Published in EMBO Rep on July 01, 2002
Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. Mol Cell Biol (2005) 1.46
Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC. J Biol Chem (2008) 0.95
Temperature-sensitive protein-DNA dimerizers. Proc Natl Acad Sci U S A (2005) 0.92
Altered regulation of beta-like globin genes by a redesigned erythroid transcription factor. Exp Hematol (2007) 0.86
Selection systems based on dominant-negative transcription factors for precise genetic engineering. Nucleic Acids Res (2010) 0.76
The hallmarks of cancer. Cell (2000) 113.05
Genome-wide location and function of DNA binding proteins. Science (2000) 31.25
Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A. Science (1991) 15.97
Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res (1998) 8.95
Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol Cell (2002) 8.59
The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu Rev Cell Dev Biol (2000) 8.47
Design and selection of novel Cys2His2 zinc finger proteins. Annu Rev Biochem (2001) 7.79
DNA recognition by Cys2His2 zinc finger proteins. Annu Rev Biophys Biomol Struct (2000) 6.61
Oncogenic transcription factors in the human acute leukemias. Science (1997) 6.45
RNAi: nature abhors a double-strand. Curr Opin Genet Dev (2002) 5.74
Zinc finger phage: affinity selection of fingers with new DNA-binding specificities. Science (1994) 5.70
Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature (1998) 5.63
Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature (1998) 5.30
Life without white fat: a transgenic mouse. Genes Dev (1998) 5.08
A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science (1997) 4.93
Engineering polydactyl zinc-finger transcription factors. Nat Biotechnol (2002) 4.40
Toward rules relating zinc finger protein sequences and DNA binding site preferences. Proc Natl Acad Sci U S A (1992) 4.15
Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions. Proc Natl Acad Sci U S A (1994) 4.12
Positive and negative regulation of endogenous genes by designed transcription factors. Proc Natl Acad Sci U S A (2000) 3.92
Molecular recognition of DNA by small molecules. Bioorg Med Chem (2001) 3.69
Expressing the human genome. Nature (2001) 3.45
GATA-1 binding sites mapped in the beta-globin locus by using mammalian chIp-chip analysis. Proc Natl Acad Sci U S A (2002) 3.41
Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38
Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem (2001) 3.35
Enhanceosomes. Curr Opin Genet Dev (2001) 3.30
In vitro selection of zinc fingers with altered DNA-binding specificity. Biochemistry (1994) 3.18
PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis. Genes Dev (2002) 3.17
Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nat Genet (1998) 2.97
Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene. J Biol Chem (2000) 2.85
Functional significance of histone deacetylase diversity. Curr Opin Genet Dev (2001) 2.79
Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase. J Natl Cancer Inst (1998) 2.64
Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator. Proc Natl Acad Sci U S A (1996) 2.16
The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. J Biol Chem (1996) 2.13
Transcriptional regulation of mammalian genes in vivo. A tale of two templates. J Biol Chem (1997) 2.11
Deciphering gene expression regulatory networks. Curr Opin Genet Dev (2002) 2.09
Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia. J Clin Invest (2001) 2.00
Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human. Nucleic Acids Res (1998) 1.85
Transcriptional coregulators in development. Science (1999) 1.72
The many faces of chromatin remodeling: SWItching beyond transcription. Cell (2001) 1.71
Levels of fetal hemoglobin necessary for treatment of sickle cell disease. N Engl J Med (1988) 1.56
Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins. Curr Opin Biotechnol (2001) 1.52
An embarrassment of niches: the many covalent modifications of histones in transcriptional regulation. Oncogene (2001) 1.46
Transcription therapy for cancer. Oncogene (2001) 1.40
Activation of gene expression by small molecule transcription factors. Proc Natl Acad Sci U S A (2000) 1.40
The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin. Cell (1999) 1.40
Regulation of the MDR1 gene by transcriptional repressors selected using peptide combinatorial libraries. Mol Pharmacol (2000) 1.38
Chemically regulated zinc finger transcription factors. J Biol Chem (2000) 1.29
Nuclear visions: functional flexibility from structural instability. Cell (2001) 1.28
Nucleosome binding by the constitutive transcription factor Sp1. J Biol Chem (1994) 1.23
Zinc finger proteins as designer transcription factors. J Biol Chem (2000) 1.16
Nucleosome positioning by human Alu elements in chromatin. J Biol Chem (1995) 1.15
A necessary good: nuclear hormone receptors and their chromatin templates. Mol Endocrinol (2001) 1.13
The theory of APL. Oncogene (2001) 1.12
Advances in zinc finger engineering. Curr Opin Struct Biol (2000) 1.11
Perturbation of nucleosome structure by the erythroid transcription factor GATA-1. J Mol Biol (1998) 1.10
Synthesis, analysis, purification, and intracellular delivery of peptide nucleic acids. Methods (2001) 1.08
Fusion genes in solid tumors. Semin Cancer Biol (1999) 1.08
Understanding nuclear receptor function: from DNA to chromatin to the interphase nucleus. Prog Nucleic Acid Res Mol Biol (2001) 1.05
Sequence-specific targeting of duplex DNA by peptide nucleic acids via triplex strand invasion. Methods (2001) 1.02
Molecular basis of pituitary dysfunction in mouse and human. Mamm Genome (2001) 0.95
Combining structure-based design with phage display to create new Cys(2)His(2) zinc finger dimers. Structure (2000) 0.91
Nucleoprotein architecture of the albumin transcriptional enhancer. Semin Cell Biol (1995) 0.87
Biotechnologies and therapeutics: chromatin as a target. Curr Opin Genet Dev (2002) 0.87
Transcription and chromatin converge: lessons from yeast genetics. Curr Opin Genet Dev (2001) 0.86
Resistance to thyroid hormone. Horm Res (1997) 0.84
A feel for the template: zinc finger protein transcription factors and chromatin. Biochem Cell Biol (2002) 0.81
Gene targeting comes to top-down drug screens. Trends Biotechnol (2002) 0.77
Design of dominant negatives to bHLHZip proteins that inhibit DNA binding. Curr Top Microbiol Immunol (1997) 0.76
A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
Genome editing with engineered zinc finger nucleases. Nat Rev Genet (2010) 18.88
An improved zinc-finger nuclease architecture for highly specific genome editing. Nat Biotechnol (2007) 17.80
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature (2005) 15.83
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol (2008) 14.75
Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nat Biotechnol (2008) 14.20
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature (2010) 13.82
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol (2009) 12.40
Knockout rats via embryo microinjection of zinc-finger nucleases. Science (2009) 12.33
Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol (2011) 11.76
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest (2008) 10.74
A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell (2011) 10.50
Targeted genome editing across species using ZFNs and TALENs. Science (2011) 9.84
Tenets of PTEN tumor suppression. Cell (2008) 8.61
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell (2005) 7.75
Pten dose dictates cancer progression in the prostate. PLoS Biol (2003) 7.62
The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol (2012) 7.32
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nat Genet (2009) 7.26
Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell (2011) 7.02
Does the ribosome translate cancer? Nat Rev Cancer (2003) 6.89
A rapid and general assay for monitoring endogenous gene modification. Methods Mol Biol (2010) 6.77
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases. Proc Natl Acad Sci U S A (2008) 6.59
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56
Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell (2007) 6.52
Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol (2007) 5.79
Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62
Essential role of Plzf in maintenance of spermatogonial stem cells. Nat Genet (2004) 5.55
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell (2007) 5.20
In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell (2011) 5.19
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med (2004) 5.01
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood (2002) 4.88
Nucleophosmin and cancer. Nat Rev Cancer (2006) 4.82
In vivo genome editing restores haemostasis in a mouse model of haemophilia. Nature (2011) 4.81
Precise genome modification in the crop species Zea mays using zinc-finger nucleases. Nature (2009) 4.71
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell (2011) 4.49
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell (2009) 4.30
Subtle variations in Pten dose determine cancer susceptibility. Nat Genet (2010) 4.19
Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. Sci Signal (2010) 4.15
The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol (2008) 4.15
Role of nucleophosmin in embryonic development and tumorigenesis. Nature (2005) 4.09
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. Dev Cell (2005) 3.96
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res (2010) 3.94
SUMO modification of Huntingtin and Huntington's disease pathology. Science (2004) 3.85
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development (2004) 3.75
Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. Nature (2005) 3.75
PML targeting eradicates quiescent leukaemia-initiating cells. Nature (2008) 3.75
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell (2011) 3.71
Identification of a tumour suppressor network opposing nuclear Akt function. Nature (2006) 3.68
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature (2008) 3.53
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev (2008) 3.50
A continuum model for tumour suppression. Nature (2011) 3.48
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest (2010) 3.47
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med (2012) 3.33
The role of PML in tumor suppression. Cell (2002) 3.28
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature (2012) 3.24
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest (2009) 3.23
The mechanisms of PML-nuclear body formation. Mol Cell (2006) 3.22
PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science (2010) 3.21
Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science (2003) 3.18
Loss of the tumor suppressor PML in human cancers of multiple histologic origins. J Natl Cancer Inst (2004) 3.17
PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis. Genes Dev (2002) 3.17
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci U S A (2010) 3.13
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature (2010) 3.09
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood (2009) 3.02
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature (2006) 3.01
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature (2007) 3.01
Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction. Nat Cell Biol (2009) 2.97
A CK2-dependent mechanism for degradation of the PML tumor suppressor. Cell (2006) 2.95
Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science (2007) 2.92
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol (2009) 2.91
Cytoplasmic PML function in TGF-beta signalling. Nature (2004) 2.89
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell (2012) 2.87
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation. Nat Med (2008) 2.85
Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells. Nat Cell Biol (2011) 2.79
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice. Genes Dev (2006) 2.76
Pro-senescence therapy for cancer treatment. Nat Rev Cancer (2011) 2.75
PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop. Mol Cell (2008) 2.66
Cancer metabolism: fatty acid oxidation in the limelight. Nat Rev Cancer (2013) 2.59
Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discov (2012) 2.53
Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors. Cancer Cell (2003) 2.53
A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res (2006) 2.50
PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat Cell Biol (2004) 2.45
PML is a direct p53 target that modulates p53 effector functions. Mol Cell (2004) 2.40
Targeted transgene integration in plant cells using designed zinc finger nucleases. Plant Mol Biol (2008) 2.40
Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell (2012) 2.39
The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation. Cell Stem Cell (2013) 2.33
Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects. J Virol (2003) 2.33
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. Nat Genet (2013) 2.29
Plzf regulates germline progenitor self-renewal by opposing mTORC1. Cell (2010) 2.29
Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases. Biotechnol Bioeng (2010) 2.23
DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation. PLoS Genet (2011) 2.22
Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nat Neurosci (2010) 2.17
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol (2002) 2.15
TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A (2009) 2.13
Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments. Proc Natl Acad Sci U S A (2013) 2.13
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nat Med (2007) 2.12
Causality and Chance in the Development of Cancer. N Engl J Med (2015) 2.10
mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. Neoplasia (2005) 2.04
PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. Gastroenterology (2002) 2.03
Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression. Genes Dev (2005) 1.99