A novel computational model of the human ventricular action potential and Ca transient.

PubWeight™: 2.36‹?› | Rank: Top 2%

🔗 View Article (PMC 2813400)

Published in J Mol Cell Cardiol on October 14, 2009

Authors

Eleonora Grandi1, Francesco S Pasqualini, Donald M Bers

Author Affiliations

1: Department of Pharmacology, University of California, 451 Health Sciences Drive, GBSF Room 3513, Davis, CA 95616-8636, USA.

Articles citing this

(truncated to the top 100)

Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation. PLoS Comput Biol (2011) 3.21

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovasc Res (2011) 2.41

Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res (2011) 1.82

R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation. Heart Rhythm (2010) 1.71

A multiscale investigation of repolarization variability and its role in cardiac arrhythmogenesis. Biophys J (2011) 1.62

Deranged sodium to sudden death. J Physiol (2015) 1.51

Electrophysiological and structural remodeling in heart failure modulate arrhythmogenesis. 2D simulation study. PLoS One (2014) 1.46

Exploiting mathematical models to illuminate electrophysiological variability between individuals. J Physiol (2012) 1.35

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis. Heart Rhythm (2011) 1.31

Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing. Br J Pharmacol (2012) 1.26

Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species. Am J Physiol Heart Circ Physiol (2011) 1.17

Na⁺ transport in the normal and failing heart - remember the balance. J Mol Cell Cardiol (2013) 1.14

Quantitative analysis of the Ca(2+) -dependent regulation of delayed rectifier K(+) current IKs in rabbit ventricular myocytes. J Physiol (2017) 1.10

Integrative systems models of cardiac excitation-contraction coupling. Circ Res (2011) 1.09

Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol (2015) 1.06

How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project. J Physiol (2012) 1.05

Myosin light chain 2-based selection of human iPSC-derived early ventricular cardiac myocytes. Stem Cell Res (2013) 1.05

Computational approaches to understand cardiac electrophysiology and arrhythmias. Am J Physiol Heart Circ Physiol (2012) 1.05

Benchmarking electrophysiological models of human atrial myocytes. Front Physiol (2013) 1.05

Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circ Res (2013) 1.04

Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization. Circulation (2011) 1.03

Ibandronate and ventricular arrhythmia risk. J Cardiovasc Electrophysiol (2013) 1.01

Prediction of Thorough QT study results using action potential simulations based on ion channel screens. J Pharmacol Toxicol Methods (2014) 1.01

Molecular Basis of Hypokalemia-Induced Ventricular Fibrillation. Circulation (2015) 0.99

Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility. J Physiol (2016) 0.98

Models of HERG gating. Biophys J (2011) 0.98

Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation. PLoS One (2014) 0.98

Modeling Timothy syndrome with iPS cells. J Cardiovasc Transl Res (2013) 0.95

Simulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failure. PLoS One (2012) 0.93

A quantitative comparison of the behavior of human ventricular cardiac electrophysiology models in tissue. PLoS One (2014) 0.92

The cardiac L-type calcium channel distal carboxy terminus autoinhibition is regulated by calcium. Am J Physiol Heart Circ Physiol (2012) 0.92

In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling. Front Physiol (2013) 0.91

Advances in modeling ventricular arrhythmias: from mechanisms to the clinic. Wiley Interdiscip Rev Syst Biol Med (2013) 0.91

Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death. Circ Res (2015) 0.91

β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. J Mol Cell Cardiol (2015) 0.90

A study of early afterdepolarizations in a model for human ventricular tissue. PLoS One (2014) 0.89

Quantitative prediction of the arrhythmogenic effects of de novo hERG mutations in computational models of human ventricular tissues. Eur Biophys J (2011) 0.89

Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations. J Gen Physiol (2015) 0.88

Fitting membrane resistance along with action potential shape in cardiac myocytes improves convergence: application of a multi-objective parallel genetic algorithm. PLoS One (2014) 0.88

Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy. J Am Heart Assoc (2015) 0.88

Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome. PLoS Comput Biol (2011) 0.87

The functional role of electrophysiological heterogeneity in the rabbit ventricle during rapid pacing and arrhythmias. Am J Physiol Heart Circ Physiol (2013) 0.86

Ca²⁺-induced delayed afterdepolarizations are triggered by dyadic subspace Ca2²⁺ affirming that increasing SERCA reduces aftercontractions. Am J Physiol Heart Circ Physiol (2011) 0.86

Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual IK1. Front Physiol (2015) 0.86

Reduced response to IKr blockade and altered hERG1a/1b stoichiometry in human heart failure. J Mol Cell Cardiol (2015) 0.86

Defective calcium inactivation causes long QT in obese insulin-resistant rat. Am J Physiol Heart Circ Physiol (2011) 0.85

There and back again: Iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes. J Mol Cell Cardiol (2015) 0.85

Modeling cardiac electromechanics and mechanoelectrical coupling in dyssynchronous and failing hearts: insight from adaptive computer models. J Cardiovasc Transl Res (2012) 0.84

Integrative modeling of the cardiac ventricular myocyte. Wiley Interdiscip Rev Syst Biol Med (2010) 0.84

Quantitative Decomposition of Dynamics of Mathematical Cell Models: Method and Application to Ventricular Myocyte Models. PLoS One (2015) 0.84

In silico Prediction of Sex-Based Differences in Human Susceptibility to Cardiac Ventricular Tachyarrhythmias. Front Physiol (2012) 0.84

Cardiac models in drug discovery and development: a review. Crit Rev Biomed Eng (2011) 0.84

Exploring susceptibility to atrial and ventricular arrhythmias resulting from remodeling of the passive electrical properties in the heart: a simulation approach. Front Physiol (2014) 0.83

Structural and functional plasticity in long-term cultures of adult ventricular myocytes. J Mol Cell Cardiol (2013) 0.83

Ion Channels in the Heart. Compr Physiol (2015) 0.83

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century. J Physiol (2016) 0.83

Mathematical model of the anatomy and fibre orientation field of the left ventricle of the heart. Biomed Eng Online (2013) 0.83

Effect of global cardiac ischemia on human ventricular fibrillation: insights from a multi-scale mechanistic model of the human heart. PLoS Comput Biol (2014) 0.82

Extending the conditions of application of an inversion of the Hodgkin-Huxley gating model. Bull Math Biol (2013) 0.82

Image-Based Personalization of Cardiac Anatomy for Coupled Electromechanical Modeling. Ann Biomed Eng (2015) 0.81

Cellular cardiac electrophysiology modeling with Chaste and CellML. Front Physiol (2015) 0.81

Electrophysiological and structural remodeling in heart failure modulate arrhythmogenesis. 1D simulation study. PLoS One (2014) 0.80

Sex differences in repolarization and slow delayed rectifier potassium current and their regulation by sympathetic stimulation in rabbits. Pflugers Arch (2012) 0.80

Three-dimensional computer model of the right atrium including the sinoatrial and atrioventricular nodes predicts classical nodal behaviours. PLoS One (2014) 0.80

A web portal for in-silico action potential predictions. J Pharmacol Toxicol Methods (2015) 0.79

Electrical wave propagation in an anisotropic model of the left ventricle based on analytical description of cardiac architecture. PLoS One (2014) 0.79

Human atrial fibrillation: insights from computational electrophysiological models. Trends Cardiovasc Med (2011) 0.79

Quantifying inter-species differences in contractile function through biophysical modelling. J Physiol (2015) 0.79

Implementation of Contraction to Electrophysiological Ventricular Myocyte Models, and Their Quantitative Characterization via Post-Extrasystolic Potentiation. PLoS One (2015) 0.78

Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis. Biomed Res Int (2015) 0.78

Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations. Front Physiol (2013) 0.78

QT/RR curvatures in healthy subjects: sex differences and covariates. Am J Physiol Heart Circ Physiol (2013) 0.78

Slow [Na]i Changes and Positive Feedback Between Membrane Potential and [Ca]i Underlie Intermittent Early Afterdepolarizations and Arrhythmias. Circ Arrhythm Electrophysiol (2015) 0.78

Recent developments in using mechanistic cardiac modelling for drug safety evaluation. Drug Discov Today (2016) 0.78

Illuminating Myocyte-Fibroblast Homotypic and Heterotypic Gap Junction Dynamics Using Dynamic Clamp. Biophys J (2016) 0.78

How computer simulations of the human heart can improve anti-arrhythmia therapy. J Physiol (2016) 0.77

Human cardiac systems electrophysiology and arrhythmogenesis: iteration of experiment and computation. Europace (2014) 0.77

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop. Europace (2015) 0.77

Anatomically accurate high resolution modeling of human whole heart electromechanics: A strongly scalable algebraic multigrid solver method for nonlinear deformation. J Comput Phys (2016) 0.77

Enhanced effects of isoflurane on the long QT syndrome 1-associated A341V mutant. Anesthesiology (2015) 0.77

The force-frequency relationship: insights from mathematical modeling. Adv Physiol Educ (2013) 0.77

Slow Calcium-Depolarization-Calcium waves may initiate fast local depolarization waves in ventricular tissue. Prog Biophys Mol Biol (2012) 0.77

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria. PLoS Comput Biol (2017) 0.77

Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion. Biophys J (2016) 0.76

Human atrial cell models to analyse haemodialysis-related effects on cardiac electrophysiology: work in progress. Comput Math Methods Med (2014) 0.76

Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure. Circ Res (2016) 0.76

A mathematical model for active contraction in healthy and failing myocytes and left ventricles. PLoS One (2017) 0.75

Sampling methods for exploring between-subject variability in cardiac electrophysiology experiments. J R Soc Interface (2016) 0.75

A human ventricular myocyte model with a refined representation of excitation-contraction coupling. Biophys J (2015) 0.75

Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus. Clin Med Insights Cardiol (2017) 0.75

Mechanisms linking electrical alternans and clinical ventricular arrhythmia in human heart failure. Heart Rhythm (2016) 0.75

Computational analysis of the electromechanical consequences of short QT syndrome. Front Physiol (2015) 0.75

Cardiac dynamics: a simplified model for action potential propagation. Theor Biol Med Model (2012) 0.75

Conditions for Waveblock Due to Anisotropy in a Model of Human Ventricular Tissue. PLoS One (2015) 0.75

Effect of ion concentration changes in the limited extracellular spaces on sarcolemmal ion transport and Ca2+ turnover in a model of human ventricular cardiomyocyte. Int J Mol Sci (2013) 0.75

Noninvasive quantification of blood potassium concentration from ECG in hemodialysis patients. Sci Rep (2017) 0.75

From Single Myocyte to Whole Heart: The Intricate Dance of Electrophysiology and Modeling. Circ Res (2016) 0.75

The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One (2016) 0.75

Computational modeling for cardiac safety pharmacology analysis: Contribution of fibroblasts. J Pharmacol Toxicol Methods (2017) 0.75

Study of the union method of microelectrode array and AFM for the recording of electromechanical activities in living cardiomyocytes. Eur Biophys J (2016) 0.75

Articles cited by this

A model for human ventricular tissue. Am J Physiol Heart Circ Physiol (2003) 4.91

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophys J (1998) 3.83

A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J (2004) 3.72

Alternans and spiral breakup in a human ventricular tissue model. Am J Physiol Heart Circ Physiol (2006) 3.36

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle. Circulation (2005) 3.31

Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophys J (2000) 3.26

Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res (2003) 2.86

Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation (2004) 2.83

Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation (2005) 2.77

Evidence for two components of delayed rectifier K+ current in human ventricular myocytes. Circ Res (1996) 2.50

Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation (1996) 2.43

Computer model of action potential of mouse ventricular myocytes. Am J Physiol Heart Circ Physiol (2004) 2.36

Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide. Circ Res (1993) 2.26

Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential. Circ Res (2002) 2.21

Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circ Res (1994) 2.16

Simulation study of cellular electric properties in heart failure. Circ Res (1998) 2.06

Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardium. Circulation (2002) 1.95

Transmural heterogeneity of action potentials and Ito1 in myocytes isolated from the human right ventricle. Am J Physiol (1998) 1.92

A computational model of the human left-ventricular epicardial myocyte. Biophys J (2004) 1.88

Transmural heterogeneity of calcium handling in canine. Circ Res (2003) 1.88

Alterations in intracellular calcium handling associated with the inverse force-frequency relation in human dilated cardiomyopathy. Circulation (1995) 1.86

The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization. J Physiol (2000) 1.82

Delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc Res (1998) 1.75

Heterogeneous transmural gene expression of calcium-handling proteins and natriuretic peptides in the failing human heart. Cardiovasc Res (1999) 1.67

Effects of the chromanol 293B, a selective blocker of the slow, component of the delayed rectifier K+ current, on repolarization in human and guinea pig ventricular myocytes. Cardiovasc Res (1998) 1.66

Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure. J Mol Cell Cardiol (1998) 1.62

Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J (2007) 1.45

Transmembrane ICa contributes to rate-dependent changes of action potentials in human ventricular myocytes. Am J Physiol (1999) 1.42

The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc Res (2001) 1.38

Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. J Physiol (2001) 1.37

Cell model for efficient simulation of wave propagation in human ventricular tissue under normal and pathological conditions. Phys Med Biol (2006) 1.30

Slow delayed rectifier potassium current (IKs) and the repolarization reserve. Ann Noninvasive Electrocardiol (2007) 1.25

Dynamic regulation of sodium/calcium exchange function in human heart failure. Circulation (2003) 1.24

Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation. Am J Physiol Heart Circ Physiol (2006) 1.23

A computationally efficient electrophysiological model of human ventricular cells. Am J Physiol Heart Circ Physiol (2002) 1.21

Calcium entry via Na/Ca exchange during the action potential directly contributes to contraction of failing human ventricular myocytes. Cardiovasc Res (2003) 1.18

Transmural heterogeneity of Na+-Ca2+ exchange: evidence for differential expression in normal and failing hearts. Circ Res (2005) 1.16

Human ether-à-go-go-related gene K+ channel gating probed with extracellular ca2+. Evidence for two distinct voltage sensors. J Gen Physiol (1999) 1.13

Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles. Heart Rhythm (2004) 1.12

Effects of endothelin-1 on calcium and potassium currents in undiseased human ventricular myocytes. Pflugers Arch (2000) 1.07

Differential expression of KvLQT1 isoforms across the human ventricular wall. Am J Physiol Heart Circ Physiol (2000) 1.01

Amiodarone reduces transmural heterogeneity of repolarization in the human heart. J Am Coll Cardiol (1998) 0.94

The cellular electrophysiologic effects of digitalis on human atrial fibers. Circulation (1978) 0.94

Transmural gradients in Na/K pump activity and [Na+]I in canine ventricle. Biophys J (2005) 0.93

Control of the cardiac action potential: The role of repolarization dynamics. J Mol Cell Cardiol (2009) 0.91

Diverse toxicity associated with cardiac Na+/K+ pump inhibition: evaluation of electrophysiological mechanisms. J Pharmacol Exp Ther (2003) 0.87

Self-augmentation of the lengthening of repolarization is related to the shape of the cardiac action potential: implications for reverse rate dependency. Br J Pharmacol (2008) 0.86

Electrical restitution in the endocardium of the intact human right ventricle. Br Heart J (1992) 0.81

Articles by these authors

(truncated to the top 100)

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res (2005) 5.34

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res (2003) 4.13

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest (2006) 3.72

A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J (2004) 3.72

Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserve. Circ Res (2003) 3.47

Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res (2007) 3.46

Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest (2006) 3.33

Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circ Res (2006) 3.26

Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure. Circ Res (2003) 3.04

Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res (2003) 3.04

Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc Med (2004) 2.97

Quantitative assessment of the SR Ca2+ leak-load relationship. Circ Res (2002) 2.93

Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res (2003) 2.86

Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca2+ channel alpha1 subunit and reduced ischemia/reperfusion injury. Circ Res (2006) 2.84

SparkMaster: automated calcium spark analysis with ImageJ. Am J Physiol Cell Physiol (2007) 2.84

CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol (2011) 2.65

Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation (2013) 2.57

Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ Res (2005) 2.50

Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell (2013) 2.33

Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation (2002) 2.32

Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32

Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res (2006) 2.30

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations. Biophys J (2008) 2.29

Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport. Circ Res (2003) 2.28

Sarcoplasmic reticulum and nuclear envelope are one highly interconnected Ca2+ store throughout cardiac myocyte. Circ Res (2006) 2.27

Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations. Circ Res (2006) 2.25

Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential. Circ Res (2002) 2.21

Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion. Circ Res (2008) 2.12

Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res (2009) 2.12

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature (2013) 2.08

Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes. Circ Res (2002) 2.06

Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes. J Physiol (2010) 2.01

Voltage dependence of cardiac excitation-contraction coupling: unitary Ca2+ current amplitude and open channel probability. Circ Res (2007) 1.96

Phospholemman-phosphorylation mediates the beta-adrenergic effects on Na/K pump function in cardiac myocytes. Circ Res (2005) 1.94

Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond. J Mol Cell Cardiol (2002) 1.94

Expression and phosphorylation of the na-pump regulatory subunit phospholemman in heart failure. Circ Res (2005) 1.92

Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes. Circ Res (2006) 1.89

Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban. J Mol Cell Cardiol (2002) 1.82

Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res (2011) 1.82

Modulation of excitation-contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger. J Physiol (2004) 1.81

Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res (2011) 1.69

Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytes. J Physiol (2002) 1.67

Calcium and cardiac rhythms: physiological and pathophysiological. Circ Res (2002) 1.67

Cardiac type 2 inositol 1,4,5-trisphosphate receptor: interaction and modulation by calcium/calmodulin-dependent protein kinase II. J Biol Chem (2005) 1.64

CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem (2007) 1.64

Dynamic changes in free Ca-calmodulin levels in adult cardiac myocytes. J Mol Cell Cardiol (2006) 1.62

Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes. Biophys J (2008) 1.61

A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res (2011) 1.61

AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res (2013) 1.59

Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circ Res (2008) 1.58

Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem Biophys Res Commun (2008) 1.57

Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ Res (2006) 1.56

Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol (2009) 1.56

Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation (2013) 1.54

Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circ Res (2012) 1.53

Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation (2007) 1.51

Deranged sodium to sudden death. J Physiol (2015) 1.51

CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation. J Mol Cell Cardiol (2006) 1.51

Modulation of SR Ca release by luminal Ca and calsequestrin in cardiac myocytes: effects of CASQ2 mutations linked to sudden cardiac death. Biophys J (2008) 1.49

Simultaneous measurements of mitochondrial NADH and Ca(2+) during increased work in intact rat heart trabeculae. Biophys J (2002) 1.47

Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model. Biophys J (2005) 1.47

Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J (2007) 1.45

Spatiotemporal characteristics of SR Ca(2+) uptake and release in detubulated rat ventricular myocytes. J Mol Cell Cardiol (2005) 1.42

Biosensors to measure inositol 1,4,5-trisphosphate concentration in living cells with spatiotemporal resolution. J Biol Chem (2005) 1.42

Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. J Clin Invest (2011) 1.41

Partial inhibition of sarcoplasmic reticulum ca release evokes long-lasting ca release events in ventricular myocytes: role of luminal ca in termination of ca release. Biophys J (2007) 1.40

Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes. Biophys J (2010) 1.39

Ca/calmodulin kinase II differentially modulates potassium currents. Circ Arrhythm Electrophysiol (2009) 1.37

Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart. Circ Res (2007) 1.37

Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes. Cardiovasc Res (2012) 1.36

Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII. J Mol Cell Cardiol (2006) 1.35

The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ Res (2010) 1.34

Ryanodine receptor S2808 phosphorylation in heart failure: smoking gun or red herring. Circ Res (2012) 1.31

Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II. J Mol Cell Cardiol (2010) 1.31

Dynamic calcium movement inside cardiac sarcoplasmic reticulum during release. Circ Res (2011) 1.30

Phospholamban oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase binding measured by fluorescence resonance energy transfer in living cells. J Biol Chem (2008) 1.29

Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol (2009) 1.28

Differential distribution and regulation of mouse cardiac Na+/K+-ATPase alpha1 and alpha2 subunits in T-tubule and surface sarcolemmal membranes. Cardiovasc Res (2006) 1.28

Phospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during beta-adrenergic stimulation in mouse ventricular myocytes. Circulation (2008) 1.27

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res (2014) 1.27

Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function. J Mol Cell Cardiol (2006) 1.26

Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res (2008) 1.25

Dynamic regulation of sodium/calcium exchange function in human heart failure. Circulation (2003) 1.24

Fluorescence resonance energy transfer-based sensor Camui provides new insight into mechanisms of calcium/calmodulin-dependent protein kinase II activation in intact cardiomyocytes. Circ Res (2011) 1.23

Isoform specificity of the Na/K-ATPase association and regulation by phospholemman. J Biol Chem (2009) 1.23

Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis. Cardiovasc Res (2003) 1.23

How does stochastic ryanodine receptor-mediated Ca leak fail to initiate a Ca spark? Biophys J (2011) 1.22

Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Circ Res (2014) 1.22

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. J Biol Chem (2012) 1.22

Free and bound intracellular calmodulin measurements in cardiac myocytes. Cell Calcium (2006) 1.21

Phospholemman phosphorylation alters its fluorescence resonance energy transfer with the Na/K-ATPase pump. J Biol Chem (2006) 1.21

Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation (2008) 1.17

Calcium cycling in heart failure: the arrhythmia connection. J Cardiovasc Electrophysiol (2002) 1.17

Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes. J Mol Cell Cardiol (2009) 1.16

Cardiac Na/Ca exchange function in rabbit, mouse and man: what's the difference? J Mol Cell Cardiol (2002) 1.16

Myocyte nitric oxide synthase 2 contributes to blunted beta-adrenergic response in failing human hearts by decreasing Ca2+ transients. Circulation (2004) 1.15

Na⁺ transport in the normal and failing heart - remember the balance. J Mol Cell Cardiol (2013) 1.14

Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure. Am J Physiol Heart Circ Physiol (2010) 1.13

Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation (2013) 1.12