Published in J Immunol on February 17, 2010
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov (2011) 3.26
Matricellular proteins in cardiac adaptation and disease. Physiol Rev (2012) 2.01
CYR61 (CCN1) overexpression induces lung injury in mice. Am J Physiol Lung Cell Mol Physiol (2015) 1.99
CCN1/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci (2011) 1.75
Altered macrophage phenotype transition impairs skeletal muscle regeneration. Am J Pathol (2014) 1.08
Cyr61 is involved in neutrophil infiltration in joints by inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther (2013) 1.06
Matricellular protein CCN1/CYR61: a new player in inflammation and leukocyte trafficking. Semin Immunopathol (2014) 1.04
Danger signals in the initiation of the inflammatory response after myocardial infarction. Mediators Inflamm (2013) 1.02
CCN1, a Pro-Inflammatory Factor, Aggravates Psoriasis Skin Lesions by Promoting Keratinocyte Activation. J Invest Dermatol (2015) 1.02
CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB. J Clin Invest (2015) 1.00
The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing. Nat Commun (2015) 0.99
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The CCN family proteins: modulators of bone development and novel targets in bone-associated tumors. Biomed Res Int (2014) 0.97
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The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy. J Biol Chem (2011) 0.94
New Insights into the Function of the Matricellular CCN1: an Emerging Target in Proliferative Retinopathies. J Ophthalmic Vis Res (2013) 0.89
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CCN1 contributes to skin connective tissue aging by inducing age-associated secretory phenotype in human skin dermal fibroblasts. J Cell Commun Signal (2011) 0.88
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CCN4 regulates vascular smooth muscle cell migration and proliferation. Mol Cells (2013) 0.86
Cell surface receptors for CCN proteins. J Cell Commun Signal (2016) 0.86
CCN1 expression in hepatocytes contributes to macrophage infiltration in nonalcoholic fatty liver disease in mice. J Lipid Res (2012) 0.86
Single and Compound Knock-outs of MicroRNA (miRNA)-155 and Its Angiogenic Gene Target CCN1 in Mice Alter Vascular and Neovascular Growth in the Retina via Resident Microglia. J Biol Chem (2015) 0.84
CCN: core regulatory proteins in the microenvironment that affect the metastasis of hepatocellular carcinoma? Oncotarget (2016) 0.84
Cysteine-rich protein 61 plays a proinflammatory role in obstructive kidney fibrosis. PLoS One (2013) 0.82
CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation. Proc Natl Acad Sci U S A (2016) 0.82
Leptin induces oncostatin M production in osteoblasts by downregulating miR-93 through the Akt signaling pathway. Int J Mol Sci (2014) 0.82
The role of CCN family genes in haematological malignancies. J Cell Commun Signal (2015) 0.81
The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6. Mucosal Immunol (2015) 0.80
CCN1 induces oncostatin M production in osteoblasts via integrin-dependent signal pathways. PLoS One (2014) 0.80
Regulation of pancreatic inflammation by connective tissue growth factor (CTGF/CCN2). Immunology (2014) 0.79
Inflammatory cascades mediate synapse elimination in spinal cord compression. J Neuroinflammation (2014) 0.77
Serum Cyr61 is associated with clinical disease activity and inflammation in patients with systemic lupus erythematosus. Medicine (Baltimore) (2015) 0.77
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Cyr61 promotes CD204 expression and the migration of macrophages via MEK/ERK pathway in esophageal squamous cell carcinoma. Cancer Med (2015) 0.76
Hepatic and serum lipid signatures specific to nonalcoholic steatohepatitis in murine models. Sci Rep (2016) 0.76
Matrix protein CCN1 induced by bacterial DNA and CpG ODN limits lung inflammation and contributes to innate immune homeostasis. Mucosal Immunol (2014) 0.76
Regulation of CCN1 via the 3'-untranslated region. J Cell Commun Signal (2013) 0.76
S. aureus blocks efferocytosis of neutrophils by macrophages through the activity of its virulence factor alpha toxin. Sci Rep (2016) 0.76
Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy. Sci Rep (2017) 0.75
CCN1 promotes IL-1β production in keratinocytes by activating p38 MAPK signaling in psoriasis. Sci Rep (2017) 0.75
CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis. Am J Pathol (2017) 0.75
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The matricellular protein CCN1 is essential for cardiac development. Circ Res (2006) 1.41
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The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J Cell Biol (2005) 1.26
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The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol (2010) 3.29
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CYR61 (CCN1) is essential for placental development and vascular integrity. Mol Cell Biol (2002) 2.94
FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J (2009) 2.11
Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells. J Biol Chem (2002) 2.00
CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J Biol Chem (2003) 1.70
Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling. EMBO J (2007) 1.65
FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. J Biol Chem (2008) 1.58
Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells. J Biol Chem (2004) 1.52
Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts. Mol Cell Biol (2013) 1.47
Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression. J Biol Chem (2002) 1.45
The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans. Endocrinology (2002) 1.45
Deregulation of FoxM1b leads to tumour metastasis. EMBO Mol Med (2010) 1.43
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The matricellular protein CCN1 is essential for cardiac development. Circ Res (2006) 1.41
Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61). J Biol Chem (2003) 1.38
Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing. J Biol Chem (2004) 1.37
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Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis. Mol Cancer Res (2009) 1.30
Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase. J Biol Chem (2009) 1.28
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The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J Cell Biol (2005) 1.26
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Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate proteoglycan coreceptor-mediated cellular functions. J Biol Chem (2004) 1.13
Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol Cell Biol (2009) 1.13
A calcium/calmodulin-dependent activation of ERK1/2 mediates JunD phosphorylation and induction of nur77 and 20alpha-hsd genes by prostaglandin F2alpha in ovarian cells. J Biol Chem (2001) 1.07
Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. J Biol Chem (2003) 1.07
Identification of a novel integrin alphaMbeta2 binding site in CCN1 (CYR61), a matricellular protein expressed in healing wounds and atherosclerotic lesions. J Biol Chem (2003) 1.06
Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells. Am J Respir Cell Mol Biol (2005) 1.01
CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB. J Clin Invest (2015) 1.00
Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol (2013) 0.99
Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor. J Biol Chem (2003) 0.94
The heparin-binding site of antithrombin is crucial for antiangiogenic activity. Blood (2005) 0.94
Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines. J Cell Commun Signal (2009) 0.93
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Degradome products of the matricellular protein CCN1 as modulators of pathological angiogenesis in the retina. J Biol Chem (2013) 0.85
CCN3 and bone marrow cells. J Cell Commun Signal (2009) 0.80
Estrogen-induced CCN1 is critical for establishment of endometriosis-like lesions in mice. Mol Endocrinol (2014) 0.78
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