Published in Cell Metab on September 01, 2009
Uncovering the 'ORIGINS' of Diabetes (ORIGINS) | NCT02226640
Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr (2011) 2.98
The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev (2010) 2.59
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proc Natl Acad Sci U S A (2011) 2.21
A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS Genet (2013) 1.89
Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure. PLoS One (2010) 1.89
The nexus of chromatin regulation and intermediary metabolism. Nature (2013) 1.87
The role of epigenetics in the pathology of diabetic complications. Am J Physiol Renal Physiol (2010) 1.83
Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nat Commun (2015) 1.65
Sex differences in human adipose tissues - the biology of pear shape. Biol Sex Differ (2012) 1.64
Human body epigenome maps reveal noncanonical DNA methylation variation. Nature (2015) 1.63
Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. Diabetes (2012) 1.54
Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets. Diabetologia (2010) 1.52
Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol (2013) 1.49
Epigenetic mechanisms in diabetic vascular complications. Cardiovasc Res (2011) 1.43
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity. Diabetes Care (2009) 1.42
Distinct epigenomic features in end-stage failing human hearts. Circulation (2011) 1.39
Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes. PLoS One (2012) 1.38
PGC-1alpha-mediated adaptations in skeletal muscle. Pflugers Arch (2010) 1.29
Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells. Nucleic Acids Res (2009) 1.29
Minireview: Epigenetics of obesity and diabetes in humans. Endocrinology (2012) 1.25
Global DNA methylation is associated with insulin resistance: a monozygotic twin study. Diabetes (2011) 1.24
Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A. Nucleic Acids Res (2012) 1.21
Potential in vivo roles of nucleic acid triple-helices. RNA Biol (2011) 1.20
Molecular nutrition research: the modern way of performing nutritional science. Nutrients (2012) 1.18
Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina. Invest Ophthalmol Vis Sci (2011) 1.17
Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A (2011) 1.16
HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors. PLoS One (2010) 1.08
The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern. DNA Res (2013) 1.07
Nuclear receptor coactivators: structural and functional biochemistry. Biochemistry (2010) 1.06
Mitochondria and PGC-1α in Aging and Age-Associated Diseases. J Aging Res (2011) 1.04
Epigenetic codes of PPARγ in metabolic disease. FEBS Lett (2011) 1.04
Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state. J Biol Chem (2010) 1.03
Genetic and epigenetic control of metabolic health. Mol Metab (2013) 1.03
Epigenetic modifications in the pathogenesis of diabetic nephropathy. Semin Nephrol (2013) 1.02
The evidence for functional non-CpG methylation in mammalian cells. Epigenetics (2014) 1.02
Mitochondrial regulation of epigenetics and its role in human diseases. Epigenetics (2012) 0.98
Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets. BMC Med (2014) 0.98
Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells. Mol Autism (2013) 0.98
From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition? Clin Epigenetics (2015) 0.98
Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning. Br J Pharmacol (2015) 0.96
Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity. J Biol Chem (2013) 0.95
Epigenetic mechanisms involved in developmental nutritional programming. World J Diabetes (2011) 0.95
Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle. PLoS One (2013) 0.94
Mitochondrial alteration in type 2 diabetes and obesity: an epigenetic link. Cell Cycle (2014) 0.94
Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Semin Immunopathol (2013) 0.93
Non-CG Methylation in the Human Genome. Annu Rev Genomics Hum Genet (2015) 0.92
Epigenetic Alterations in Human Liver From Subjects With Type 2 Diabetes in Parallel With Reduced Folate Levels. J Clin Endocrinol Metab (2015) 0.92
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase. Nat Commun (2015) 0.91
Obesity, oxidative stress, and fibrosis in chronic kidney disease. Kidney Int Suppl (2011) (2014) 0.90
Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophrenia. Front Behav Neurosci (2013) 0.89
Linking the metabolic state and mitochondrial DNA in chronic disease, health, and aging. Diabetes (2013) 0.89
The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance. J Mol Cell Cardiol (2011) 0.88
Assessing the efficiency and significance of Methylated DNA Immunoprecipitation (MeDIP) assays in using in vitro methylated genomic DNA. BMC Res Notes (2010) 0.88
The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes. Int J Obes (Lond) (2015) 0.88
Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proc Natl Acad Sci U S A (2015) 0.87
Mammalian Non-CpG Methylation: Stem Cells and Beyond. Biology (Basel) (2014) 0.87
Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation. Am J Physiol Endocrinol Metab (2013) 0.87
Inflammation, HIF-1, and the epigenetics that follows. Mediators Inflamm (2010) 0.87
Aberrant regulation of DNA methylation in amyotrophic lateral sclerosis: a new target of disease mechanisms. Neurotherapeutics (2013) 0.86
Disclosing bias in bisulfite assay: MethPrimers underestimate high DNA methylation. PLoS One (2015) 0.86
A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits. PLoS One (2016) 0.85
PGC-1α Promoter Methylation in Parkinson's Disease. PLoS One (2015) 0.85
Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes? PLoS One (2013) 0.84
Epigenetic mechanisms underlying the link between non-alcoholic fatty liver diseases and nutrition. Nutrients (2014) 0.84
DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? Environ Epigenet (2016) 0.84
The Ups and Downs of Insulin Resistance and Type 2 Diabetes: Lessons from Genomic Analyses in Humans. Curr Cardiovasc Risk Rep (2012) 0.84
DNA Methylation in Skeletal Muscle Stem Cell Specification, Proliferation, and Differentiation. Stem Cells Int (2016) 0.84
Recent progress in genetic and epigenetic research on type 2 diabetes. Exp Mol Med (2016) 0.83
DNA methylation dynamics in muscle development and disease. Front Aging Neurosci (2015) 0.83
Age effect on myocellular remodeling: response to exercise and nutrition in humans. Ageing Res Rev (2011) 0.82
Epigenetic associations of type 2 diabetes and BMI in an Arab population. Clin Epigenetics (2016) 0.82
Temperature affects methylation of the myogenin putative promoter, its expression and muscle cellularity in Senegalese sole larvae. Epigenetics (2013) 0.82
Epigenetic Modifications of the PGC-1α Promoter during Exercise Induced Expression in Mice. PLoS One (2015) 0.81
Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity. Physiol Genomics (2014) 0.81
Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver. Diabetes (2012) 0.81
Human native lipoprotein-induced de novo DNA methylation is associated with repression of inflammatory genes in THP-1 macrophages. BMC Genomics (2011) 0.81
Developmental epigenetics of the murine secondary palate. ILAR J (2012) 0.81
Diabetes Induces Aberrant DNA Methylation in the Proximal Tubules of the Kidney. J Am Soc Nephrol (2015) 0.81
Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. Am J Physiol Endocrinol Metab (2011) 0.81
DNA methylation as a dynamic regulator of development and disease processes: spotlight on the prostate. Epigenomics (2015) 0.81
Epigenetic changes predisposing to type 2 diabetes in intrauterine growth retardation. Front Endocrinol (Lausanne) (2010) 0.81
Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c. Proc Natl Acad Sci U S A (2015) 0.80
Increased Cord Blood Betatrophin Levels in the Offspring of Mothers with Gestational Diabetes. PLoS One (2016) 0.80
Epigenetics of diabetic complications. Expert Rev Endocrinol Metab (2010) 0.80
Metabolic response to 36 hours of fasting in young men born small vs appropriate for gestational age. Diabetologia (2014) 0.80
Mmu-miR-615-3p regulates lipoapoptosis by inhibiting C/EBP homologous protein. PLoS One (2014) 0.80
Pathways to aging: the mitochondrion at the intersection of biological and psychosocial sciences. J Aging Res (2011) 0.80
Nuclear receptors and epigenetic regulation: opportunities for nutritional targeting and disease prevention. Adv Nutr (2014) 0.80
Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. J Neurosci (2016) 0.79
Associations between whole peripheral blood fatty acids and DNA methylation in humans. Sci Rep (2016) 0.79
Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients. Mol Metab (2016) 0.79
A Review of Mitochondrial-derived Fatty Acids in Epigenetic Regulation of Obesity and Type 2 Diabetes. J Nutrit Health Food Sci (2014) 0.79
Lipid exposure elicits differential responses in gene expression and DNA methylation in primary human skeletal muscle cells from severely obese women. Physiol Genomics (2015) 0.79
Effects of non-CpG site methylation on DNA thermal stability: a fluorescence study. Nucleic Acids Res (2015) 0.79
PGC1α -1 Nucleosome Position and Splice Variant Expression and Cardiovascular Disease Risk in Overweight and Obese Individuals. PPAR Res (2014) 0.78
Maternal undernutrition and cardiometabolic disease: a Latin American perspective. BMC Med (2015) 0.78
The potential use of DNA methylation biomarkers to identify risk and progression of type 2 diabetes. Front Endocrinol (Lausanne) (2015) 0.78
Protective role of PGC-1α in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling. PLoS One (2015) 0.78
Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Biol (2013) 4.04
Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release (2006) 3.85
N-terminal pro-B-type natriuretic peptide and long-term mortality in acute coronary syndromes. Circulation (2002) 3.79
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab (2010) 3.46
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem (2003) 3.45
AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest (2006) 3.39
TXNIP regulates peripheral glucose metabolism in humans. PLoS Med (2007) 3.27
Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab (2013) 2.47
Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab (2012) 2.46
Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgery. Eur J Cardiothorac Surg (2011) 2.41
Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. Diabetes (2005) 2.35
Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress. Circulation (2007) 2.26
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity. Nat Genet (2008) 2.14
Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes (2008) 2.03
Glutamate is a positive autocrine signal for glucagon release. Cell Metab (2008) 2.01
Epicardial/Mesothelial cell line retains vasculogenic potential of embryonic epicardium. Circ Res (2003) 2.01
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell (2008) 1.97
The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J Biol Chem (2004) 1.94
T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice. Circ Res (2009) 1.93
Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes (2005) 1.89
Acupuncture for migraine prophylaxis: a randomized controlled trial. CMAJ (2012) 1.87
AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits. Diabetes (2006) 1.85
Overstretching and force-driven strand separation of double-helix DNA. Phys Rev E Stat Nonlin Soft Matter Phys (2004) 1.82
Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts. Circulation (2011) 1.78
A divalent switch drives H-NS/DNA-binding conformations between stiffening and bridging modes. Genes Dev (2010) 1.76
Mechanism of chromosome compaction and looping by the Escherichia coli nucleoid protein Fis. J Mol Biol (2006) 1.73
Role of the CHADS2 score in acute coronary syndromes: risk of subsequent death or stroke in patients with and without atrial fibrillation. Chest (2011) 1.72
Disturbed right ventricular diastolic function in patients with systemic sclerosis: a Doppler tissue imaging study. Chest (2005) 1.70
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. PLoS Biol (2009) 1.61
Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise. Am J Physiol Endocrinol Metab (2004) 1.58
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat Commun (2012) 1.58
Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans. FASEB J (2005) 1.55
MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. J Biol Chem (2007) 1.53
Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways. J Biol Chem (2003) 1.53
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab (2006) 1.48
Sensitive and specific ELISA coated by TpN15-TpN17-TpN47 fusion protein for detection of antibodies to Treponema pallidum. Clin Chem Lab Med (2009) 1.46
Strenuous physical exercise adversely affects monocyte chemotaxis. Thromb Haemost (2010) 1.45
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes (2003) 1.45
Circulating osteoprotegerin levels and long-term prognosis in patients with acute coronary syndromes. J Am Coll Cardiol (2008) 1.45
Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle. Mol Endocrinol (2006) 1.43
Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. J Clin Invest (2007) 1.40
Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle. J Biol Chem (2007) 1.40
Two distinct overstretched DNA states. Nucleic Acids Res (2010) 1.39
Diagnostic and referral delay in patients with aortic stenosis is common and negatively affects outcome. Scand Cardiovasc J (2007) 1.39
Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle. Diabetes (2007) 1.37
Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle. Diabetes (2006) 1.37
Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination. Proc Natl Acad Sci U S A (2011) 1.36
Transition dynamics and selection of the distinct S-DNA and strand unpeeling modes of double helix overstretching. Nucleic Acids Res (2010) 1.35
Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle. Am J Physiol Endocrinol Metab (2003) 1.32
Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep (2013) 1.31
Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity. Diabetes Metab Res Rev (2011) 1.30
Defining a centromere-like element in Bacillus subtilis by Identifying the binding sites for the chromosome-anchoring protein RacA. Mol Cell (2005) 1.29
Changes in exercise-induced gene expression in 5'-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice. Diabetes (2005) 1.29
Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta. Diabetes (2005) 1.28
Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J (2002) 1.28
Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta. Pharmacol Rev (2009) 1.27
Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation. J Biol Chem (2009) 1.27
Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. J Biol Chem (2010) 1.25
Low-force DNA condensation and discontinuous high-force decondensation reveal a loop-stabilizing function of the protein Fis. Phys Rev Lett (2005) 1.23
Acupuncture for treating acute attacks of migraine: a randomized controlled trial. Headache (2009) 1.23
Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury. J Clin Invest (2011) 1.21
Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients. Diabetes (2006) 1.19
Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab (2012) 1.19
Proposed regulation of gene expression by glucose in rodent heart. Gene Regul Syst Bio (2007) 1.18
Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression. J Biol Chem (2006) 1.18
Two distinct overstretched DNA structures revealed by single-molecule thermodynamics measurements. Proc Natl Acad Sci U S A (2012) 1.17
Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle. J Biol Chem (2008) 1.17
Improved high-force magnetic tweezers for stretching and refolding of proteins and short DNA. Biophys J (2011) 1.17
Effects of electroacupuncture on gastric myoelectric activity and substance P in the dorsal vagal complex of rats. Neurosci Lett (2004) 1.17
Evaluation of the value of fasting plasma glucose in the first prenatal visit to diagnose gestational diabetes mellitus in china. Diabetes Care (2012) 1.17
MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways. Am J Physiol Cell Physiol (2004) 1.16
Transcriptional responses of Leptospira interrogans to host innate immunity: significant changes in metabolism, oxygen tolerance, and outer membrane. PLoS Negl Trop Dis (2010) 1.16
Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training. J Physiol (2013) 1.16
Gene silencing H-NS paralogue StpA forms a rigid protein filament along DNA that blocks DNA accessibility. Nucleic Acids Res (2011) 1.15