Published in Free Radic Biol Med on July 01, 2002
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta (2009) 2.05
Retracted Alpha-lipoic acid supplementation and diabetes. Nutr Rev (2008) 1.86
(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch Biochem Biophys (2004) 1.14
Transfer of ascorbic acid across the vascular endothelium: mechanism and self-regulation. Am J Physiol Cell Physiol (2009) 1.12
Mechanisms of ascorbic acid stimulation of norepinephrine synthesis in neuronal cells. Biochem Biophys Res Commun (2012) 1.06
Diabetes and alpha lipoic Acid. Front Pharmacol (2011) 1.01
Provision of antioxidant therapy in hemodialysis (PATH): a randomized clinical trial. J Am Soc Nephrol (2013) 0.93
Lipoic acid significantly restores, in rats, the age-related decline in vasomotion. Br J Pharmacol (2008) 0.92
Ascorbic acid prevents increased endothelial permeability caused by oxidized low density lipoprotein. Free Radic Res (2010) 0.92
Ca2+-mediated ascorbate release from coronary artery endothelial cells. Br J Pharmacol (2006) 0.92
Ascorbic acid efflux and re-uptake in endothelial cells: maintenance of intracellular ascorbate. Mol Cell Biochem (2009) 0.91
The effects of thrombin and cytokines upon the biomechanics and remodeling of isolated amnion membrane, in vitro. Placenta (2011) 0.89
Nitric oxide mediates tightening of the endothelial barrier by ascorbic acid. Biochem Biophys Res Commun (2010) 0.89
Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine. Brain Res Bull (2012) 0.89
Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy. J Hematol Oncol (2008) 0.89
Ascorbic acid uptake and regulation of type I collagen synthesis in cultured vascular smooth muscle cells. J Vasc Res (2008) 0.88
Physiological and histopathological investigations on the effects of alpha-lipoic acid in rats exposed to malathion. J Biomed Biotechnol (2010) 0.87
Cobalt-induced oxidant stress in cultured endothelial cells: prevention by ascorbate in relation to HIF-1alpha. Biofactors (2009) 0.86
R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles. Am J Physiol Regul Integr Comp Physiol (2011) 0.84
Oxidized lipoprotein induces the macrophage ascorbate transporter (SVCT2): protection by intracellular ascorbate against oxidant stress and apoptosis. Arch Biochem Biophys (2009) 0.83
Ascorbic acid prevents high glucose-induced apoptosis in human brain pericytes. Biochem Biophys Res Commun (2014) 0.83
Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation. Nutrients (2015) 0.82
Oxidized LDL up-regulates the ascorbic acid transporter SVCT2 in endothelial cells. Mol Cell Biochem (2010) 0.81
Uptake and reduction of alpha-lipoic acid by human erythrocytes. Clin Biochem (2007) 0.81
Alpha-lipoic acid improves subclinical left ventricular dysfunction in asymptomatic patients with type 1 diabetes. Rev Diabet Stud (2013) 0.80
Intracellular Ascorbate Prevents Endothelial Barrier Permeabilization by Thrombin. J Biol Chem (2015) 0.80
Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms. J Nutr Biochem (2010) 0.80
Effect of EPA and vitamin C on superoxide dismutase, glutathione peroxidase, total antioxidant capacity and malondialdehyde in type 2 diabetic patients. Oman Med J (2014) 0.80
Ascorbic acid transport in brain microvascular pericytes. Biochem Biophys Res Commun (2015) 0.79
Ascorbic acid prevents oxidant-induced increases in endothelial permeability. Biofactors (2010) 0.78
Chelation of intracellular iron enhances endothelial barrier function: a role for vitamin C? Arch Biochem Biophys (2010) 0.78
Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes. Mediators Inflamm (2014) 0.78
Lipoic acid attenuates innate immune infiltration and activation in the visceral adipose tissue of obese insulin resistant mice. Lipids (2011) 0.78
Ascorbate reverses high glucose- and RAGE-induced leak of the endothelial permeability barrier. Biochem Biophys Res Commun (2014) 0.78
Ascorbic acid prevents VEGF-induced increases in endothelial barrier permeability. Mol Cell Biochem (2015) 0.76
Ascorbic acid efflux from human brain microvascular pericytes: Role of re-uptake. Biofactors (2015) 0.75
The relationship between alanerv(®) consumption and erythrocytes' redox status in post-acute stroke patients undergoing rehabilitation. Maedica (Buchar) (2014) 0.75
Dietary Supplementation of Vitamin E and α-Lipoic Acid Upregulates Cell Growth and Signaling Genes in Rat Myocardium. Int J Biomed Sci (2006) 0.75
α-Lipoic Acid Inhibits Expression of IL-8 by Suppressing Activation of MAPK, Jak/Stat, and NF-κB in H. pylori-Infected Gastric Epithelial AGS Cells. Yonsei Med J (2016) 0.75
Assessing the reductive capacity of cells by measuring the recycling of ascorbic and lipoic acids. Methods Mol Biol (2010) 0.75
Alpha-lipoic acid activates eNOS through activation of PI3-kinase/Akt signaling pathway. Vascul Pharmacol (2014) 0.75
Intracellular ascorbate tightens the endothelial permeability barrier through Epac1 and the tubulin cytoskeleton. Am J Physiol Cell Physiol (2016) 0.75
Compartmentalization of transport and phosphorylation of glucose in a hepatoma cell line. Biochem J (2005) 0.75
Efficacy of α-lipoic acid against cadmium toxicity on metal ion and oxidative imbalance, and expression of metallothionein and antioxidant genes in rabbit brain. Environ Sci Pollut Res Int (2017) 0.75
APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Res (2008) 4.23
Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation. Immunity (2011) 3.75
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
A high-resolution map of segmental DNA copy number variation in the mouse genome. PLoS Genet (2006) 3.24
China: the aging giant. J Am Geriatr Soc (2007) 2.89
Towards precise classification of cancers based on robust gene functional expression profiles. BMC Bioinformatics (2005) 2.01
Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol (2002) 1.97
MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features. Nucleic Acids Res (2010) 1.94
Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med (2009) 1.94
Transmission of MDR and XDR tuberculosis in Shanghai, China. PLoS One (2009) 1.93
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet (2011) 1.92
Brain cannabinoid CB₂ receptors modulate cocaine's actions in mice. Nat Neurosci (2011) 1.88
Major taste loss in carnivorous mammals. Proc Natl Acad Sci U S A (2012) 1.81
The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J Clin Invest (2013) 1.76
trans-Diaqua-bis[5-carb-oxy-4-carboxyl-ato-2-(4-pyridinio)-1H-imidazol-1-ido-κN,O]iron(II). Acta Crystallogr Sect E Struct Rep Online (2009) 1.72
Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease. J Magn Reson Imaging (2009) 1.64
High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic Acids Res (2013) 1.61
The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein. PLoS Biol (2012) 1.60
Effect of transcutaneous auricular vagus nerve stimulation on impaired glucose tolerance: a pilot randomized study. BMC Complement Altern Med (2014) 1.54
Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience. Cell Transplant (2013) 1.53
Apparently low reproducibility of true differential expression discoveries in microarray studies. Bioinformatics (2008) 1.48
Cross-priming amplification for rapid detection of Mycobacterium tuberculosis in sputum specimens. J Clin Microbiol (2008) 1.47
Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. J Neurosci (2006) 1.46
Prioritizing risk pathways: a novel association approach to searching for disease pathways fusing SNPs and pathways. Bioinformatics (2008) 1.46
SubpathwayMiner: a software package for flexible identification of pathways. Nucleic Acids Res (2009) 1.45
Allelic variation of the Tas1r3 taste receptor gene selectively affects behavioral and neural taste responses to sweeteners in the F2 hybrids between C57BL/6ByJ and 129P3/J mice. J Neurosci (2004) 1.43
Sem1, the yeast ortholog of a human BRCA2-binding protein, is a component of the proteasome regulatory particle that enhances proteasome stability. J Cell Sci (2004) 1.42
QDMR: a quantitative method for identification of differentially methylated regions by entropy. Nucleic Acids Res (2011) 1.37
Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid. J Neurochem (2008) 1.35
Plasticity in eucaryotic 20S proteasome ring assembly revealed by a subunit deletion in yeast. EMBO J (2004) 1.34
Disruption of the cellulose synthase gene, AtCesA8/IRX1, enhances drought and osmotic stress tolerance in Arabidopsis. Plant J (2005) 1.34
Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. Cell Res (2010) 1.33
The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions. Br J Pharmacol (2003) 1.33
The relationship between body mass index and hip osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine (2010) 1.33
Female oxytocin-deficient mice display enhanced anxiety-related behavior. Endocrinology (2003) 1.32
MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer. J Pathol (2014) 1.31
Identification and expression analysis of miRNAs from nitrogen-fixing soybean nodules. Biochem Biophys Res Commun (2008) 1.30
A robust hybrid between genetic algorithm and support vector machine for extracting an optimal feature gene subset. Genomics (2005) 1.30
Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor. J Biol Chem (2004) 1.30
Heavy metal sources identification and sampling uncertainty analysis in a field-scale vegetable soil of Hangzhou, China. Environ Pollut (2008) 1.29
The Salt Overly Sensitive (SOS) pathway: established and emerging roles. Mol Plant (2013) 1.28
Allelic variation of the Tas1r3 taste receptor gene selectively affects taste responses to sweeteners: evidence from 129.B6-Tas1r3 congenic mice. Physiol Genomics (2007) 1.28
HHMD: the human histone modification database. Nucleic Acids Res (2009) 1.27
NDRG2 expression and mutation in human liver and pancreatic cancers. World J Gastroenterol (2004) 1.27
A comparative study of salt tolerance parameters in 11 wild relatives of Arabidopsis thaliana. J Exp Bot (2010) 1.24
An endoplasmic reticulum response pathway mediates programmed cell death of root tip induced by water stress in Arabidopsis. New Phytol (2010) 1.23
KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3. J Biol Chem (2008) 1.23
N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis. Nucleic Acids Res (2008) 1.22
Association between NSAIDs use and breast cancer risk: a systematic review and meta-analysis. Breast Cancer Res Treat (2008) 1.22
Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study. Arthritis Res Ther (2014) 1.22
Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropsychopharmacology (2007) 1.21
Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Immunol (2009) 1.20
The analysis of the drug-targets based on the topological properties in the human protein-protein interaction network. J Drug Target (2009) 1.20
Salt modulates gravity signaling pathway to regulate growth direction of primary roots in Arabidopsis. Plant Physiol (2007) 1.17
Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother (2007) 1.17
A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis. Arthritis Res Ther (2012) 1.17
YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice. Addict Biol (2011) 1.16
Gene therapy following subretinal AAV5 vector delivery is not affected by a previous intravitreal AAV5 vector administration in the partner eye. Mol Vis (2009) 1.16
Overexpression of SOS (Salt Overly Sensitive) genes increases salt tolerance in transgenic Arabidopsis. Mol Plant (2008) 1.16
Is K-ras gene mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis. Dis Colon Rectum (2012) 1.15
IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma. Neuro Oncol (2013) 1.15
Unravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering. BMC Genomics (2007) 1.15
Science and Government. Reforming China's S&T system. Science (2013) 1.14
H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin. Genes Dev (2013) 1.14
Arabidopsis EIN2 modulates stress response through abscisic acid response pathway. Plant Mol Biol (2007) 1.14
Accuracy of image registration between MRI and light microscopy in the ex vivo brain. Magn Reson Imaging (2011) 1.14
Prioritizing candidate disease miRNAs by topological features in the miRNA target-dysregulated network: case study of prostate cancer. Mol Cancer Ther (2011) 1.14
Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus. PLoS One (2012) 1.13
Transfer of ascorbic acid across the vascular endothelium: mechanism and self-regulation. Am J Physiol Cell Physiol (2009) 1.12
Quantitative effects of common genetic variations in the 3'UTR of the human LDL-receptor gene and their associations with plasma lipid levels in the Atherosclerosis Risk in Communities study. Hum Genet (2007) 1.12
Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. J Neurochem (2009) 1.11
Inflammation in the vascular bed: importance of vitamin C. Pharmacol Ther (2008) 1.11
Maturational loss of the vitamin C transporter in erythrocytes. Biochem Biophys Res Commun (2007) 1.11
Transport and intracellular accumulation of vitamin C in endothelial cells: relevance to collagen synthesis. Arch Biochem Biophys (2005) 1.11
Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains. Mamm Genome (2003) 1.11
Comprehensive analysis of the functional microRNA-mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression. Nucleic Acids Res (2013) 1.11
Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures. Mol Cell Biol (2004) 1.10
A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genet (2010) 1.09
Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs. Am J Clin Nutr (2003) 1.09
Isolation and characterization of Methanoculleus receptaculi sp. nov. from Shengli oil field, China. FEMS Microbiol Lett (2008) 1.09
Prevalence of fluoroquinolone resistance among tuberculosis patients in Shanghai, China. Antimicrob Agents Chemother (2009) 1.09
SM2miR: a database of the experimentally validated small molecules' effects on microRNA expression. Bioinformatics (2012) 1.08
Selection of mutations to detect multidrug-resistant Mycobacterium tuberculosis strains in Shanghai, China. Antimicrob Agents Chemother (2009) 1.08
Coordinate regulation of L-arginine uptake and nitric oxide synthase activity in cultured endothelial cells. Free Radic Biol Med (2002) 1.08
Finding a role for leptin in the regulation of the Th17 response in experimental arthritis: comment on the article by Deng et al. Arthritis Rheum (2013) 1.08
Clinical manifestations of dermatomyositis and clinically amyopathic dermatomyositis patients with positive expression of anti-melanoma differentiation-associated gene 5 antibody. Arthritis Care Res (Hoboken) (2012) 1.08
Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements. BMC Syst Biol (2008) 1.08
PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis. Cell Res (2010) 1.08
The role of magnetic resonance imaging biomarkers in clinical trials of treatment response in cancer. Semin Oncol (2011) 1.07
Molecular mechanism of species-dependent sweet taste toward artificial sweeteners. J Neurosci (2011) 1.07
Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity. J Neurosci Res (2007) 1.07
Cross-regulation between the renin-angiotensin system and inflammatory mediators in cardiac hypertrophy and failure. Cardiovasc Res (2004) 1.07
Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross. Genome Res (2002) 1.07
Self-complementary AAV5 vector facilitates quicker transgene expression in photoreceptor and retinal pigment epithelial cells of normal mouse. Exp Eye Res (2010) 1.07
Effects of replacing the unreliable cDNA microarray measurements on the disease classification based on gene expression profiles and functional modules. Bioinformatics (2006) 1.07
Bisphenol A diglycidyl ether induces adipogenic differentiation of multipotent stromal stem cells through a peroxisome proliferator-activated receptor gamma-independent mechanism. Environ Health Perspect (2012) 1.07
Reduction and uptake of methylene blue by human erythrocytes. Am J Physiol Cell Physiol (2004) 1.07
Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE. J Biomed Biotechnol (2012) 1.06