Published in Annu Rev Genomics Hum Genet on April 15, 2002
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell (2008) 6.78
Heterozygous TGFBR2 mutations in Marfan syndrome. Nat Genet (2004) 6.15
Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology (2008) 5.19
Human RAS superfamily proteins and related GTPases. Sci STKE (2004) 3.80
Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. Cancer Cell (2012) 2.94
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Proc Natl Acad Sci U S A (2004) 2.42
Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia (2005) 2.18
Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog (2009) 2.06
Transforming growth factor beta (TGF-beta) and inflammation in cancer. Cytokine Growth Factor Rev (2009) 1.95
TGF-beta signaling alterations and susceptibility to colorectal cancer. Hum Mol Genet (2007) 1.77
Cancer genome sequencing--an interim analysis. Cancer Res (2009) 1.52
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. Gastroenterology (2009) 1.50
Smad4-mediated TGF-beta signaling in tumorigenesis. Int J Biol Sci (2010) 1.47
Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. J Clin Invest (2014) 1.46
The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck. J Med Genet (2005) 1.34
Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers. Mol Cancer (2008) 1.31
Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. Proc Natl Acad Sci U S A (2003) 1.30
Functional specificity of ras isoforms: so similar but so different. Genes Cancer (2011) 1.30
Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools. PLoS One (2009) 1.24
Overexpression of OATP1B3 confers apoptotic resistance in colon cancer. Cancer Res (2008) 1.20
The transcriptional repressor SNAIL is overexpressed in human colon cancer. Dig Dis Sci (2005) 1.18
Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. Mol Cell Biol (2012) 1.17
BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK. Cell Signal (2007) 1.15
Colorectal cancer "methylator phenotype": fact or artifact? Neoplasia (2005) 1.13
A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proc Natl Acad Sci U S A (2011) 1.09
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. Int J Cancer (2008) 1.06
Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimates. Radiat Environ Biophys (2010) 1.05
Modelling oncogenic Ras/Raf signalling in the mouse. Curr Opin Genet Dev (2009) 1.02
Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model. Mol Carcinog (2010) 1.00
RAS Mutations and Oncogenesis: Not all RAS Mutations are Created Equally. Front Genet (2012) 0.99
Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma. Expert Rev Dermatol (2007) 0.98
Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas. World J Gastroenterol (2010) 0.98
Genetics of the hamartomatous polyposis syndromes: a molecular review. Int J Colorectal Dis (2009) 0.95
Sensitive detection of KRAS mutations in archived formalin-fixed paraffin-embedded tissue using mutant-enriched PCR and reverse-hybridization. J Mol Diagn (2009) 0.95
Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population. Int J Colorectal Dis (2007) 0.94
Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics. Cancer Epidemiol Biomarkers Prev (2006) 0.94
High sensitivity EndoV mutation scanning through real-time ligase proofreading. Nucleic Acids Res (2004) 0.94
Epigenetic mechanisms of promigratory chemokine CXCL14 regulation in human prostate cancer cells. Cancer Res (2010) 0.93
Reversibility of aberrant global DNA and estrogen receptor-alpha gene methylation distinguishes colorectal precancer from cancer. Int J Clin Exp Pathol (2008) 0.93
Genome-wide screening of genes regulated by DNA methylation in colon cancer development. PLoS One (2012) 0.92
Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives. Curr Pharm Des (2013) 0.91
Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility. PLoS One (2013) 0.91
Essential role of CR6-interacting factor 1 (Crif1) in E74-like factor 3 (ELF3)-mediated intestinal development. J Biol Chem (2009) 0.90
Cdx1 and Cdx2 function as tumor suppressors. J Biol Chem (2014) 0.90
Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells. J Med Genet (2006) 0.89
Down-regulation of c9orf86 in human breast cancer cells inhibits cell proliferation, invasion and tumor growth and correlates with survival of breast cancer patients. PLoS One (2013) 0.87
Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary. World J Gastroenterol (2008) 0.87
FasL gene knock-down therapy enhances the antiglioma immune response. Neuro Oncol (2010) 0.86
The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers. Int J Cancer (2014) 0.86
Intestinal GUCY2C prevents TGF-β secretion coordinating desmoplasia and hyperproliferation in colorectal cancer. Cancer Res (2013) 0.86
Targeting mTOR network in colorectal cancer therapy. World J Gastroenterol (2014) 0.86
Diet and epigenetics in colon cancer. World J Gastroenterol (2009) 0.85
Wnt signaling in cancer stem cells and colon cancer metastasis. F1000Res (2016) 0.84
Colonic 15-PGDH levels are stable across distance and time and are not perturbed by aspirin intervention. Dig Dis Sci (2013) 0.83
Targeting Wnt pathway in mantle cell lymphoma-initiating cells. J Hematol Oncol (2015) 0.83
Expression of a novel immunoglobulin gene SNC73 in human cancer and non-cancerous tissues. World J Gastroenterol (2003) 0.82
Next generation sequencing and a new era of medicine. Gut (2012) 0.82
Association of overexpression of TIF1γ with colorectal carcinogenesis and advanced colorectal adenocarcinoma. World J Gastroenterol (2011) 0.82
Nutritional-pharmacological combinations--a novel approach to reducing colon cancer incidence. Eur J Nutr (2004) 0.80
Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter. Oncogene (2016) 0.80
Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease. Int J Colorectal Dis (2009) 0.80
Debate about TGFBR1 and the susceptibility to colorectal cancer. World J Gastrointest Oncol (2012) 0.79
Positive expression of protein chromosome 9 open reading frame 86 (C9orf86) correlated with poor prognosis in non-small cell lung cancer patients. J Thorac Dis (2016) 0.79
Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase. Cancer Res (2008) 0.79
Clinical and molecular biologic characteristics of early-onset versus late-onset colorectal carcinoma in Filipinos. World J Surg (2004) 0.78
Transformation by oncogenic Ras expands the early genomic response to transforming growth factor beta in intestinal epithelial cells. Neoplasia (2008) 0.78
JMJD5 is a potential oncogene for colon carcinogenesis. Int J Clin Exp Pathol (2015) 0.78
DNA alkylation and DNA methylation: cooperating mechanisms driving the formation of colorectal adenomas and adenocarcinomas? Gut (2007) 0.76
Genetic and epigenetic marker-based DNA test of stool is a promising approach for colorectal cancer screening. Yonsei Med J (2009) 0.76
NOB1 is essential for the survival of RKO colorectal cancer cells. World J Gastroenterol (2015) 0.75
Gastrointestinal tract cancers: Genetics, heritability and germ line mutations. Oncol Lett (2017) 0.75
Pazopanib, a novel multi-kinase inhibitor, shows potent antitumor activity in colon cancer through PUMA-mediated apoptosis. Oncotarget (2016) 0.75
Development of primary early-onset colorectal cancers due to biallelic mutations of the FANCD1/BRCA2 gene. Eur J Hum Genet (2013) 0.75
Effect of deleted pancreatic cancer locus 4 gene transfection on biological behaviors of human colorectal carcinoma cells. World J Gastroenterol (2005) 0.75
Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes. Mol Genet Genomic Med (2017) 0.75
The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02
The genomic landscapes of human breast and colorectal cancers. Science (2007) 38.12
Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A (2008) 10.52
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet (2004) 7.78
Heteroplasmic mitochondrial DNA mutations in normal and tumour cells. Nature (2010) 4.53
Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci U S A (2008) 4.13
Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene. J Natl Cancer Inst (2005) 3.73
Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A (2011) 2.54
The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer (2008) 2.52
Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res (2004) 2.51
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Proc Natl Acad Sci U S A (2004) 2.42
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. Proc Natl Acad Sci U S A (2006) 2.41
Sensitive digital quantification of DNA methylation in clinical samples. Nat Biotechnol (2009) 2.34
DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Sci Signal (2010) 2.04
SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. Proc Natl Acad Sci U S A (2003) 2.01
Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination. J Cell Biol (2006) 1.85
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. Proc Natl Acad Sci U S A (2003) 1.84
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc Natl Acad Sci U S A (2008) 1.84
Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions. Cancer Cell (2013) 1.74
BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells. Cancer Res (2009) 1.74
PRL-3 expression in metastatic cancers. Clin Cancer Res (2003) 1.73
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. Cancer Prev Res (Phila) (2008) 1.71
15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors. Proc Natl Acad Sci U S A (2009) 1.65
Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin Cancer Res (2005) 1.59
Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers. Cancer Res (2003) 1.58
Aberrant vimentin methylation is characteristic of upper gastrointestinal pathologies. Cancer Epidemiol Biomarkers Prev (2012) 1.57
Clinical trial resources on the internet must be designed to reach underrepresented minorities. Cancer J (2007) 1.56
The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. J Physiol (2004) 1.53
Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers. Proc Natl Acad Sci U S A (2009) 1.51
Aspirin and colon cancer--targeting prevention? N Engl J Med (2007) 1.50
Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. J Clin Invest (2014) 1.46
CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. Genes Chromosomes Cancer (2006) 1.44
HLTF gene silencing in human colon cancer. Proc Natl Acad Sci U S A (2002) 1.43
Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients. Cancer Res (2009) 1.38
Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. Proc Natl Acad Sci U S A (2010) 1.30
Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases. J Biol Chem (2011) 1.19
Allele-specific expression of TGFBR1 in colon cancer patients. Carcinogenesis (2010) 1.17
Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. Am J Hum Genet (2008) 1.10
Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD). Sci Transl Med (2014) 1.07
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. Int J Cancer (2008) 1.06
The microRNAs, MiR-31 and MiR-375, as candidate markers in Barrett's esophageal carcinogenesis. Genes Chromosomes Cancer (2012) 1.06
Global mutational profiling of formalin-fixed human colon cancers from a pathology archive. Mod Pathol (2012) 1.01
15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer. Cancer Res (2008) 1.00
Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells. Genes Chromosomes Cancer (2008) 0.97
NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer. PLoS Genet (2013) 0.96
Confirmation of linkage to and localization of familial colon cancer risk haplotype on chromosome 9q22. Cancer Res (2010) 0.96
Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility. PLoS One (2013) 0.91
H3K4me3 inversely correlates with DNA methylation at a large class of non-CpG-island-containing start sites. Genome Med (2012) 0.90
Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes. Mol Cancer Res (2012) 0.88
Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia? Cancer Epidemiol Biomarkers Prev (2007) 0.88
Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations. Int J Cancer (2006) 0.88
C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer. Int J Cancer (2004) 0.88
An improved method for staining cell colonies in clonogenic assays. Cytotechnology (2007) 0.86
Colonic 15-PGDH levels are stable across distance and time and are not perturbed by aspirin intervention. Dig Dis Sci (2013) 0.83
The effectiveness of colonoscopy in reducing mortality from colorectal cancer. Ann Intern Med (2009) 0.82
Two Distinct Categories of Focal Deletions in Cancer Genomes. PLoS One (2013) 0.82
MethyLight droplet digital PCR for detection and absolute quantification of infrequently methylated alleles. Epigenetics (2015) 0.82
Detection of mononucleotide repeat sequence alterations in a large background of normal DNA for screening high-frequency microsatellite instability cancers. Clin Cancer Res (2006) 0.79
Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase. Cancer Res (2008) 0.79
Hereditary colon cancer genes. Methods Mol Biol (2003) 0.78
Early loss of deleted in colorectal carcinoma gene transcript detected in a group of benign colon adenomas. J Biomed Sci (2002) 0.77
The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening. Dig Dis Sci (2014) 0.76