Heat shock factors: integrators of cell stress, development and lifespan.

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Published in Nat Rev Mol Cell Biol on July 14, 2010

Authors

Malin Akerfelt1, Richard I Morimoto, Lea Sistonen

Author Affiliations

1: Department of Biosciences, Abo Akademi University, BioCity, 20520 Turku, Finland.

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Protein homeostasis as a therapeutic target for diseases of protein conformation. Curr Top Med Chem (2012) 1.10

Regulation of the members of the mammalian heat shock factor family. FEBS J (2010) 1.09

Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression. Genes Dev (2006) 1.09

Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2009) 1.08

Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain. J Biol Chem (2001) 1.08

Mammalian heat shock factor 1 is essential for oocyte meiosis and directly regulates Hsp90alpha expression. J Biol Chem (2009) 1.08

The ubiquitin-proteasome pathway. Ann Med (2004) 1.08

Identification of a tissue-selective heat shock response regulatory network. PLoS Genet (2013) 1.07

Disease-modifying pathways in neurodegeneration. J Neurosci (2006) 1.06

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition. Proc Natl Acad Sci U S A (2014) 1.05

miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis. Development (2010) 1.05

In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. J Biol Chem (2010) 1.04

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation. Hum Mol Genet (2007) 1.03

Spreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegans. PLoS Genet (2013) 1.00

Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Hum Mol Genet (2011) 1.00

Promoter ChIP-chip analysis in mouse testis reveals Y chromosome occupancy by HSF2. Proc Natl Acad Sci U S A (2008) 1.00

Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells: dependency on glutamic acid at position 45 in the B pocket of HLA-B27. Arthritis Rheum (2004) 0.99

Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis. Bioorg Med Chem (2010) 0.99

Heat shock transcription factor 1 localizes to sex chromatin during meiotic repression. J Biol Chem (2010) 0.93

Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases. Dis Model Mech (2014) 0.92

Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease. J Biol Chem (2013) 0.91

HLA-B27 modulates nuclear factor kappaB activation in human monocytic cells exposed to lipopolysaccharide. Arthritis Rheum (2002) 0.91

Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets. ACS Chem Biol (2012) 0.90

Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress. Mol Cell Biol (2010) 0.90

Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Dev Dyn (2010) 0.90

In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome. Proc Natl Acad Sci U S A (2012) 0.89

Evidence that the p38 MAP kinase pathway is dysregulated in HLA-B27-expressing human monocytic cells: correlation with HLA-B27 misfolding. Arthritis Rheum (2007) 0.88

Macro-level modeling of the response of C. elegans reproduction to chronic heat stress. PLoS Comput Biol (2012) 0.88

Nuclear stress granules: the awakening of a sleeping beauty? J Cell Biol (2004) 0.87

Fever-like hyperthermia controls T Lymphocyte persistence by inducing degradation of cellular FLIPshort. J Immunol (2007) 0.87

Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells. Bioorg Med Chem (2011) 0.87

Protein inhibitor of activated STAT3 (PIAS3) protein promotes SUMOylation and nuclear sequestration of the intracellular domain of ErbB4 protein. J Biol Chem (2012) 0.87

Transcellular chaperone signaling: an organismal strategy for integrated cell stress responses. J Exp Biol (2014) 0.86

Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol. J Am Chem Soc (2011) 0.85

Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease. BMC Biol (2013) 0.84