Published in Proc Natl Acad Sci U S A on October 31, 2011
The Hippo pathway and human cancer. Nat Rev Cancer (2013) 5.17
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β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell (2012) 3.33
Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol (2012) 3.07
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov (2013) 3.03
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell (2015) 2.31
Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol (2015) 2.21
The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PLoS One (2013) 2.14
Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers. Nat Med (2014) 2.03
Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells. J Biol Chem (2012) 1.89
Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology (2013) 1.85
The Hippo signaling pathway and stem cell biology. Trends Cell Biol (2012) 1.84
YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prognosis for ovarian cancer patients. PLoS One (2014) 1.82
The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep (2014) 1.73
Protein kinases of the Hippo pathway: regulation and substrates. Semin Cell Dev Biol (2012) 1.61
Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma. Gastroenterology (2013) 1.58
A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature (2015) 1.56
TAZ expression as a prognostic indicator in colorectal cancer. PLoS One (2013) 1.55
Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1. Sci Signal (2015) 1.52
cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. EMBO J (2013) 1.42
YAP oncogene overexpression supercharges colon cancer proliferation. Cell Cycle (2012) 1.34
Disease implications of the Hippo/YAP pathway. Trends Mol Med (2015) 1.32
Intestinal stem cell function in Drosophila and mice. Curr Opin Genet Dev (2012) 1.30
YAP and TAZ: a nexus for Hippo signaling and beyond. Trends Cell Biol (2015) 1.29
Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein. Cell Rep (2014) 1.28
Reparative inflammation takes charge of tissue regeneration. Nature (2016) 1.21
Hippo signaling regulates pancreas development through inactivation of Yap. Mol Cell Biol (2012) 1.21
Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis. Clin Cancer Res (2013) 1.18
Signal integration in TGF-β, WNT, and Hippo pathways. F1000Prime Rep (2013) 1.15
Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer. Nature (2015) 1.14
Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes Dev (2015) 1.12
A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun (2014) 1.12
Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling. Cell Biosci (2013) 1.09
CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation. Cancer Res (2013) 1.03
Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. J Clin Invest (2013) 1.02
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense. Cell Rep (2013) 1.01
A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ. Oncotarget (2015) 1.00
Yap1 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin. J Biol Chem (2012) 1.00
The role of the Hippo pathway in human disease and tumorigenesis. Clin Transl Med (2014) 0.99
Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patients. Clin Cancer Res (2014) 0.99
β-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Genes Dev (2015) 0.96
NDR functions as a physiological YAP1 kinase in the intestinal epithelium. Curr Biol (2015) 0.93
Integration of mechanical and chemical signals by YAP and TAZ transcription coactivators. Cell Biosci (2013) 0.91
What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease. Exp Eye Res (2013) 0.90
Intestinal barrier: Molecular pathways and modifiers. World J Gastrointest Pathophysiol (2013) 0.90
YAP/TEAD co-activator regulated pluripotency and chemoresistance in ovarian cancer initiated cells. PLoS One (2014) 0.90
Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ Cell Rep (2015) 0.90
Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci U S A (2013) 0.90
Merlin is a negative regulator of human melanoma growth. PLoS One (2012) 0.89
A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis. Cell Res (2015) 0.89
The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells. Nat Commun (2016) 0.88
Hippo pathway in intestinal homeostasis and tumorigenesis. Protein Cell (2012) 0.88
A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas. Front Oncol (2015) 0.88
Constitutive expression of Yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy. PLoS One (2013) 0.88
Overexpression of MYC and EZH2 cooperates to epigenetically silence MST1 expression. Epigenetics (2014) 0.87
Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway. Mol Cancer Res (2015) 0.87
Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1. J Biol Chem (2012) 0.87
Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease. World J Biol Chem (2015) 0.87
Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration. Cell Res (2013) 0.86
The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation. Protein Cell (2012) 0.86
Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis. Sci Rep (2015) 0.85
Mst1 and Mst2 kinases: regulations and diseases. Cell Biosci (2013) 0.85
MST kinases in development and disease. J Cell Biol (2015) 0.84
Energy stress tames the Hippo pathway. Nat Cell Biol (2015) 0.84
Major signaling pathways in intestinal stem cells. Biochim Biophys Acta (2012) 0.83
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development. Nat Commun (2016) 0.83
Expression of hippo pathway in colorectal cancer. Saudi J Gastroenterol (2014) 0.83
FGF8 promotes colorectal cancer growth and metastasis by activating YAP1. Oncotarget (2015) 0.83
The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol (2016) 0.82
Two-signal requirement for growth-promoting function of Yap in hepatocytes. Elife (2015) 0.81
The mammalian Ste20-like kinase 2 (Mst2) modulates stress-induced cardiac hypertrophy. J Biol Chem (2014) 0.81
The Hippo pathway regulates homeostatic growth of stem cell niche precursors in the Drosophila ovary. PLoS Genet (2015) 0.81
Notch inhibits Yorkie activity in Drosophila wing discs. PLoS One (2014) 0.81
Prostaglandin E2 Activates YAP and a Positive-signaling Loop to Promote Colon Regeneration Following Colitis but Also Carcinogenesis in Mice. Gastroenterology (2016) 0.79
The Hippo pathway member YAP enhances human neural crest cell fate and migration. Sci Rep (2016) 0.79
The hippo tumor suppressor network: from organ size control to stem cells and cancer. Cancer Res (2013) 0.79
Effects of mTOR Inhibitors on Components of the Salvador-Warts-Hippo Pathway. Cells (2012) 0.79
Functional role of Mst1/Mst2 in embryonic stem cell differentiation. PLoS One (2013) 0.79
The Hippo signaling pathway provides novel anti-cancer drug targets. Oncotarget (2016) 0.79
Emerging role of Hippo pathway in gastric and other gastrointestinal cancers. World J Gastroenterol (2016) 0.79
MST2 phosphorylation at serine 385 in mitosis inhibits its tumor suppressing activity. Cell Signal (2016) 0.79
Alcohol interacts with genetic alteration of the Hippo tumor suppressor pathway to modulate tissue growth in Drosophila. PLoS One (2013) 0.78
The Roles of NDR Protein Kinases in Hippo Signalling. Genes (Basel) (2016) 0.77
LIX1 regulates YAP1 activity and controls the proliferation and differentiation of stomach mesenchymal progenitors. BMC Biol (2016) 0.76
The hippo signaling pathway: implications for heart regeneration and disease. Clin Transl Med (2014) 0.76
The interplay between centrosomes and the Hippo tumor suppressor pathway. Chromosome Res (2016) 0.76
Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse. Oncotarget (2016) 0.76
Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest (2016) 0.75
Genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1) improves cell reprogramming efficiency and increases induced pluripotent stem cell proliferation and survival. Stem Cell Res (2017) 0.75
The Hippo pathway in tissue homeostasis and regeneration. Protein Cell (2017) 0.75
Awakening the Hippo co-activator YAP1, a mercurial cancer gene, in hematologic cancers. Mol Cell Oncol (2014) 0.75
Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration. J Immunol (2016) 0.75
Inhibitory effect and mechanism of exogenous mammalian sterile 20-like kinase 1 on the growth of human colorectal cancer. Oncol Lett (2017) 0.75
MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells. EMBO Rep (2017) 0.75
Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development. Proc Natl Acad Sci U S A (2016) 0.75
The Hippo/MST Pathway Member SAV1 Plays a Suppressive Role in Development of the Prehierarchical Follicles in Hen Ovary. PLoS One (2016) 0.75
A genetic variant in large tumor suppressor kinase 2 of Hippo signaling pathway contributes to prognosis of hepatocellular carcinoma. Onco Targets Ther (2016) 0.75
Fluid shear stress activates YAP1 to promote cancer cell motility. Nat Commun (2017) 0.75
RASSF1A Signaling in the Heart: Novel Functions beyond Tumor Suppression. Mol Biol Int (2012) 0.75
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Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell (2007) 13.04
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell (2009) 11.52
Signalling downstream of activated mammalian Notch. Nature (1995) 11.08
The hippo signaling pathway in development and cancer. Dev Cell (2010) 10.54
TEAD mediates YAP-dependent gene induction and growth control. Genes Dev (2008) 9.88
YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11
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Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39
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Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science (2001) 7.17
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Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol (2003) 6.60
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature (2008) 5.59
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev (2010) 5.38
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Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A (2010) 4.95
Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell (2011) 4.85
Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet (2006) 4.82
Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science (2011) 4.76
Expression of Yes-associated protein in common solid tumors. Hum Pathol (2008) 4.61
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proc Natl Acad Sci U S A (2008) 4.60
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol (2001) 4.33
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Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology (2009) 4.16
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev (2010) 3.37
The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci U S A (2010) 3.18
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev (2010) 3.02
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J (2004) 2.78
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci U S A (2009) 2.63
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol (2008) 2.62
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A (2009) 2.34
Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nat Immunol (2006) 2.34
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Upstream regulation of the hippo size control pathway. Curr Biol (2010) 2.09
Hes1 is a negative regulator of inner ear hair cell differentiation. Development (2000) 1.85
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Target disruption of the mutant beta-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype. Oncogene (2002) 1.24
The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells. Cancer Res (2009) 1.09
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Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A (2008) 10.52
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature (2008) 8.69
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet (2004) 7.78
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39
Rheb binds and regulates the mTOR kinase. Curr Biol (2005) 6.09
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Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell (2011) 4.85
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Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev (2012) 3.62
Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature (2012) 3.54
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MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol (2008) 2.62
YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29. Nat Cell Biol (2012) 2.59
The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer (2008) 2.52
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Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev (2002) 1.87
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A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem (2003) 1.75
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The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Mol Cell Biol (2008) 1.61
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A (2008) 1.61
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The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. J Physiol (2004) 1.53
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CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. Genes Chromosomes Cancer (2006) 1.44
HLTF gene silencing in human colon cancer. Proc Natl Acad Sci U S A (2002) 1.43
Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding. Mol Biol Cell (2003) 1.42
Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J Biol Chem (2002) 1.41
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Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinases. Oncogene (2004) 1.35
Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J (2011) 1.34
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The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. J Cell Sci (2008) 1.32
Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. Proc Natl Acad Sci U S A (2010) 1.30
Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis. EMBO J (2014) 1.30