitors for malaria treatment. Bioengineered (2016) 0.75
Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future. Acta Crystallogr F Struct Biol Commun (2015) 0.75
Chemical interrogation of the malaria kinome. Chembiochem (2014) 0.75
Muddled mechanisms: recent progress towards antimalarial target identification. F1000Res (2016) 0.75
Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance. BMC Genomics (2017) 0.75
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25
Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10
Thousands of chemical starting points for antimalarial lead identification. Nature (2010) 8.28
Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev (2005) 6.14
Spiroindolones, a potent compound class for the treatment of malaria. Science (2010) 5.94
Chemical genetics of Plasmodium falciparum. Nature (2010) 5.52
Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat Genet (1999) 5.06
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A (2008) 4.80
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nat Rev Microbiol (2009) 3.84
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol (2008) 3.23
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (2011) 3.07
An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science (2007) 2.82
The effects of anti-bacterials on the malaria parasite Plasmodium falciparum. Mol Biochem Parasitol (2007) 2.47
Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures. Nat Protoc (2007) 2.36
Interaction of pseudomonic acid A with Escherichia coli B isoleucyl-tRNA synthetase. Biochem J (1980) 2.24
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol (2009) 2.23
Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chem Biol (2000) 1.75
Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents. Antimicrob Agents Chemother (2005) 1.71
The state of the art in anti-malarial drug discovery and development. Curr Top Med Chem (2011) 1.66
In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. J Biol Chem (2006) 1.65
Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response. Proc Natl Acad Sci U S A (2005) 1.55
Validation of isoleucine utilization targets in Plasmodium falciparum. Proc Natl Acad Sci U S A (2011) 1.46
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice. Antimicrob Agents Chemother (2011) 1.37
A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor. ACS Chem Biol (2011) 1.31
Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs): a triad for cellular homeostasis. IUBMB Life (2010) 1.26
The yeast lysyl-tRNA synthetase gene. Evidence for general amino acid control of its expression and domain structure of the encoded protein. J Biol Chem (1988) 1.23
Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation. Proc Natl Acad Sci U S A (2008) 1.11
Cladosporin, a new antifungal metabolite from Cladosporium cladosporioides. J Antibiot (Tokyo) (1971) 1.06
Inflammation-associated gene transcription and expression in mouse lungs induced by low molecular weight compounds from fungi from the built environment. Chem Biol Interact (2010) 1.02
Target identification and validation of novel antimalarials. Future Microbiol (2011) 1.00
New lead structures in antifungal drug discovery. Curr Med Chem (2011) 0.89
Metabolic products of microorganisms. 184. On the mode of action of cladosporin. J Antibiot (Tokyo) (1979) 0.85
Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90
The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36
Discovery of gene function by expression profiling of the malaria parasite life cycle. Science (2003) 10.57
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
Bidirectional transport of amino acids regulates mTOR and autophagy. Cell (2009) 7.88
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08
Spiroindolones, a potent compound class for the treatment of malaria. Science (2010) 5.94
Immunity-related genes and gene families in Anopheles gambiae. Science (2002) 5.47
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell (2004) 4.98
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A (2008) 4.80
Cell type-specific gene expression differences in complex tissues. Nat Methods (2010) 4.75
heart of glass regulates the concentric growth of the heart in zebrafish. Curr Biol (2003) 4.09
Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Science (2007) 4.03
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A (2003) 3.93
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res (2004) 3.63
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell (2004) 3.43
Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity (2003) 3.36
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol (2008) 3.23
Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol (2007) 3.17
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (2011) 3.07
The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification. Mol Biochem Parasitol (2005) 3.02
A systematic map of genetic variation in Plasmodium falciparum. PLoS Pathog (2006) 2.92
Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science (2005) 2.81
A web-based genotyping resource for viral sequences. Nucleic Acids Res (2004) 2.68
The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae. Proc Natl Acad Sci U S A (2003) 2.65
High-throughput assay for small molecules that modulate zebrafish embryonic heart rate. Nat Chem Biol (2005) 2.64
In vivo imaging of proteolytic activity in atherosclerosis. Circulation (2002) 2.62
Semaphorin-plexin signaling guides patterning of the developing vasculature. Dev Cell (2004) 2.62
Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. Development (2002) 2.61
Genome expression analysis of Anopheles gambiae: responses to injury, bacterial challenge, and malaria infection. Proc Natl Acad Sci U S A (2002) 2.59
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol (2004) 2.57
The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. PLoS Med (2012) 2.42
Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart. Circ Res (2006) 2.36
In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes. J Exp Med (2009) 2.34
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. PLoS Genet (2008) 2.32
Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev (2006) 2.29
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol (2009) 2.23
Microbially derived artemisinin: a biotechnology solution to the global problem of access to affordable antimalarial drugs. Am J Trop Med Hyg (2007) 2.15
The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands. J Exp Med (2010) 2.08
From Zebrafish to human: modular medical models. Annu Rev Genomics Hum Genet (2002) 2.07
Patterning of angiogenesis in the zebrafish embryo. Development (2002) 2.03
Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury. Nat Biotechnol (2010) 2.00
Spiroindolone KAE609 for falciparum and vivax malaria. N Engl J Med (2014) 1.99
Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin. Nat Genet (2002) 1.99
The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome. Development (2002) 1.97
Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov (2009) 1.95
Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structure (2006) 1.92
Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu. J Am Chem Soc (2009) 1.92
Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell (2007) 1.90
Parallel identification of new genes in Saccharomyces cerevisiae. Genome Res (2002) 1.89
Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nat Chem Biol (2005) 1.87
Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria. J Med Chem (2010) 1.84
santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish. Development (2006) 1.82
M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition. J Innate Immun (2009) 1.80
The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast. Proc Natl Acad Sci U S A (2002) 1.74
Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes. Proc Natl Acad Sci U S A (2010) 1.74
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A (2009) 1.74
Discovery and use of small molecules for probing biological processes in zebrafish. Methods Cell Biol (2004) 1.69
Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes. Genome Res (2002) 1.68
Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrob Agents Chemother (2011) 1.67
Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. J Biol Chem (2007) 1.65
Optimal deconvolution of transcriptional profiling data using quadratic programming with application to complex clinical blood samples. PLoS One (2011) 1.62
A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function. Nat Biotechnol (2010) 1.62
Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One (2008) 1.61
Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast. Proc Natl Acad Sci U S A (2002) 1.61
Antimalarial drug discovery - approaches and progress towards new medicines. Nat Rev Microbiol (2013) 1.60
A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis. ACS Chem Biol (2012) 1.59
Endothelial signaling in kidney morphogenesis: a role for hemodynamic forces. Curr Biol (2002) 1.58
Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials. Cell Host Microbe (2013) 1.58
Treasures and traps in genome-wide data sets: case examples from yeast. Nat Rev Genet (2002) 1.57
Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families. PLoS Genet (2013) 1.54
VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart. Genes Dev (2005) 1.53
Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science (2002) 1.52
A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling. Genome Res (2004) 1.49
In silico discovery of transcription regulatory elements in Plasmodium falciparum. BMC Genomics (2008) 1.48
In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. J Infect Dis (2005) 1.46
Validation of isoleucine utilization targets in Plasmodium falciparum. Proc Natl Acad Sci U S A (2011) 1.46
In silico gene function prediction using ontology-based pattern identification. Bioinformatics (2004) 1.44
Small molecule inhibitors that selectively block dengue virus methyltransferase. J Biol Chem (2010) 1.40
Ubiquitin signals protein trafficking via interaction with a novel ubiquitin binding domain in the membrane fusion regulator, Vps9p. Curr Biol (2003) 1.39
siRNA in human cells selectively localizes to target RNA sites. Proc Natl Acad Sci U S A (2006) 1.39
Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth. Cancer Discov (2012) 1.37
Life cycle transcriptome of the malaria mosquito Anopheles gambiae and comparison with the fruitfly Drosophila melanogaster. Proc Natl Acad Sci U S A (2007) 1.36