Published in Proc Natl Acad Sci U S A on March 12, 2002
A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR. Proc Natl Acad Sci U S A (2002) 9.55
Formation of native prions from minimal components in vitro. Proc Natl Acad Sci U S A (2007) 5.94
Structural insights into a yeast prion illuminate nucleation and strain diversity. Nature (2005) 3.86
Evidence for assembly of prions with left-handed beta-helices into trimers. Proc Natl Acad Sci U S A (2004) 3.64
High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy. Proc Natl Acad Sci U S A (2004) 3.58
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Natural and synthetic prion structure from X-ray fiber diffraction. Proc Natl Acad Sci U S A (2009) 1.97
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Trafficking of prion proteins through a caveolae-mediated endosomal pathway. J Cell Biol (2003) 1.51
NMR structure of the bovine prion protein isolated from healthy calf brains. EMBO Rep (2004) 1.43
Transmission barriers for bovine, ovine, and human prions in transgenic mice. J Virol (2005) 1.43
Inactivation of prions by acidic sodium dodecyl sulfate. J Virol (2006) 1.43
Engineering nanoscale order into a designed protein fiber. Proc Natl Acad Sci U S A (2007) 1.31
Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants. Proc Natl Acad Sci U S A (2004) 1.31
Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion. J Biol Chem (2011) 1.29
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. Biochemistry (2011) 1.27
Sheep-passaged bovine spongiform encephalopathy agent exhibits altered pathobiological properties in bovine-PrP transgenic mice. J Virol (2006) 1.25
NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106-126. Proc Natl Acad Sci U S A (2003) 1.22
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BETASCAN: probable beta-amyloids identified by pairwise probabilistic analysis. PLoS Comput Biol (2009) 1.14
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Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases. Expert Rev Mol Med (2010) 1.04
Prions and the potential transmissibility of protein misfolding diseases. Annu Rev Microbiol (2013) 1.04
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Strain-associated variations in abnormal PrP trafficking of sheep scrapie. Brain Pathol (2008) 1.02
Theoretical model of prion propagation: a misfolded protein induces misfolding. Proc Natl Acad Sci U S A (2005) 1.02
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Prion fibrillization is mediated by a native structural element that comprises helices H2 and H3. J Biol Chem (2010) 1.00
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Observation of intermediate states of the human prion protein by high pressure NMR spectroscopy. BMC Struct Biol (2006) 0.95
Creutzfeldt-Jakob disease (CJD) with a mutation at codon 148 of prion protein gene: relationship with sporadic CJD. Am J Pathol (2005) 0.93
The charge structure of helix 1 in the prion protein regulates conversion to pathogenic PrPSc. J Virol (2006) 0.93
Theoretical modeling of prion disease incubation. Biophys J (2003) 0.91
Comparative computational analysis of prion proteins reveals two fragments with unusual structural properties and a pattern of increase in hydrophobicity associated with disease-promoting mutations. Protein Sci (2004) 0.90
Mapping of possible prion protein self-interaction domains using peptide arrays. BMC Biochem (2007) 0.89
Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulations. Biophys J (2006) 0.88
Generation of prions in vitro and the protein-only hypothesis. Prion (2010) 0.88
Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs. J Cell Biol (2014) 0.88
Comparative analysis of essential collective dynamics and NMR-derived flexibility profiles in evolutionarily diverse prion proteins. Prion (2011) 0.87
Structural organization of mammalian prions as probed by limited proteolysis. PLoS One (2012) 0.87
Probing the conformation of a prion protein fibril with hydrogen exchange. J Biol Chem (2010) 0.85
Beta-sheet containment by flanking prolines: molecular dynamic simulations of the inhibition of beta-sheet elongation by proline residues in human prion protein. Biophys J (2006) 0.85
STITCHER: Dynamic assembly of likely amyloid and prion β-structures from secondary structure predictions. Proteins (2011) 0.85
Reversible monomer-oligomer transition in human prion protein. Prion (2008) 0.85
PrP assemblies: spotting the responsible regions in prion propagation. Prion (2011) 0.84
A structural overview of the vertebrate prion proteins. Prion (2007) 0.84
Probing structural differences in prion protein isoforms by tyrosine nitration. Biochemistry (2007) 0.83
Structure-Based Drug Discovery for Prion Disease Using a Novel Binding Simulation. EBioMedicine (2016) 0.83
Misfolding pathways of the prion protein probed by molecular dynamics simulations. Biophys J (2004) 0.83
Rapid formation of amyloid from alpha-monomeric recombinant human PrP in vitro. Protein Sci (2005) 0.83
Structural and dynamic properties of the human prion protein. Biophys J (2014) 0.82
Sialylation of the prion protein glycans controls prion replication rate and glycoform ratio. Sci Rep (2015) 0.82
SAXS structural study of PrP(Sc) reveals ~11 nm diameter of basic double intertwined fibers. Prion (2013) 0.82
Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein. Proc Natl Acad Sci U S A (2009) 0.82
Solid-state NMR as a probe of amyloid structure. Protein Pept Lett (2006) 0.81
Conformational polymorphism of the amyloidogenic peptide homologous to residues 113-127 of the prion protein. Biophys J (2003) 0.81
Solution structure and dynamics of the I214V mutant of the rabbit prion protein. PLoS One (2010) 0.81
Structural studies of truncated forms of the prion protein PrP. Biophys J (2015) 0.81
Computational approaches to shed light on molecular mechanisms in biological processes. Theor Chem Acc (2007) 0.80
Disulfide mapping reveals the domain swapping as the crucial process of the structural conversion of prion protein. Prion (2011) 0.80
Mouse prion protein (PrP) segment 100 to 104 regulates conversion of PrP(C) to PrP(Sc) in prion-infected neuroblastoma cells. J Virol (2012) 0.80
The diversity and relationship of prion protein self-replicating states. Virus Res (2014) 0.80
Similar folds with different stabilization mechanisms: the cases of Prion and Doppel proteins. BMC Struct Biol (2006) 0.79
Acid-induced molten globule state of a prion protein: crucial role of Strand 1-Helix 1-Strand 2 segment. J Biol Chem (2014) 0.79
Multifaceted Role of Sialylation in Prion Diseases. Front Neurosci (2016) 0.79
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases. Mol Neurodegener (2010) 0.79
Decrypting Prion Protein Conversion into a β-Rich Conformer by Molecular Dynamics. J Chem Theory Comput (2013) 0.78
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The structure of human prions: from biology to structural models-considerations and pitfalls. Viruses (2014) 0.78
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An emerging concept of prion infections as a form of transmissible cerebral amyloidosis. Prion (2009) 0.77
Nucleic acid induced unfolding of recombinant prion protein globular fragment is pH dependent. Protein Sci (2014) 0.77
Techniques to elucidate the conformation of prions. World J Biol Chem (2015) 0.76
Effect of hydrophobic mutations in the H2-H3 subdomain of prion protein on stability and conversion in vitro and in vivo. PLoS One (2011) 0.76
Prion protein self-peptides modulate prion interactions and conversion. BMC Biochem (2009) 0.76
Detection and partial discrimination of atypical and classical bovine spongiform encephalopathies in cattle and primates using real-time quaking-induced conversion assay. PLoS One (2017) 0.75
Solvent microenvironments and copper binding alters the conformation and toxicity of a prion fragment. PLoS One (2013) 0.75
N(ε)-Carboxymethyl Modification of Lysine Residues in Pathogenic Prion Isoforms. Mol Neurobiol (2015) 0.75
Searching for factors that distinguish disease-prone and disease-resistant prions via sequence analysis. Bioinform Biol Insights (2008) 0.75
Mass spectroscopic analysis of Sup35NM prion polymerization. Biophys J (2005) 0.75
Melanosomal formation of PMEL core amyloid is driven by aromatic residues. Sci Rep (2017) 0.75
Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency. PLoS Pathog (2017) 0.75
The intrinsic helical propensities of the helical fragments in prion protein under neutral and low pH conditions: a replica exchange molecular dynamics study. J Mol Model (2013) 0.75
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