Published in Nucleic Acids Res on April 28, 2013
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system. Nat Biotechnol (2013) 4.58
Comparing zinc finger nucleases and transcription activator-like effector nucleases for gene targeting in Drosophila. G3 (Bethesda) (2013) 1.14
Highly efficient targeted mutagenesis in mice using TALENs. Genetics (2013) 1.12
Production of Sry knockout mouse using TALEN via oocyte injection. Sci Rep (2013) 1.11
Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems. Sci Rep (2014) 1.10
CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos. Nat Protoc (2014) 1.08
Targeted gene deletion of miRNAs in mice by TALEN system. PLoS One (2013) 1.06
Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA. Nat Protoc (2013) 0.99
The position of DNA cleavage by TALENs and cell synchronization influences the frequency of gene editing directed by single-stranded oligonucleotides. PLoS One (2014) 0.96
New and TALENted genome engineering toolbox. Circ Res (2013) 0.96
Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a. Genesis (2013) 0.96
Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos. Sci Rep (2015) 0.93
TALEN and CRISPR/Cas Genome Editing Systems: Tools of Discovery. Acta Naturae (2014) 0.89
BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes. Nat Struct Mol Biol (2016) 0.89
Genetic and genomic tools for the marine annelid Platynereis dumerilii. Genetics (2014) 0.88
Screening methods to identify TALEN-mediated knockout mice. Exp Anim (2014) 0.86
Damaging the Integrated HIV Proviral DNA with TALENs. PLoS One (2015) 0.83
TALENs mediate efficient and heritable mutation of endogenous genes in the marine annelid Platynereis dumerilii. Genetics (2014) 0.83
Rapid assembly of customized TALENs into multiple delivery systems. PLoS One (2013) 0.83
Genome-editing tools for stem cell biology. Cell Death Dis (2015) 0.81
Highly specific contractions of a single CAG/CTG trinucleotide repeat by TALEN in yeast. PLoS One (2014) 0.81
Application of oocyte cryopreservation technology in TALEN-mediated mouse genome editing. Exp Anim (2014) 0.81
Efficient Production of Gene-Modified Mice using Staphylococcus aureus Cas9. Sci Rep (2016) 0.80
Mutagenesis at specific genomic loci of amphioxus Branchiostoma belcheri using TALEN method. J Genet Genomics (2014) 0.80
TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis. Stem Cells Dev (2015) 0.80
Loss of KLF14 triggers centrosome amplification and tumorigenesis. Nat Commun (2015) 0.79
Utilization of TALEN and CRISPR/Cas9 technologies for gene targeting and modification. Exp Biol Med (Maywood) (2015) 0.78
Simultaneous gene editing by injection of mRNAs encoding transcription activator-like effector nucleases into mouse zygotes. Mol Cell Biol (2014) 0.78
Generation of myostatin B knockout yellow catfish (Tachysurus fulvidraco) using transcription activator-like effector nucleases. Zebrafish (2014) 0.78
TALEN-mediated genome engineering to generate targeted mice. Chromosome Res (2015) 0.77
Genetically engineered humanized mouse models for preclinical antibody studies. BioDrugs (2014) 0.77
Genome annotation by shotgun inactivation of a native gene in hemizygous cells: application to BRCA2 with implication of hypomorphic variants. Hum Mutat (2015) 0.76
Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions. Oncotarget (2016) 0.76
TALEN-mediated homologous recombination in Daphnia magna. Sci Rep (2015) 0.76
Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis. Elife (2017) 0.75
Long Evans rat spermatogonial lines are effective germline vectors for transgenic rat production. Transgenic Res (2017) 0.75
Establishment in culture of pluripotential cells from mouse embryos. Nature (1981) 30.49
A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
Breaking the code of DNA binding specificity of TAL-type III effectors. Science (2009) 22.33
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell (1987) 20.47
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature (1988) 20.36
A simple cipher governs DNA recognition by TAL effectors. Science (2009) 19.99
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 18.96
Genome editing with engineered zinc finger nucleases. Nat Rev Genet (2010) 18.88
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting. Nucleic Acids Res (2011) 16.53
Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nat Biotechnol (2008) 14.20
FLASH assembly of TALENs for high-throughput genome editing. Nat Biotechnol (2012) 12.97
Knockout rats via embryo microinjection of zinc-finger nucleases. Science (2009) 12.33
Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc Natl Acad Sci U S A (1996) 12.25
Targeted genome editing across species using ZFNs and TALENs. Science (2011) 9.84
Knockout rats generated by embryo microinjection of TALENs. Nat Biotechnol (2011) 8.45
Heritable gene targeting in zebrafish using customized TALENs. Nat Biotechnol (2011) 8.34
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity. Nucleic Acids Res (2011) 7.93
The knockout mouse project. Nat Genet (2004) 7.80
Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell (1996) 7.45
In vivo genome editing using a high-efficiency TALEN system. Nature (2012) 7.11
TALENs: a widely applicable technology for targeted genome editing. Nat Rev Mol Cell Biol (2012) 7.01
TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain. Nucleic Acids Res (2010) 6.65
Targeted integration in rat and mouse embryos with zinc-finger nucleases. Nat Biotechnol (2010) 5.60
Efficient TALEN-mediated gene knockout in livestock. Proc Natl Acad Sci U S A (2012) 4.99
Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene. Science (2007) 4.39
Knockout mice created by TALEN-mediated gene targeting. Nat Biotechnol (2013) 4.31
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature (1990) 3.92
Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs. Nucleic Acids Res (2012) 3.41
Targeted genome modification in mice using zinc-finger nucleases. Genetics (2010) 3.38
DNA resection in eukaryotes: deciding how to fix the break. Nat Struct Mol Biol (2010) 2.81
TALEN-mediated precise genome modification by homologous recombination in zebrafish. Nat Methods (2013) 2.64
A detailed study of the substrate specificity of a chimeric restriction enzyme. Nucleic Acids Res (1999) 2.54
Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). Proc Natl Acad Sci U S A (2012) 2.53
Engineering synthetic TAL effectors with orthogonal target sites. Nucleic Acids Res (2012) 2.25
The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes. Genes Cells (1999) 2.16
Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage. Biochem Biophys Res Commun (2005) 2.15
DNA repair in mammalian cells: DNA double-strand break repair: how to fix a broken relationship. Cell Mol Life Sci (2009) 2.14
Advances in targeted genome editing. Curr Opin Chem Biol (2012) 1.97
Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology (2008) 1.86
Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs). PLoS One (2012) 1.85
Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases. PLoS One (2011) 1.69
Leptin revisited: its mechanism of action and potential for treating diabetes. Nat Rev Drug Discov (2012) 1.63
Criteria that optimize the potential of murine embryonic stem cells for in vitro and in vivo developmental studies. In Vitro Cell Dev Biol (1993) 0.95
Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice. Am J Physiol Regul Integr Comp Physiol (2000) 0.88
Method of the Year 2011. Nat Methods (2012) 0.83
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell (2012) 8.41
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol (2003) 5.77
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system. Nat Biotechnol (2013) 4.58
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33
APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Res (2008) 4.23
Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med (2011) 3.87
Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation. Immunity (2011) 3.75
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell (2003) 3.66
Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. Infect Immun (2003) 3.61
A PCR-based strategy to generate integrative targeting alleles with large regions of homology. Microbiology (2002) 3.58
Ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med (2003) 3.54
Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later. J Pediatr (2007) 3.45
A high-resolution map of segmental DNA copy number variation in the mouse genome. PLoS Genet (2006) 3.24
Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem (2002) 3.14
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95
Validation of internal control for gene expression study in soybean by quantitative real-time PCR. BMC Mol Biol (2008) 2.94
NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem (2003) 2.92
Genome-wide analysis for discovery of rice microRNAs reveals natural antisense microRNAs (nat-miRNAs). Proc Natl Acad Sci U S A (2008) 2.92
China: the aging giant. J Am Geriatr Soc (2007) 2.89
Functional genetic analysis of mouse chromosome 11. Nature (2003) 2.87
Poly[bis[aquaneodymium(III)]-mu2-oxalato-di-mu4-succinato]. Acta Crystallogr C (2007) 2.84
Michigan Molecular Interactions (MiMI): putting the jigsaw puzzle together. Nucleic Acids Res (2006) 2.77
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat Neurosci (2003) 2.70
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet (2008) 2.63
Inhaled carbon monoxide confers antiinflammatory effects against ventilator-induced lung injury. Am J Respir Crit Care Med (2004) 2.60
Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat Rev Immunol (2005) 2.59
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum Mol Genet (2006) 2.53
RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design. J Insect Physiol (2010) 2.47
Crystal structure of a soluble CD28-Fab complex. Nat Immunol (2005) 2.46
A phase diagram for jammed matter. Nature (2008) 2.45
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma. Nat Med (2007) 2.43
Glycoprotein structural genomics: solving the glycosylation problem. Structure (2007) 2.40
The effect of intraoperative rectal washout on local recurrence after rectal cancer surgery: a meta-analysis. Ann Surg Oncol (2012) 2.38
Pigs in sequence space: a 0.66X coverage pig genome survey based on shotgun sequencing. BMC Genomics (2005) 2.34
Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Mol Ther (2010) 2.30
Relationship between neural, vascular, and BOLD signals in isoflurane-anesthetized rat somatosensory cortex. Cereb Cortex (2006) 2.28
Adenosine A2A receptor activation: another potential therapy for trauma and hemorrhagic shock. Crit Care Med (2006) 2.18
Mesoscopic CH3NH3PbI3/TiO2 heterojunction solar cells. J Am Chem Soc (2012) 2.17
A heterozygous moth genome provides insights into herbivory and detoxification. Nat Genet (2013) 2.13
Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis. Circ Res (2006) 2.12
Is C677T polymorphism in methylenetetrahydrofolate reductase gene a risk factor for diabetic nephropathy or diabetes mellitus in a Chinese population? Arch Med Res (2011) 2.10
(Z)-Ethyl 2,4-diphenyl-3-(propyl-amino)-but-2-enoate. Acta Crystallogr Sect E Struct Rep Online (2009) 2.09
Endoscopic submucosal dissection for treatment of esophageal submucosal tumors originating from the muscularis propria layer. Gastrointest Endosc (2011) 2.08
The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells. J Mol Med (Berl) (2008) 2.04
A 70-year-old man with blue skin. Clin Chem (2014) 2.03
Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature (2007) 2.01
Towards precise classification of cancers based on robust gene functional expression profiles. BMC Bioinformatics (2005) 2.01
Structural insights into the YAP and TEAD complex. Genes Dev (2010) 2.00
Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinology (2008) 1.97
Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol (2002) 1.97
The feasibility of measuring renal blood flow using transesophageal echocardiography in patients undergoing cardiac surgery. Anesth Analg (2009) 1.97
Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Neuron (2002) 1.96
MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features. Nucleic Acids Res (2010) 1.94
Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med (2005) 1.93
Transmission of MDR and XDR tuberculosis in Shanghai, China. PLoS One (2009) 1.93
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet (2011) 1.92
The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Crit Care Med (2006) 1.92
Hysteresis in single-layer MoS2 field effect transistors. ACS Nano (2012) 1.92
Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database Syst Rev (2013) 1.91
Cortical layer-dependent BOLD and CBV responses measured by spin-echo and gradient-echo fMRI: insights into hemodynamic regulation. Neuroimage (2006) 1.90
Derivation of Escherichia coli O157:H7 from its O55:H7 precursor. PLoS One (2010) 1.90
Brain cannabinoid CB₂ receptors modulate cocaine's actions in mice. Nat Neurosci (2011) 1.88
Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis. Proc Natl Acad Sci U S A (2005) 1.88
Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J Neurosci (2002) 1.87
Novel anti-inflammatory therapy for Parkinson's disease. Trends Pharmacol Sci (2003) 1.87
Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome (2009) 1.87
A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model. Mol Ther (2003) 1.86
Relationship between obesity and diabetes in a US adult population: findings from the National Health and Nutrition Examination Survey, 1999-2006. Obes Surg (2011) 1.85
Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma. Clin Cancer Res (2008) 1.85
Blue light-dependent interaction of CRY2 with SPA1 regulates COP1 activity and floral initiation in Arabidopsis. Curr Biol (2011) 1.84
Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer's disease. Behav Brain Res (2008) 1.83
Gender differences in methamphetamine use and responses: a review. Gend Med (2008) 1.83
Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration. J Biol Chem (2003) 1.82
Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease. FASEB J (2003) 1.81
Major taste loss in carnivorous mammals. Proc Natl Acad Sci U S A (2012) 1.81
Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation. J Thorac Cardiovasc Surg (2005) 1.81
A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. Nature (2008) 1.79
Antiangiogenic properties of gold nanoparticles. Clin Cancer Res (2005) 1.78
A novel method to determine the engulfment of apoptotic cells by macrophages using pHrodo succinimidyl ester. J Immunol Methods (2009) 1.78
Technique for prolonged normothermic ex vivo lung perfusion. J Heart Lung Transplant (2008) 1.77
Vitamin D deficiency, myositis-myalgia, and reversible statin intolerance. Curr Med Res Opin (2011) 1.77
Improved spatial localization of post-stimulus BOLD undershoot relative to positive BOLD. Neuroimage (2006) 1.76
The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J Clin Invest (2013) 1.76
PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. Cancer Cell (2010) 1.75
MiR-93 enhances angiogenesis and metastasis by targeting LATS2. Cell Cycle (2012) 1.74
The immune protein CD3zeta is required for normal development of neural circuits in the retina. Neuron (2010) 1.74
Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J Neurosci (2003) 1.73
Functional repair of human donor lungs by IL-10 gene therapy. Sci Transl Med (2009) 1.72