Published in Lab Invest on July 01, 2002
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci U S A (2013) 2.47
The use of animal models in diabetes research. Br J Pharmacol (2012) 2.15
The outliers become a stampede as immunometabolism reaches a tipping point. Immunol Rev (2012) 1.08
The Bidirectional Relationship between Metabolism and Immune Responses. Discoveries (Craiova) (2015) 0.78
Current status and patent prospective of animal models in diabetic research. Adv Biomed Res (2015) 0.77
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
An efficient SNP system for mouse genome scanning and elucidating strain relationships. Genome Res (2004) 3.96
Mouse models of diabetic nephropathy. J Am Soc Nephrol (2009) 3.74
Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proc Natl Acad Sci U S A (2006) 3.48
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell (2008) 2.65
An Aging Interventions Testing Program: study design and interim report. Aging Cell (2007) 2.54
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell (2014) 2.35
Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone. J Lipid Res (2002) 2.30
Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens. Gastroenterology (2005) 1.81
Resistance of C57BL/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production. J Immunol (2006) 1.77
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell (2013) 1.71
Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics (2004) 1.49
Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) gene. Obesity (Silver Spring) (2010) 1.38
Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes. Am J Physiol Endocrinol Metab (2007) 1.23
Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice. Diabetes (2002) 1.22
Refined histopathologic scoring system improves power to detect colitis QTL in mice. Mamm Genome (2004) 1.20
New mouse model to study islet transplantation in insulin-dependent diabetes mellitus. Transplantation (2002) 1.17
Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene. J Lipid Res (2009) 1.16
Caspase-1 is not required for type 1 diabetes in the NOD mouse. Diabetes (2004) 1.16
Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse. Mech Ageing Dev (2002) 1.15
Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated. Blood (2007) 1.14
CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins. J Immunol (2005) 1.12
Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains. Proc Natl Acad Sci U S A (2012) 1.12
Altered oxidative stress response of the long-lived Snell dwarf mouse. Biochem Biophys Res Commun (2004) 1.08
Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm. Mech Ageing Dev (2002) 1.06
Altered cholesterologenic and lipogenic transcriptional profile in livers of aging Snell dwarf (Pit1dw/dwJ) mice. Aging Cell (2004) 1.06
Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. J Immunol (2006) 1.06
Adverse hepatic and cardiac responses to rosiglitazone in a new mouse model of type 2 diabetes: relation to dysregulated phosphatidylcholine metabolism. Vascul Pharmacol (2006) 1.04
Mechanisms underlying resistance of pancreatic islets from ALR/Lt mice to cytokine-induced destruction. J Immunol (2005) 1.04
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes. Proc Natl Acad Sci U S A (2004) 1.03
Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells. J Biol Chem (2005) 1.03
Genetic and environmental context determines the course of colitis developing in IL-10-deficient mice. Inflamm Bowel Dis (2002) 1.01
P2X7 receptor-dependent and -independent T cell death is induced by nicotinamide adenine dinucleotide. J Immunol (2005) 1.00
Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping. PLoS One (2010) 0.96
A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein. FEBS Lett (2006) 0.94
Neuroendocrine inhibition of glucose production and resistance to cancer in dwarf mice. Exp Gerontol (2008) 0.93
Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity. Inflamm Bowel Dis (2010) 0.93
Low utilization of circulating glucose after food withdrawal in Snell dwarf mice. J Biol Chem (2007) 0.92
Mice severely deficient in growth hormone have normal hematopoiesis. Exp Hematol (2005) 0.92
Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice. Mech Ageing Dev (2005) 0.92
Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress. Immunogenetics (2003) 0.92
CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. J Immunol (2006) 0.91
"Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mamm Genome (2005) 0.90
Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice. J Immunol (2011) 0.88
Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice. Free Radic Biol Med (2002) 0.88
Pharmacogenetic analysis of rosiglitazone-induced hepatosteatosis in new mouse models of type 2 diabetes. Diabetes (2005) 0.88
mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic β-cell. Diabetes (2010) 0.86
Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine. Anal Biochem (2003) 0.86
Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex. Diabetes (2005) 0.86
Gene expression profiling of leukemic cells and primary thymocytes predicts a signature for apoptotic sensitivity to glucocorticoids. Cancer Cell Int (2007) 0.85
Commonalities of genetic resistance to spontaneous autoimmune and free radical--mediated diabetes. Free Radic Biol Med (2008) 0.85
Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis. Diabetes (2005) 0.85
ALS/Lt: a new type 2 diabetes mouse model associated with low free radical scavenging potential. Diabetes (2004) 0.84
Contributions of dysregulated energy metabolism to type 2 diabetes development in NZO/H1Lt mice with polygenic obesity. Metabolism (2004) 0.84
Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis. Diabetes (2006) 0.84
Pituitary removal in adult mice increases life span. Mech Ageing Dev (2006) 0.82
Animal models of diabetic uropathy. J Urol (2009) 0.82
A reduced peripheral blood CD4(+) lymphocyte proportion is a consistent ageing phenotype. Mech Ageing Dev (2002) 0.81
Altered growth characteristics of skin fibroblasts from wild-derived mice, and genetic loci regulating fibroblast clone size. Aging Cell (2006) 0.79
The diabetes-prone NZO/Hl strain. II. Pancreatic immunopathology. Lab Invest (2002) 0.78
Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain. J Gerontol A Biol Sci Med Sci (2012) 0.77
Reproductive ageing: Of worms and women. Nature (2010) 0.77
Adoptive transfer of islet antigen-autoreactive T cell clones to transgenic NOD.Ea(d)mice induces diabetes indicating a lack of I-E mediated protection against activated effector T cells. J Autoimmun (2003) 0.76
Tracking autoimmune T cells in diabetes. J Clin Invest (2003) 0.75
The diabetes-prone NZO/Hl strain. Proliferation capacity of beta cells in hyperinsulinemia and hyperglycemia. Arch Physiol Biochem (2006) 0.75
Bone marrow expressing a diabetes resistance MHC class II allele: diabetes deviation by chronic immune stimulation. Novartis Found Symp (2008) 0.75
Anti-insulin receptor autoantibodies are not required for type 2 diabetes pathogenesis in NZL/Lt mice, a New Zealand obese (NZO)-derived mouse strain. Exp Diabesity Res (2004) 0.75