Published in J Biol Chem on February 12, 2009
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Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins. Proc Natl Acad Sci U S A (2016) 0.75
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The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol (2004) 3.09
Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development (2003) 3.08
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R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell (2004) 2.73
Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J Cell Biochem (2004) 2.71
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DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. J Bone Miner Res (2005) 2.46
Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res (2004) 2.46
R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell (2008) 2.37
Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science (1998) 2.28
In vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insights into in vivo functions. J Biol Chem (2004) 2.25
Wnt signaling inhibits adipogenesis through beta-catenin-dependent and -independent mechanisms. J Biol Chem (2005) 1.85
WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo. Cell (2001) 1.79
Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J (2000) 1.77
Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation. J Cell Biochem (2005) 1.69
R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development (2008) 1.66
Bone regeneration is regulated by wnt signaling. J Bone Miner Res (2007) 1.63
Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Mol Cell Biol (2002) 1.50
Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation. J Biol Chem (2006) 1.44
Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia. J Clin Invest (2008) 1.38
Wnt-3A enhances bone morphogenetic protein-2-mediated chondrogenesis of murine C3H10T1/2 mesenchymal cells. J Biol Chem (2002) 1.25
Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb. Dev Biol (2007) 1.23
R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression. FEBS Lett (2008) 1.11
Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment. Biochem Biophys Res Commun (2005) 1.03
Characterization of native and recombinant bone sialoprotein: delineation of the mineral-binding and cell adhesion domains and structural analysis of the RGD domain. J Bone Miner Res (1997) 1.02
Regulation of mesenchymal stem cell and chondrocyte differentiation by MIA. Exp Cell Res (2005) 1.00
R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development. Dev Growth Differ (2007) 0.93
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GAGE: generally applicable gene set enrichment for pathway analysis. BMC Bioinformatics (2009) 3.86
Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma. J Biol Chem (2007) 2.69
Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation. J Bone Miner Res (2007) 1.77
Gene targeting in stem cells from individuals with osteogenesis imperfecta. Science (2004) 1.75
Matricellular proteins: Extracellular modulators of bone development, remodeling, and regeneration. Bone (2006) 1.72
Bone mass is inversely proportional to Dkk1 levels in mice. Bone (2007) 1.71
Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein-6. J Cell Biochem (2006) 1.65
Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation. J Cell Biochem (2011) 1.59
Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele. Mol Cell Biol (2006) 1.51
Learning transcriptional regulatory networks from high throughput gene expression data using continuous three-way mutual information. BMC Bioinformatics (2008) 1.30
Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism. Mol Biol Cell (2002) 1.26
Leptin functions peripherally to regulate differentiation of mesenchymal progenitor cells. Stem Cells (2010) 1.24
Thrombospondin 2 potentiates notch3/jagged1 signaling. J Biol Chem (2009) 1.14
Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing. J Bone Miner Res (2009) 1.10
Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing. Am J Pathol (2002) 1.05
Evaluation of tail biopsy collection in laboratory mice (Mus musculus): vertebral ossification, DNA quantity, and acute behavioral responses. J Am Assoc Lab Anim Sci (2008) 1.03
Thrombospondin-2 regulates matrix mineralization in MC3T3-E1 pre-osteoblasts. Bone (2009) 1.02
Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Hum Mol Genet (2004) 1.01
The transcription factor osterix (SP7) regulates BMP6-induced human osteoblast differentiation. J Cell Physiol (2012) 1.00
Notch signaling components are upregulated during both endochondral and intramembranous bone regeneration. J Orthop Res (2011) 0.98
Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1. J Bone Miner Res (2006) 0.96
Systemic inhibition of canonical Notch signaling results in sustained callus inflammation and alters multiple phases of fracture healing. PLoS One (2013) 0.96
Megakaryocytes require thrombospondin-2 for normal platelet formation and function. Blood (2003) 0.95
A simple method for stem cell labeling with fluorine 18. Nucl Med Biol (2005) 0.94
Disruption of cell-matrix interactions by heparin enhances mesenchymal progenitor adipocyte differentiation. Exp Cell Res (2008) 0.92
Thrombospondin-2 is an endogenous adipocyte inhibitor. Matrix Biol (2010) 0.91
Growth factors: beyond bone morphogenetic proteins. J Orthop Trauma (2010) 0.90
Fractures in geriatric mice show decreased callus expansion and bone volume. Clin Orthop Relat Res (2014) 0.89
Animal models of tendon and ligament injuries for tissue engineering applications. Biomaterials (2004) 0.88
PKCδ is required for Jagged-1 induction of human mesenchymal stem cell osteogenic differentiation. Stem Cells (2013) 0.87
Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging. Stem Cells (2013) 0.86
Identification of variables that optimize isolation and culture of multipotent mesenchymal stem cells from equine umbilical-cord blood. Am J Vet Res (2009) 0.86
Cyp1B1 expression promotes angiogenesis by suppressing NF-κB activity. Am J Physiol Cell Physiol (2013) 0.86
Osteoblast-targeted suppression of PPARγ increases osteogenesis through activation of mTOR signaling. Stem Cells (2013) 0.85
Effects of donor characteristics and ex vivo expansion on canine mesenchymal stem cell properties: implications for MSC-based therapies. Cell Transplant (2012) 0.85
Ectopic expression of Col2.3 and Col3.6 promoters in the brain and association with leptin signaling. Cells Tissues Organs (2011) 0.83
Jagged1 immobilization to an osteoconductive polymer activates the Notch signaling pathway and induces osteogenesis. J Biomed Mater Res A (2013) 0.82
Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production. J Cell Biochem (2011) 0.82
Disruption of thrombospondin-2 accelerates ischemic fracture healing. J Orthop Res (2012) 0.81
Evaluation of equine peripheral blood apheresis product, bone marrow, and adipose tissue as sources of mesenchymal stem cells and their differentation potential. Am J Vet Res (2011) 0.81
Time series gene expression profiling and temporal regulatory pathway analysis of BMP6 induced osteoblast differentiation and mineralization. BMC Syst Biol (2011) 0.81
Type III collagen regulates osteoblastogenesis and the quantity of trabecular bone. Calcif Tissue Int (2014) 0.80
The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice. J Orthop Res (2013) 0.80
A ChIP-seq-defined genome-wide map of MEF2C binding reveals inflammatory pathways associated with its role in bone density determination. Calcif Tissue Int (2013) 0.80
Osseointegrative properties of electrospun hydroxyapatite-containing nanofibrous chitosan scaffolds. Tissue Eng Part A (2014) 0.80
Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis. Dis Model Mech (2014) 0.79
Notch signaling in mesenchymal stem cells harvested from geriatric mice. J Orthop Trauma (2014) 0.79
Use of quantitative polymerase chain reaction analysis to compare quantity and stability of isolated murine DNA. Lab Anim (NY) (2010) 0.78
Novel explant model to study mechanotransduction and cell-cell communication. J Orthop Res (2006) 0.78
Multiple recombinant adeno-associated viral vector serotypes display persistent in vivo gene expression in vector-transduced rat stifle joints. Hum Gene Ther Methods (2013) 0.77
Type III collagen modulates fracture callus bone formation and early remodeling. J Orthop Res (2015) 0.75
Identification of osteoconductive and biodegradable polymers from a combinatorial polymer library. J Biomed Mater Res A (2010) 0.75
What is your diagnosis? Diagnosis: Luxation of the left patella with DJD involving the left stifle joint and subluxation of the left hip joint. J Am Vet Med Assoc (2008) 0.75