PubRank

Fred E Cohen

Author PubWeight™ 70.60‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Synthetic mammalian prions. Science 2004 7.35
2 Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray. Genome Biol 2003 4.24
3 Evidence for assembly of prions with left-handed beta-helices into trimers. Proc Natl Acad Sci U S A 2004 3.64
4 GPCRDB information system for G protein-coupled receptors. Nucleic Acids Res 2003 3.34
5 Automated extraction of mutation data from the literature: application of MuteXt to G protein-coupled receptors and nuclear hormone receptors. Bioinformatics 2004 3.03
6 Pathway complexity of prion protein assembly into amyloid. J Biol Chem 2002 2.96
7 Structural studies of the scrapie prion protein by electron crystallography. Proc Natl Acad Sci U S A 2002 2.91
8 Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes. Proc Natl Acad Sci U S A 2006 2.69
9 Strain-specified characteristics of mouse synthetic prions. Proc Natl Acad Sci U S A 2005 2.25
10 Protease-sensitive synthetic prions. PLoS Pathog 2010 2.14
11 Searching for new antimalarial therapeutics amongst known drugs. Chem Biol Drug Des 2006 2.10
12 Mutant PrPSc conformers induced by a synthetic peptide and several prion strains. J Virol 2004 2.07
13 Natural and synthetic prion structure from X-ray fiber diffraction. Proc Natl Acad Sci U S A 2009 1.97
14 Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A 2005 1.91
15 Co-evolutionary analysis reveals insights into protein-protein interactions. J Mol Biol 2002 1.77
16 Dominant-negative inhibition of prion replication in transgenic mice. Proc Natl Acad Sci U S A 2002 1.65
17 Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem 2002 1.64
18 Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. Nat Biotechnol 2004 1.63
19 Genes contributing to prion pathogenesis. J Gen Virol 2008 1.51
20 Automatic extraction of protein point mutations using a graph bigram association. PLoS Comput Biol 2007 1.48
21 Molecular phylogeny and evolution of the plant-specific seven-transmembrane MLO family. J Mol Evol 2003 1.45
22 Potent inhibition of scrapie prion replication in cultured cells by bis-acridines. Proc Natl Acad Sci U S A 2003 1.32
23 Cell division modulates prion accumulation in cultured cells. Proc Natl Acad Sci U S A 2007 1.25
24 Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation. J Mol Biol 2006 1.06
25 Toward the synthesis of artificial proteins: the discovery of an amphiphilic helical peptoid assembly. Chem Biol 2002 1.05
26 Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics. J Med Chem 2007 1.05
27 Differences between the prion protein and its homolog Doppel: a partially structured state with implications for scrapie formation. J Mol Biol 2002 1.04
28 Electron crystallography of the scrapie prion protein complexed with heavy metals. Arch Biochem Biophys 2007 1.03
29 JEvTrace: refinement and variations of the evolutionary trace in JAVA. Genome Biol 2002 0.99
30 Analysis of the sequence and structural features of the left-handed beta-helical fold. Proteins 2008 0.93
31 Prions: so many fibers, so little infectivity. Trends Biochem Sci 2004 0.89
32 Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells. Bioorg Med Chem Lett 2006 0.88
33 CoMFA and HQSAR of acylhydrazide cruzain inhibitors. Bioorg Med Chem Lett 2002 0.87
34 Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother 2007 0.86
35 Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies. J Med Chem 2002 0.85
36 Molecular modeling of the misfolded insulin subunit and amyloid fibril. Biophys J 2009 0.83
37 Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds. J Gen Virol 2007 0.81
38 New local potential useful for genome annotation and 3D modeling. J Mol Biol 2003 0.80
39 Site-directed mutagenesis demonstrates the plasticity of the beta helix: implications for the structure of the misfolded prion protein. Structure 2009 0.79
40 Developing therapeutics for the diseases of protein misfolding. Neurology 2006 0.77
41 Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int J Antimicrob Agents 2002 0.75