Published in J Biol Chem on December 09, 2003
Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures. FEBS J (2007) 1.70
The role of bacterial enhancer binding proteins as specialized activators of σ54-dependent transcription. Microbiol Mol Biol Rev (2012) 1.53
Unconventional serine proteases: variations on the catalytic Ser/His/Asp triad configuration. Protein Sci (2008) 1.44
Multitasking in the mitochondrion by the ATP-dependent Lon protease. Biochim Biophys Acta (2011) 1.41
Protease gene families in Populus and Arabidopsis. BMC Plant Biol (2006) 1.22
Functional mechanics of the ATP-dependent Lon protease- lessons from endogenous protein and synthetic peptide substrates. Biochim Biophys Acta (2008) 1.09
Bacterial proteolytic complexes as therapeutic targets. Nat Rev Drug Discov (2012) 1.08
An extracelluar protease, SepM, generates functional competence-stimulating peptide in Streptococcus mutans UA159. J Bacteriol (2012) 1.07
Slicing a protease: structural features of the ATP-dependent Lon proteases gleaned from investigations of isolated domains. Protein Sci (2006) 1.03
CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease. Am J Hum Genet (2015) 1.02
Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber. EMBO J (2010) 1.00
Crystal structure of the N-terminal domain of E. coli Lon protease. Protein Sci (2005) 0.99
The Lon protease is essential for full virulence in Pseudomonas aeruginosa. PLoS One (2012) 0.93
Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease. Biochemistry (2006) 0.90
Structure of the catalytic domain of the human mitochondrial Lon protease: proposed relation of oligomer formation and activity. Protein Sci (2010) 0.88
Identification of patterns in diffraction intensities affected by radiation exposure. J Synchrotron Radiat (2012) 0.87
Detection and characterization of two ATP-dependent conformational changes in proteolytically inactive Escherichia coli Lon mutants by stopped flow kinetic techniques. Biochemistry (2007) 0.85
Distinct quaternary structures of the AAA+ Lon protease control substrate degradation. Proc Natl Acad Sci U S A (2013) 0.84
Structure of the N-terminal fragment of Escherichia coli Lon protease. Acta Crystallogr D Biol Crystallogr (2010) 0.83
Polyphosphate, cyclic AMP, guanosine tetraphosphate, and c-di-GMP reduce in vitro Lon activity. Bioengineered (2014) 0.83
Lon protease of Azorhizobium caulinodans ORS571 is required for suppression of reb gene expression. Appl Environ Microbiol (2012) 0.83
Evidence that two ATP-dependent (Lon) proteases in Borrelia burgdorferi serve different functions. PLoS Pathog (2009) 0.82
Single-turnover kinetic experiments confirm the existence of high- and low-affinity ATPase sites in Escherichia coli Lon protease. Biochemistry (2006) 0.82
Characterization of three putative Lon proteases of Thermus thermophilus HB27 and use of their defective mutants as hosts for production of heterologous proteins. Extremophiles (2007) 0.80
Crystal structure of a viral protease intramolecular acyl-enzyme complex: insights into cis-cleavage at the VP4/VP3 junction of Tellina birnavirus. J Biol Chem (2011) 0.80
Alteration of oligomeric state and domain architecture is essential for functional transformation between transferase and hydrolase with the same scaffold. Protein Sci (2009) 0.80
Evolution and significance of the Lon gene family in Arabidopsis organelle biogenesis and energy metabolism. Front Plant Sci (2014) 0.80
YoeB toxin is activated during thermal stress. Microbiologyopen (2015) 0.78
Crystal structures of yellowtail ascites virus VP4 protease: trapping an internal cleavage site trans acyl-enzyme complex in a native Ser/Lys dyad active site. J Biol Chem (2013) 0.77
Inactivation of Cell Division Protein FtsZ by SulA Makes Lon Indispensable for the Viability of a ppGpp0 Strain of Escherichia coli. J Bacteriol (2015) 0.77
Crystallization and preliminary X-ray crystallographic analysis of Lon from Thermococcus onnurineus NA1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.76
Purification, crystallization and preliminary X-ray analysis of truncated and mutant forms of VP4 protease from infectious pancreatic necrosis virus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.76
The N-terminal domain plays a crucial role in the structure of a full-length human mitochondrial Lon protease. Sci Rep (2016) 0.76
A mutation in the N domain of Escherichia coli lon stabilizes dodecamers and selectively alters degradation of model substrates. J Bacteriol (2013) 0.76
SepM, a Streptococcal Protease Involved in Quorum Sensing, Displays Strict Substrate Specificity. J Bacteriol (2015) 0.75
Expression, purification and crystallization of a birnavirus-encoded protease, VP4, from blotched snakehead virus (BSNV). Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.75
Defining the Crucial Domain and Amino Acid Residues in Bacterial Lon Protease for DNA Binding and Processing of DNA-interacting Substrates. J Biol Chem (2017) 0.75
A Lon-like protease with no ATP-powered unfolding activity. PLoS One (2012) 0.75
Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer. Nat Commun (2017) 0.75
Bacterial RadA is a DnaB-type helicase interacting with RecA to promote bidirectional D-loop extension. Nat Commun (2017) 0.75
Stereochemical restraints revisited: how accurate are refinement targets and how much should protein structures be allowed to deviate from them? Acta Crystallogr D Biol Crystallogr (2007) 4.51
Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell (2005) 4.11
Improved molecular replacement by density- and energy-guided protein structure optimization. Nature (2011) 2.74
Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat Struct Mol Biol (2005) 2.50
The DCX-domain tandems of doublecortin and doublecortin-like kinase. Nat Struct Biol (2003) 2.22
Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding. Structure (2006) 2.16
Structural insight into the mechanism of double-stranded RNA processing by ribonuclease III. Cell (2006) 2.15
Noncatalytic assembly of ribonuclease III with double-stranded RNA. Structure (2004) 2.04
A crystallographic study of bright far-red fluorescent protein mKate reveals pH-induced cis-trans isomerization of the chromophore. J Biol Chem (2008) 1.98
Crystal structure of ClpA, an Hsp100 chaperone and regulator of ClpAP protease. J Biol Chem (2002) 1.97
Expression and purification of soluble His(6)-tagged TEV protease. Methods Mol Biol (2009) 1.94
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat Struct Mol Biol (2009) 1.84
The crystal structure of the endothelial protein C receptor and a bound phospholipid. J Biol Chem (2002) 1.84
Molecular replacement with pseudosymmetry and model dissimilarity: a case study. Acta Crystallogr D Biol Crystallogr (2006) 1.80
Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha. J Biol Chem (2003) 1.79
Efficient site-specific processing of fusion proteins by tobacco vein mottling virus protease in vivo and in vitro. Protein Expr Purif (2004) 1.78
Triclinic lysozyme at 0.65 A resolution. Acta Crystallogr D Biol Crystallogr (2007) 1.77
Structural basis for the substrate specificity of tobacco etch virus protease. J Biol Chem (2002) 1.72
Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides. J Biol Chem (2002) 1.71
Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures. FEBS J (2007) 1.70
Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase. Nat Struct Biol (2003) 1.54
HIVdb: a database of the structures of human immunodeficiency virus protease. Proteins (2002) 1.51
Structural basis for inhibition of translation by the tumor suppressor Pdcd4. Mol Cell Biol (2006) 1.49
Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP. Chem Biol (2010) 1.48
B. subtilis ykuD protein at 2.0 A resolution: insights into the structure and function of a novel, ubiquitous family of bacterial enzymes. Proteins (2006) 1.47
The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle. Structure (2004) 1.45
A stepwise model for double-stranded RNA processing by ribonuclease III. Mol Microbiol (2007) 1.44
Deposition of structural data redux. Acta Crystallogr D Biol Crystallogr (2007) 1.41
Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI. RNA (2005) 1.40
Similar modes of polypeptide recognition by export chaperones in flagellar biosynthesis and type III secretion. Nat Struct Biol (2003) 1.39
The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures. Structure (2002) 1.37
Three-dimensional structure of a macromolecular assembly that regulates type III secretion in Yersinia pestis. J Mol Biol (2005) 1.35
The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression. Biochim Biophys Acta (2005) 1.35
Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. J Biol Chem (2008) 1.35
Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity. Structure (2010) 1.33
Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases. Structure (2004) 1.32
Structure of CFA/I fimbriae from enterotoxigenic Escherichia coli. Proc Natl Acad Sci U S A (2009) 1.31
Structural effects of radiation damage and its potential for phasing. Acta Crystallogr D Biol Crystallogr (2004) 1.28
Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation. Structure (2009) 1.28
Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP. J Struct Biol (2004) 1.27
Piecing together the structure of retroviral integrase, an important target in AIDS therapy. FEBS J (2009) 1.27
1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors. Chembiochem (2005) 1.27
Numerology versus reality: a voice in a recent dispute. Acta Crystallogr D Biol Crystallogr (2007) 1.26
A generic method for the production of recombinant proteins in Escherichia coli using a dual hexahistidine-maltose-binding protein affinity tag. Methods Mol Biol (2007) 1.26
Structural characterization of the Yersinia pestis type III secretion system needle protein YscF in complex with its heterodimeric chaperone YscE/YscG. J Mol Biol (2008) 1.26
Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP. J Biol Chem (2002) 1.24
PDZ tandem of human syntenin: crystal structure and functional properties. Structure (2003) 1.21
The impact of Glu-->Ala and Glu-->Asp mutations on the crystallization properties of RhoGDI: the structure of RhoGDI at 1.3 A resolution. Acta Crystallogr D Biol Crystallogr (2002) 1.21
Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin. Proteins (2007) 1.20
Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors. Mol Endocrinol (2007) 1.20
Radiation-induced site-specific damage of mercury derivatives: phasing and implications. Acta Crystallogr D Biol Crystallogr (2005) 1.18
A family portrait of the RIO kinases. J Biol Chem (2005) 1.17
Locating the anomalous scatterer substructures in halide and sulfur phasing. Acta Crystallogr D Biol Crystallogr (2002) 1.17
Crystal structure at 1.9A of E. coli ClpP with a peptide covalently bound at the active site. J Struct Biol (2006) 1.17
Retroviral proteases. Genome Biol (2002) 1.17
Crystal structure of the heterodimeric complex of the adaptor, ClpS, with the N-domain of the AAA+ chaperone, ClpA. J Biol Chem (2002) 1.15
Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition. J Mol Biol (2005) 1.15
Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41. PLoS Pathog (2010) 1.14
Structural characterization of B and non-B subtypes of HIV-protease: insights into the natural susceptibility to drug resistance development. J Mol Biol (2007) 1.14
Proteins that bind high-mannose sugars of the HIV envelope. Prog Biophys Mol Biol (2005) 1.14
High-resolution structure of the Yersinia pestis protein tyrosine phosphatase YopH in complex with a phosphotyrosyl mimetic-containing hexapeptide. Biochemistry (2003) 1.14
Alternating translocation of protein substrates from both ends of ClpXP protease. EMBO J (2002) 1.14
The N-terminal substrate-binding domain of ClpA unfoldase is highly mobile and extends axially from the distal surface of ClpAP protease. J Struct Biol (2004) 1.13
Structure of the Yersinia pestis type III secretion chaperone SycH in complex with a stable fragment of YscM2. Acta Crystallogr D Biol Crystallogr (2004) 1.13
A receptor-binding site as revealed by the crystal structure of CfaE, the colonization factor antigen I fimbrial adhesin of enterotoxigenic Escherichia coli. J Biol Chem (2007) 1.13
Structure and activity of the atypical serine kinase Rio1. FEBS J (2005) 1.12
Structure of ERA in complex with the 3' end of 16S rRNA: implications for ribosome biogenesis. Proc Natl Acad Sci U S A (2009) 1.11
Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. J Pharmacol Exp Ther (2009) 1.11
Structural studies of algal lectins with anti-HIV activity. Acta Biochim Pol (2006) 1.10
Phasing on anomalous signal of sulfurs: what is the limit? Acta Crystallogr D Biol Crystallogr (2003) 1.10
Three-dimensional structure of the type III secretion chaperone SycE from Yersinia pestis. Acta Crystallogr D Biol Crystallogr (2002) 1.10
ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexes. J Struct Biol (2004) 1.10
Atomic-resolution crystal structure of the proteolytic domain of Archaeoglobus fulgidus lon reveals the conformational variability in the active sites of lon proteases. J Mol Biol (2005) 1.09
Structural basis for phototoxicity of the genetically encoded photosensitizer KillerRed. J Biol Chem (2009) 1.09
Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1. J Mol Biol (2010) 1.09
(2R)-8-Benzyl-2-[(S)-hy-droxy(phen-yl)meth-yl]-8-aza-bicyclo-[3.2.1]octan-3-one. Acta Crystallogr Sect E Struct Rep Online (2011) 1.09
Crystal structure of interleukin-19 defines a new subfamily of helical cytokines. J Biol Chem (2002) 1.09
Turnover of endogenous SsrA-tagged proteins mediated by ATP-dependent proteases in Escherichia coli. J Biol Chem (2008) 1.08