Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling.

PubWeight™: 1.22‹?› | Rank: Top 10%

🔗 View Article (PMC 2597572)

Published in J Immunol on November 15, 2008

Authors

Surinder Kaur1, Antonella Sassano, Ajith M Joseph, Beata Majchrzak-Kita, Elizabeth A Eklund, Amit Verma, Saskia M Brachmann, Eleanor N Fish, Leonidas C Platanias

Author Affiliations

1: Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, Chicago, IL 60611, USA.

Articles citing this

Immunomodulatory functions of type I interferons. Nat Rev Immunol (2012) 3.73

Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity (2010) 2.39

Innate immune response to influenza A virus in differentiated human alveolar type II cells. Am J Respir Cell Mol Biol (2011) 1.21

Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses. Proc Natl Acad Sci U S A (2009) 1.17

Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling. J Immunol (2010) 1.17

Make yourself at home: viral hijacking of the PI3K/Akt signaling pathway. Viruses (2013) 1.03

Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses. Proc Natl Acad Sci U S A (2012) 1.03

The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. Proc Natl Acad Sci U S A (2012) 1.02

Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation. Respir Res (2009) 1.01

Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes. Mol Cancer Res (2014) 0.99

Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis. J Biol Chem (2010) 0.99

Pro-angiogenic effect of IFNgamma is dependent on the PI3K/mTOR/translational pathway in human retinal pigmented epithelial cells. Mol Vis (2010) 0.98

Beta interferon regulation of glucose metabolism is PI3K/Akt dependent and important for antiviral activity against coxsackievirus B3. J Virol (2014) 0.91

Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses. Mol Cell Biol (2012) 0.90

Central role of ULK1 in type I interferon signaling. Cell Rep (2015) 0.90

Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway. Cell Rep (2015) 0.89

Alterations of the gene expression profile in renal cell carcinoma after treatment with the histone deacetylase-inhibitor valproic acid and interferon-alpha. World J Urol (2010) 0.87

Interferons modulate mitogen-induced protein synthesis in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2010) 0.84

Critical roles for Rictor/Sin1 complexes in interferon-dependent gene transcription and generation of antiproliferative responses. J Biol Chem (2014) 0.84

Interferon gamma induces protective non-canonical signaling pathways in primary neurons. J Neurochem (2015) 0.83

Virus Multiplicity of Infection Affects Type I Interferon Subtype Induction Profiles and Interferon-Stimulated Genes. J Virol (2015) 0.82

Regulation of interferon-dependent mRNA translation of target genes. J Interferon Cytokine Res (2014) 0.82

Prediction of human protein-protein interaction by a mixed Bayesian model and its application to exploring underlying cancer-related pathway crosstalk. J R Soc Interface (2010) 0.81

IFNγ-induced suppression of β-catenin signaling: evidence for roles of Akt and 14.3.3ζ. Mol Biol Cell (2014) 0.80

Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1. Scientifica (Cairo) (2013) 0.80

Regulatory effects of SKAR in interferon α signaling and its role in the generation of type I IFN responses. Proc Natl Acad Sci U S A (2014) 0.78

Akt1, EMSY, BRCA2 and type I IFN signaling: a novel arm of the IFN response. Transcription (2012) 0.77

Type I Interferon Signaling Is Decoupled from Specific Receptor Orientation through Lenient Requirements of the Transmembrane Domain. J Biol Chem (2015) 0.77

Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes. PLoS One (2015) 0.76

Beyond autophagy: New roles for ULK1 in immune signaling and interferon responses. Cytokine Growth Factor Rev (2016) 0.76

Deficiency in either 4E-BP1 or 4E-BP2 augments innate antiviral immune responses. PLoS One (2014) 0.75

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses. J Biol Chem (2017) 0.75

Type I Interferon-Mediated Induction of Antiviral Genes and Proteins Fails to Protect Cells from the Cytopathic Effects of Sendai Virus Infection. J Interferon Cytokine Res (2016) 0.75

CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection. J Immunol (2015) 0.75

Articles cited by this

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science (1994) 26.02

The phosphoinositide 3-kinase pathway. Science (2002) 24.72

How cells respond to interferons. Annu Rev Biochem (1998) 24.27

STATs and gene regulation. Science (1997) 16.55

IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature (2005) 13.23

Triggering the interferon antiviral response through an IKK-related pathway. Science (2003) 11.62

Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol (2005) 11.57

Interferons and their actions. Annu Rev Biochem (1987) 8.36

A road map for those who don't know JAK-STAT. Science (2002) 5.67

The Akt-mTOR tango and its relevance to cancer. Cancer Cell (2005) 5.34

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci U S A (2007) 3.98

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc Natl Acad Sci U S A (1997) 2.63

Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection. Nat Med (2004) 2.59

Translational control of the innate immune response through IRF-7. Nature (2008) 2.30

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J Exp Med (2008) 2.02

Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement. Mol Cell Biol (2005) 1.94

Activation of the p38 mitogen-activated protein kinase by type I interferons. J Biol Chem (1999) 1.94

Signaling pathways activated by interferons. Exp Hematol (1999) 1.85

Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc Natl Acad Sci U S A (2008) 1.81

Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study. JAMA (2003) 1.81

Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J Biol Chem (2002) 1.72

Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression. J Biol Chem (2001) 1.71

Interferons: mechanisms of action and clinical applications. Curr Opin Oncol (2003) 1.56

Interferon alpha /beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt. J Biol Chem (2001) 1.53

ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors. Cancer Res (2005) 1.50

Cutting edge: activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia. J Immunol (2002) 1.41

Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling. J Biol Chem (2006) 1.41

Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. J Biol Chem (2003) 1.36

The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells. J Biol Chem (2001) 1.33

The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta. Blood (1997) 1.32

Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase. J Biol Chem (1995) 1.31

Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-delta, and NF-kappa B signaling pathways. J Immunol (2003) 1.29

Activation of protein kinase C delta by IFN-gamma. J Immunol (2003) 1.25

Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp Cell Res (2004) 1.25

Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway. J Biol Chem (2004) 1.24

Role of p38alpha Map kinase in Type I interferon signaling. J Biol Chem (2003) 1.23

The PI3' kinase pathway in interferon signaling. J Interferon Cytokine Res (2005) 1.17

A linear signal transduction pathway involving phosphatidylinositol 3-kinase, protein kinase Cepsilon, and MAPK in mesangial cells regulates interferon-gamma-induced STAT1alpha transcriptional activation. J Biol Chem (2004) 1.13

Role of the p38 mitogen-activated protein kinase pathway in cytokine-mediated hematopoietic suppression in myelodysplastic syndromes. Cancer Res (2005) 1.13

Therapeutic role of beta-interferons in multiple sclerosis. Pharmacol Ther (2005) 1.13

Gamma interferon-inducible protein 10 induces HeLa cell apoptosis through a p53-dependent pathway initiated by suppression of human papillomavirus type 18 E6 and E7 expression. Mol Cell Biol (2005) 1.10

A collaborative study on larval excretory/secretory antigens of Toxocara canis for the immunodiagnosis of human toxocariasis with ELISA. Acta Trop (1984) 1.08

Activation of nonreceptor tyrosine kinase Bmx/Etk mediated by phosphoinositide 3-kinase, epidermal growth factor receptor, and ErbB3 in prostate cancer cells. J Biol Chem (2007) 1.08

Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-alpha. J Immunol (1997) 1.06

Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. J Biol Chem (1997) 1.01

Interferon-alpha promotes survival of human primary B-lymphocytes via phosphatidylinositol 3-kinase. Biochem Biophys Res Commun (2001) 0.99

Interferon-gamma induces Fas trafficking and sensitization to apoptosis in vascular smooth muscle cells via a PI3K- and Akt-dependent mechanism. Am J Pathol (2006) 0.99

A PI-3 kinase-dependent, Stat1-independent signaling pathway regulates interferon-stimulated monocyte adhesion. J Leukoc Biol (2003) 0.97

Role of protein kinase C-delta (PKC-delta) in the generation of the effects of IFN-alpha in chronic myelogenous leukemia cells. Exp Hematol (2005) 0.94

Introduction: interferon signals: what is classical and what is nonclassical? J Interferon Cytokine Res (2005) 0.93

The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-alpha receptors. Blood (1997) 0.92

The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. J Biol Chem (1996) 0.90

Phosphatidylinositol 3'-kinase is a critical mediator of interferon-gamma-induced increases in enteric epithelial permeability. J Pharmacol Exp Ther (2006) 0.90

Interferon-dependent activation of the serine kinase PI 3'-kinase requires engagement of the IRS pathway but not the Stat pathway. Biochem Biophys Res Commun (2000) 0.89

Interferon beta promotes survival in primary astrocytes through phosphatidylinositol 3-kinase. J Neuroimmunol (2003) 0.89

Phosphoinositide 3-kinase regulates a subset of interferon-alpha-stimulated genes. Exp Cell Res (2006) 0.88

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res (2005) 5.07

Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection. Proc Natl Acad Sci U S A (2006) 3.43

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A (2001) 2.49

Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol (2009) 2.48

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol (2002) 2.42

Cytosine methylation dysregulation in neonates following intrauterine growth restriction. PLoS One (2010) 2.10

Stats: multifaceted regulators of transcription. J Interferon Cytokine Res (2005) 2.02

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations. Blood (2012) 1.98

Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol (2005) 1.97

Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS. Blood (2008) 1.95

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1. J Cell Biol (2003) 1.91

Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway. Cancer Res (2006) 1.82

Inhibition of autophagy in mitotic animal cells. Traffic (2002) 1.81

Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc Natl Acad Sci U S A (2008) 1.81

Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study. JAMA (2003) 1.81

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Res (2009) 1.80

Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells. Proc Natl Acad Sci U S A (2010) 1.75

Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J Biol Chem (2002) 1.72

Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis. J Biol Chem (2001) 1.71

Contribution of interferon-beta to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharide. J Biol Chem (2006) 1.70

Sex affects immunity. J Autoimmun (2012) 1.68

Fibrocyte activation in rheumatoid arthritis. Rheumatology (Oxford) (2009) 1.68

Chemokines: attractive mediators of the immune response. Semin Immunol (2003) 1.66

Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. Blood (2012) 1.66

AMPK as a therapeutic target in renal cell carcinoma. Cancer Biol Ther (2010) 1.66

Circulating fibrocytes contribute to the pathogenesis of collagen antibody-induced arthritis. Arthritis Rheum (2012) 1.65

Interferons: mechanisms of action and clinical applications. Curr Opin Oncol (2003) 1.56

Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials. Mol Cancer Ther (2014) 1.56

Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitry. J Interferon Cytokine Res (2002) 1.55

Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma. Blood (2010) 1.53

Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib. Leuk Lymphoma (2009) 1.53

Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development. Genome Biol (2013) 1.52

Jak family of kinases in cancer. Cancer Metastasis Rev (2003) 1.52

Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma. Gastroenterology (2013) 1.49

Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysis. J Biol Chem (2004) 1.49

Outcome from therapeutic hypothermia and EEG. J Clin Neurophysiol (2011) 1.48

Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood (2006) 1.48

Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis. PLoS Genet (2011) 1.47

MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. Proc Natl Acad Sci U S A (2002) 1.47

Cancer biomarkers - current perspectives. Indian J Med Res (2010) 1.44

Primary care physicians' awareness, experience and opinions of direct-to-consumer genetic testing. J Genet Couns (2011) 1.42

Cutting edge: activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia. J Immunol (2002) 1.41

Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling. J Biol Chem (2006) 1.41

Protective role for interferon-beta in coxsackievirus B3 infection. Circulation (2004) 1.40

Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation. J Cell Sci (2003) 1.40

Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells. Cancer Res (2005) 1.40

Therapeutic implications for interferon-alpha in arthritis: a pilot study. J Rheumatol (2003) 1.39

Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome. Blood (2009) 1.37

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS. Blood (2012) 1.36

p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. Mol Cell Biol (2009) 1.36

Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. J Biol Chem (2003) 1.36

Statins in tumor suppression. Cancer Lett (2008) 1.34

Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis. Blood (2012) 1.33

Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia. J Clin Invest (2008) 1.33

Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene (2002) 1.32

Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses. Cancer Res (2006) 1.31

Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors. Clin Cancer Res (2011) 1.29

The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1. J Biol Chem (2004) 1.29

Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling. PLoS One (2010) 1.29

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment. Nat Immunol (2013) 1.28

Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines. Mol Cancer Ther (2008) 1.28

Sex differences in the vaccine-specific and non-targeted effects of vaccines. Vaccine (2011) 1.27

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood (2013) 1.26

Targeting mTOR for the treatment of AML. New agents and new directions. Oncotarget (2011) 1.26

The yin and yang of viruses and interferons. Trends Immunol (2012) 1.25

Hyposialylation of integrins stimulates the activity of myeloid fibronectin receptors. J Biol Chem (2002) 1.25

Activation of protein kinase C delta by IFN-gamma. J Immunol (2003) 1.25

Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp Cell Res (2004) 1.25

The p38 mitogen-activated protein kinase pathway in interferon signal transduction. J Interferon Cytokine Res (2005) 1.23

Role of p38alpha Map kinase in Type I interferon signaling. J Biol Chem (2003) 1.23