Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism.

PubWeight™: 1.26‹?› | Rank: Top 10%

🔗 View Article (PMC 117612)

Published in Mol Biol Cell on June 01, 2002

Authors

Lucas C Armstrong1, Benny Björkblom, Kurt D Hankenson, Anthony W Siadak, Charlotte E Stiles, Paul Bornstein

Author Affiliations

1: Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.

Articles citing this

Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat Med (2005) 3.60

Thrombospondins function as regulators of angiogenesis. J Cell Commun Signal (2009) 1.40

Thrombospondin-based antiangiogenic therapy. Microvasc Res (2007) 1.26

Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis. Am J Pathol (2008) 1.25

Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment. PLoS One (2013) 1.24

Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling. Mol Cell Biol (2003) 1.16

Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer (2010) 1.14

Matricellular proteins: a sticky affair with cancers. J Oncol (2012) 1.10

Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing. J Bone Miner Res (2009) 1.10

New molecular targets in angiogenic vessels of glioblastoma tumours. Expert Rev Mol Med (2008) 1.08

Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells. Mol Biol Cell (2007) 1.03

Thrombospondin-2 regulates matrix mineralization in MC3T3-E1 pre-osteoblasts. Bone (2009) 1.02

Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis. Am J Pathol (2004) 1.01

Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1. J Cell Physiol (2009) 1.00

Oxidative stress-mediated thrombospondin-2 upregulation impairs bone marrow-derived angiogenic cell function in diabetes mellitus. Arterioscler Thromb Vasc Biol (2013) 0.99

Thrombospondin and apoptosis: molecular mechanisms and use for design of complementation treatments. Curr Drug Targets (2008) 0.97

Endogenous inhibitors of angiogenesis in malignant gliomas: nature's antiangiogenic therapy. Neuro Oncol (2005) 0.94

Enhanced angiogenesis and reduced contraction in thrombospondin-2-null wounds is associated with increased levels of matrix metalloproteinases-2 and -9, and soluble VEGF. J Histochem Cytochem (2008) 0.94

Thrombospondins in the heart: potential functions in cardiac remodeling. J Cell Commun Signal (2009) 0.93

Modulation of growth and angiogenic potential of oral squamous carcinoma cells in vitro using salvianolic acid B. BMC Complement Altern Med (2011) 0.88

Down regulation of Thrombospondin2 predicts poor prognosis in patients with gastric cancer. Mol Cancer (2014) 0.88

Genetic heterogeneity of skin microvasculature. Dev Biol (2010) 0.85

Lack of thrombospondin-2 reduces fibrosis and increases vascularity around cardiac cell grafts. Cardiovasc Pathol (2012) 0.83

Expression of angiogenic basic fibroblast growth factor, platelet derived growth factor, thrombospondin-1 and their receptors at the porcine maternal-fetal interface. Reprod Biol Endocrinol (2011) 0.83

Thrombospondin-2 gene silencing in human aortic smooth muscle cells improves cell attachment. J Am Coll Surg (2011) 0.82

Differential gene expression in the periprosthetic membrane: lubricin as a new possible pathogenetic factor in prosthesis loosening. Virchows Arch (2003) 0.80

Pregnancy-associated genes contribute to antiluteolytic mechanisms in ovine corpus luteum. Physiol Genomics (2013) 0.80

Differentiation state determines neural effects on microvascular endothelial cells. Exp Cell Res (2012) 0.78

Long-term gene therapy with thrombospondin 2 inhibits TGF-β activation, inflammation and angiogenesis in chronic allograft nephropathy. PLoS One (2013) 0.75

Articles cited by this

Angiogenesis in cancer and other diseases. Nature (2000) 28.28

Cutaneous wound healing. N Engl J Med (1999) 19.12

A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J Immunol (1979) 16.56

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem (1998) 8.30

An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem (1994) 6.31

Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse. Proc Natl Acad Sci U S A (1991) 5.52

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med (2000) 5.05

Macrophages and angiogenesis. J Leukoc Biol (1994) 3.85

Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J Biol Chem (1998) 3.78

CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. J Cell Biol (1997) 3.52

Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1. J Cell Biol (1995) 3.44

Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis. J Cell Biol (1998) 3.27

Angiogenesis in wound healing. J Investig Dermatol Symp Proc (2000) 3.12

Thrombospondins as matricellular modulators of cell function. J Clin Invest (2001) 2.95

Synthesis and secretion of thrombospondin by cultured human endothelial cells. J Cell Biol (1982) 2.72

The cell biology of thrombospondin-1. Matrix Biol (2000) 2.41

Isolation and characterization of a glycoprotein secreted by aortic endothelial cells in culture. Apparent identity with platelet thrombospondin. J Biol Chem (1981) 2.25

Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2. J Biol Chem (2000) 2.18

Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats. Circulation (1999) 2.11

Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro. Proc Natl Acad Sci U S A (1991) 1.94

Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells. Biochem Biophys Res Commun (1999) 1.93

Differential expression of thrombospondin 1, 2, and 3 during murine development. Dev Dyn (1993) 1.92

Matricellular proteins as modulators of cell-matrix interactions: adhesive defect in thrombospondin 2-null fibroblasts is a consequence of increased levels of matrix metalloproteinase-2. Mol Biol Cell (2000) 1.85

Thrombospondin 1 and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells. Cancer Res (1997) 1.81

Accelerated wound healing in mice with a disruption of the thrombospondin 2 gene. J Invest Dermatol (1999) 1.79

Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. Am J Pathol (2001) 1.64

A short-duration polyethylene glycol fusion technique for increasing production of monoclonal antibody-secreting hybridomas. J Immunol Methods (1985) 1.58

Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism. EMBO J (2001) 1.51

Thrombospondin 2, a matricellular protein with diverse functions. Matrix Biol (2000) 1.51

Inhibition of angiogenesis by thrombospondin-2. Biochem Biophys Res Commun (1995) 1.48

Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity. Oncogene (1997) 1.47

Altered extracellular matrix remodeling and angiogenesis in sponge granulomas of thrombospondin 2-null mice. Am J Pathol (2001) 1.45

Paracrine induction of angiogenesis in vitro by Swiss 3T3 fibroblasts. J Cell Sci (1993) 1.44

Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity. Proc Natl Acad Sci U S A (1999) 1.42

Thrombospondin-1 induces endothelial cell apoptosis and inhibits angiogenesis by activating the caspase death pathway. J Vasc Res (2000) 1.42

Macrophages kill capillary cells in G1 phase of the cell cycle during programmed vascular regression. Development (1999) 1.40

Increased marrow-derived osteoprogenitor cells and endosteal bone formation in mice lacking thrombospondin 2. J Bone Miner Res (2000) 1.35

Thrombospondin 2 modulates collagen fibrillogenesis and angiogenesis. J Investig Dermatol Symp Proc (2000) 1.28

The distribution of the matricellular protein thrombospondin 2 in tissues of embryonic and adult mice. J Histochem Cytochem (1998) 1.27

Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting. Am J Pathol (2001) 1.27

Downregulation of endothelial cell thrombospondin 1 enhances in vitro angiogenesis. J Vasc Res (1994) 1.20

Fibrosis and angiogenesis. Curr Opin Nephrol Hypertens (2000) 1.18

Properties of recombinant mouse thrombospondin 2 expressed in Spodoptera cells. J Biol Chem (1994) 1.17

Paracrine interactions between fibroblasts and endothelial cells in a serum-free coculture model. Modulation of angiogenesis and collagen gel contraction. Lab Invest (1994) 1.13

The 140-kilodalton antiangiogenic fragment of thrombospondin-1 binds to basic fibroblast growth factor. Cell Growth Differ (1997) 1.07

Restricted localization of thrombospondin-2 protein during mouse embryogenesis: a comparison to thrombospondin-1. Matrix Biol (1998) 1.01

Physical characterization of the procollagen module of human thrombospondin 1 expressed in insect cells. J Biol Chem (2000) 1.01

Endothelial cell mitogenesis induced by LPA: inhibition by thrombospondin-1 and thrombospondin-2. J Lab Clin Med (1997) 0.93

Lumen formation and other angiogenic activities of cultured capillary endothelial cells are inhibited by thrombospondin-1. Microvasc Res (1997) 0.91

Induction of endothelial cell differentiation in vitro by fibroblast-derived soluble factors. Exp Cell Res (1994) 0.90

Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3. FEBS Lett (1996) 0.87

Release of pro- and anti-angiogenic factors by human cardiac fibroblasts: effects on DNA synthesis and protection under hypoxia in human endothelial cells. Biochim Biophys Acta (2001) 0.86

Articles by these authors

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell (2005) 7.41

Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A (2005) 4.48

GAGE: generally applicable gene set enrichment for pathway analysis. BMC Bioinformatics (2009) 3.86

Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat Med (2005) 3.60

Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma. J Biol Chem (2007) 2.69

Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. Circ Res (2004) 2.31

The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice. Am J Pathol (2002) 2.22

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat Neurosci (2009) 1.95

The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation. Am J Pathol (2004) 1.88

Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation. J Bone Miner Res (2007) 1.77

Thrombospondins 1 and 2 function as inhibitors of angiogenesis. Matrix Biol (2003) 1.76

Gene targeting in stem cells from individuals with osteogenesis imperfecta. Science (2004) 1.75

Matricellular proteins: Extracellular modulators of bone development, remodeling, and regeneration. Bone (2006) 1.72

JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. J Cell Biol (2006) 1.69

SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts. J Biol Chem (2007) 1.68

Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein-6. J Cell Biochem (2006) 1.65

Dynamic reciprocity in the wound microenvironment. Wound Repair Regen (2011) 1.62

Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation. J Cell Biochem (2011) 1.59

Matricellular proteins as modulators of wound healing and the foreign body response. Thromb Haemost (2003) 1.52

Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele. Mol Cell Biol (2006) 1.51

Interactions between CD47 and thrombospondin reduce inflammation. J Immunol (2007) 1.46

Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9. J Leukoc Biol (2009) 1.41

Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis. Invest Ophthalmol Vis Sci (2004) 1.40

Thrombospondins function as regulators of angiogenesis. J Cell Commun Signal (2009) 1.40

Anti-CD40 therapy extends renal allograft survival in rhesus macaques. Transplantation (2002) 1.40

Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis. Matrix Biol (2009) 1.40

In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate. Clin Cancer Res (2005) 1.38

Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization. J Clin Invest (2006) 1.35

Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1). J Cell Physiol (2007) 1.35

Learning transcriptional regulatory networks from high throughput gene expression data using continuous three-way mutual information. BMC Bioinformatics (2008) 1.30

Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate. Nat Neurosci (2011) 1.29

Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis. Am J Pathol (2008) 1.25

Leptin functions peripherally to regulate differentiation of mesenchymal progenitor cells. Stem Cells (2010) 1.24

Glycosylation mediates up-regulation of a potent antiangiogenic and proatherogenic protein, thrombospondin-1, by glucose in vascular smooth muscle cells. J Biol Chem (2006) 1.21

Thrombospondin-4 regulates vascular inflammation and atherogenesis. Circ Res (2010) 1.19

Proteolysis of cell-surface tissue transglutaminase by matrix metalloproteinase-2 contributes to the adhesive defect and matrix abnormalities in thrombospondin-2-null fibroblasts and mice. Am J Pathol (2005) 1.17

Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen. Am J Pathol (2008) 1.17

The secreted protein thrombospondin 2 is an autocrine inhibitor of marrow stromal cell proliferation. J Bone Miner Res (2002) 1.15

Thrombospondin 2 potentiates notch3/jagged1 signaling. J Biol Chem (2009) 1.14

Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2--deficient mice. Blood (2002) 1.14

Mice with a deletion in the first intron of the Col1a1 gene develop age-dependent aortic dissection and rupture. Circ Res (2003) 1.12

Thrombospondin 2 levels are increased in aged mice: consequences for cutaneous wound healing and angiogenesis. Matrix Biol (2004) 1.11

Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras. Cancer Res (2005) 1.10

Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing. J Bone Miner Res (2009) 1.10

pH-sensitive polymers that enhance intracellular drug delivery in vivo. J Control Release (2002) 1.05

Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing. Am J Pathol (2002) 1.05

The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation. J Cell Sci (2010) 1.05

Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials. Am J Pathol (2003) 1.04

Evaluation of tail biopsy collection in laboratory mice (Mus musculus): vertebral ossification, DNA quantity, and acute behavioral responses. J Am Assoc Lab Anim Sci (2008) 1.03

Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head. Mol Cell Biol (2005) 1.03

Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells. Mol Biol Cell (2007) 1.03

Thrombospondin-2 regulates matrix mineralization in MC3T3-E1 pre-osteoblasts. Bone (2009) 1.02

Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J Biol Chem (2009) 1.01

Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Hum Mol Genet (2004) 1.01

Absence of thrombospondin-2 causes age-related dilated cardiomyopathy. Circulation (2009) 1.00

The transcription factor osterix (SP7) regulates BMP6-induced human osteoblast differentiation. J Cell Physiol (2012) 1.00

Functional analysis of the matricellular protein SPARC with novel monoclonal antibodies. J Histochem Cytochem (2004) 0.99

Notch signaling components are upregulated during both endochondral and intramembranous bone regeneration. J Orthop Res (2011) 0.98

Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina. Am J Physiol Heart Circ Physiol (2009) 0.97

Systemic inhibition of canonical Notch signaling results in sustained callus inflammation and alters multiple phases of fracture healing. PLoS One (2013) 0.96

Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1. J Bone Miner Res (2006) 0.96

Megakaryocytes require thrombospondin-2 for normal platelet formation and function. Blood (2003) 0.95

Low-density lipoprotein receptor-related protein contributes to the antiangiogenic activity of thrombospondin-2 in a murine glioma model. Cancer Res (2005) 0.95

A simple method for stem cell labeling with fluorine 18. Nucl Med Biol (2005) 0.94

Enhanced angiogenesis and reduced contraction in thrombospondin-2-null wounds is associated with increased levels of matrix metalloproteinases-2 and -9, and soluble VEGF. J Histochem Cytochem (2008) 0.94

SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges. J Histochem Cytochem (2005) 0.93

Disruption of cell-matrix interactions by heparin enhances mesenchymal progenitor adipocyte differentiation. Exp Cell Res (2008) 0.92

Thrombospondin-2 is an endogenous adipocyte inhibitor. Matrix Biol (2010) 0.91

Thrombospondin 2 deficiency in pregnant mice results in premature softening of the uterine cervix. Biol Reprod (2003) 0.91

Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in experimental glomerulonephritis in mice. J Am Soc Nephrol (2007) 0.91

Growth factors: beyond bone morphogenetic proteins. J Orthop Trauma (2010) 0.90

Fractures in geriatric mice show decreased callus expansion and bone volume. Clin Orthop Relat Res (2014) 0.89

Mice lacking thrombospondin 2 show an atypical pattern of endocortical and periosteal bone formation in response to mechanical loading. Bone (2005) 0.89

Animal models of tendon and ligament injuries for tissue engineering applications. Biomaterials (2004) 0.88

PKCδ is required for Jagged-1 induction of human mesenchymal stem cell osteogenic differentiation. Stem Cells (2013) 0.87

Propidium monoazide combined with real-time quantitative PCR underestimates heat-killed Listeria innocua. J Microbiol Methods (2011) 0.87

Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging. Stem Cells (2013) 0.86

The Muenke syndrome mutation (FgfR3P244R) causes cranial base shortening associated with growth plate dysfunction and premature perichondrial ossification in murine basicranial synchondroses. Dev Dyn (2011) 0.86

Cyp1B1 expression promotes angiogenesis by suppressing NF-κB activity. Am J Physiol Cell Physiol (2013) 0.86

Osteoblast-targeted suppression of PPARγ increases osteogenesis through activation of mTOR signaling. Stem Cells (2013) 0.85

Effects of donor characteristics and ex vivo expansion on canine mesenchymal stem cell properties: implications for MSC-based therapies. Cell Transplant (2012) 0.85

The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function. J Biol Chem (2006) 0.83

Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells. Cell Signal (2009) 0.83

Lack of thrombospondin-2 reduces fibrosis and increases vascularity around cardiac cell grafts. Cardiovasc Pathol (2012) 0.83

Ectopic expression of Col2.3 and Col3.6 promoters in the brain and association with leptin signaling. Cells Tissues Organs (2011) 0.83

Restoration of thrombospondin 1 expression in tumor cells harbouring mutant ras oncogene by treatment with low doses of doxycycline. Biochem Biophys Res Commun (2003) 0.82

Jagged1 immobilization to an osteoconductive polymer activates the Notch signaling pathway and induces osteogenesis. J Biomed Mater Res A (2013) 0.82

Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production. J Cell Biochem (2011) 0.82

Disruption of thrombospondin-2 accelerates ischemic fracture healing. J Orthop Res (2012) 0.81

Time series gene expression profiling and temporal regulatory pathway analysis of BMP6 induced osteoblast differentiation and mineralization. BMC Syst Biol (2011) 0.81

Metaxin deficiency alters mitochondrial membrane permeability and leads to resistance to TNF-induced cell killing. Protein Cell (2010) 0.81

The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer. Breast Cancer Res Treat (2012) 0.81

Evaluation of equine peripheral blood apheresis product, bone marrow, and adipose tissue as sources of mesenchymal stem cells and their differentation potential. Am J Vet Res (2011) 0.81

A ChIP-seq-defined genome-wide map of MEF2C binding reveals inflammatory pathways associated with its role in bone density determination. Calcif Tissue Int (2013) 0.80

The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice. J Orthop Res (2013) 0.80

Type III collagen regulates osteoblastogenesis and the quantity of trabecular bone. Calcif Tissue Int (2014) 0.80

Osseointegrative properties of electrospun hydroxyapatite-containing nanofibrous chitosan scaffolds. Tissue Eng Part A (2014) 0.80