Published in J Neurosci on April 13, 2005
Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11
Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. Annu Rev Neurosci (2008) 5.12
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell (2009) 4.82
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron (2008) 4.00
Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res (2008) 3.99
Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology (2009) 3.26
Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci (2009) 2.90
Dynamic aspects of CNS synapse formation. Annu Rev Neurosci (2007) 2.47
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci U S A (2008) 2.09
Brain-derived neurotrophic factor and the development of structural neuronal connectivity. Dev Neurobiol (2010) 2.04
Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization. Anesthesiology (2011) 1.95
BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nat Rev Neurosci (2013) 1.91
Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development. Neuron (2013) 1.79
Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function. J Neurosci (2009) 1.58
Guidance molecules in synapse formation and plasticity. Cold Spring Harb Perspect Biol (2010) 1.56
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses. Exp Brain Res (2009) 1.42
BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin-beta-catenin interactions. J Cell Biol (2006) 1.41
Control and function of the homeostatic sleep response by adenosine A1 receptors. J Neurosci (2009) 1.40
An essential role for histone deacetylase 4 in synaptic plasticity and memory formation. J Neurosci (2012) 1.35
Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signaling. J Neurosci (2008) 1.32
Synaptic cell adhesion. Cold Spring Harb Perspect Biol (2012) 1.30
Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus. Proc Natl Acad Sci U S A (2006) 1.20
Loss of histone deacetylase 2 improves working memory and accelerates extinction learning. J Neurosci (2013) 1.18
Autocrine BDNF-TrkB signalling within a single dendritic spine. Nature (2016) 1.16
Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. J Exp Med (2012) 1.15
Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity. Nature (2016) 1.14
Impairment of TrkB-PSD-95 signaling in Angelman syndrome. PLoS Biol (2013) 1.13
Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc Natl Acad Sci U S A (2010) 1.07
Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration. Nat Commun (2011) 1.06
Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. Mol Autism (2013) 1.04
Sustained expression of brain-derived neurotrophic factor is required for maintenance of dendritic spines and normal behavior. Neuroscience (2012) 1.04
Neurofibromin is required for barrel formation in the mouse somatosensory cortex. J Neurosci (2008) 1.03
Transient receptor potential channels as novel effectors of brain-derived neurotrophic factor signaling: potential implications for Rett syndrome. Pharmacol Ther (2006) 1.03
Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro. Mol Biol Cell (2008) 1.01
TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine. Neuropharmacology (2010) 1.01
Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development. Proc Natl Acad Sci U S A (2012) 0.99
TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry. J Neurosci (2012) 0.99
Regulation of the actin cytoskeleton in dendritic spines. Adv Exp Med Biol (2012) 0.98
Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proc Natl Acad Sci U S A (2014) 0.98
Secreted factors as synaptic organizers. Eur J Neurosci (2010) 0.94
The BDNF effects on dendritic spines of mature hippocampal neurons depend on neuronal activity. Front Synaptic Neurosci (2014) 0.93
Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan. Neuroscience (2012) 0.93
Requirement of TrkB for synapse elimination in developing cerebellar Purkinje cells. Brain Cell Biol (2007) 0.92
Retinal TrkB receptors regulate neural development in the inner, but not outer, retina. Mol Cell Neurosci (2008) 0.88
Essential role for vav Guanine nucleotide exchange factors in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity. J Neurosci (2011) 0.88
LIM kinase 1 (LIMK1) interacts with tropomyosin-related kinase B (TrkB) and Mediates brain-derived neurotrophic factor (BDNF)-induced axonal elongation. J Biol Chem (2012) 0.87
Divergent roles of p75NTR and Trk receptors in BDNF's effects on dendritic spine density and morphology. Neural Plast (2012) 0.87
Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation. Mol Cell Neurosci (2013) 0.86
BDNF and the maturation of posttranscriptional regulatory networks in human SH-SY5Y neuroblast differentiation. Front Cell Neurosci (2014) 0.83
Postnatal Loss of Mef2c Results in Dissociation of Effects on Synapse Number and Learning and Memory. Biol Psychiatry (2015) 0.81
Mice lacking TrkB in parvalbumin-positive cells exhibit sexually dimorphic behavioral phenotypes. Behav Brain Res (2014) 0.81
Ethanol alters BDNF-induced Rho GTPase activation in axonal growth cones. Alcohol Clin Exp Res (2011) 0.80
Complexity of trophic factor signaling in experimental autoimmune encephalomyelitis: differential expression of neurotrophic and gliotrophic factors. J Neuroimmunol (2013) 0.80
Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function. J Neurosci (2014) 0.79
Histone deacetylase 3 is necessary for proper brain development. J Biol Chem (2014) 0.79
NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development. Genes Dev (2014) 0.79
Neuroprotection, Growth Factors and BDNF-TrkB Signalling in Retinal Degeneration. Int J Mol Sci (2016) 0.78
Loss of Nogo receptor homolog NgR2 alters spine morphology of CA1 neurons and emotionality in adult mice. Front Behav Neurosci (2014) 0.78
TrkB Signaling in Dorsal Raphe Nucleus is Essential for Antidepressant Efficacy and Normal Aggression Behavior. Neuropsychopharmacology (2016) 0.77
Chronic Fluoxetine Induces the Enlargement of Perforant Path-Granule Cell Synapses in the Mouse Dentate Gyrus. PLoS One (2016) 0.77
TrkB downregulation is required for dendrite retraction in developing neurons of chicken nucleus magnocellularis. J Neurosci (2012) 0.77
Star Trk(B): the astrocyte path to neurodegeneration. Cell Cycle (2012) 0.75
A restricted cell population propagates glioblastoma growth after chemotherapy. Nature (2012) 8.88
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature (2011) 6.40
Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11
SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science (2002) 5.69
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell (2005) 5.51
Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science (2002) 5.08
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell (2009) 4.82
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32
An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmission. Neuron (2005) 4.05
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron (2008) 4.00
Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res (2008) 3.99
Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci (2009) 2.90
Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell (2012) 2.85
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell (2008) 2.84
Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol (2002) 2.65
Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell (2008) 2.65
Nf1 has an essential role in endothelial cells. Nat Genet (2002) 2.63
ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab (2006) 2.55
The molecular and genetic basis of neurological tumours. Nat Rev Cancer (2002) 2.41
Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. Neuron (2004) 2.38
Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol Psychiatry (2006) 2.36
Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res (2003) 2.30
MeCP2-dependent transcriptional repression regulates excitatory neurotransmission. Curr Biol (2006) 2.25
Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation. J Neurosci (2008) 2.18
Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration. J Neurosci (2002) 2.16
Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas. Cell Stem Cell (2009) 2.12
Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol (2004) 2.11
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci U S A (2008) 2.09
Vti1a identifies a vesicle pool that preferentially recycles at rest and maintains spontaneous neurotransmission. Neuron (2012) 2.08
Spontaneous and evoked glutamate release activates two populations of NMDA receptors with limited overlap. J Neurosci (2008) 2.08
PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci U S A (2009) 2.07
Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis. Neuron (2009) 2.03
Perinatal exposure to bisphenol a alters early adipogenesis in the rat. Environ Health Perspect (2009) 1.98
Selective capability of SynCAM and neuroligin for functional synapse assembly. J Neurosci (2005) 1.97
Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial. Lancet Oncol (2012) 1.95
Testis determination requires insulin receptor family function in mice. Nature (2003) 1.94
Loss of Insl3: a potential predisposing factor for testicular torsion. J Urol (2010) 1.93
Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. Proc Natl Acad Sci U S A (2005) 1.93
Development of vesicle pools during maturation of hippocampal synapses. J Neurosci (2002) 1.87
Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development (2005) 1.85
Pancreatic insulin content regulation by the estrogen receptor ER alpha. PLoS One (2008) 1.81
Cellular source and mechanisms of high transcriptome complexity in the mammalian testis. Cell Rep (2013) 1.79
Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A (2007) 1.74
Development of a steroidogenic factor 1/Cre transgenic mouse line. Genesis (2006) 1.69
Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion. J Neurosci (2006) 1.68
Reelin modulates NMDA receptor activity in cortical neurons. J Neurosci (2005) 1.65
Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmission. J Neurosci (2010) 1.62
A crucial role for Olig2 in white matter astrocyte development. Development (2007) 1.60
Fast vesicle recycling supports neurotransmission during sustained stimulation at hippocampal synapses. J Neurosci (2002) 1.59
Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function. J Neurosci (2009) 1.58
Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol Psychiatry (2008) 1.55
Deletion of Nf1 in neurons induces increased axon collateral branching after dorsal root injury. J Neurosci (2007) 1.54
The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell (2008) 1.54
CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors. Cell (2013) 1.53
mRNA expression of ephrins and Eph receptor tyrosine kinases in the neonatal and adult mouse central nervous system. J Neurosci Res (2003) 1.53
miR-132 mediates the integration of newborn neurons into the adult dentate gyrus. PLoS One (2011) 1.52
Differential regulation of spontaneous and evoked neurotransmitter release at central synapses. Curr Opin Neurobiol (2011) 1.52
Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. EMBO J (2005) 1.49
Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling. Hum Mol Genet (2006) 1.48
Soy, phytoestrogens and metabolism: A review. Mol Cell Endocrinol (2009) 1.47
Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations. Genesis (2006) 1.43
Acute suppression of spontaneous neurotransmission drives synaptic potentiation. J Neurosci (2013) 1.43
Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission. J Neurophysiol (2007) 1.43
PTEN signaling in autism spectrum disorders. Curr Opin Neurobiol (2012) 1.43
In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. PLoS One (2012) 1.40
Temporally regulated expression of Cre recombinase in neural stem cells. Genesis (2005) 1.38
Molecular regulation of visual system development: more than meets the eye. Genes Dev (2007) 1.37
Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol (2008) 1.37
Cholesterol-dependent balance between evoked and spontaneous synaptic vesicle recycling. J Physiol (2006) 1.35
An essential role for histone deacetylase 4 in synaptic plasticity and memory formation. J Neurosci (2012) 1.35
microRNAs in the testis: building up male fertility. J Androl (2009) 1.34
Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis. J Neurosci (2012) 1.34
Reelin signaling antagonizes beta-amyloid at the synapse. Proc Natl Acad Sci U S A (2009) 1.32
Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signaling. J Neurosci (2008) 1.32
Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system. Mol Cell Biol (2005) 1.31
Inducible site-specific recombination in neural stem/progenitor cells. Genesis (2009) 1.31
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission. Nat Neurosci (2012) 1.30
Multiple roles for neurofibromin in skeletal development and growth. Hum Mol Genet (2007) 1.29
Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling. EMBO J (2003) 1.29
Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury. J Neurosci (2011) 1.29
The molecular chaperone Hsp90α is required for meiotic progression of spermatocytes beyond pachytene in the mouse. PLoS One (2010) 1.28
Genetic modeling of gliomas in mice: new tools to tackle old problems. Glia (2011) 1.28
NMDA receptor activation by spontaneous glutamatergic neurotransmission. J Neurophysiol (2009) 1.28
PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development (2008) 1.23
A critical role for dorsal progenitors in cortical myelination. J Neurosci (2006) 1.22
The impact of MeCP2 loss- or gain-of-function on synaptic plasticity. Neuropsychopharmacology (2012) 1.22
Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage. J Comp Neurol (2006) 1.22
Ca²⁺ influx slows single synaptic vesicle endocytosis. J Neurosci (2011) 1.20
PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation. J Biol Chem (2009) 1.20
Dicer is required for haploid male germ cell differentiation in mice. PLoS One (2011) 1.20
A phytoestrogen-rich diet increases energy expenditure and decreases adiposity in mice. Environ Health Perspect (2007) 1.19
A mouse model for MeCP2 duplication syndrome: MeCP2 overexpression impairs learning and memory and synaptic transmission. J Neurosci (2012) 1.18
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev (2010) 1.17
Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism. Diabetes (2008) 1.17