Published in Oncogene on June 23, 2014
Mass spectrometry-based detection and assignment of protein posttranslational modifications. ACS Chem Biol (2015) 0.84
Roles of ubiquitination and SUMOylation on prostate cancer: mechanisms and clinical implications. Int J Mol Sci (2015) 0.79
The retinal determination gene network: from developmental regulator to cancer therapeutic target. Oncotarget (2016) 0.78
EYA1 expression and subcellular localization in neuroblastoma and its association with prognostic markers. J Cancer Res Ther (Manch) (2016) 0.75
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell (2006) 27.36
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res (2008) 7.65
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem (2001) 7.10
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev (2001) 6.15
Activation of AKT kinases in cancer: implications for therapeutic targeting. Adv Cancer Res (2005) 4.74
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery. PLoS One (2009) 4.62
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science (2006) 4.42
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. PLoS One (2008) 4.12
Something about SUMO inhibits transcription. Curr Opin Genet Dev (2005) 4.05
Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol (2005) 4.00
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature (2003) 3.72
The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell (1997) 3.61
Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila. Cell (1997) 3.58
Deregulated homeobox gene expression in cancer: cause or consequence? Nat Rev Cancer (2002) 3.53
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature (2009) 3.36
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell (2008) 3.27
Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet (1999) 3.24
SUMO promotes HDAC-mediated transcriptional repression. Mol Cell (2004) 2.97
SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol Cell (2002) 2.93
Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs. J Biol Chem (2002) 2.79
Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer. Breast Cancer Res (2011) 2.19
The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1. Proc Natl Acad Sci U S A (2004) 2.11
Eyes absent represents a class of protein tyrosine phosphatases. Nature (2003) 2.05
The transcription factor Eyes absent is a protein tyrosine phosphatase. Nature (2003) 2.04
SUMO1 haploinsufficiency leads to cleft lip and palate. Science (2006) 2.01
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. J Clin Invest (2009) 2.01
Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. Mol Cell Biol (1999) 1.96
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. Biochem J (2008) 1.96
Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis. Proc Natl Acad Sci U S A (1998) 1.86
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. Mol Cell (2009) 1.81
Regulation of the innate immune response by threonine-phosphatase of Eyes absent. Nature (2009) 1.69
Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition. J Clin Invest (2009) 1.67
A recurrent phospho-sumoyl switch in transcriptional repression and beyond. Mol Cell (2006) 1.60
Gene amplification is a mechanism of Six1 overexpression in breast cancer. Cancer Res (2005) 1.49
A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest (2011) 1.39
Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties. Oncogene (2011) 1.30
The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells. Oncogene (2010) 1.28
Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol (2005) 1.17
Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 conjugating enzyme, in normal and malignant tissues. Hum Pathol (2010) 1.16
The Eyes Absent proteins in development and disease. Cell Mol Life Sci (2012) 1.16
p38 Mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase-, and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expression. Mol Biol Cell (2002) 1.13
EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1. Cancer Res (2013) 1.10
Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. Proc Natl Acad Sci U S A (2012) 1.05
Common variants in the UBC9 gene encoding the SUMO-conjugating enzyme are associated with breast tumor grade. Int J Cancer (2009) 1.02
Akt SUMOylation regulates cell proliferation and tumorigenesis. Cancer Res (2013) 0.99
Polymorphisms in the UBC9 and PIAS3 genes of the SUMO-conjugating system and breast cancer risk. Breast Cancer Res Treat (2009) 0.87
Efficacy of DNA double-strand breaks repair in breast cancer is decreased in carriers of the variant allele of the UBC9 gene c.73G>A polymorphism. Mutat Res (2010) 0.86
Yeast two-hybrid system identifies the ubiquitin-conjugating enzyme mUbc9 as a potential partner of mouse Dac. Mech Dev (2000) 0.77