Microvascular blood flow is altered in patients with sepsis.

How to evaluate the microcirculation: report of a round table conference. Crit Care (2007) 4.24

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med (2014) 3.37

The microcirculation is the motor of sepsis. Crit Care (2005) 3.29

Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med (2008) 3.14

Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest (2009) 2.71

Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study. Crit Care (2005) 2.47

Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Crit Care (2009) 2.32

A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury. Shock (2014) 2.11

Measurement of functional microcirculatory geometry and velocity distributions using automated image analysis. Med Biol Eng Comput (2008) 1.92

Bench-to-bedside review: sepsis is a disease of the microcirculation. Crit Care (2004) 1.66

Sublingual microcirculation in pulmonary arterial hypertension. Ann Am Thorac Soc (2014) 1.64

Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med (2008) 1.61

Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock? Intensive Care Med (2015) 1.59

Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide. Crit Care (2003) 1.55

Cerebral microcirculation shear stress levels determine Neisseria meningitidis attachment sites along the blood-brain barrier. J Exp Med (2006) 1.51

Re-thinking resuscitation: leaving blood pressure cosmetics behind and moving forward to permissive hypotension and a tissue perfusion-based approach. Crit Care (2013) 1.50

Sublingual microcirculation is impaired in post-cardiac arrest patients. Resuscitation (2013) 1.48

Microvascular dysfunction as a cause of organ dysfunction in severe sepsis. Crit Care (2005) 1.42

Endothelial and Microcirculatory Function and Dysfunction in Sepsis. Clin Chest Med (2016) 1.42

Cerebral microcirculation is impaired during sepsis: an experimental study. Crit Care (2010) 1.39

Septic cardiomyopathy - A not yet discovered cardiomyopathy? Exp Clin Cardiol (2006) 1.36

Early and innovative interventions for severe sepsis and septic shock: taking advantage of a window of opportunity. CMAJ (2005) 1.36

Is thenar tissue hemoglobin oxygen saturation in septic shock related to macrohemodynamic variables and outcome? Crit Care (2009) 1.30

Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations. J Infect Dis (2008) 1.26

Abnormal blood flow in the sublingual microcirculation at high altitude. Eur J Appl Physiol (2009) 1.25

Clinical manifestations of disordered microcirculatory perfusion in severe sepsis. Crit Care (2005) 1.24

A microfluidics approach towards high-throughput pathogen removal from blood using margination. Biomicrofluidics (2012) 1.23

Mechanisms of critical illness--classifying microcirculatory flow abnormalities in distributive shock. Crit Care (2006) 1.21

Cytocam-IDF (incident dark field illumination) imaging for bedside monitoring of the microcirculation. Intensive Care Med Exp (2015) 1.18

Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock. Virulence (2013) 1.16

The microcirculation as a functional system. Crit Care (2005) 1.16

Accuracy of blood-glucose measurements using glucose meters and arterial blood gas analyzers in critically ill adult patients: systematic review. Crit Care (2013) 1.15

Microcirculatory alterations: potential mechanisms and implications for therapy. Ann Intensive Care (2011) 1.14

Near-infrared spectroscopy technique to evaluate the effects of red blood cell transfusion on tissue oxygenation. Crit Care (2009) 1.14

Functional haemodynamic monitoring. Curr Opin Crit Care (2014) 1.11

Clinical review: Clinical imaging of the sublingual microcirculation in the critically ill--where do we stand? Crit Care (2012) 1.11

From macrohemodynamic to the microcirculation. Crit Care Res Pract (2013) 1.09

Assessment of tissue oxygen saturation during a vascular occlusion test using near-infrared spectroscopy: the role of probe spacing and measurement site studied in healthy volunteers. Crit Care (2009) 1.07

Effects of changes in arterial pressure on organ perfusion during septic shock. Crit Care (2011) 1.06

Timing of vasopressor initiation and mortality in septic shock: a cohort study. Crit Care (2014) 1.05

Red blood cell transfusion in the critically ill patient. Ann Intensive Care (2011) 1.04

Intensive Care Unit-acquired infection as a side effect of sedation. Crit Care (2010) 1.03

Early course of microcirculatory perfusion in eye and digestive tract during hypodynamic sepsis. Crit Care (2012) 1.02

Glycocalyx and sepsis-induced alterations in vascular permeability. Crit Care (2015) 1.01

Assessment of erythrocyte shape by flow cytometry techniques. J Clin Pathol (2006) 1.01

Microvascular resuscitation as a therapeutic goal in severe sepsis. Crit Care (2005) 1.01

Sepsis-induced acute kidney injury revisited: pathophysiology, prevention and future therapies. Curr Opin Crit Care (2014) 1.00

Renin-angiotensin system activation correlates with microvascular dysfunction in a prospective cohort study of clinical sepsis. Crit Care (2010) 0.99

Microvascular obstruction and endothelial activation are independently associated with the clinical manifestations of severe falciparum malaria in adults: an observational study. BMC Med (2015) 0.98

Hemodynamic and morphological vasculature response to a burn monitored using a combined dual-wavelength laser speckle and optical microangiography imaging system. Biomed Opt Express (2012) 0.98

Continuous on-line glucose measurement by microdialysis in a central vein. A pilot study. Crit Care (2013) 0.98

Clinical review: Circulatory shock--an update: a tribute to Professor Max Harry Weil. Crit Care (2012) 0.97

Clinical applicability of functional hemodynamic monitoring. Ann Intensive Care (2011) 0.96

Theoretical comparison of wall-derived and erythrocyte-derived mechanisms for metabolic flow regulation in heterogeneous microvascular networks. Am J Physiol Heart Circ Physiol (2012) 0.96

Early goal-directed resuscitation of patients with septic shock: current evidence and future directions. Crit Care (2015) 0.95

Towards integrative physiological monitoring of the critically ill: from cardiovascular to microcirculatory and cellular function monitoring at the bedside. Crit Care (2013) 0.95

Effects of thoracic epidural anesthesia on survival and microcirculation in severe acute pancreatitis: a randomized experimental trial. Crit Care (2013) 0.94

Initial emergency department diagnosis and management of adult patients with severe sepsis and septic shock. Scand J Trauma Resusc Emerg Med (2012) 0.94

Rapid automatic assessment of microvascular density in sidestream dark field images. Med Biol Eng Comput (2011) 0.94

Cytokine signalling in rat pulp interstitial fluid and transcapillary fluid exchange during lipopolysaccharide-induced acute inflammation. J Physiol (2006) 0.94

Hemodynamic coherence and the rationale for monitoring the microcirculation. Crit Care (2015) 0.94

Dengue therapeutics, chemoprophylaxis, and allied tools: state of the art and future directions. PLoS Negl Trop Dis (2014) 0.94

Recombinant activated protein C treatment improves tissue perfusion and oxygenation in septic patients measured by near-infrared spectroscopy. Crit Care (2009) 0.91

Acute microflow changes after stop and restart of intra-aortic balloon pump in cardiogenic shock. Clin Res Cardiol (2009) 0.91

Improved microcirculation in patients with an acute ST-elevation myocardial infarction treated with the Impella LP2.5 percutaneous left ventricular assist device. Clin Res Cardiol (2009) 0.91

Isoproterenol infusion and microcirculation in septic shock. Heart Lung Vessel (2014) 0.91

Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow. Crit Care (2007) 0.90

Qualitative real-time analysis by nurses of sublingual microcirculation in intensive care unit: the MICRONURSE study. Crit Care (2015) 0.90

Monitoring the microcirculation. J Clin Monit Comput (2012) 0.90

Withdrawing intra-aortic balloon pump support paradoxically improves microvascular flow. Crit Care (2010) 0.90

Comparison of different methods for the calculation of the microvascular flow index. Crit Care Res Pract (2012) 0.90

The deleterious effect of red blood cell storage on microvascular response to transfusion. J Trauma Acute Care Surg (2013) 0.90

Non-invasive imaging of microcirculation: a technology review. Med Devices (Auckl) (2014) 0.89

Pulmonary microvascular albumin leak is associated with endothelial cell death in murine sepsis-induced lung injury in vivo. PLoS One (2014) 0.89

Increased blood flow prevents intramucosal acidosis in sheep endotoxemia: a controlled study. Crit Care (2005) 0.89

Microcirculatory alterations in ischemia-reperfusion injury and sepsis: effects of activated protein C and thrombin inhibition. Crit Care (2005) 0.89

Microvascular response to red blood cell transfusion in trauma patients. Shock (2012) 0.89

Mesenteric microcirculatory dysfunctions and translocation of indigenous bacteria in a rat model of strangulated small bowel obstruction. Clinics (Sao Paulo) (2009) 0.89

The effect of red blood cell transfusion on tissue oxygenation and microcirculation in severe septic patients. Ann Intensive Care (2011) 0.88

Relationship of systemic, hepatosplanchnic, and microcirculatory perfusion parameters with 6-hour lactate clearance in hyperdynamic septic shock patients: an acute, clinical-physiological, pilot study. Ann Intensive Care (2012) 0.88

Clinical review: influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock. Crit Care (2003) 0.88

Red blood cell clearance in inflammation. Transfus Med Hemother (2012) 0.87

Evaluation of left ventricular systolic function revisited in septic shock. Crit Care (2013) 0.87

Sublingual microcirculatory changes during high-volume hemofiltration in hyperdynamic septic shock patients. Crit Care (2010) 0.87

A high mean arterial pressure target is associated with improved microcirculation in septic shock patients with previous hypertension: a prospective open label study. Crit Care (2015) 0.87

Personalizing blood pressure management in septic shock. Ann Intensive Care (2015) 0.86

THE ENDOTHELIUM IN SEPSIS. Shock (2016) 0.86

Role of pulmonary microvascular endothelial cell apoptosis in murine sepsis-induced lung injury in vivo. Respir Res (2015) 0.86

Disparity between skin perfusion and sublingual microcirculatory alterations in severe sepsis and septic shock: a prospective observational study. Intensive Care Med (2008) 0.86

Quantification of microcirculatory blood flow: a sensitive and clinically relevant prognostic marker in murine models of sepsis. J Appl Physiol (1985) (2014) 0.86

Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat. Crit Care (2006) 0.85

Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis? World J Exp Med (2015) 0.85

Improvement of sidestream dark field imaging with an image acquisition stabilizer. BMC Med Imaging (2010) 0.85

Regulation and prognostic relevance of symmetric dimethylarginine serum concentrations in critical illness and sepsis. Mediators Inflamm (2013) 0.85

A guide to human in vivo microcirculatory flow image analysis. Crit Care (2016) 0.85

Gut and sublingual microvascular effect of esmolol during septic shock in a porcine model. Crit Care (2015) 0.85

Bedside sublingual video imaging of microcirculation in assessing bacterial infection in cirrhosis. Dig Dis Sci (2009) 0.84

The dynamic regulation of microcirculatory conduit function: features relevant to transfusion medicine. Transfus Apher Sci (2010) 0.84

Dissociation between sublingual and gut microcirculation in the response to a fluid challenge in postoperative patients with abdominal sepsis. Ann Intensive Care (2014) 0.84

Cutaneous vascular reactivity and flow motion response to vasopressin in advanced vasodilatory shock and severe postoperative multiple organ dysfunction syndrome. Crit Care (2006) 0.84

Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56

Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68

Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med (2004) 24.47

Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39

Mortality after surgery in Europe: a 7 day cohort study. Lancet (2012) 9.96

Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med (2010) 8.58

Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33

Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med (2004) 5.90

Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA (2010) 5.80

Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial. Anesthesiology (2015) 5.52

Circulatory shock. N Engl J Med (2013) 4.95

Sepsis biomarkers: a review. Crit Care (2010) 4.76

Procalcitonin usefulness for the initiation of antibiotic treatment in intensive care unit patients. Crit Care Med (2012) 4.76

Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med (2004) 4.56

Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis (2012) 4.07

Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Crit Care Med (2003) 4.04

Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med (2005) 3.97

Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90

Pulse pressure variations to predict fluid responsiveness: influence of tidal volume. Intensive Care Med (2005) 3.81

Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78

Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care (2013) 3.65

High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest (2005) 3.58

The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med (2006) 3.53

Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Crit Care Med (2011) 3.34

The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18

Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18

The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17

Stress hyperglycaemia. Lancet (2009) 3.13

Management of bleeding following major trauma: an updated European guideline. Crit Care (2010) 3.09

Microvascular response to red blood cell transfusion in patients with severe sepsis. Crit Care Med (2007) 3.06

Glucose variability and mortality in patients with sepsis. Crit Care Med (2008) 3.00

C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest (2003) 2.95

Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest (2008) 2.90

Let us use the pulmonary artery catheter correctly and only when we need it. Crit Care Med (2005) 2.83

Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma (2010) 2.82

Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study. Crit Care Med (2006) 2.74

Do all nonsurvivors of cardiogenic shock die with a low cardiac index? Chest (2003) 2.73

Has mortality from acute renal failure decreased? A systematic review of the literature. Am J Med (2005) 2.73

Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome. Crit Care Med (2013) 2.72

Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med (2009) 2.68

Abandon the mouse research ship? Not just yet! Shock (2014) 2.60

Year in review in Intensive Care Medicine 2011: III. ARDS and ECMO, weaning, mechanical ventilation, noninvasive ventilation, pediatrics and miscellanea. Intensive Care Med (2012) 2.52

Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis. Crit Care Med (2004) 2.48

Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study. Crit Care Med (2006) 2.47

Sublingual capnometry tracks microcirculatory changes in septic patients. Intensive Care Med (2006) 2.40

Management of bleeding following major trauma: a European guideline. Crit Care (2007) 2.40

Ethics and end-of-life care for adults in the intensive care unit. Lancet (2010) 2.40

Antibiotic strategies in severe nosocomial sepsis: why do we not de-escalate more often? Crit Care Med (2012) 2.39

Goal-directed intraoperative therapy reduces morbidity and length of hospital stay in high-risk surgical patients. Chest (2007) 2.38

Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit Care Med (2004) 2.33

Severe sepsis in cirrhosis. Hepatology (2009) 2.33

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med (2010) 2.31

Obesity is associated with increased morbidity but not mortality in critically ill patients. Intensive Care Med (2008) 2.27

The prognostic value of muscle StO2 in septic patients. Intensive Care Med (2007) 2.25

Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best? Crit Care Med (2003) 2.23

Gamma-globulin levels in patients with community-acquired septic shock. Shock (2009) 2.21

Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis (2004) 2.17

A large-bolus injection, but not continuous infusion of sodium selenite improves outcome in peritonitis. Shock (2009) 2.17

Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock. Crit Care (2010) 2.11

Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis. Crit Care Med (2010) 2.11

Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality? Transfusion (2009) 2.11

Randomized, controlled clinical trials in sepsis: has methodological quality improved over time? Crit Care Med (2002) 2.10

When should we add parenteral to enteral nutrition? Lancet (2012) 2.08

The Surviving Sepsis Campaign: raising awareness to reduce mortality. Crit Care (2003) 2.07

Dopamine versus norepinephrine in the treatment of septic shock: a meta-analysis*. Crit Care Med (2012) 2.06

Effects of fluids on microvascular perfusion in patients with severe sepsis. Intensive Care Med (2010) 2.05

Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial. Intensive Care Med (2003) 2.05

Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000. Crit Care Med (2003) 2.01

An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study. Intensive Care Med (2006) 2.00

Multicenter, randomized, controlled trials evaluating mortality in intensive care: doomed to fail? Crit Care Med (2008) 2.00

Clinical trials of immunomodulatory therapies in severe sepsis and septic shock. Clin Infect Dis (2002) 1.99

Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis. Crit Care Med (2003) 1.98

Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy. Crit Care (2011) 1.91

Monitoring the microcirculation in the critically ill patient: current methods and future approaches. Intensive Care Med (2010) 1.88

Microvascular alterations in patients with acute severe heart failure and cardiogenic shock. Am Heart J (2004) 1.86

The impact of hospital and ICU organizational factors on outcome in critically ill patients: results from the Extended Prevalence of Infection in Intensive Care study. Crit Care Med (2015) 1.85

Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest (2009) 1.83

Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study. Int J Antimicrob Agents (2011) 1.80

Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum. Crit Care Med (2005) 1.77

Arterial pressure-based cardiac output monitoring: a multicenter validation of the third-generation software in septic patients. Intensive Care Med (2010) 1.77

Global prospective epidemiologic and surveillance study of ventilator-associated pneumonia due to Pseudomonas aeruginosa. Crit Care Med (2014) 1.77

Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials. Ann Surg (2003) 1.77

Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial. Crit Care (2012) 1.76

Clinical review: Consensus recommendations on measurement of blood glucose and reporting glycemic control in critically ill adults. Crit Care (2013) 1.72

Relative adrenal insufficiency in patients with septic shock: comparison of low-dose and conventional corticotropin tests. Crit Care Med (2005) 1.72