Published in J Biol Chem on July 10, 2002
HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells. PLoS Pathog (2007) 1.90
Protein acrobatics in pairs--dimerization via domain swapping. Curr Opin Struct Biol (2009) 1.74
Structural basis of the anti-HIV activity of the cyanobacterial Oscillatoria Agardhii agglutinin. Structure (2011) 1.57
HIV-1 infection of human penile explant tissue and protection by candidate microbicides. AIDS (2009) 1.49
Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin. Antimicrob Agents Chemother (2003) 1.21
Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes. J Virol (2006) 1.21
Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A. J Virol (2005) 1.13
Solution and crystal structures of a sugar binding site mutant of cyanovirin-N: no evidence of domain swapping. Structure (2008) 1.13
Algal lectins as potential HIV microbicide candidates. Mar Drugs (2012) 1.08
Novel fold and carbohydrate specificity of the potent anti-HIV cyanobacterial lectin from Oscillatoria agardhii. J Biol Chem (2010) 1.06
Identification of the optimal DC-SIGN binding site on human immunodeficiency virus type 1 gp120. J Virol (2007) 1.05
Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope. Antimicrob Agents Chemother (2010) 1.05
High-mannose-specific deglycosylation of HIV-1 gp120 induced by resistance to cyanovirin-N and the impact on antibody neutralization. Virology (2007) 1.05
Microvirin, a novel alpha(1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile. J Biol Chem (2010) 1.04
HIV entry inhibitors and their potential in HIV therapy. Med Res Rev (2009) 1.04
The novel fold of scytovirin reveals a new twist for antiviral entry inhibitors. J Mol Biol (2007) 1.02
Rapid sampling of molecular motions with prior information constraints. PLoS Comput Biol (2009) 0.99
Structure-function analysis of a CVNH-LysM lectin expressed during plant infection by the rice blast fungus Magnaporthe oryzae. Structure (2011) 0.97
Structural insights into the anti-HIV activity of the Oscillatoria agardhii agglutinin homolog lectin family. J Biol Chem (2012) 0.94
Solution and crystal molecular dynamics simulation study of m4-cyanovirin-N mutants complexed with di-mannose. Biophys J (2009) 0.94
Conformational gating of dimannose binding to the antiviral protein cyanovirin revealed from the crystal structure at 1.35 A resolution. Protein Sci (2008) 0.93
Tracing conformational changes in proteins. BMC Struct Biol (2010) 0.92
Domain swapping proceeds via complete unfolding: a 19F- and 1H-NMR study of the Cyanovirin-N protein. J Am Chem Soc (2012) 0.92
Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family. J Antimicrob Chemother (2014) 0.90
HIV-1 neutralization profile and plant-based recombinant expression of actinohivin, an Env glycan-specific lectin devoid of T-cell mitogenic activity. PLoS One (2010) 0.87
The role of individual carbohydrate-binding sites in the function of the potent anti-HIV lectin griffithsin. Mol Pharm (2012) 0.87
Sugar-binding proteins potently inhibit dendritic cell human immunodeficiency virus type 1 (HIV-1) infection and dendritic-cell-directed HIV-1 transfer. J Virol (2005) 0.87
A designed chimeric cyanovirin-N homolog lectin: structure and molecular basis of sucrose binding. Proteins (2009) 0.86
High mannose-binding lectin with preference for the cluster of alpha1-2-mannose from the green alga Boodlea coacta is a potent entry inhibitor of HIV-1 and influenza viruses. J Biol Chem (2011) 0.86
Designed oligomers of cyanovirin-N show enhanced HIV neutralization. Proc Natl Acad Sci U S A (2011) 0.86
New carbohydrate specificity and HIV-1 fusion blocking activity of the cyanobacterial protein MVL: NMR, ITC and sedimentation equilibrium studies. J Mol Biol (2004) 0.85
Computational models explain the oligosaccharide specificity of cyanovirin-N. Protein Sci (2008) 0.84
Imidazolium cation supported solution-phase assembly of homolinear alpha(1-->6)-linked octamannoside: an efficient alternate approach for oligosaccharide synthesis. J Org Chem (2009) 0.84
NMR solution structure of a cyanovirin homolog from wheat head blight fungus. Proteins (2011) 0.82
Current progress and challenges in HIV gene therapy. Future Virol (2011) 0.82
Different 3D domain-swapped oligomeric cyanovirin-N structures suggest trapped folding intermediates. Proc Natl Acad Sci U S A (2013) 0.82
SIMS: a hybrid method for rapid conformational analysis. PLoS One (2013) 0.80
Carbohydrate recognition by the antiviral lectin cyanovirin-N. J Am Chem Soc (2012) 0.79
Insights into Protein Sequence and Structure-Derived Features Mediating 3D Domain Swapping Mechanism using Support Vector Machine Based Approach. Bioinform Biol Insights (2010) 0.79
Unprecedented glycosidase activity at a lectin carbohydrate-binding site exemplified by the cyanobacterial lectin MVL. J Am Chem Soc (2009) 0.78
A flexible docking scheme efficiently captures the energetics of glycan-cyanovirin binding. Biophys J (2014) 0.78
How a plant lectin recognizes high mannose oligosaccharides. Plant Physiol (2007) 0.77
Fluorinated carbohydrates as lectin ligands: dissecting glycan-cyanovirin interactions by using 19F NMR spectroscopy. Chemistry (2013) 0.77
Sweet entanglements--protein:glycan interactions in two HIV-inactivating lectin families. Biopolymers (2012) 0.76
Structural insights into the specific anti-HIV property of actinohivin: structure of its complex with the α(1-2)mannobiose moiety of gp120. Acta Crystallogr D Biol Crystallogr (2012) 0.75
Structure and Glycan Binding of a New Cyanovirin-N Homolog. J Biol Chem (2016) 0.75
Linker-extended native cyanovirin-N facilitates PEGylation and potently inhibits HIV-1 by targeting the glycan ligand. PLoS One (2014) 0.75
The Tetrameric Plant Lectin BanLec Neutralizes HIV through Bidentate Binding to Specific Viral Glycans. Structure (2017) 0.75
Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins. Chembiochem (2017) 0.75
Stereochemical restraints revisited: how accurate are refinement targets and how much should protein structures be allowed to deviate from them? Acta Crystallogr D Biol Crystallogr (2007) 4.51
Improved molecular replacement by density- and energy-guided protein structure optimization. Nature (2011) 2.74
Exploring the structural diversity of mammalian carbohydrates ("glycospace") by statistical databank analysis. ACS Chem Biol (2007) 2.42
Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria. Nature (2002) 2.31
Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions. Chem Biol (2004) 2.22
Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models. AIDS Res Hum Retroviruses (2004) 2.22
Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding. Structure (2006) 2.16
Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. J Biol Chem (2004) 2.07
A crystallographic study of bright far-red fluorescent protein mKate reveals pH-induced cis-trans isomerization of the chromophore. J Biol Chem (2008) 1.98
Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells. Chem Biol (2008) 1.95
Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaques. AIDS Res Hum Retroviruses (2003) 1.92
The use of carbohydrate microarrays to study carbohydrate-cell interactions and to detect pathogens. Chem Biol (2004) 1.91
Potentiation of fibroblast growth factor activity by synthetic heparin oligosaccharide glycodendrimers. Chem Biol (2007) 1.89
Continuous-flow synthesis of the anti-malaria drug artemisinin. Angew Chem Int Ed Engl (2012) 1.85
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat Struct Mol Biol (2009) 1.84
Molecular replacement with pseudosymmetry and model dissimilarity: a case study. Acta Crystallogr D Biol Crystallogr (2006) 1.80
Structural basis for the substrate specificity of tobacco etch virus protease. J Biol Chem (2002) 1.72
Synthetic GPI array to study antitoxic malaria response. Nat Chem Biol (2008) 1.67
Microreactors as tools for synthetic chemists-the chemists' round-bottomed flask of the 21st century? Chemistry (2006) 1.56
Preparation and use of microarrays containing synthetic heparin oligosaccharides for the rapid analysis of heparin-protein interactions. Chemistry (2006) 1.54
Neamphamide A, a new HIV-inhibitory depsipeptide from the Papua New Guinea marine sponge Neamphius huxleyi. J Nat Prod (2004) 1.54
Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase. Nat Struct Biol (2003) 1.54
HIVdb: a database of the structures of human immunodeficiency virus protease. Proteins (2002) 1.51
Structural basis for inhibition of translation by the tumor suppressor Pdcd4. Mol Cell Biol (2006) 1.49
Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides. Nucleic Acids Res (2006) 1.47
Deposition of structural data redux. Acta Crystallogr D Biol Crystallogr (2007) 1.41
Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI. RNA (2005) 1.40
Chemical approaches to define the structure-activity relationship of heparin-like glycosaminoglycans. Chem Biol (2005) 1.39
Profiling heparin-chemokine interactions using synthetic tools. ACS Chem Biol (2007) 1.38
Probing protein-carbohydrate interactions with microarrays of synthetic oligosaccharides. Chembiochem (2004) 1.38
The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures. Structure (2002) 1.37
A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Biochemistry (2003) 1.37
Total synthesis of antigen bacillus anthracis tetrasaccharide--creation of an anthrax vaccine candidate. Angew Chem Int Ed Engl (2005) 1.36
The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression. Biochim Biophys Acta (2005) 1.35
Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. J Biol Chem (2008) 1.35
Microarrays of synthetic heparin oligosaccharides. J Am Chem Soc (2006) 1.35
Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity. Structure (2010) 1.33
The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site. J Biol Chem (2003) 1.33
Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases. Structure (2004) 1.32
Tools for glycomics: mapping interactions of carbohydrates in biological systems. Chembiochem (2004) 1.32
Multisite and multivalent binding between cyanovirin-N and branched oligomannosides: calorimetric and NMR characterization. Chem Biol (2002) 1.32
Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate. PLoS One (2011) 1.30
Modular synthesis of heparin oligosaccharides. Chemistry (2003) 1.30
Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus. Antiviral Res (2003) 1.29
Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation. Structure (2009) 1.28
The affinity of the FimH fimbrial adhesin is receptor-driven and quasi-independent of Escherichia coli pathotypes. Mol Microbiol (2006) 1.28
Natural cytotoxicity receptors NKp30, NKp44 and NKp46 bind to different heparan sulfate/heparin sequences. J Proteome Res (2009) 1.27
Piecing together the structure of retroviral integrase, an important target in AIDS therapy. FEBS J (2009) 1.27
1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors. Chembiochem (2005) 1.27
Numerology versus reality: a voice in a recent dispute. Acta Crystallogr D Biol Crystallogr (2007) 1.26
Asymmetric reactions in continuous flow. Beilstein J Org Chem (2009) 1.23
Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. PLoS Pathog (2010) 1.23
Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin. Antimicrob Agents Chemother (2003) 1.21
Automated synthesis of the tumor-associated carbohydrate antigens Gb-3 and Globo-H: incorporation of alpha-galactosidic linkages. J Am Chem Soc (2007) 1.21
Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin. Proteins (2007) 1.20
Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii. Eukaryot Cell (2009) 1.20
Anti-carbohydrate antibodies for the detection of anthrax spores. Angew Chem Int Ed Engl (2006) 1.19
XPS and SPR analysis of glycoarray surface density. Langmuir (2009) 1.18
A family portrait of the RIO kinases. J Biol Chem (2005) 1.17
Retroviral proteases. Genome Biol (2002) 1.17
Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins. J Biol Chem (2006) 1.17
Glycomics, glycoproteomics and the immune system. Curr Opin Chem Biol (2012) 1.17
Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. ACS Chem Biol (2008) 1.16
A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa. Mol Microbiol (2006) 1.16
Carbohydrate arrays as tools for research and diagnostics. Chem Soc Rev (2008) 1.15
Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition. J Mol Biol (2005) 1.15
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. J Virol (2009) 1.15
Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41. PLoS Pathog (2010) 1.14
Structural characterization of B and non-B subtypes of HIV-protease: insights into the natural susceptibility to drug resistance development. J Mol Biol (2007) 1.14
Proteins that bind high-mannose sugars of the HIV envelope. Prog Biophys Mol Biol (2005) 1.14
Highly efficient continuous flow reactions using singlet oxygen as a "green" reagent. Org Lett (2011) 1.13
Structure and activity of the atypical serine kinase Rio1. FEBS J (2005) 1.12
In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots. J Am Chem Soc (2009) 1.12
Structural studies of algal lectins with anti-HIV activity. Acta Biochim Pol (2006) 1.10
Synthesis of a sialic acid alpha(2-3) galactose building block and its use in a linear synthesis of sialyl Lewis X. Org Lett (2007) 1.10
Oligosaccharide synthesis in microreactors. Org Lett (2007) 1.10
Carbohydrate arrays as tools for glycomics. Angew Chem Int Ed Engl (2002) 1.10
Atomic-resolution crystal structure of the proteolytic domain of Archaeoglobus fulgidus lon reveals the conformational variability in the active sites of lon proteases. J Mol Biol (2005) 1.09
Detection of bacteria with carbohydrate-functionalized fluorescent polymers. J Am Chem Soc (2004) 1.09
Crystal structure of interleukin-19 defines a new subfamily of helical cytokines. J Biol Chem (2002) 1.09
Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1. J Mol Biol (2010) 1.09