Published in J Mol Biol on December 20, 1993
Principles of protein-protein interactions. Proc Natl Acad Sci U S A (1996) 14.51
Structure of the cross-beta spine of amyloid-like fibrils. Nature (2005) 11.56
ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer. Mol Cell (2002) 4.79
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature (2010) 4.61
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature (2006) 3.21
Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science (2010) 3.03
Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle. Science (2010) 3.00
The juxtamembrane region of the EGF receptor functions as an activation domain. Mol Cell (2009) 2.90
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Nat Struct Mol Biol (2006) 2.85
Computational design of ligand-binding proteins with high affinity and selectivity. Nature (2013) 2.81
Influenza virus neuraminidase: structure, antibodies, and inhibitors. Protein Sci (1994) 2.81
Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure (2008) 2.79
Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies. Proc Natl Acad Sci U S A (2006) 2.51
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature (2011) 2.46
Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus. J Virol (2009) 2.39
Are protein-protein interfaces more conserved in sequence than the rest of the protein surface? Protein Sci (2004) 2.38
The molecular basis of TCR germline bias for MHC is surprisingly simple. Nat Immunol (2009) 2.34
Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science (2012) 2.33
Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins. Proc Natl Acad Sci U S A (1999) 2.32
The structural basis of 5' triphosphate double-stranded RNA recognition by RIG-I C-terminal domain. Structure (2010) 2.29
Molecular recognition of parathyroid hormone by its G protein-coupled receptor. Proc Natl Acad Sci U S A (2008) 2.27
Structural and kinetic basis for heightened immunogenicity of T cell vaccines. J Exp Med (2005) 2.22
Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. Cancer Cell (2008) 2.21
High-affinity single-domain binding proteins with a binary-code interface. Proc Natl Acad Sci U S A (2007) 2.18
ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor. Nature (2009) 2.08
Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35. Nat Struct Mol Biol (2010) 2.01
Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. EMBO J (2005) 1.98
Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization. Structure (2004) 1.97
Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci (2010) 1.95
Structural basis of respiratory syncytial virus neutralization by motavizumab. Nat Struct Mol Biol (2010) 1.89
Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Protein Sci (2008) 1.89
Structural recognition and functional activation of FcgammaR by innate pentraxins. Nature (2008) 1.88
An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proc Natl Acad Sci U S A (2007) 1.85
The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. Proc Natl Acad Sci U S A (2005) 1.84
Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature (2009) 1.83
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA. J Biol Chem (2009) 1.78
Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution. EMBO J (1997) 1.77
Recognition determinants of broadly neutralizing human antibodies against dengue viruses. Nature (2015) 1.72
Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling. Structure (2012) 1.68
Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature (2011) 1.67
Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease. J Virol (2004) 1.65
The importance of being tyrosine: lessons in molecular recognition from minimalist synthetic binding proteins. ACS Chem Biol (2009) 1.65
Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair. EMBO J (2004) 1.61
Structural and functional insights into RAGE activation by multimeric S100B. EMBO J (2007) 1.59
Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement. Proc Natl Acad Sci U S A (2011) 1.58
Structural analysis of CsoS1A and the protein shell of the Halothiobacillus neapolitanus carboxysome. PLoS Biol (2007) 1.57
Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels. J Biol Chem (2009) 1.56
Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. Structure (2012) 1.56
T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility. Immunity (2009) 1.55
Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol (2009) 1.55
Structure and stability of the ankyrin domain of the Drosophila Notch receptor. Protein Sci (2003) 1.54
Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope. Cell (2015) 1.51
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. Nat Chem Biol (2012) 1.50
Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase. J Virol (2007) 1.48
Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen. J Biol Chem (2009) 1.48
A survey of available tools and web servers for analysis of protein-protein interactions and interfaces. Brief Bioinform (2009) 1.47
The structural biology of protein aggregation diseases: Fundamental questions and some answers. Acc Chem Res (2006) 1.47
A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat Struct Mol Biol (2010) 1.47
Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc Natl Acad Sci U S A (2006) 1.47
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature (2008) 1.47
TCRs used in cancer gene therapy cross-react with MART-1/Melan-A tumor antigens via distinct mechanisms. J Immunol (2011) 1.46
A general binding mechanism for all human sulfatases by the formylglycine-generating enzyme. Proc Natl Acad Sci U S A (2005) 1.45
Free energy of burying hydrophobic residues in the interface between protein subunits. Proc Natl Acad Sci U S A (1998) 1.45
A dominant conformational role for amino acid diversity in minimalist protein-protein interfaces. J Mol Biol (2008) 1.45
Structural basis for the attachment of a paramyxoviral polymerase to its template. Proc Natl Acad Sci U S A (2004) 1.45
Transition states. Trapping a transition state in a computationally designed protein bottle. Science (2015) 1.44
Computer-aided antibody design. Protein Eng Des Sel (2012) 1.44
Modeling the Alzheimer Abeta17-42 fibril architecture: tight intermolecular sheet-sheet association and intramolecular hydrated cavities. Biophys J (2007) 1.44
AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation. Cell (2014) 1.43
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding. EMBO J (2007) 1.43
Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization. J Mol Biol (2007) 1.42
Design of a hyperstable 60-subunit protein icosahedron. Nature (2016) 1.42
A feature-based approach to modeling protein-protein interaction hot spots. Nucleic Acids Res (2009) 1.41
Design of protein function leaps by directed domain interface evolution. Proc Natl Acad Sci U S A (2008) 1.39
Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus. J Mol Biol (2011) 1.39
The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases. Biochemistry (2006) 1.38
Structure of a major antigenic site on the respiratory syncytial virus fusion glycoprotein in complex with neutralizing antibody 101F. J Virol (2010) 1.38
Protein-protein docking using region-based 3D Zernike descriptors. BMC Bioinformatics (2009) 1.38
Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Mol Cell (2010) 1.38
Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy. J Virol (2003) 1.37
Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides. J Biol Chem (2009) 1.36
Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists. Proc Natl Acad Sci U S A (2010) 1.36
Cavities and packing at protein interfaces. Protein Sci (1994) 1.34
The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction. Proc Natl Acad Sci U S A (2010) 1.34
Crystal structures of C4-dicarboxylate ligand complexes with sensor domains of histidine kinases DcuS and DctB. J Biol Chem (2008) 1.33
The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding. EMBO J (2009) 1.33
Structure and mechanism of a pentameric formate channel. Nat Struct Mol Biol (2009) 1.32
Crystal structure of an RNA aptamer bound to thrombin. RNA (2008) 1.32
Promiscuous substrate recognition in folding and assembly activities of the trigger factor chaperone. Cell (2009) 1.32
Structural basis and kinetics of inter- and intramolecular disulfide exchange in the redox catalyst DsbD. EMBO J (2004) 1.32
Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity. Protein Sci (2006) 1.31
Comparison of protein-protein interactions in serine protease-inhibitor and antibody-antigen complexes: implications for the protein docking problem. Protein Sci (1999) 1.30
An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2. Proc Natl Acad Sci U S A (2005) 1.30
Accurate design of co-assembling multi-component protein nanomaterials. Nature (2014) 1.29
Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling. Structure (2009) 1.29
Structure and kinetics of a transient antibody binding intermediate reveal a kinetic discrimination mechanism in antigen recognition. Proc Natl Acad Sci U S A (2005) 1.29
Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP. Nat Struct Mol Biol (2009) 1.29
Electrostatic contributions to protein-protein interactions: fast energetic filters for docking and their physical basis. Protein Sci (2001) 1.29
The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. Proc Natl Acad Sci U S A (2010) 1.28
Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution. Nature (1983) 5.56
Structure of the catalytic and antigenic sites in influenza virus neuraminidase. Nature (1983) 5.11
The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor. Proteins (1992) 3.44
Three-dimensional structure of a complex of antibody with influenza virus neuraminidase. Nature (1987) 3.26
Crystallographic structure studies of an IgG molecule and an Fc fragment. Nature (1976) 3.00
Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 A resolution. J Mol Biol (1991) 2.57
The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion. Structure (2001) 2.41
Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors. J Virol (1998) 2.40
Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family. Cell Death Differ (2007) 2.12
Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure (1998) 1.95
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands. Cell Death Differ (2008) 1.80
Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en. Virology (1995) 1.77
The structure of thermolysin: an electron density map at 2-3 A resolution. J Mol Biol (1972) 1.77
Influenza virus neuraminidase with hemagglutinin activity. Virology (1984) 1.73
Three-dimensional structure of neuraminidase of subtype N9 from an avian influenza virus. Proteins (1987) 1.69
Electrostatic complementarity at protein/protein interfaces. J Mol Biol (1997) 1.67
Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase. Protein Sci (1995) 1.61
Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants. J Mol Biol (1991) 1.49
Structure and diversity of influenza virus neuraminidase. Curr Top Microbiol Immunol (1985) 1.48
Structure of the human antibody molecule Kol (immunoglobulin G1): an electron density map at 5 A resolution. J Mol Biol (1976) 1.47
Structure of phaseolin at 2.2 A resolution. Implications for a common vicilin/legumin structure and the genetic engineering of seed storage proteins. J Mol Biol (1994) 1.47
Mutation in the influenza virus neuraminidase gene resulting in decreased sensitivity to the neuraminidase inhibitor 4-guanidino-Neu5Ac2en leads to instability of the enzyme. Virology (1996) 1.46
Antigenic structure and variation in an influenza virus N9 neuraminidase. J Virol (1987) 1.42
Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases. Proc Natl Acad Sci U S A (1997) 1.37
Three-dimensional structures of two plant beta-glucan endohydrolases with distinct substrate specificities. Proc Natl Acad Sci U S A (1994) 1.36
The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli. Structure (1994) 1.32
The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody. Structure (1994) 1.32
Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex. J Mol Biol (1992) 1.32
Structure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyase. J Mol Biol (1997) 1.28
Crystal structures of neuraminidase-antibody complexes. Cold Spring Harb Symp Quant Biol (1989) 1.26
The three-dimensional structure of the seed storage protein phaseolin at 3 A resolution. EMBO J (1990) 1.14
Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface. J Mol Biol (1992) 1.12
Crystallographic structural studies of a human Fc fragment. II. A complete model based on a Fourier map at 3.5 A resolution. Hoppe Seylers Z Physiol Chem (1976) 1.12
Bax activation by Bim? Cell Death Differ (2009) 1.08
Three-dimensional structure of thermolysin. Nat New Biol (1972) 1.05
Structure of an escape mutant of glycoprotein N2 neuraminidase of influenza virus A/Tokyo/3/67 at 3 A. J Mol Biol (1988) 1.04
Cloning, expression, and crystallization of the fusion protein of Newcastle disease virus. Virology (2001) 1.02
Distribution of sequence differences in influenza N9 neuraminidase of tern and whale viruses and crystallization of the whale neuraminidase complexed with antibodies. Virology (1987) 1.02
Analysis of inhibitor binding in influenza virus neuraminidase. Protein Sci (2001) 1.02
The structure determination of the variable portion of the Bence-Jones protein Au. Biophys Struct Mech (1975) 1.00
Crystal structure of the human Fab fragment Kol and its comparison with the intact Kol molecule. J Mol Biol (1978) 1.00
The disulphide bonds of an Asian influenza virus neuraminidase. FEBS Lett (1983) 0.97
Recombinant antineuraminidase single chain antibody: expression, characterization, and crystallization in complex with antigen. Proteins (1993) 0.94
Gene and protein sequence of an influenza neuraminidase with hemagglutinin activity. Virology (1985) 0.94
The structure of cucurbitin: subunit symmetry and organization in situ. Eur J Biochem (1980) 0.92
Crystal and molecular structure of the dimer of variable domains of the Bence-Jones protein ROY. J Mol Biol (1977) 0.92
CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13. Cell Death Differ (2006) 0.92
Crystallographic structural studies of a human Fc-fragment. I. An electron-density map at 4 A resolution and a partial model. Hoppe Seylers Z Physiol Chem (1976) 0.91
EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency. Cell Death Differ (2008) 0.89
Substrate, inhibitor, or antibody stabilizes the Glu 119 Gly mutant influenza virus neuraminidase. Virology (1998) 0.89
Three-dimensional structure of the Mcg IgG1 immunoglobulin. Mol Immunol (1983) 0.89
Shape and electrostatic complementarity at viral antigen-antibody complexes. Curr Top Microbiol Immunol (2001) 0.88
Rare earths as isomorphous calcium replacements for protein crystallography. Biochem Biophys Res Commun (1972) 0.88
Mobile Fc region in the Zie IgG2 cryoglobulin: comparison of crystals of the F(ab')2 fragment and the intact immunoglobulin. Biochemistry (1978) 0.87
Crystals of antibodies complexed with influenza virus neuraminidase show isosteric binding of antibody to wild-type and variant antigens. Virology (1987) 0.87
Three-dimensional structures of single-chain Fv-neuraminidase complexes. J Mol Biol (1998) 0.84
Letter: Preliminary x-ray data from well-ordered crystals of a human immunoglobulin G molecule. J Mol Biol (1974) 0.83
Crystallization of phaseolin from Phaseolus vulgaris. J Biol Chem (1983) 0.82
Symmetry, molecular weight and crystallographic data for sweet potato -amylase. J Mol Biol (1971) 0.82
Structure of thermolysin. Nat New Biol (1972) 0.81
Preliminary crystallographic data for a basic copper-containing protein from cucumber seedlings. J Mol Biol (1977) 0.81
The use of rotation and translation functions in the interpretation of low resolution electron density maps. J Mol Biol (1976) 0.80
Preliminary crystallographic data for a copper-containing protein, plastocyanin. J Mol Biol (1977) 0.79
Electron and X-ray diffraction studies of influenza neuraminidase complexed with monoclonal antibodies. J Mol Biol (1986) 0.79
Proceedings: X-ray diffraction analysis of immunoglobulin structure. Hoppe Seylers Z Physiol Chem (1976) 0.77
Subunit symmetry of tetrameric phosphorylase a. Biophys Struct Mech (1976) 0.75
Particle and crystal symmetry of Erysimum latent virus. J Mol Biol (1980) 0.75
X-ray studies on antibody fragments. FEBS Lett (1974) 0.75
Crystalline monoclonal fab fragment with specificity towards an influenza virus neuraminidase. J Mol Biol (1981) 0.75