Published in FASEB J on August 01, 2002
Intermittent hypoxia increases insulin resistance in genetically obese mice. J Physiol (2003) 2.71
Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes (2008) 1.88
Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients. Am J Physiol Endocrinol Metab (2008) 1.60
Adipokines linking obesity with colorectal cancer risk in postmenopausal women. Cancer Res (2012) 1.35
Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun (2009) 1.27
Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective study. Diabetes (2009) 1.13
Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes. Curr Diabetes Rev (2014) 1.12
Obesity, inflammation and diet. Pediatr Gastroenterol Hepatol Nutr (2013) 1.11
Sleep Apnea and Metabolic Dysfunction: Cause or Co-Relation? Sleep Med Clin (2007) 1.04
Leptin and Adiponectin: new players in the field of tumor cell and leukocyte migration. Cell Commun Signal (2009) 1.04
Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes. Diabetes (2011) 1.03
Diet-induced obesity is associated with hyperleptinemia, hyperinsulinemia, hepatic steatosis, and glomerulopathy in C57Bl/6J mice. Endocrine (2009) 1.00
Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Mol Cell Biol (2015) 0.93
Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns. Arch Med Sci (2015) 0.93
Association between serum leptin concentrations and insulin resistance: a population-based study from China. PLoS One (2013) 0.93
Serum concentrations of cortisol, interleukin 6, leptin and adiponectin predict stress induced insulin resistance in acute inflammatory reactions. Crit Care (2008) 0.93
Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance. Diabetes (2010) 0.92
A new insulin-mimetic bis(allixinato)zinc(II) complex: structure-activity relationship of zinc(II) complexes. J Biol Inorg Chem (2004) 0.92
Sarcopenic obesity and endocrinal adaptation with age. Int J Endocrinol (2013) 0.91
Obesity and lipodystrophy--where do the circles intersect? Endocrinology (2008) 0.91
Association of C-peptide and leptin with prostate cancer incidence in the Health Professionals Follow-up Study. Cancer Causes Control (2014) 0.89
Serum leptin level is reduced in non-obese subjects with type 2 diabetes. Int J Endocrinol Metab (2012) 0.85
Leptin reduces the expression and increases the phosphorylation of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4 in muscle of ob/ob mice. PLoS One (2012) 0.83
Leptin therapy, insulin sensitivity, and glucose homeostasis. Indian J Endocrinol Metab (2012) 0.81
Increased Gustatory Response Score in Obesity and Association Levels with IL-6 and Leptin. J Nutr Metab (2016) 0.79
Age impacts on the independent relationships of leptin with cardiometabolic risk and surrogate markers of enhanced early atherogenesis in black and white patients with rheumatoid arthritis: a cross-sectional study. Rheumatol Int (2014) 0.79
Hyperleptinemia, adiposity, and risk of metabolic syndrome in older adults. J Nutr Metab (2013) 0.78
Chronic angiotensin AT2R activation prevents high-fat diet-induced adiposity and obesity in female mice independent of estrogen. Metabolism (2015) 0.77
Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects. World J Gastroenterol (2005) 0.76
Effect of exogenous leptin on serum levels of lipids, glucose, renal and hepatic variables in both genders of obese and streptozotocin-induced diabetic rats. Iran J Basic Med Sci (2015) 0.75
Beneficial Effect of Leptin on Spatial Learning and Memory in Streptozotocin-Induced Diabetic Rats. Balkan Med J (2016) 0.75
Relationships between plasma leptin levels, leptin G2548A, leptin receptor Gln223Arg polymorphisms and gestational diabetes mellitus in Chinese population. Sci Rep (2016) 0.75
Relationship of postprandial nonesterified fatty acids, adipokines, and insulin across gender in human immunodeficiency virus-positive patients undergoing highly active antiretroviral therapy. Metab Syndr Relat Disord (2009) 0.75
The glucoregulatory actions of leptin. Mol Metab (2017) 0.75
Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med (2014) 6.12
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab (2010) 3.46
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem (2003) 3.45
Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin Chem (2006) 3.44
AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest (2006) 3.39
TXNIP regulates peripheral glucose metabolism in humans. PLoS Med (2007) 3.27
Cardiac remodeling in obesity. Physiol Rev (2008) 2.95
Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab (2009) 2.76
Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab (2013) 2.47
Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab (2012) 2.46
Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. Diabetes (2005) 2.35
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity. Nat Genet (2008) 2.14
Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes (2008) 2.03
Glutamate is a positive autocrine signal for glucagon release. Cell Metab (2008) 2.01
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell (2008) 1.97
The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J Biol Chem (2004) 1.94
T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice. Circ Res (2009) 1.93
Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes (2005) 1.89
AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits. Diabetes (2006) 1.85
Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality. Am J Physiol Endocrinol Metab (2008) 1.79
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes (2010) 1.71
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. PLoS Biol (2009) 1.61
Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise. Am J Physiol Endocrinol Metab (2004) 1.58
Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans. FASEB J (2005) 1.55
MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. J Biol Chem (2007) 1.53
Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways. J Biol Chem (2003) 1.53
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab (2006) 1.48
Strenuous physical exercise adversely affects monocyte chemotaxis. Thromb Haemost (2010) 1.45
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes (2003) 1.45
Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle. Mol Endocrinol (2006) 1.43
Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle. Diabetes (2007) 1.37
Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle. Diabetes (2006) 1.37
APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice. Cell Metab (2009) 1.36
A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation. J Biol Chem (2002) 1.35
Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle. Am J Physiol Endocrinol Metab (2003) 1.32
Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep (2013) 1.31
Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity. Diabetes Metab Res Rev (2011) 1.30
Changes in exercise-induced gene expression in 5'-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice. Diabetes (2005) 1.29
Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta. Diabetes (2005) 1.28
Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. J Biol Chem (2010) 1.27
Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation. J Biol Chem (2009) 1.27
Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice. Diabetes (2011) 1.26
Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients. Diabetes (2006) 1.19
Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab (2012) 1.19
Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression. J Biol Chem (2006) 1.18
Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle. J Biol Chem (2008) 1.17
MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways. Am J Physiol Cell Physiol (2004) 1.16
Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training. J Physiol (2013) 1.16
USF1 and dyslipidemias: converging evidence for a functional intronic variant. Hum Mol Genet (2005) 1.16
Sending the signal: molecular mechanisms regulating glucose uptake. Med Sci Sports Exerc (2004) 1.15
Globular adiponectin, acting via AdipoR1/APPL1, protects H9c2 cells from hypoxia/reoxygenation-induced apoptosis. PLoS One (2011) 1.13
Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise. J Physiol (2003) 1.13
Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. J Cell Physiol (2009) 1.12
Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes. Cardiovasc Res (2007) 1.11
DNA methylation in metabolic disorders. Am J Clin Nutr (2011) 1.11
Low-intensity exercise increases skeletal muscle protein expression of PPARdelta and UCP3 in type 2 diabetic patients. Diabetes Metab Res Rev (2006) 1.11
Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study. Diabetes (2005) 1.10
IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients. Diabetes (2006) 1.10
Insulin signaling and glucose transport in insulin resistant human skeletal muscle. Cell Biochem Biophys (2007) 1.10
5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics. FASEB J (2005) 1.09
Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes. J Clin Endocrinol Metab (2004) 1.08
An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart. Am J Physiol Endocrinol Metab (2010) 1.08
Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function. Am J Physiol Cell Physiol (2008) 1.08
Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis. Diabetes (2012) 1.07
Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes. Curr Diabetes Rev (2005) 1.06
Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation. Am J Physiol Endocrinol Metab (2003) 1.05
Functional significance of skeletal muscle adiponectin production, changes in animal models of obesity and diabetes, and regulation by rosiglitazone treatment. Am J Physiol Endocrinol Metab (2009) 1.05
Creatine supplementation increases glucose oxidation and AMPK phosphorylation and reduces lactate production in L6 rat skeletal muscle cells. J Physiol (2004) 1.05
Adenosine 5'-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle. Endocrinology (2008) 1.05
Epigenetic flexibility in metabolic regulation: disease cause and prevention? Trends Cell Biol (2012) 1.04
Implications of myocardial matrix remodeling by adipokines in obesity-related heart failure. Trends Cardiovasc Med (2008) 1.03
Total and high molecular weight but not trimeric or hexameric forms of adiponectin correlate with markers of the metabolic syndrome and liver injury in Thai subjects. J Clin Endocrinol Metab (2007) 1.03
The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism. Am J Physiol Endocrinol Metab (2012) 1.02
Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase- and phosphatidylinositol 3-kinase-dependent signaling pathways. Endocrinology (2004) 1.02
Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study. Clin Endocrinol (Oxf) (2008) 1.02
Insulin signaling defects in type 2 diabetes. Rev Endocr Metab Disord (2004) 1.02
siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. Diabetes (2008) 1.02
Kinetics of GLUT4 trafficking in rat and human skeletal muscle. Diabetes (2009) 1.01
Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin. FEBS Lett (2005) 1.00
Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice. J Biol Chem (2006) 0.99
Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle. Proc Nutr Soc (2004) 0.99
Equilibrative nucleoside transporter 1 plays an essential role in cardioprotection. Am J Physiol Heart Circ Physiol (2009) 0.99
Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction. Diabetes (2002) 0.99
Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeletal reorganization and leads to enhanced cell migration. Endocrinology (2011) 0.99
Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle. Am J Physiol Endocrinol Metab (2008) 0.99
Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes. Cardiovasc Res (2005) 0.99
Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes (2012) 0.98
Activation of the glucose transporter GLUT4 by insulin. Biochem Cell Biol (2002) 0.98
Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus. Metabolism (2011) 0.97
Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7. Am J Physiol Endocrinol Metab (2013) 0.97
APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes (2011) 0.96
The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells. Mol Immunol (2010) 0.95
Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation. J Biol Chem (2011) 0.95