A family portrait of the RIO kinases.

Powering through ribosome assembly. RNA (2009) 2.19

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proc Natl Acad Sci U S A (2008) 1.92

Investigating the role of RIO protein kinases in Caenorhabditis elegans. PLoS One (2015) 1.38

ABC1K atypical kinases in plants: filling the organellar kinase void. Trends Plant Sci (2012) 0.96

Conservation, variability and the modeling of active protein kinases. PLoS One (2007) 0.95

The ancient microbial RIO kinases. J Biol Chem (2014) 0.95

Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes. Nucleic Acids Res (2014) 0.94

A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. PLoS Genet (2013) 0.92

Post-translational modifications in the rat lumbar spinal cord in experimental autoimmune encephalomyelitis. J Proteome Res (2007) 0.90

Interaction of Rio1 kinase with toyocamycin reveals a conformational switch that controls oligomeric state and catalytic activity. PLoS One (2012) 0.87

Transgenesis in Strongyloides and related parasitic nematodes: historical perspectives, current functional genomic applications and progress towards gene disruption and editing. Parasitology (2016) 0.87

Human RioK3 is a novel component of cytoplasmic pre-40S pre-ribosomal particles. RNA Biol (2012) 0.87

Phosphorylation and methylation of proteasomal proteins of the haloarcheon Haloferax volcanii. Archaea (2010) 0.86

Mechanisms regulating the protein kinases of Saccharomyces cerevisiae. Eukaryot Cell (2007) 0.85

Post-translation modification in Archaea: lessons from Haloferax volcanii and other haloarchaea. FEMS Microbiol Rev (2012) 0.83

Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. Nucleic Acids Res (2015) 0.82

p53- and ERK7-dependent ribosome surveillance response regulates Drosophila insulin-like peptide secretion. PLoS Genet (2014) 0.82

Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation. Nat Commun (2015) 0.81

Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression. J Biol Chem (2011) 0.81

New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer. World J Gastroenterol (2014) 0.81

The Link between Protein Kinase CK2 and Atypical Kinase Rio1. Pharmaceuticals (Basel) (2017) 0.80

Tv-RIO1 - an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus. Parasit Vectors (2008) 0.79

Flatworms have lost the right open reading frame kinase 3 gene during evolution. Sci Rep (2015) 0.79

Expanding the archaellum regulatory network - the eukaryotic protein kinases ArnC and ArnD influence motility of Sulfolobus acidocaldarius. Microbiologyopen (2016) 0.77

Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene (2014) 0.77

Toward understanding the functional role of Ss-RIOK-1, a RIO protein kinase-encoding gene of Strongyloides stercoralis. PLoS Negl Trop Dis (2014) 0.77

TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma. J Clin Cell Immunol (2012) 0.77

Protein phosphorylation and its role in archaeal signal transduction. FEMS Microbiol Rev (2016) 0.76

The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior. EBioMedicine (2017) 0.75

Exploring features and function of Ss-riok-3, an enigmatic kinase gene from Strongyloides stercoralis. Parasit Vectors (2014) 0.75

Promoter-enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase. Nucleic Acids Res (2016) 0.75

Stereochemical restraints revisited: how accurate are refinement targets and how much should protein structures be allowed to deviate from them? Acta Crystallogr D Biol Crystallogr (2007) 4.51

Improved molecular replacement by density- and energy-guided protein structure optimization. Nature (2011) 2.74

Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding. Structure (2006) 2.16

A crystallographic study of bright far-red fluorescent protein mKate reveals pH-induced cis-trans isomerization of the chromophore. J Biol Chem (2008) 1.98

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat Struct Mol Biol (2009) 1.84

Molecular replacement with pseudosymmetry and model dissimilarity: a case study. Acta Crystallogr D Biol Crystallogr (2006) 1.80

Structural basis for the substrate specificity of tobacco etch virus protease. J Biol Chem (2002) 1.72

Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides. J Biol Chem (2002) 1.71

Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase. Nat Struct Biol (2003) 1.54

HIVdb: a database of the structures of human immunodeficiency virus protease. Proteins (2002) 1.51

Structural basis for inhibition of translation by the tumor suppressor Pdcd4. Mol Cell Biol (2006) 1.49

Deposition of structural data redux. Acta Crystallogr D Biol Crystallogr (2007) 1.41

Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI. RNA (2005) 1.40

The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures. Structure (2002) 1.37

The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression. Biochim Biophys Acta (2005) 1.35

Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. J Biol Chem (2008) 1.35

Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity. Structure (2010) 1.33

The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site. J Biol Chem (2003) 1.33

Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases. Structure (2004) 1.32

Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation. Structure (2009) 1.28

Piecing together the structure of retroviral integrase, an important target in AIDS therapy. FEBS J (2009) 1.27

1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors. Chembiochem (2005) 1.27

Numerology versus reality: a voice in a recent dispute. Acta Crystallogr D Biol Crystallogr (2007) 1.26

Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin. Proteins (2007) 1.20

Retroviral proteases. Genome Biol (2002) 1.17

Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition. J Mol Biol (2005) 1.15

Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41. PLoS Pathog (2010) 1.14

Proteins that bind high-mannose sugars of the HIV envelope. Prog Biophys Mol Biol (2005) 1.14

Structural characterization of B and non-B subtypes of HIV-protease: insights into the natural susceptibility to drug resistance development. J Mol Biol (2007) 1.14

Structure and activity of the atypical serine kinase Rio1. FEBS J (2005) 1.12

Structural studies of algal lectins with anti-HIV activity. Acta Biochim Pol (2006) 1.10

Atomic-resolution crystal structure of the proteolytic domain of Archaeoglobus fulgidus lon reveals the conformational variability in the active sites of lon proteases. J Mol Biol (2005) 1.09

Crystal structure of interleukin-19 defines a new subfamily of helical cytokines. J Biol Chem (2002) 1.09

Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1. J Mol Biol (2010) 1.09

Structural basis for phototoxicity of the genetically encoded photosensitizer KillerRed. J Biol Chem (2009) 1.09

Understanding blue-to-red conversion in monomeric fluorescent timers and hydrolytic degradation of their chromophores. J Am Chem Soc (2010) 1.07

Unmet challenges of structural genomics. Curr Opin Struct Biol (2010) 1.06

Determination of protein structures--a series of fortunate events. Biophys J (2008) 1.06

Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation. Biochemistry (2009) 1.05

Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Protein Expr Purif (2005) 1.03

Slicing a protease: structural features of the ATP-dependent Lon proteases gleaned from investigations of isolated domains. Protein Sci (2006) 1.03

Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexes. FEBS J (2005) 1.02

NMR and crystal structures of the Pyrococcus horikoshii RadA intein guide a strategy for engineering a highly efficient and promiscuous intein. J Mol Biol (2012) 1.01

Classification of ATP-dependent proteases Lon and comparison of the active sites of their proteolytic domains. Eur J Biochem (2004) 1.00

Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20. Biochemistry (2003) 0.99

Crystal structure of the N-terminal domain of E. coli Lon protease. Protein Sci (2005) 0.99

Pathological crystallography: case studies of several unusual macromolecular crystals. Acta Crystallogr D Biol Crystallogr (2005) 0.99

Crystal structure of the AAA+ alpha domain of E. coli Lon protease at 1.9A resolution. J Struct Biol (2004) 0.99

Refined crystal structures of red and green fluorescent proteins from the button polyp Zoanthus. Acta Crystallogr D Biol Crystallogr (2007) 0.99

Crystal structure of XMRV protease differs from the structures of other retropepsins. Nat Struct Mol Biol (2011) 0.97

Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes. Acta Crystallogr D Biol Crystallogr (2010) 0.97

Atomic-resolution crystal structure of the antiviral lectin scytovirin. Protein Sci (2007) 0.96

Atomic resolution structure of Erwinia chrysanthemi L-asparaginase. Acta Crystallogr D Biol Crystallogr (2002) 0.95

Proteins do not have strong spines after all. Structure (2009) 0.94

Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine. Protein Sci (2007) 0.94

Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding. PLoS One (2011) 0.94

Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design. Proc Natl Acad Sci U S A (2005) 0.93

Carbohydrates contribute to the interactions between cockroach allergen Bla g 2 and a monoclonal antibody. J Immunol (2010) 0.93

Impact of synchrotron radiation on macromolecular crystallography: a personal view. J Synchrotron Radiat (2010) 0.93

Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana. J Biol Chem (2001) 0.93

Comparison of the substrate specificity of two potyvirus proteases. FEBS J (2005) 0.92

Structural basis for bathochromic shift of fluorescence in far-red fluorescent proteins eqFP650 and eqFP670. Acta Crystallogr D Biol Crystallogr (2012) 0.92

Structural evidence for variable oligomerization of the N-terminal domain of cyclase-associated protein (CAP). Proteins (2005) 0.91

Crystallographic study of red fluorescent protein eqFP578 and its far-red variant Katushka reveals opposite pH-induced isomerization of chromophore. Protein Sci (2011) 0.91

The quality and validation of structures from structural genomics. Methods Mol Biol (2014) 0.90

Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum. J Mol Biol (2009) 0.90

The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster. Eur J Biochem (2003) 0.90

Chemical compound navigator: a web-based chem-BLAST, chemical taxonomy-based search engine for browsing compounds. Proteins (2006) 0.89

Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri. Protein Sci (2008) 0.89

A structural basis for reversible photoswitching of absorbance spectra in red fluorescent protein rsTagRFP. J Mol Biol (2012) 0.88

The expanding diversity of serine hydrolases. Curr Opin Struct Biol (2007) 0.88

Structural evidence for a dehydrated intermediate in green fluorescent protein chromophore biosynthesis. J Biol Chem (2010) 0.86

A model of the ternary complex of interleukin-10 with its soluble receptors. BMC Struct Biol (2005) 0.86

Domain-swapped structure of a mutant of cyanovirin-N. Biochem Biophys Res Commun (2002) 0.86

Lessons learned fighting HIV can be applied to anti-cancer drug design. Cell Cycle (2006) 0.86

Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site. FEBS J (2006) 0.86

A general acid-base mechanism for the stabilization of a tetrahedral adduct in a serine-carboxyl peptidase: a computational study. J Am Chem Soc (2005) 0.85

An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae. Biochem Biophys Res Commun (2002) 0.85

The importance of dynamics in substrate-assisted catalysis and specificity. J Am Chem Soc (2006) 0.84

The future of crystallography in drug discovery. Expert Opin Drug Discov (2013) 0.84

Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41. PLoS One (2013) 0.83

Structure of the N-terminal fragment of Escherichia coli Lon protease. Acta Crystallogr D Biol Crystallogr (2010) 0.83

Limited proteolysis of E. coli ATP-dependent protease Lon - a unified view of the subunit architecture and characterization of isolated enzyme fragments. Acta Biochim Pol (2008) 0.83

Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies. Mol Immunol (2009) 0.83

Structure and mechanism of the saposin-like domain of a plant aspartic protease. J Biol Chem (2011) 0.83

Topology of the disulfide bonds in the antiviral lectin scytovirin. Protein Sci (2010) 0.83

Kinetic stability and crystal structure of the viral capsid protein SHP. J Mol Biol (2004) 0.83

Crystal structure of a truncated version of the phage lambda protein gpD. Proteins (2004) 0.83

Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus. J Struct Biol (2012) 0.83

Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum. J Struct Biol (2011) 0.82

The QM/MM molecular dynamics and free energy simulations of the acylation reaction catalyzed by the serine-carboxyl peptidase kumamolisin-As. Biochemistry (2007) 0.82

Catalytic role of proton transfers in the formation of a tetrahedral adduct in a serine carboxyl peptidase. Biochemistry (2006) 0.82

A comparative study of the expression of serine proteinases in quiescent seeds and in developing Canavalia ensiformis plants. J Exp Bot (2006) 0.82

Cloning, expression, purification, crystallization and preliminary X-ray diffraction data of the Pyrococcus horikoshii RadA intein. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.81

Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid. J Biol Chem (2002) 0.81

Structural studies of vacuolar plasmepsins. Biochim Biophys Acta (2011) 0.81

Localization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysis. PLoS One (2011) 0.81

Structural studies of the interaction of Crataeva tapia bark protein with heparin and other glycosaminoglycans. Biochemistry (2013) 0.81

Crystal Structure of Crataeva tapia Bark Protein (CrataBL) and Its Effect in Human Prostate Cancer Cell Lines. PLoS One (2013) 0.80

Structure of the Taz2 domain of p300: insights into ligand binding. Acta Crystallogr D Biol Crystallogr (2009) 0.80