Published in Nat Rev Cancer on August 01, 2002
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell (2005) 5.51
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature (2008) 5.00
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell (2009) 4.82
Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res (2008) 3.99
TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets. J Clin Invest (2012) 2.10
PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci U S A (2009) 2.07
Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas. Neuro Oncol (2009) 2.04
Tumor microenvironment and neurofibromatosis type I: connecting the GAPs. Oncogene (2007) 1.97
The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev (2008) 1.93
USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma. Nat Med (2012) 1.93
Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development (2005) 1.85
TWIST is expressed in human gliomas and promotes invasion. Neoplasia (2005) 1.70
MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop. J Clin Invest (2011) 1.60
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol (2008) 1.57
Significant association of multiple human cytomegalovirus genomic Loci with glioblastoma multiforme samples. J Virol (2011) 1.56
MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma. Oncotarget (2014) 1.44
Astrocyte elevated gene-1: a novel target for human glioma therapy. Mol Cancer Ther (2010) 1.39
Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev (2007) 1.38
Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells. J Virol (2007) 1.33
MMP-2 siRNA inhibits radiation-enhanced invasiveness in glioma cells. PLoS One (2011) 1.27
Oncogenic extracellular vesicles in brain tumor progression. Front Physiol (2012) 1.15
Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes Dev (2010) 1.11
GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma. Mol Cancer Res (2009) 1.09
Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway. J Cell Biol (2008) 1.08
Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras. Hum Mol Genet (2006) 1.08
Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma. Cell Cycle (2011) 1.06
Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models. BMB Rep (2011) 1.04
Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safety. Curr Gene Ther (2009) 1.04
Notch signaling in glioblastoma: a developmental drug target? BMC Med (2010) 1.04
ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis. Oncogene (2012) 1.04
MicroRNA-195 inhibits the proliferation of human glioma cells by directly targeting cyclin D1 and cyclin E1. PLoS One (2013) 1.02
Signaling in malignant astrocytomas: role of neural stem cells and its therapeutic implications. Clin Cancer Res (2009) 1.00
Growth of peripheral and central nervous system tumors is supported by cytoplasmic c-Fos in humans and mice. PLoS One (2010) 1.00
Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors. Oncotarget (2015) 1.00
β-Catenin Signalling in Glioblastoma Multiforme and Glioma-Initiating Cells. Chemother Res Pract (2012) 0.99
Gene therapy for brain tumors: basic developments and clinical implementation. Neurosci Lett (2012) 0.98
Gene therapy and targeted toxins for glioma. Curr Gene Ther (2011) 0.97
Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway. BMC Cancer (2012) 0.96
Epidermal growth factor (EGF)-enhanced vascular cell adhesion molecule-1 (VCAM-1) expression promotes macrophage and glioblastoma cell interaction and tumor cell invasion. J Biol Chem (2013) 0.93
Vertebrate animal models of glioma: understanding the mechanisms and developing new therapies. Biochim Biophys Acta (2013) 0.93
Dynamics of chemosensitivity and chromosomal instability in recurrent glioblastoma. Br J Cancer (2007) 0.93
Bmi-1 promotes glioma angiogenesis by activating NF-κB signaling. PLoS One (2013) 0.92
Gliotypic neural stem cells transiently adopt tumorigenic properties during normal differentiation. Stem Cells (2009) 0.90
Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients. BMC Cancer (2008) 0.89
Transcriptional signature of an adult brain tumor in Drosophila. BMC Genomics (2004) 0.88
The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro. Aging Cell (2011) 0.88
Gliomagenesis and the use of neural stem cells in brain tumor treatment. Anticancer Agents Med Chem (2010) 0.86
Cell of origin for malignant gliomas and its implication in therapeutic development. Cold Spring Harb Perspect Biol (2015) 0.85
Somatic alterations in brain tumors. Oncol Rep (2008) 0.85
WNT signaling in glioblastoma and therapeutic opportunities. Lab Invest (2015) 0.84
Brain neoplasms and coagulation-lessons from heterogeneity. Rambam Maimonides Med J (2014) 0.83
Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions. Neuro Oncol (2015) 0.83
A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype. Cell Death Dis (2014) 0.82
Cell of origin determines tumor phenotype in an oncogenic Ras/p53 knockout transgenic model of high-grade glioma. J Neuropathol Exp Neurol (2012) 0.82
Integrated analysis of genome-wide DNA methylation, gene expression and protein expression profiles in molecular subtypes of WHO II-IV gliomas. J Exp Clin Cancer Res (2015) 0.82
NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma. Mol Cancer (2015) 0.81
Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells. Mol Cancer Ther (2013) 0.81
Polish natural bee honeys are anti-proliferative and anti-metastatic agents in human glioblastoma multiforme U87MG cell line. PLoS One (2014) 0.81
Loss of protein-tyrosine phosphatase α (PTPα) increases proliferation and delays maturation of oligodendrocyte progenitor cells. J Biol Chem (2012) 0.80
N-(4-Hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma C6 and RG2 cells. Brain Res (2009) 0.80
The p53-microRNA-34a axis regulates cellular entry receptors for tumor-associated human herpes viruses. Med Hypotheses (2013) 0.80
ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas. BMC Cancer (2013) 0.79
Leukaemia 'firsts' in cancer research and treatment. Nat Rev Cancer (2016) 0.79
Cbx7 is epigenetically silenced in glioblastoma and inhibits cell migration by targeting YAP/TAZ-dependent transcription. Sci Rep (2016) 0.79
Anti-tumour efficacy on glioma models of PHA-848125, a multi-kinase inhibitor able to cross the blood-brain barrier. Br J Pharmacol (2013) 0.78
Processing of primary brain tumor tissue for stem cell assays and flow sorting. J Vis Exp (2012) 0.77
Improved killing of human high-grade glioma cells by combining ionizing radiation with oncolytic parvovirus H-1 infection. J Biomed Biotechnol (2010) 0.77
ROS and Brain Gliomas: An Overview of Potential and Innovative Therapeutic Strategies. Int J Mol Sci (2016) 0.77
'Cut from the same cloth': Shared microsatellite variants among cancers link to ectodermal tissues-neural tube and crest cells. Oncotarget (2015) 0.76
Up-Regulation of microRNA-183 Promotes Cell Proliferation and Invasion in Glioma By Directly Targeting NEFL. Cell Mol Neurobiol (2016) 0.76
Extracellular Vesicles in Brain Tumor Progression. Cell Mol Neurobiol (2016) 0.76
XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis. Oncotarget (2016) 0.75
PI3 kinase pathway regulated miRNome in glioblastoma: identification of miR-326 as a tumour suppressor miRNA. Mol Cancer (2016) 0.75
Mouse models of inherited cancer syndromes. Hematol Oncol Clin North Am (2010) 0.75
Metagenomics: A new horizon in cancer research. Meta Gene (2015) 0.75
Bioinformatics analysis reveals potential candidate drugs for different subtypes of glioma. Neurol Sci (2012) 0.75
Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles. Nano Res (2017) 0.75
Expression of histone acetylases p300 and PCAF in pediatric astrocytomas. Childs Nerv Syst (2013) 0.75
A restricted cell population propagates glioblastoma growth after chemotherapy. Nature (2012) 8.88
Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell (2005) 5.51
Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science (2002) 5.08
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell (2009) 4.82
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron (2008) 4.00
Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res (2008) 3.99
Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci (2009) 2.90
Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell (2012) 2.85
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell (2008) 2.84
Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol (2002) 2.65
Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell (2008) 2.65
Nf1 has an essential role in endothelial cells. Nat Genet (2002) 2.63
ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab (2006) 2.55
Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. Neuron (2004) 2.38
Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol Psychiatry (2006) 2.36
Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res (2003) 2.30
TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses. J Neurosci (2005) 2.21
Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration. J Neurosci (2002) 2.16
Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas. Cell Stem Cell (2009) 2.12
PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci U S A (2009) 2.07
Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial. Lancet Oncol (2012) 1.95
Testis determination requires insulin receptor family function in mice. Nature (2003) 1.94
Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. Proc Natl Acad Sci U S A (2005) 1.93
Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development (2005) 1.85
Development of a steroidogenic factor 1/Cre transgenic mouse line. Genesis (2006) 1.69
A crucial role for Olig2 in white matter astrocyte development. Development (2007) 1.60
Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol Psychiatry (2008) 1.55
Deletion of Nf1 in neurons induces increased axon collateral branching after dorsal root injury. J Neurosci (2007) 1.54
The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell (2008) 1.54
CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors. Cell (2013) 1.53
mRNA expression of ephrins and Eph receptor tyrosine kinases in the neonatal and adult mouse central nervous system. J Neurosci Res (2003) 1.53
miR-132 mediates the integration of newborn neurons into the adult dentate gyrus. PLoS One (2011) 1.52
Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling. Hum Mol Genet (2006) 1.48
Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations. Genesis (2006) 1.43
PTEN signaling in autism spectrum disorders. Curr Opin Neurobiol (2012) 1.43
Temporally regulated expression of Cre recombinase in neural stem cells. Genesis (2005) 1.38
Molecular regulation of visual system development: more than meets the eye. Genes Dev (2007) 1.37
Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis. J Neurosci (2012) 1.34
Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signaling. J Neurosci (2008) 1.32
Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system. Mol Cell Biol (2005) 1.31
Inducible site-specific recombination in neural stem/progenitor cells. Genesis (2009) 1.31
Multiple roles for neurofibromin in skeletal development and growth. Hum Mol Genet (2007) 1.29
Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury. J Neurosci (2011) 1.29
Genetic modeling of gliomas in mice: new tools to tackle old problems. Glia (2011) 1.28
A critical role for dorsal progenitors in cortical myelination. J Neurosci (2006) 1.22
Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage. J Comp Neurol (2006) 1.22
Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. J Exp Med (2012) 1.15
ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation. Clin Cancer Res (2013) 1.15
Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. Mol Neurodegener (2009) 1.10
A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice. Brain Res (2007) 1.09
Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle. Genes Dev (2011) 1.08
Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors. Mol Cell Neurosci (2003) 1.08
Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc Natl Acad Sci U S A (2010) 1.07
The zinc finger transcription factor Klf7 is required for TrkA gene expression and development of nociceptive sensory neurons. Genes Dev (2005) 1.06
Epidermal growth factor receptor signaling pathways are associated with tumorigenesis in the Nf1:p53 mouse tumor model. Cancer Res (2002) 1.06
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice. Blood (2006) 1.06
Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration. Nat Commun (2011) 1.06
Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development. Cancer Res (2011) 1.05
Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models. BMB Rep (2011) 1.04
Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1. Hum Mol Genet (2009) 1.03
Neurofibromin is required for barrel formation in the mouse somatosensory cortex. J Neurosci (2008) 1.03
Effect of p75NTR on the regulation of naturally occurring cell death and retinal ganglion cell number in the mouse eye. Dev Biol (2005) 1.01
Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. Development (2003) 1.01
The tumor suppressor CDKN3 controls mitosis. J Cell Biol (2013) 1.01
Signaling in malignant astrocytomas: role of neural stem cells and its therapeutic implications. Clin Cancer Res (2009) 1.00
Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism. Proc Natl Acad Sci U S A (2013) 0.99
Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development. Proc Natl Acad Sci U S A (2012) 0.99
TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry. J Neurosci (2012) 0.99
Transcription factor Sox11 is essential for both embryonic and adult neurogenesis. Dev Dyn (2013) 0.98
Receptor tyrosine kinase B-mediated excitatory synaptogenesis. Prog Brain Res (2006) 0.95
Neurotrophin-3 is required for appropriate establishment of thalamocortical connections. Neuron (2002) 0.95
NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F. Genes Dev (2008) 0.93
Brn3a and Klf7 cooperate to control TrkA expression in sensory neurons. Dev Biol (2006) 0.92
Neurofibromin modulates adult hippocampal neurogenesis and behavioral effects of antidepressants. J Neurosci (2012) 0.92
The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research. Am J Med Genet A (2012) 0.91
Injury signals cooperate with Nf1 loss to relieve the tumor-suppressive environment of adult peripheral nerve. Cell Rep (2013) 0.91
Role of neurotrophin-4/5 in neural cell death during retinal development and ischemic retinal injury in vivo. Invest Ophthalmol Vis Sci (2005) 0.90
Neurofibromatosis type 1: modeling CNS dysfunction. J Neurosci (2012) 0.89
Ral overactivation in malignant peripheral nerve sheath tumors. Mol Cell Biol (2009) 0.88
TrkB signaling regulates the developmental maturation of the somatosensory cortex. Int J Dev Neurosci (2005) 0.88
Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth. PLoS One (2012) 0.87
The Ras GTPase-activating protein neurofibromin 1 promotes the positive selection of thymocytes. Mol Immunol (2013) 0.85
Differential expression of the four untranslated BDNF exons in the adult mouse brain. J Neurosci Res (2006) 0.85
Ras signaling influences permissiveness of malignant peripheral nerve sheath tumor cells to oncolytic herpes. Am J Pathol (2008) 0.85
Retinoic acid delineates the topography of neuronal plasticity in postnatal cerebral cortex. Eur J Neurosci (2006) 0.85
Back to the future: proceedings from the 2010 NF Conference. Am J Med Genet A (2010) 0.84
Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary. Endocrinology (2005) 0.84
Effects of orchiopexy on congenitally cryptorchid insulin-3 knockout mice. J Urol (2002) 0.83
PTEN knockdown alters dendritic spine/protrusion morphology, not density. J Comp Neurol (2014) 0.82
Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors. Cancer Res (2013) 0.81
Analysis of FMR1 deletion in a subpopulation of post-mitotic neurons in mouse cortex and hippocampus. Autism Res (2014) 0.80
Overactivation of Ras signaling pathway in CD133+ MPNST cells. J Neurooncol (2012) 0.80
BDNF activated TrkB/IRR receptor chimera promotes survival of sympathetic neurons through Ras and PI-3 kinase signaling. J Neurosci Res (2002) 0.79
Mice lacking neurofibromin develop gastric hyperplasia. Am J Physiol Gastrointest Liver Physiol (2009) 0.79
Hormonal regulation of male reproductive tract development. Ann N Y Acad Sci (2005) 0.78
Stem cells in brain tumor development. Curr Top Dev Biol (2011) 0.78
The insulin-3 gene: lack of a genetic basis for human cryptorchidism. J Urol (2002) 0.77
Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight. Obesity (Silver Spring) (2013) 0.77
A motor driving PTEN. Nat Cell Biol (2009) 0.77