Published in J Immunol on August 15, 2002
Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev (2010) 4.48
Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc Natl Acad Sci U S A (2003) 2.64
Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts. Arthritis Res Ther (2007) 1.55
Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut (2005) 1.55
Neural immune pathways and their connection to inflammatory diseases. Arthritis Res Ther (2003) 1.40
Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis. Arthritis Res Ther (2005) 1.05
Apoptosis of rheumatoid arthritis fibroblast-like synoviocytes: possible roles of nitric oxide and the thioredoxin 1. Mediators Inflamm (2013) 0.94
The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases. Arthritis Res Ther (2009) 0.86
Kynurenic acid, an endogenous constituent of rheumatoid arthritis synovial fluid, inhibits proliferation of synoviocytes in vitro. Rheumatol Int (2005) 0.85
Anti-interleukin-15 prevents arthritis in Borrelia-vaccinated and -infected mice. Clin Vaccine Immunol (2006) 0.85
Interleukin-15 enhances proliferation and chemokine secretion of human follicular dendritic cells. Immunology (2010) 0.84
IL-15 expression on RA synovial fibroblasts promotes B cell survival. PLoS One (2012) 0.81
Serum concentration of interleukin 15, interleukin 2 receptor and TNF receptor in patients with polymyositis and dermatomyositis: correlation to disease activity. Rheumatol Int (2010) 0.81
Immunomodulatory activity of a Chinese herbal drug Yi Shen Juan Bi in adjuvant arthritis. Indian J Pharmacol (2010) 0.81
Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts. Immunology (2014) 0.80
[Pathogenesis of RA: more than just immune cells]. Z Rheumatol (2005) 0.79
Interleukin-12 to interleukin 'infinity': the rationale for future therapeutic cytokine targeting. Springer Semin Immunopathol (2006) 0.78
[Expression analyses for rheumatoid arthritis]. Z Rheumatol (2008) 0.77
Smooth muscle homeostasis in human atherosclerotic plaques through interleukin 15 signalling. Int J Clin Exp Pathol (2011) 0.75
AAA-ATPase p97 suppresses apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts. Oncotarget (2016) 0.75
[Intracellular signaling pathways of synovial fibroblasts in rheumatoid arthritis]. Z Rheumatol (2007) 0.75
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature (2006) 46.36
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med (2007) 10.00
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol (2005) 7.80
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med (2007) 7.73
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol (2008) 6.41
Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature (2006) 5.49
Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol (2003) 5.07
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol (2003) 4.66
Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol (2003) 3.86
TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol (2005) 3.00
Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity (2003) 2.80
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature (2011) 2.44
T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res (2009) 2.43
Clinical islet transplantation: advances and immunological challenges. Nat Rev Immunol (2004) 2.40
TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol (2009) 2.00
Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion. Blood (2008) 1.91
Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A (2008) 1.83
Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells. Eur J Immunol (2007) 1.70
CD39 and control of cellular immune responses. Purinergic Signal (2007) 1.68
Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. J Clin Invest (2008) 1.66
Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med (2005) 1.63
In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response. Nat Med (2010) 1.63
TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol (2008) 1.58
Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation. Blood (2003) 1.57
Tracking the immunoregulatory mechanisms active during allograft tolerance. J Immunol (2002) 1.50
High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappa B ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor alpha treatment. Arthritis Rheum (2002) 1.44
Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol (2008) 1.41
Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs. Gastroenterology (2010) 1.39
Stimulating PD-1-negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival. Transplantation (2003) 1.38
Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells. Eur J Immunol (2008) 1.36
Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A (2007) 1.35
Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6. Cell Cycle (2009) 1.34
Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol (2004) 1.33
Critical role of OX40 in CD28 and CD154-independent rejection. J Immunol (2004) 1.19
Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. J Immunol (2006) 1.19
CD154 on the surface of CD4+CD25+ regulatory T cells contributes to skin transplant tolerance. Transplantation (2003) 1.19
Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest (2012) 1.15
Significance of bone marrow edema in pathogenesis of rheumatoid arthritis. Pol J Radiol (2013) 1.14
The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors. Arthritis Res Ther (2007) 1.13
Taurine and inflammatory diseases. Amino Acids (2012) 1.12
Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J Clin Invest (2002) 1.12
Human CD4 memory T cells can become CD4+IL-9+ T cells. PLoS One (2010) 1.12
Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size. J Immunol (2002) 1.12
The balance of deletion and regulation in allograft tolerance. Immunol Rev (2003) 1.11
Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery. Mol Pharm (2010) 1.11
Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells. FASEB J (2005) 1.10
Elevated number of recently activated T cells in bone marrow of patients with rheumatoid arthritis: a role for interleukin 15? Ann Rheum Dis (2010) 1.10
Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol. J Immunol (2005) 1.08
On the intraoperative molecular status of renal allografts after vascular reperfusion and clinical outcomes. J Am Soc Nephrol (2005) 1.07
Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens. Immunology (2009) 1.04
Airway epithelial IL-15 transforms monocytes into dendritic cells. Am J Respir Cell Mol Biol (2007) 1.03
Functional TLR9 modulates bone marrow B cells from rheumatoid arthritis patients. Eur J Immunol (2009) 1.00
Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival. Proc Natl Acad Sci U S A (2012) 0.98
Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. Blood (2012) 0.98
Regulation of T cell dependent immune responses by TIM family members. Philos Trans R Soc Lond B Biol Sci (2005) 0.96
Requirements for induction and maintenance of peripheral tolerance in stringent allograft models. Proc Natl Acad Sci U S A (2005) 0.96
Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation. J Immunol (2009) 0.96
Donor-specific antibody levels and three generations of crossmatches to predict antibody-mediated rejection in kidney transplantation. Transplantation (2010) 0.95
Routes to transplant tolerance versus rejection; the role of cytokines. Immunity (2004) 0.95
Expression of protective genes in human renal allografts: a regulatory response to injury associated with graft rejection. Transplantation (2002) 0.95
TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77. Sci Signal (2012) 0.94
Neural progenitors derived from human embryonic stem cells are targeted by allogeneic T and natural killer cells. J Cell Mol Med (2009) 0.93
Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis. J Am Soc Nephrol (2012) 0.92
Influence of direct and indirect allorecognition pathways on CD4+CD25+ regulatory T-cell function in transplantation. Transpl Int (2007) 0.92
Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells. Eur J Immunol (2014) 0.91
Activated intrarenal transcription of CTL-effectors and TGF-beta1 in children with focal segmental glomerulosclerosis. Kidney Int (2002) 0.90
Evidence for cyclin D3 as a novel target of rapamycin in human T lymphocytes. J Biol Chem (2004) 0.90
In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis. Am J Respir Cell Mol Biol (2008) 0.89
Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory. J Clin Invest (2014) 0.88
Anti-inflammatory effects of taurine derivatives (taurine chloramine, taurine bromamine, and taurolidine) are mediated by different mechanisms. Adv Exp Med Biol (2006) 0.87
The role of TNF-α in mice with type 1- and 2- diabetes. PLoS One (2012) 0.87
Humoral and cellular rejection after combined liver-kidney transplantation in low immunologic risk recipients. Transpl Int (2008) 0.87
An antagonist mutant IL-15/Fc promotes transplant tolerance. Transplantation (2006) 0.87
On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response. J Immunol (2002) 0.86
The Role of EGFR Inhibitors in the Treatment of Metastatic Anal Canal Carcinoma: A Case Series. J Oncol (2011) 0.86
Acute rejection in vascularized composite allotransplantation. Curr Opin Organ Transplant (2014) 0.86
Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger. Int Immunol (2004) 0.85
Intra-articular adipose-derived mesenchymal stem cells from rheumatoid arthritis patients maintain the function of chondrogenic differentiation. Rheumatology (Oxford) (2012) 0.85
Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label. PLoS One (2013) 0.84
CD8(+) T cells resistant to costimulatory blockade are controlled by an antagonist interleukin-15/Fc protein. Transplantation (2006) 0.84
Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms. J Immunol (2003) 0.84
The complement dependent cytotoxicity (CDC) immune effector mechanism contributes to anti-CD154 induced immunosuppression. Transplantation (2002) 0.84
Inhibition of T cell-dependent and RANKL-dependent osteoclastogenic processes associated with high levels of bone mass in interleukin-15 receptor-deficient mice. Arthritis Rheum (2010) 0.82
Gene expression profiling of the donor kidney at the time of transplantation predicts clinical outcomes 2 years after transplantation. Hum Immunol (2010) 0.82
Immunological tolerance and liver transplantation. J Hepatol (2004) 0.82
Lactobacillus rhamnosus exopolysaccharide ameliorates arthritis induced by the systemic injection of collagen and lipopolysaccharide in DBA/1 mice. Arch Immunol Ther Exp (Warsz) (2012) 0.82
Postoperative evaluation of plasma interleukin-6 concentration in patients after total hip arthroplasty. Ortop Traumatol Rehabil (2006) 0.81
Innate immunity for better or worse govern the allograft response. Curr Opin Organ Transplant (2015) 0.81
Natural killer cell receptor--repertoire and functions after induction therapy by polyclonal rabbit anti-thymocyte globulin in unsensitized kidney transplant recipients. Clin Immunol (2010) 0.81
Taurine haloamines and heme oxygenase-1 cooperate in the regulation of inflammation and attenuation of oxidative stress. Adv Exp Med Biol (2009) 0.81
[Prevalence of autoantibodies directed against 1,25(OH)2D3 in patients with systemic lupus erythematosus]. Pol Merkur Lekarski (2010) 0.81
The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children. PLoS One (2013) 0.80
Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance. Int Immunol (2006) 0.80
Cytokines in the treatment and prevention of autoimmune responses-a role of IL-15. Adv Exp Med Biol (2003) 0.79
Selective inhibition of cyclooxygenase 2-generated prostaglandin E2 synthesis in rheumatoid arthritis synoviocytes by taurine chloramine. Arthritis Rheum (2003) 0.79
Rapamycin generates graft-homing murine suppressor CD8(+) T cells that confer donor-specific graft protection. Cell Transplant (2011) 0.79
In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFbeta, but has no immediate effect on Foxp3. Transpl Int (2008) 0.79
Proteomic analysis of the allograft response. Transplantation (2006) 0.79