Published in Blood on June 15, 2002
Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A (2004) 4.31
Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol (2008) 3.62
CYR61 (CCN1) is essential for placental development and vascular integrity. Mol Cell Biol (2002) 2.94
Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin. J Invest Dermatol (2009) 1.93
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell (2004) 1.83
CCN1/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci (2011) 1.75
Tissue factor-factor VIIa signaling. Arterioscler Thromb Vasc Biol (2004) 1.69
Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages. J Immunol (2010) 1.42
Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts. PLoS One (2017) 1.39
CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins. J Cell Biochem (2006) 1.26
Secretome from mesenchymal stem cells induces angiogenesis via Cyr61. J Cell Physiol (2009) 1.16
Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol Cell Biol (2009) 1.13
Differential expression of CCN-family members in primary human bone marrow-derived mesenchymal stem cells during osteogenic, chondrogenic and adipogenic differentiation. Cell Commun Signal (2005) 1.12
Genomic expression profiling of human inflammatory cardiomyopathy (DCMi) suggests novel therapeutic targets. J Mol Med (Berl) (2006) 1.12
The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis. Crit Rev Eukaryot Gene Expr (2011) 1.11
Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase. J Biol Chem (2007) 1.08
Cyr61 is involved in neutrophil infiltration in joints by inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther (2013) 1.06
Matricellular protein CCN1/CYR61: a new player in inflammation and leukocyte trafficking. Semin Immunopathol (2014) 1.04
Integrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding properties. Blood (2005) 1.04
Angiotensin II induces connective tissue growth factor gene expression via calcineurin-dependent pathways. Am J Pathol (2003) 1.03
Expressions of cysteine-rich61, connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significance. World J Gastroenterol (2004) 1.00
Increased expression of CYR61, an extracellular matrix signaling protein, in human benign prostatic hyperplasia and its regulation by lysophosphatidic acid. Endocrinology (2004) 1.00
The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing. Nat Commun (2015) 0.99
Matricellular protein CCN3 mitigates abdominal aortic aneurysm. J Clin Invest (2016) 0.96
A physiological role for connective tissue growth factor in early wound healing. Lab Invest (2012) 0.95
Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance. Mol Ther (2014) 0.94
Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2). J Cell Mol Med (2010) 0.92
Signal regulatory protein alpha negatively regulates beta2 integrin-mediated monocyte adhesion, transendothelial migration and phagocytosis. PLoS One (2008) 0.91
Proteolysis of CCN1 by plasmin: functional implications. Cancer Res (2005) 0.91
The heparan sulfate proteoglycan form of epithelial CD44v3 serves as a CD11b/CD18 counter-receptor during polymorphonuclear leukocyte transepithelial migration. J Biol Chem (2008) 0.90
Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to connective tissue growth factor/CCN2 because of an increase in the levels of endogenous fibronectin. J Biol Chem (2009) 0.90
New strategy to control cell migration and metastasis regulated by CCN2/CTGF. Cancer Cell Int (2014) 0.89
G protein-coupled receptors go extracellular: RhoA integrates the integrins. Mol Interv (2008) 0.89
Fell-Muir lecture: Connective tissue growth factor (CCN2) -- a pernicious and pleiotropic player in the development of kidney fibrosis. Int J Exp Pathol (2012) 0.87
Plasminogen on the surfaces of fibrin clots prevents adhesion of leukocytes and platelets. J Thromb Haemost (2009) 0.87
Cell surface receptors for CCN proteins. J Cell Commun Signal (2016) 0.86
Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro. Mol Vis (2011) 0.86
CCN1 expression in hepatocytes contributes to macrophage infiltration in nonalcoholic fatty liver disease in mice. J Lipid Res (2012) 0.86
Degradome products of the matricellular protein CCN1 as modulators of pathological angiogenesis in the retina. J Biol Chem (2013) 0.85
Cysteine-rich protein 61 (CCN1) and connective tissue growth factor (CCN2) at the crosshairs of ocular neovascular and fibrovascular disease therapy. J Cell Commun Signal (2013) 0.85
Single and Compound Knock-outs of MicroRNA (miRNA)-155 and Its Angiogenic Gene Target CCN1 in Mice Alter Vascular and Neovascular Growth in the Retina via Resident Microglia. J Biol Chem (2015) 0.84
Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-deficient mice. PLoS One (2014) 0.84
Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci U S A (2016) 0.84
Early and late postnatal myocardial and vascular changes in a protein restriction rat model of intrauterine growth restriction. PLoS One (2011) 0.83
Molecular control of vascular development by the matricellular proteins CCN1 (Cyr61) and CCN2 (CTGF). Trends Dev Biol (2013) 0.83
CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation. Proc Natl Acad Sci U S A (2016) 0.82
Ligand recognition specificity of leukocyte integrin αMβ2 (Mac-1, CD11b/CD18) and its functional consequences. Biochemistry (2015) 0.82
CCN1 Induces β-Catenin Translocation in Esophageal Squamous Cell Carcinoma through Integrin α11. ISRN Gastroenterol (2012) 0.82
The role of integrin alpha D beta2 (CD11d/CD18) in monocyte/macrophage migration. Exp Cell Res (2008) 0.81
The role of CCN family genes in haematological malignancies. J Cell Commun Signal (2015) 0.81
Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities. Hum Genomics (2015) 0.80
The opioid peptide dynorphin A induces leukocyte responses via integrin Mac-1 (αMβ2, CD11b/CD18). Mol Pain (2015) 0.76
Endogenous migration modulators as parent compounds for the development of novel cardiovascular and anti-inflammatory drugs. Br J Pharmacol (2012) 0.75
Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC-derived exosomes. FEBS Lett (2016) 0.75
Crucial Role of Mesangial Cell-derived Connective Tissue Growth Factor in a Mouse Model of Anti-Glomerular Basement Membrane Glomerulonephritis. Sci Rep (2017) 0.75
Emerging roles of CCN proteins in vascular development and pathology. J Cell Commun Signal (2016) 0.75
Identification of Human Cathelicidin Peptide LL-37 as a Ligand for Macrophage Integrin αMβ2 (Mac-1, CD11b/CD18) that Promotes Phagocytosis by Opsonizing Bacteria. Res Rep Biochem (2016) 0.75
Connective tissue growth factor (CTGF/CCN2) in haemophilic arthropathy and arthrofibrosis: a histological analysis. Haemophilia (2016) 0.75
Increased Expression of Connective Tissue Growth Factor (CTGF) in Multiple Organs After Exposure of Non-Human Primates (NHP) to Lethal Doses of Radiation. Health Phys (2015) 0.75
Cardiovascular disease: A turbulent path to plaque formation. Nature (2016) 0.75
Atheroprotective laminar flow inhibits Hippo pathway effector YAP in endothelial cells. Transl Res (2016) 0.75
CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis. Am J Pathol (2017) 0.75
Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol (2008) 3.62
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol (2010) 3.29
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov (2011) 3.26
CYR61 (CCN1) is essential for placental development and vascular integrity. Mol Cell Biol (2002) 2.94
FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J (2009) 2.11
G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling. Science (2010) 2.09
Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells. J Biol Chem (2002) 2.00
Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury. Am J Physiol Lung Cell Mol Physiol (2007) 1.97
Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R. Blood (2002) 1.92
A directional switch of integrin signalling and a new anti-thrombotic strategy. Nature (2013) 1.92
Cutting edge: TLR2 is a functional receptor for acute-phase serum amyloid A. J Immunol (2008) 1.89
CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J Biol Chem (2003) 1.70
Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway. J Immunol (2009) 1.70
Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling. EMBO J (2007) 1.65
FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. J Biol Chem (2008) 1.58
Serum amyloid A is an endogenous ligand that differentially induces IL-12 and IL-23. J Immunol (2006) 1.57
The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nat Immunol (2011) 1.55
A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell (2003) 1.54
Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells. J Biol Chem (2004) 1.52
Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts. Mol Cell Biol (2013) 1.47
Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2. Blood (2008) 1.46
Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression. J Biol Chem (2002) 1.45
The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans. Endocrinology (2002) 1.45
Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nat Immunol (2012) 1.43
Deregulation of FoxM1b leads to tumour metastasis. EMBO Mol Med (2010) 1.43
Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Mol Cell (2004) 1.42
Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase. Mol Cell Biol (2008) 1.42
Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages. J Immunol (2010) 1.42
The matricellular protein CCN1 is essential for cardiac development. Circ Res (2006) 1.41
Evaluation of the Modified Diet in Renal Disease equation for calculation of carboplatin dose. Ann Pharmacother (2009) 1.41
Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61). J Biol Chem (2003) 1.38
Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing. J Biol Chem (2004) 1.37
Cellular senescence controls fibrosis in wound healing. Aging (Albany NY) (2010) 1.36
Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells. Circ Res (2002) 1.36
Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling. J Cell Biol (2003) 1.34
Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling. Cancer Res (2004) 1.33
Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis. Mol Cancer Res (2009) 1.30
Regulated unmasking of the cryptic binding site for integrin alpha M beta 2 in the gamma C-domain of fibrinogen. Biochemistry (2002) 1.30
Identification of formyl peptides from Listeria monocytogenes and Staphylococcus aureus as potent chemoattractants for mouse neutrophils. J Immunol (2008) 1.30
Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase. J Biol Chem (2009) 1.28
Assays for ribosomal RNA processing and ribosome assembly. Curr Protoc Cell Biol (2008) 1.27
Akt isoforms differentially regulate neutrophil functions. Blood (2010) 1.27
The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J Cell Biol (2005) 1.26
A molecular basis for integrin alphaMbeta 2 ligand binding promiscuity. J Biol Chem (2002) 1.25
FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression. J Biol Chem (2007) 1.25
Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J Immunol (2004) 1.20
A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1. J Biol Chem (2009) 1.17
Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme. EMBO J (2010) 1.16
Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition. Mol Pharmacol (2009) 1.14
Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate proteoglycan coreceptor-mediated cellular functions. J Biol Chem (2004) 1.13
Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol Cell Biol (2009) 1.13
Multiple binding sites in fibrinogen for integrin alphaMbeta2 (Mac-1). J Biol Chem (2004) 1.12
CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation. J Cell Biol (2006) 1.09
Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells. J Mol Biol (2005) 1.09
A calcium/calmodulin-dependent activation of ERK1/2 mediates JunD phosphorylation and induction of nur77 and 20alpha-hsd genes by prostaglandin F2alpha in ovarian cells. J Biol Chem (2001) 1.07
Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-kappaB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cdelta. J Biol Chem (2008) 1.07
Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. J Biol Chem (2003) 1.07
A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol Pharmacol (2004) 1.07
Identification of a novel binding site for platelet integrins alpha IIb beta 3 (GPIIbIIIa) and alpha 5 beta 1 in the gamma C-domain of fibrinogen. J Biol Chem (2003) 1.06
Identification of a novel integrin alphaMbeta2 binding site in CCN1 (CYR61), a matricellular protein expressed in healing wounds and atherosclerotic lesions. J Biol Chem (2003) 1.06
beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation. Biochem J (2009) 1.05
Role of G protein-coupled receptors in inflammation. Acta Pharmacol Sin (2012) 1.05
Integrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding properties. Blood (2005) 1.04
The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels. J Biol Chem (2009) 1.03
Differential activation of formyl peptide receptor-like 1 by peptide ligands. J Immunol (2003) 1.03
The interplay between integrins alphaMbeta2 and alpha5beta1 during cell migration to fibronectin. Exp Cell Res (2003) 1.02
Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells. Am J Respir Cell Mol Biol (2005) 1.01
Activation of the small GTPase Rac1 by cGMP-dependent protein kinase. Cell Signal (2004) 1.01
Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression. J Immunol (2012) 1.00
Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice. Gene (2002) 1.00
CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB. J Clin Invest (2015) 1.00
A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. EMBO J (2009) 0.99
Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells. J Immunol (2004) 0.99
Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol (2013) 0.99
Heterotrimeric G protein signaling outside the realm of seven transmembrane domain receptors. Mol Pharmacol (2010) 0.99
The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis. J Biol Chem (2003) 0.99
Differential activation of formyl peptide receptor signaling by peptide ligands. Mol Pharmacol (2003) 0.98
Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation. J Leukoc Biol (2002) 0.97
Regulation of leukocyte degranulation by cGMP-dependent protein kinase and phosphoinositide 3-kinase: potential roles in phosphorylation of target membrane SNARE complex proteins in rat mast cells. J Immunol (2007) 0.97
6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors. J Med Chem (2009) 0.97
Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP. J Immunol (2005) 0.97
Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras. Mol Cell Biol (2003) 0.97
Functional characterization of three mouse formyl peptide receptors. Mol Pharmacol (2012) 0.95
High-throughput flow cytometry for drug discovery. Expert Opin Drug Discov (2007) 0.95
Identification of novel formyl peptide receptor-like 1 agonists that induce macrophage tumor necrosis factor alpha production. Mol Pharmacol (2008) 0.94