Published in Crit Care Med on April 01, 2003
The DIPOD Study (Diagnosis Improvement of Pneumonia by Organ Dysfunction) (DIPOD) | NCT02683122
Evaluation of the Heparin Binding Protein Levels in Sepsis (HBP) | NCT02533011
Impact of CVVHD With Increased Adsorption Membranes in Septic Acute Kidney Injury | NCT01790620
Plasma Inducible Nitric Oxide Synthase (iNOS) Assay and Sepsis Study (PliNOSa® Test) | NCT01371929
Pilot Trial of Statin Use in Burn Patients (BURNSTAT) | NCT00978419
Predict Sepsis; the Predictive Value of Bedside Measures in the Ambulance | NCT03249597
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
Harmful molecular mechanisms in sepsis. Nat Rev Immunol (2008) 6.03
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65
Sepsis definitions: time for change. Lancet (2013) 5.63
Sepsis biomarkers: a review. Crit Care (2010) 4.76
Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med (2010) 4.69
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
The enigma of sepsis. J Clin Invest (2003) 4.32
Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study. Crit Care (2005) 3.96
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit Care (2007) 3.80
Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med (2006) 3.72
Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care (2008) 3.32
Factors associated with nonadherence to early goal-directed therapy in the ED. Chest (2010) 3.23
Pathophysiology of sepsis. Am J Pathol (2007) 3.19
Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int (2009) 2.97
Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality. Crit Care Med (2012) 2.97
A multibiomarker-based outcome risk stratification model for adult septic shock*. Crit Care Med (2014) 2.94
The era of molecular and other non-culture-based methods in diagnosis of sepsis. Clin Microbiol Rev (2010) 2.90
The value of residual liver volume as a predictor of hepatic dysfunction and infection after major liver resection. Gut (2005) 2.82
The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia. Crit Care Med (2015) 2.81
Randomized controlled trial of calcitriol in severe sepsis. Am J Respir Crit Care Med (2014) 2.79
Population burden of long-term survivorship after severe sepsis in older Americans. J Am Geriatr Soc (2012) 2.78
Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest (2009) 2.71
Spurious inferences about long-term outcomes: the case of severe sepsis and geriatric conditions. Am J Respir Crit Care Med (2012) 2.60
A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Nat Immunol (2013) 2.60
Into the eye of the cytokine storm. Microbiol Mol Biol Rev (2012) 2.58
Incidence and Prognostic Value of the Systemic Inflammatory Response Syndrome and Organ Dysfunctions in Ward Patients. Am J Respir Crit Care Med (2015) 2.53
Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med (2013) 2.52
Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial. Crit Care (2010) 2.50
Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med (2009) 2.49
Severe sepsis cohorts derived from claims-based strategies appear to be biased toward a more severely ill patient population. Crit Care Med (2013) 2.48
Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intensive Care Med (2013) 2.44
Sepsis: definition, epidemiology, and diagnosis. BMJ (2007) 2.43
Increased fluid administration in the first three hours of sepsis resuscitation is associated with reduced mortality: a retrospective cohort study. Chest (2014) 2.39
Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection. Nat Med (2010) 2.38
Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am J Respir Crit Care Med (2008) 2.37
Septic Shock: Advances in Diagnosis and Treatment. JAMA (2015) 2.37
Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther (2012) 2.34
Acute kidney injury in intensive care unit patients: a comparison between the RIFLE and the Acute Kidney Injury Network classifications. Crit Care (2008) 2.29
Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. JAMA (2010) 2.27
Epidemiology of severe sepsis. Virulence (2013) 2.26
Administrative codes combined with medical records based criteria accurately identified bacterial infections among rheumatoid arthritis patients. J Clin Epidemiol (2008) 2.25
Plasma neutrophil gelatinase-associated lipocalin predicts recovery from acute kidney injury following community-acquired pneumonia. Kidney Int (2011) 2.22
Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems. Antimicrob Agents Chemother (2014) 2.18
Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock. Crit Care (2010) 2.11
Do hospitals provide lower quality of care to black patients for pneumonia? Crit Care Med (2010) 2.07
ABO blood type A is associated with increased risk of ARDS in whites following both major trauma and severe sepsis. Chest (2014) 2.07
Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples. Am J Hematol (2015) 2.06
Concomitant use of beta-1 adrenoreceptor blocker and norepinephrine in patients with septic shock. Wien Klin Wochenschr (2012) 2.04
Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. J Clin Invest (2008) 2.04
Clinical outcomes of type III Pseudomonas aeruginosa bacteremia. Crit Care Med (2012) 2.03
Clinical review: RIFLE and AKIN--time for reappraisal. Crit Care (2009) 2.00
Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Crit Care Med (2014) 1.98
The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study*. Crit Care Med (2012) 1.97
The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: the VISIONS cohort magnetic resonance imaging study*. Crit Care Med (2012) 1.96
Cecal ligation and puncture-induced murine sepsis does not cause lung injury. Crit Care Med (2013) 1.94
Multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis - a systemic review and meta-analysis. PLoS One (2013) 1.94
Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy. Crit Care (2011) 1.91
Clinical outcomes of patients requiring ventilatory support in Brazilian intensive care units: a multicenter, prospective, cohort study. Crit Care (2013) 1.90
Hemoglobin conformation couples erythrocyte S-nitrosothiol content to O2 gradients. Proc Natl Acad Sci U S A (2005) 1.88
Extravascular lung water in patients with severe sepsis: a prospective cohort study. Crit Care (2005) 1.86
Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity (2013) 1.83
Depressive symptoms in spouses of older patients with severe sepsis. Crit Care Med (2012) 1.78
Predicting high vancomycin minimum inhibitory concentration in methicillin-resistant Staphylococcus aureus bloodstream infections. Clin Infect Dis (2011) 1.78
Understanding the potential role of statins in pneumonia and sepsis. Crit Care Med (2011) 1.77
Arterial pressure-based cardiac output monitoring: a multicenter validation of the third-generation software in septic patients. Intensive Care Med (2010) 1.77
The late phase of sepsis is characterized by an increased microbiological burden and death rate. Crit Care (2011) 1.77
Significance of serum procalcitonin in sepsis. Indian J Crit Care Med (2011) 1.76
Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial. Crit Care Med (2016) 1.76
Mechanical ventilation and acute lung injury in emergency department patients with severe sepsis and septic shock: an observational study. Acad Emerg Med (2013) 1.75
Prediction of hospital outcome in septic shock: a prospective comparison of tissue Doppler and cardiac biomarkers. Crit Care (2010) 1.73
Differences in immune response may explain lower survival among older men with pneumonia. Crit Care Med (2009) 1.71
Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol (2010) 1.70
Randomized trial of automated, electronic monitoring to facilitate early detection of sepsis in the intensive care unit*. Crit Care Med (2012) 1.69
A multicenter, prospective validation study of the Japanese Association for Acute Medicine disseminated intravascular coagulation scoring system in patients with severe sepsis. Crit Care (2013) 1.67
Hospital Incidence and Mortality Rates of Sepsis. Dtsch Arztebl Int (2016) 1.65
2013 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg (2013) 1.65
Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study. BMJ (2011) 1.64
Hypoglycemia at admission is associated with inhospital mortality in Ugandan patients with severe sepsis. Crit Care Med (2011) 1.64
Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med (2013) 1.64
The host response to sepsis and developmental impact. Pediatrics (2010) 1.62
Esophageal perforation: principles of diagnosis and surgical management. Surg Today (2006) 1.60
Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock? Intensive Care Med (2015) 1.59
Statins and outcomes in patients with bloodstream infection: a propensity-matched analysis. Crit Care Med (2012) 1.59
Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis). PLoS Med (2007) 1.58
Risk factors for systemic inflammatory response syndrome following percutaneous nephrolithotomy. Urolithiasis (2013) 1.58
Time for a neonatal-specific consensus definition for sepsis. Pediatr Crit Care Med (2014) 1.56
Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. N Engl J Med (2017) 1.56
Microcirculatory effects of the transfusion of leukodepleted or non-leukodepleted red blood cells in patients with sepsis: a pilot study. Crit Care (2014) 1.56
Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target. Br J Pharmacol (2009) 1.55
Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection. Crit Care (2010) 1.55
Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA). World J Emerg Surg (2016) 1.55
NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. J Biol Chem (2012) 1.55
Cytokines in sepsis: potent immunoregulators and potential therapeutic targets--an updated view. Mediators Inflamm (2013) 1.54
Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis. Crit Care (2012) 1.52
Inflammasome mRNA expression in human monocytes during early septic shock. Am J Respir Crit Care Med (2008) 1.52
Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis. Crit Care (2015) 1.50
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
Intensive versus conventional glucose control in critically ill patients. N Engl J Med (2009) 26.30
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med (2004) 24.47
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37
One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med (2003) 11.77
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39
Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med (2011) 9.96
Mortality after surgery in Europe: a 7 day cohort study. Lancet (2012) 9.96
Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19
A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med (2013) 8.94
Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med (2010) 8.58
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem (2003) 8.34
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A (2003) 7.14
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med (2005) 6.86
Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA (2012) 6.69
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69
Quality indicators for colonoscopy. Am J Gastroenterol (2006) 6.51
Hypoglycemia and risk of death in critically ill patients. N Engl J Med (2012) 6.17
Aspirin in patients undergoing noncardiac surgery. N Engl J Med (2014) 6.10
Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med (2004) 5.90
Perioperative fluid therapy with tetrastarch and gelatin in cardiac surgery--a prospective sequential analysis*. Crit Care Med (2013) 5.88
Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med (2002) 5.84
Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA (2010) 5.80
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65
Sepsis definitions: time for change. Lancet (2013) 5.63
Medical sequencing at the extremes of human body mass. Am J Hum Genet (2007) 5.61
No surgical innovation without evaluation: the IDEAL recommendations. Lancet (2009) 5.57
Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial. Anesthesiology (2015) 5.52
Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumonia. Am J Respir Crit Care Med (2006) 5.35
The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. Crit Care Med (2004) 5.23
High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol (2005) 5.04
Circulatory shock. N Engl J Med (2013) 4.95
Sepsis biomarkers: a review. Crit Care (2010) 4.76
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med (2010) 4.71
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study. Crit Care Med (2005) 4.61
Dalteparin versus unfractionated heparin in critically ill patients. N Engl J Med (2011) 4.59
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med (2004) 4.56
Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. Biol Psychiatry (2004) 4.46
Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. J Clin Invest (2003) 4.42
Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2009) 4.41
Toothbrushing for critically ill mechanically ventilated patients: a systematic review and meta-analysis of randomized trials evaluating ventilator-associated pneumonia. Crit Care Med (2013) 4.29
Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med (2008) 4.21
Quality indicators for colonoscopy. Gastrointest Endosc (2014) 4.17
Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. JAMA (2002) 4.09
The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med (2005) 4.07
Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis (2012) 4.07
Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Crit Care Med (2003) 4.04
Transfusion-related acute lung injury: definition and review. Crit Care Med (2005) 3.98
Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med (2005) 3.97
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Quality indicators for colonoscopy. Gastrointest Endosc (2006) 3.83
Pulse pressure variations to predict fluid responsiveness: influence of tidal volume. Intensive Care Med (2005) 3.81
The tight calorie control study (TICACOS): a prospective, randomized, controlled pilot study of nutritional support in critically ill patients. Intensive Care Med (2011) 3.79
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A (2002) 3.68
Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care (2013) 3.65
Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med (2004) 3.61
High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest (2005) 3.58
The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med (2006) 3.53
Publication bias in editorial decision making. JAMA (2002) 3.52
Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol (2005) 3.38
Pathogenesis, treatment, and prevention of pneumococcal pneumonia. Lancet (2009) 3.38
Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Crit Care Med (2011) 3.34
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17
Management of bleeding following major trauma: an updated European guideline. Crit Care (2010) 3.09
Microvascular response to red blood cell transfusion in patients with severe sepsis. Crit Care Med (2007) 3.06
Evaluation and stages of surgical innovations. Lancet (2009) 3.04
C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest (2003) 2.95
HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology (2002) 2.95
Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest (2008) 2.90