Age-related clonal hematopoiesis associated with adverse outcomes.

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Published in N Engl J Med on November 26, 2014

Authors

Siddhartha Jaiswal1, Pierre Fontanillas, Jason Flannick, Alisa Manning, Peter V Grauman, Brenton G Mar, R Coleman Lindsley, Craig H Mermel, Noel Burtt, Alejandro Chavez, John M Higgins, Vladislav Moltchanov, Frank C Kuo, Michael J Kluk, Brian Henderson, Leena Kinnunen, Heikki A Koistinen, Claes Ladenvall, Gad Getz, Adolfo Correa, Benjamin F Banahan, Stacey Gabriel, Sekar Kathiresan, Heather M Stringham, Mark I McCarthy, Michael Boehnke, Jaakko Tuomilehto, Christopher Haiman, Leif Groop, Gil Atzmon, James G Wilson, Donna Neuberg, David Altshuler, Benjamin L Ebert

Author Affiliations

1: The authors' affiliations are listed in the Appendix.

Associated clinical trials:

Epigenetics, Vitamin C, and Abnormal Blood Cell Formation - Vitamin C in Patients With Low-Risk Myeloid Malignancies (EVITA) | NCT03682029

Aging of Hematopoietic Stem Cells - Molecular Architecture of Marrow Dysplasia and Clinical Contribution of Ineffective Hematopoiesis to Frailty in the Elderly | NCT03907553

Clonal Hematopoiesis is a Risk Factor for Chemotherapy-Related Complications | NCT04053439

An European Platform for Translational Research in Myelodysplastic Syndromes | NCT04174547

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