Published in Crit Care Med on May 01, 2003
Sepsis biomarkers: a review. Crit Care (2010) 4.76
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit Care (2007) 3.80
The value of residual liver volume as a predictor of hepatic dysfunction and infection after major liver resection. Gut (2005) 2.82
Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med (2009) 2.23
New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev (2012) 2.01
Admission chemokine (C-C motif) ligand 4 levels predict survival in pediatric septic shock. Pediatr Crit Care Med (2010) 1.57
Genome-wide transcription profiling of human sepsis: a systematic review. Crit Care (2010) 1.48
Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock. J Inflamm (Lond) (2010) 1.44
Early and innovative interventions for severe sepsis and septic shock: taking advantage of a window of opportunity. CMAJ (2005) 1.36
C-reactive protein, an early marker of community-acquired sepsis resolution: a multi-center prospective observational study. Crit Care (2011) 1.31
Clinical review: sepsis and septic shock--the potential of gene arrays. Crit Care (2012) 1.25
Genetics and genomics in pediatric septic shock. Crit Care Med (2012) 1.23
Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response. Recent Pat Inflamm Allergy Drug Discov (2009) 1.14
Early identification of intensive care unit-acquired infections with daily monitoring of C-reactive protein: a prospective observational study. Crit Care (2006) 1.12
Early assessment of pancreatic infections and overall prognosis in severe acute pancreatitis by procalcitonin (PCT): a prospective international multicenter study. Ann Surg (2007) 1.09
A multicentre study of acute kidney injury in severe sepsis and septic shock: association with inflammatory phenotype and HLA genotype. PLoS One (2012) 1.03
Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis. BMC Infect Dis (2012) 0.99
Lack of evidence for qualitative treatment by disease severity interactions in clinical studies of severe sepsis. Crit Care (2005) 0.93
Biomarker-guided antibiotic therapy in adult critically ill patients: a critical review. Ann Intensive Care (2012) 0.92
The staging of sepsis: understanding heterogeneity in treatment efficacy. Crit Care (2005) 0.90
Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit. Crit Care (2015) 0.90
AME evidence series 001-The Society for Translational Medicine: clinical practice guidelines for diagnosis and early identification of sepsis in the hospital. J Thorac Dis (2016) 0.89
Toward an operative diagnosis in sepsis: a latent class approach. BMC Infect Dis (2008) 0.88
Diagnosis-dependent relationships between cytokine levels and survival in patients admitted for surgical critical care. J Am Coll Surg (2010) 0.88
Biomarkers for Sepsis: What Is and What Might Be? Biomark Insights (2015) 0.87
Procalcitonin: improved biochemical severity stratification and postoperative monitoring in severe abdominal inflammation and sepsis. Langenbecks Arch Surg (2004) 0.86
Diffuse postoperative peritonitis -- value of diagnostic parameters and impact of early indication for relaparotomy. Eur J Med Res (2009) 0.85
Combination of C-reactive protein, procalcitonin and sepsis-related organ failure score for the diagnosis of sepsis in critical patients. Ann Intensive Care (2016) 0.83
Changes in serum cytokines in response to musculoskeletal surgical trauma. BMC Res Notes (2014) 0.83
The Nociceptin/Orphanin FQ system is modulated in patients admitted to ICU with sepsis and after cardiopulmonary bypass. PLoS One (2013) 0.82
Substance P in polymicrobial sepsis: molecular fingerprint of lung injury in preprotachykinin-A-/- mice. Mol Med (2010) 0.81
Plasma cytokine profiles in preprotachykinin-A knockout mice subjected to polymicrobial sepsis. Mol Med (2009) 0.81
PIRO and sepsis stratification: reality or a mirage? Rev Bras Ter Intensiva (2015) 0.81
Systems engineering medicine: engineering the inflammation response to infectious and traumatic challenges. J R Soc Interface (2010) 0.80
Early diagnosis of sepsis using serum hemoglobin subunit Beta. Inflammation (2015) 0.80
Mean platelet volume: is it a predictive parameter in diagnosis of acute mesenteric ischemia? Int Surg (2015) 0.79
Mechanisms of splenic hypertrophy following hepatic resection. HPB (Oxford) (2013) 0.78
Temporal trends of circulating nitric oxide and pro-inflammatory cytokine responses ex vivo in intra-abdominal sepsis: results from a cohort study. Inflamm Res (2010) 0.78
Cytokine profile in elderly patients with sepsis. Indian J Crit Care Med (2009) 0.78
Comparison of C-reactive protein and serum amyloid a protein in septic shock patients. Mediators Inflamm (2008) 0.78
Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data. Mediators Inflamm (2015) 0.77
Use of biomarkers in sepsis: many questions, few answers. Rev Bras Ter Intensiva (2013) 0.76
Relationship between Sequential Organ Failure Assessment (SOFA) and intra-abdominal pressure in intensive care unit. Arq Bras Cir Dig (2015) 0.75
Role of suPAR and Lactic Acid in Diagnosing Sepsis and Predicting Mortality in Elderly Patients. Eur J Microbiol Immunol (Bp) (2016) 0.75
A Study of Inflammatory/Necrosis Biomarkers in the Fracture of the Femur Treated with Proximal Femoral Nail Antirotation. Mediators Inflamm (2015) 0.75
Prediction of sepsis in trauma patients. Burns Trauma (2014) 0.75
Cardiac Troponin Is a Predictor of Septic Shock Mortality in Cancer Patients in an Emergency Department: A Retrospective Cohort Study. PLoS One (2016) 0.75
Modeling longitudinal data in acute illness. Crit Care (2007) 0.75
Raftlin: a new biomarker in human sepsis. Inflammation (2014) 0.75
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med (2004) 24.47
Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med (2008) 19.93
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37
Hydrocortisone therapy for patients with septic shock. N Engl J Med (2008) 15.85
Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA (2009) 13.00
Sepsis in European intensive care units: results of the SOAP study. Crit Care Med (2006) 11.78
International study of the prevalence and outcomes of infection in intensive care units. JAMA (2009) 11.57
Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med (2008) 11.00
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39
Mortality after surgery in Europe: a 7 day cohort study. Lancet (2012) 9.96
Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med (2010) 8.58
Randomized trials stopped early for benefit: a systematic review. JAMA (2005) 8.43
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
Anemia and blood transfusion in critically ill patients. JAMA (2002) 7.83
Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A (2003) 7.14
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med (2005) 6.86
A guide for the design and conduct of self-administered surveys of clinicians. CMAJ (2008) 6.72
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69
High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med (2013) 6.56
Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ (2009) 6.27
Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA (2010) 5.90
Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med (2004) 5.90
Perioperative fluid therapy with tetrastarch and gelatin in cardiac surgery--a prospective sequential analysis*. Crit Care Med (2013) 5.88
Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med (2002) 5.84
Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA (2010) 5.80
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65
Comparison of mortality between private for-profit and private not-for-profit hemodialysis centers: a systematic review and meta-analysis. JAMA (2002) 5.57
Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial. Anesthesiology (2015) 5.52
An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations. Am J Respir Crit Care Med (2006) 5.29
The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. Crit Care Med (2004) 5.23
Circulatory shock. N Engl J Med (2013) 4.95
A systematic review and meta-analysis of studies comparing mortality rates of private for-profit and private not-for-profit hospitals. CMAJ (2002) 4.84
Sepsis biomarkers: a review. Crit Care (2010) 4.76
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med (2004) 4.56
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA (2003) 4.54
Prognostic value of extravascular lung water in critically ill patients. Chest (2002) 4.46
Need for expertise based randomised controlled trials. BMJ (2005) 4.34
A positive fluid balance is associated with a worse outcome in patients with acute renal failure. Crit Care (2008) 4.31
An observational study of orthopaedic abstracts and subsequent full-text publications. J Bone Joint Surg Am (2002) 4.25
Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. JAMA (2002) 4.09
Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis (2012) 4.07
Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Crit Care Med (2003) 4.04
Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med (2005) 3.97
Fluid resuscitation in sepsis: a systematic review and network meta-analysis. Ann Intern Med (2014) 3.96
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Pulse pressure variations to predict fluid responsiveness: influence of tidal volume. Intensive Care Med (2005) 3.81
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A (2002) 3.68
Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care (2013) 3.65
High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest (2005) 3.58
Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med (2015) 3.55
The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med (2006) 3.53
The effect of selenium therapy on mortality in patients with sepsis syndrome: a systematic review and meta-analysis of randomized controlled trials. Crit Care Med (2013) 3.43
Family satisfaction with care in the intensive care unit: results of a multiple center study. Crit Care Med (2002) 3.36
Barriers to full-text publication following presentation of abstracts at annual orthopaedic meetings. J Bone Joint Surg Am (2003) 3.36
Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Crit Care Med (2011) 3.34
The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med (2009) 3.30
Quality of care in for-profit and not-for-profit nursing homes: systematic review and meta-analysis. BMJ (2009) 3.22
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17
Challenges in end-of-life care in the ICU. Statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003. Intensive Care Med (2004) 3.16
Intensive care unit quality improvement: a "how-to" guide for the interdisciplinary team. Crit Care Med (2006) 3.15
Current practice in nutritional support and its association with mortality in septic patients--results from a national, prospective, multicenter study. Crit Care Med (2008) 3.12
Management of bleeding following major trauma: an updated European guideline. Crit Care (2010) 3.09
Patient and healthcare professional factors influencing end-of-life decision-making during critical illness: a systematic review. Crit Care Med (2011) 3.07
Microvascular response to red blood cell transfusion in patients with severe sepsis. Crit Care Med (2007) 3.06
Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients. Crit Care Med (2006) 3.06
Epidemiology of sepsis in Germany: results from a national prospective multicenter study. Intensive Care Med (2007) 2.97
Challenges in end-of-life care in the ICU: statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003: executive summary. Crit Care Med (2004) 2.95
C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest (2003) 2.95
HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology (2002) 2.95
Microvascular endothelial injury and dysfunction during ischemic acute renal failure. Kidney Int (2002) 2.94
Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest (2008) 2.90
Methodologic issues in systematic reviews and meta-analyses. Clin Orthop Relat Res (2003) 2.90
Biomarkers of sepsis. Crit Care Med (2009) 2.88
Rationing critical care beds: a systematic review. Crit Care Med (2004) 2.86
The efficacy and safety of heparin in patients with sepsis: a systematic review and metaanalysis. Crit Care Med (2015) 2.85
Let us use the pulmonary artery catheter correctly and only when we need it. Crit Care Med (2005) 2.83
Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma (2010) 2.82
Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock. Crit Care Med (2009) 2.77
Payments for care at private for-profit and private not-for-profit hospitals: a systematic review and meta-analysis. CMAJ (2004) 2.76
Palliative sedation in dying patients: "we turn to it when everything else hasn't worked". JAMA (2005) 2.74