Published in J Med Chem on January 11, 2007
Discovery of 2-aminothiazoles as potent antiprion compounds. J Virol (2009) 1.51
Hot spots in prion protein for pathogenic conversion. Proc Natl Acad Sci U S A (2007) 1.31
2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem (2011) 1.19
Attention-deficit-hyperactivity disorder and reward deficiency syndrome. Neuropsychiatr Dis Treat (2008) 1.14
Estimating prion adsorption capacity of soil by BioAssay of Subtracted Infectivity from Complex Solutions (BASICS). PLoS One (2013) 0.83
2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease. ChemMedChem (2013) 0.81
Discovery and Preliminary SAR of Arylpiperazines as Novel, Brainpenetrant Antiprion Compounds. ACS Med Chem Lett (2013) 0.78
Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds. ACS Med Chem Lett (2013) 0.78
2-Aminopyridines via reaction of pyridine N-oxides and activated isocyanides. J Org Chem (2014) 0.75
Multi-component synthesis of 2-amino-6-(alkyllthio)pyridine-3,5-dicarbonitriles using Zn(II) and Cd(II) metal-organic frameworks (MOFs) under solvent-free conditions. Tetrahedron Lett (2012) 0.75
Synthetic mammalian prions. Science (2004) 7.35
Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray. Genome Biol (2003) 4.24
Evidence for assembly of prions with left-handed beta-helices into trimers. Proc Natl Acad Sci U S A (2004) 3.64
A change in the conformation of prions accompanies the emergence of a new prion strain. Neuron (2002) 3.36
GPCRDB information system for G protein-coupled receptors. Nucleic Acids Res (2003) 3.34
Prions. Cold Spring Harb Perspect Biol (2011) 3.17
Automated extraction of mutation data from the literature: application of MuteXt to G protein-coupled receptors and nuclear hormone receptors. Bioinformatics (2004) 3.03
Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol (2008) 2.98
Pathway complexity of prion protein assembly into amyloid. J Biol Chem (2002) 2.96
Structural studies of the scrapie prion protein by electron crystallography. Proc Natl Acad Sci U S A (2002) 2.91
Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes. Proc Natl Acad Sci U S A (2006) 2.69
Design and construction of diverse mammalian prion strains. Proc Natl Acad Sci U S A (2009) 2.41
Analysis of proteome dynamics in the mouse brain. Proc Natl Acad Sci U S A (2010) 2.37
Purified and synthetic Alzheimer's amyloid beta (Aβ) prions. Proc Natl Acad Sci U S A (2012) 2.36
Prion detection by an amyloid seeding assay. Proc Natl Acad Sci U S A (2007) 2.34
Strain-specified characteristics of mouse synthetic prions. Proc Natl Acad Sci U S A (2005) 2.25
Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice. Nat Biotechnol (2002) 2.24
Transmission and detection of prions in feces. J Infect Dis (2008) 2.20
Transmission of multiple system atrophy prions to transgenic mice. Proc Natl Acad Sci U S A (2013) 2.19
Protease-sensitive synthetic prions. PLoS Pathog (2010) 2.14
Diagnosis of human prion disease. Proc Natl Acad Sci U S A (2005) 2.13
Asymptomatic deer excrete infectious prions in faeces. Nature (2009) 2.10
Searching for new antimalarial therapeutics amongst known drugs. Chem Biol Drug Des (2006) 2.10
Mutant PrPSc conformers induced by a synthetic peptide and several prion strains. J Virol (2004) 2.07
Transmission of elk and deer prions to transgenic mice. J Virol (2006) 2.03
Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene. Proc Natl Acad Sci U S A (2003) 2.01
Natural and synthetic prion structure from X-ray fiber diffraction. Proc Natl Acad Sci U S A (2009) 1.97
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A (2005) 1.91
Prion clearance in bigenic mice. J Gen Virol (2005) 1.79
Co-evolutionary analysis reveals insights into protein-protein interactions. J Mol Biol (2002) 1.77
Small-molecule activators of a proenzyme. Science (2009) 1.72
Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels. Nat Neurosci (2008) 1.66
Conformational transformation and selection of synthetic prion strains. J Mol Biol (2011) 1.66
Copper coordination in the full-length, recombinant prion protein. Biochemistry (2003) 1.66
Dominant-negative inhibition of prion replication in transgenic mice. Proc Natl Acad Sci U S A (2002) 1.65
Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem (2002) 1.64
Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. Nat Biotechnol (2004) 1.63
Measuring prions by bioluminescence imaging. Proc Natl Acad Sci U S A (2009) 1.59
Continuous quinacrine treatment results in the formation of drug-resistant prions. PLoS Pathog (2009) 1.58
Is Parkinson's disease a prion disorder? Proc Natl Acad Sci U S A (2009) 1.56
Polio and Nobel prizes: looking back 50 years. Ann Neurol (2007) 1.54
The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation. Immunol Rev (2003) 1.52
Genes contributing to prion pathogenesis. J Gen Virol (2008) 1.51
Trafficking of prion proteins through a caveolae-mediated endosomal pathway. J Cell Biol (2003) 1.51
Discovery of 2-aminothiazoles as potent antiprion compounds. J Virol (2009) 1.51
Prion proteins in subpopulations of white blood cells from patients with sporadic Creutzfeldt-Jakob disease. Lab Invest (2009) 1.48
Prions in skeletal muscle. Proc Natl Acad Sci U S A (2002) 1.48
Automatic extraction of protein point mutations using a graph bigram association. PLoS Comput Biol (2007) 1.48
Molecular phylogeny and evolution of the plant-specific seven-transmembrane MLO family. J Mol Evol (2003) 1.45
Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro. J Neurochem (2005) 1.45
Search for a prion-specific nucleic acid. J Virol (2005) 1.44
Mechanisms of prion protein assembly into amyloid. Proc Natl Acad Sci U S A (2008) 1.43
Transmission barriers for bovine, ovine, and human prions in transgenic mice. J Virol (2005) 1.43
Inactivation of prions by acidic sodium dodecyl sulfate. J Virol (2006) 1.43
Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A (2011) 1.39
Cytosolic prion protein in neurons. J Neurosci (2003) 1.34
Potent inhibition of scrapie prion replication in cultured cells by bis-acridines. Proc Natl Acad Sci U S A (2003) 1.32
A data processing pipeline for mammalian proteome dynamics studies using stable isotope metabolic labeling. Mol Cell Proteomics (2011) 1.31
Cell division modulates prion accumulation in cultured cells. Proc Natl Acad Sci U S A (2007) 1.25
Locally disordered conformer of the hamster prion protein: a crucial intermediate to PrPSc? Biochemistry (2002) 1.24
Prion uptake in the gut: identification of the first uptake and replication sites. PLoS Pathog (2011) 1.21
2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem (2011) 1.19
Notch-1 activation and dendritic atrophy in prion disease. Proc Natl Acad Sci U S A (2005) 1.17
De novo generation of prion strains. Nat Rev Microbiol (2011) 1.17
Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein. J Gen Virol (2009) 1.15
The neurodegeneration sequence in prion diseases: evidence from functional, morphological and ultrastructural studies of the GABAergic system. J Neuropathol Exp Neurol (2004) 1.14
Resistance of bovine spongiform encephalopathy (BSE) prions to inactivation. PLoS Pathog (2008) 1.14
Assembly of natural and recombinant prion protein into fibrils. Biol Chem (2005) 1.13
Cryo-immunogold electron microscopy for prions: toward identification of a conversion site. J Neurosci (2008) 1.12
Drug resistance confounding prion therapeutics. Proc Natl Acad Sci U S A (2013) 1.10
Spontaneous generation of anchorless prions in transgenic mice. Proc Natl Acad Sci U S A (2011) 1.08
Thioaptamer interactions with prion proteins: sequence-specific and non-specific binding sites. J Mol Biol (2007) 1.07