Published in Science on September 29, 1995
Transition states. Trapping a transition state in a computationally designed protein bottle. Science (2015) 1.44
Distributed Drug Discovery, Part 1: linking academia and combinatorial chemistry to find drug leads for developing world diseases. J Comb Chem (2009) 1.43
Multiple event activation of a generic prodrug trigger by antibody catalysis. Proc Natl Acad Sci U S A (1999) 1.21
Chemical complementation: a reaction-independent genetic assay for enzyme catalysis. Proc Natl Acad Sci U S A (2002) 1.07
Evolution of the folding ability of proteins through functional selection. Proc Natl Acad Sci U S A (1997) 1.02
A method for directed evolution and functional cloning of enzymes. Proc Natl Acad Sci U S A (1998) 1.01
On the failure of de novo-designed peptides as biocatalysts. Proc Natl Acad Sci U S A (1996) 1.01
Identification and characterization of single chain anti-cocaine catalytic antibodies. J Mol Biol (2006) 0.99
Catalyst selection based on intermediate stability measured by mass spectrometry. Nat Chem (2010) 0.91
A general assay for antibody catalysis using acridone as a fluorescent tag. Proc Natl Acad Sci U S A (1996) 0.89
Analysis of highly disfavored processes through pathway-specific correlated fluorescence. Proc Natl Acad Sci U S A (1997) 0.89
Phage display of a catalytic antibody to optimize affinity for transition-state analog binding. Proc Natl Acad Sci U S A (1997) 0.87
A general kinetic approach to investigation of active-site availability in macromolecular catalysts. Biochem J (2000) 0.87
Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution. Proc Natl Acad Sci U S A (1996) 0.86
A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis. Proc Natl Acad Sci U S A (1998) 0.82
Comparison of DNA-hydrolyzing antibodies from the cerebrospinal fluid and serum of patients with multiple sclerosis. PLoS One (2014) 0.82
Multiple roles for ATP hydrolysis in nucleic acid modifying enzymes. EMBO J (2003) 0.82
Engineered proteins: redox properties and their applications. Antioxid Redox Signal (2012) 0.81
Structural evidence for a programmed general base in the active site of a catalytic antibody. Proc Natl Acad Sci U S A (2000) 0.81
Conformational isomerism can limit antibody catalysis. J Biol Chem (2008) 0.81
A structural basis for the activity of retro-Diels-Alder catalytic antibodies: evidence for a catalytic aromatic residue. Proc Natl Acad Sci U S A (2002) 0.81
Changes in structure and dynamics of the Fv fragment of a catalytic antibody upon binding of inhibitor. Protein Sci (2003) 0.80
Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases. Nat Chem (2011) 0.80
Biochemical characterization of selenium-containing catalytic antibody as a cytosolic glutathione peroxidase mimic. Biochem J (1998) 0.80
Bringing biological solutions to chemical problems. Proc Natl Acad Sci U S A (1998) 0.79
A human germ line antibody light chain with hydrolytic properties associated with multimerization status. J Biol Chem (2009) 0.79
Comparison of antibodies hydrolyzing myelin basic protein from the cerebrospinal fluid and serum of patients with multiple sclerosis. PLoS One (2014) 0.78
An active immunization approach to generate protective catalytic antibodies. Biochem J (2001) 0.77
A glycosidase antibody elicited against a chair-like transition state analog by in vitro immunization. Proc Natl Acad Sci U S A (1998) 0.76
DNA-hydrolysing activity of IgG antibodies from the sera of patients with schizophrenia. Open Biol (2015) 0.75
Comparison of Antibodies with Amylase Activity from Cerebrospinal Fluid and Serum of Patients with Multiple Sclerosis. PLoS One (2016) 0.75
Mechanism-dependent selection of immunoglobulin gene library for obtaining covalent biocatalysts. Dokl Biochem Biophys (2007) 0.75
Nucleotide sequence of Moloney murine leukaemia virus. Nature (1981) 24.82
Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol Cell Biol (1988) 13.78
The structure of an antigenic determinant in a protein. Cell (1984) 10.85
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature (1996) 8.99
Immunogenic structure of the influenza virus hemagglutinin. Cell (1982) 8.93
Mitotic misregulation and human aging. Science (2000) 8.47
Radioiodination of proteins in single polyacrylamide gel slices. Tryptic peptide analysis of all the major members of complex multicomponent systems using microgram quantities of total protein. J Biol Chem (1977) 8.03
The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med (1967) 6.81
Biochemical evidence that MCF murine leukemia viruses are envelope (env) gene recombinants. Proc Natl Acad Sci U S A (1977) 6.80
A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. Proc Natl Acad Sci U S A (1991) 6.13
Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc Natl Acad Sci U S A (1991) 5.94
Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science (1989) 5.73
Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence. Nature (1982) 5.50
Tapping the immunological repertoire to produce antibodies of predetermined specificity. Nature (1982) 5.11
Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition. Proc Natl Acad Sci U S A (1983) 4.56
Chemical synthesis of a polypeptide predicted from nucleotide sequence allows detection of a new retroviral gene product. Nature (1980) 4.35
Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: virion associated and differentiation antigens encoded by a multi-gene family. Nature (1977) 4.31
Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proc Natl Acad Sci U S A (1981) 4.26
The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. Nature (1984) 4.05
Shwartzman reaction after human renal homotransplantation. N Engl J Med (1968) 4.05
Encoded combinatorial chemistry. Proc Natl Acad Sci U S A (1992) 4.00
Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes. Science (1995) 3.82
Endogenous oncornaviral gene expression in adult and fetal mice: quantitative, histologic, and physiologic studies of the major viral glycorprotein, gp70. J Exp Med (1976) 3.51
Sequence-specific antibodies show that maturation of Moloney leukemia virus envelope polyprotein involves removal of a COOH-terminal peptide. Proc Natl Acad Sci U S A (1981) 3.13
Nucleotide sequence of Moloney leukemia virus: 3' end reveals details of replications, analogy to bacterial transposons, and an unexpected gene. Proc Natl Acad Sci U S A (1980) 2.90
Antibody catalysis of the oxidation of water. Science (2001) 2.74
Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome. J Virol (1986) 2.71
Chemical characterization of a family of brain lipids that induce sleep. Science (1995) 2.69
Chemical basis of antigenic variation in foot-and-mouth disease virus. Nature (1984) 2.52
Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. Proc Natl Acad Sci U S A (1991) 2.42
Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum. J Exp Med (1966) 2.42
An Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA5) partly encoded by the transformation-associated Bam WYH region of EBV DNA: preferential expression in lymphoblastoid cell lines. Proc Natl Acad Sci U S A (1986) 2.42
Catalytic antibodies. Science (1986) 2.41
The oncornavirus glycoprotein gp69/71: a constituent of the surface of normal and malignant thymocytes. J Exp Med (1975) 2.37
Folding of immunogenic peptide fragments of proteins in water solution. II. The nascent helix. J Mol Biol (1988) 2.33
Folding of immunogenic peptide fragments of proteins in water solution. I. Sequence requirements for the formation of a reverse turn. J Mol Biol (1988) 2.30
Immune versus natural selection: antibody aldolases with enzymic rates but broader scope. Science (1997) 2.27
Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding. Biochemistry (1988) 2.21
Immunopathogenicity and oncogenicity of murine leukemia viruses. I. Induction of immunologic disease and lymphoma in (BALB-c times NZB)F1 mice by Scripps leukemia virus. J Exp Med (1974) 2.12
Gene expression in synchronized lymphocytes: studies on the control of synthesis of immunoglobulin polypeptides. J Cell Physiol (1971) 2.11
In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library. Proc Natl Acad Sci U S A (1992) 2.08
Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees. Proc Natl Acad Sci U S A (1983) 2.00
Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A. Science (1990) 1.98
Common 82-nucleotide sequence unique to brain RNA. Proc Natl Acad Sci U S A (1982) 1.98
Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition. Proc Natl Acad Sci U S A (1985) 1.97
Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: construction of a heavy chain variable region-specific cDNA library. Proc Natl Acad Sci U S A (1989) 1.96
Identifier sequences are transcribed specifically in brain. Nature (1984) 1.95
Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem. Proc Natl Acad Sci U S A (1992) 1.93
Antibodies that react with predetermined sites on proteins. Science (1983) 1.87
Antibody catalysis of a disfavored chemical transformation. Science (1993) 1.82
Chemistry of antibody binding to a protein. Science (1987) 1.82
Folding of peptide fragments comprising the complete sequence of proteins. Models for initiation of protein folding. I. Myohemerythrin. J Mol Biol (1992) 1.79
Antibodies have the intrinsic capacity to destroy antigens. Proc Natl Acad Sci U S A (2000) 1.79
Antibodies of predetermined specificity in biology and medicine. Adv Immunol (1984) 1.77
Brain-specific genes have identifier sequences in their introns. Proc Natl Acad Sci U S A (1984) 1.71
Blue-fluorescent antibodies. Science (2000) 1.71
Properties of an oncornavirus glycoprotein: evidence for its presence on the surface of virions and infected cells. Virology (1973) 1.71
The induction of acute glomerulonephritis in rabbits with soluble antigens isolated from normal homologous and autologous urine. J Immunol (1968) 1.68
Karyotypic, virologic, and immunologic analyses of two continuous lymphocyte lines established from New Zealand black mice: possible relationship of chromosomal mosaicism to autoimmunity. Proc Natl Acad Sci U S A (1972) 1.65
Antibodies to peptides detect new hepatitis B antigen: serological correlation with hepatocellular carcinoma. Science (1985) 1.63
Production of macrophage migration inhibition factor by continuous cell lines. J Exp Med (1972) 1.62
Isolation and characterization of plasma membrane associated immunoglobulin from cultured human diploid lymphocytes. J Mol Biol (1973) 1.56
Site-directed serology with synthetic peptides representing the large glycoprotein G of respiratory syncytial virus. Proc Natl Acad Sci U S A (1987) 1.55
Mechanisms of antibody binding to a protein. Science (1987) 1.55
Cell cycle-dependent immune lysis of Moloney virus-transformed lymphocytes: presence of viral antigen, accessibility to antibody, and complement activation. Proc Natl Acad Sci U S A (1971) 1.53
Developmentally regulated proteins of the plasma membrane of Dictyostelium discoideum. The carbohydrate-binding protein. J Mol Biol (1976) 1.53
Antibodies to chemically synthesized peptides predicted from DNA sequences as probes of gene expression. Cell (1981) 1.52
Structural markers on core protein p30 of murine leukemia virus: functional correlation with Fv-1 tropism. Proc Natl Acad Sci U S A (1978) 1.51
The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. J Cell Biol (1997) 1.51
Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes. Proc Natl Acad Sci U S A (1984) 1.50
Identification of a cell surface glycoprotein involved in cell aggregation in D. discoideum. Cell (1979) 1.49
Differential expression of two distinct xenotropic viruses in NZB mice. Clin Immunol Immunopathol (1980) 1.48
Human combinatorial antibody libraries to hepatitis B surface antigen. Proc Natl Acad Sci U S A (1992) 1.43
Membrane-associated DNA in the cytoplasm of diploid human lymphocytes. Proc Natl Acad Sci U S A (1971) 1.43
Biological, immunological, and biochemical evidence that HIX virus is a recombinant between Moloney leukemia virus and a murine xenotropic C type virus. Virology (1978) 1.42
The atomic mobility component of protein antigenicity. Annu Rev Immunol (1985) 1.40
Spontaneous glomerulonephritis in sheep. Lab Invest (1966) 1.39
Synthetic peptide immunogens as vaccines. Annu Rev Microbiol (1983) 1.39
Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis. Proc Natl Acad Sci U S A (1998) 1.37
The chemistry and mechanism of antibody binding to protein antigens. Adv Immunol (1988) 1.37
On signal sequence polymorphisms and diseases of distribution. Proc Natl Acad Sci U S A (1996) 1.35
Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein alpha-helix. Proc Natl Acad Sci U S A (1987) 1.34
The immunodominant site of a synthetic immunogen has a conformational preference in water for a type-II reverse turn. Nature (1986) 1.33
Physical properties of cytoplasmic membrane-associated DNA. J Mol Biol (1973) 1.31
A stereospecific cyclization catalyzed by an antibody. Science (1987) 1.31
Folding of peptide fragments comprising the complete sequence of proteins. Models for initiation of protein folding. II. Plastocyanin. J Mol Biol (1992) 1.29
Relationship between the oncornavirus gene product gp70 and a major protein secretion of the mouse genital tract. Nature (1976) 1.28
An immunological study of the fates of nuclear and nucleolar macromoleculus during the cell cycle. J Mol Biol (1972) 1.27
Synthesis of plasma membrane-associated and secretory immunoglobulin in diploid lymphocytes. J Exp Med (1972) 1.27
Metalloantibodies. Science (1990) 1.27
Synthetic idiotypes: the third hypervariable region of murine anti-dextran antibodies. Cell (1983) 1.26
Mutants of Dictyostelium discoideum blocked in expression of all members of the developmentally regulated discoidin multigene family. Cell (1983) 1.26
Control of the exo and endo pathways of the Diels-Alder reaction by antibody catalysis. Science (1993) 1.26
Mimicking the alloantigenicity of proteins with chemically synthesized peptides differing in single amino acids. Nature (1984) 1.26
In vitro construction of a B-tropic virus by recombination: B-tropism is a cryptic phenotype of xenotropic murine retroviruses. Proc Natl Acad Sci U S A (1980) 1.25
Selection of human anti-hapten antibodies from semisynthetic libraries. Gene (1993) 1.23
Multiple event activation of a generic prodrug trigger by antibody catalysis. Proc Natl Acad Sci U S A (1999) 1.21
The physical basis for induction of protein-reactive antipeptide antibodies. Annu Rev Biophys Biophys Chem (1988) 1.21
Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket. Proc Natl Acad Sci U S A (1990) 1.20
Induction of an antibody that catalyzes the hydrolysis of an amide bond. Science (1988) 1.19